公开(公告)号：WO2004006989A3

公开(公告)日：2004-03-25

申请号：PCT/US0322161

申请日：2003-07-15

Applicant: APPLIED MED RESOURCES ,  DULAK GARY R ,  CLAYMAN RALPH V

Inventor： DULAK GARY R ,  CLAYMAN RALPH V

IPC: A61M20060101 ,  A61M25/00 ,  A61M25/06

CPC classification number: A61M25/0662 ,  A61M25/0009 ,  A61M25/0017

Abstract: A ureteral access sheath (10) adapted for insertion into a urethra includes an elongate tube (14) extending between a proximal end and a distal end. A handle assembly is disposed at the proximal end and includes enlarged portions (18), which inhibit migration of the sheath into the urethra. The enlarged portions are shaped like the bell of a horn with a concave, distally facing outer surface and a convex, proximally-facing inner surface. The inner surface functions as a funnel while the outer surface is sized and configured to receive adjacent fingers of a user's hand held in its natural position. In an associated method, this shape of the handle assembly facilitates maintaining the sheath in a stationary position during insertion and removal of instrumentation. The handle assembly can be movable on the tube to facilitate variation of the sheath link in situ.

Abstract translation: 适于插入尿道的输尿管通路护套（10）包括在近端和远端之间延伸的细长管（14）。 手柄组件设置在近端处并且包括放大的部分（18），其抑制护套向尿道的迁移。 扩大部分的形状类似喇叭的钟形，具有凹面的，面向远端的外表面和凸起的面向近侧的内表面。 内表面用作漏斗，而外表面的尺寸和构造适于接纳保持在其自然位置的用户手的相邻手指。 在相关联的方法中，手柄组件的这种形状便于在插入和移除仪器时将护套保持在静止位置。 手柄组件可以在管上移动以便于原位将护套连接件变化。

公开(公告)号：WO1997017094A1

公开(公告)日：1997-05-15

申请号：PCT/US1996017795

申请日：1996-11-06

Applicant: BOSTON SCIENTIFIC CORPORATION ,  CLAYMAN, Ralph, V. ,  DASSA, Alyssa, J. ,  FISHBEIN, Christopher ,  GODSHALL, Douglas, E. ,  WHITMORE, Willet, F. III

Inventor： BOSTON SCIENTIFIC CORPORATION

IPC: A61M05/00

CPC classification number: A61F2/94 ,  A61B2017/003 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/00791 ,  A61F2002/048 ,  A61F2220/0008 ,  A61F2220/005 ,  A61M27/008

Abstract: This invention is a ureteral stent (100) for assisting movement of urine along a patient's ureter and into the patient's bladder. The stent (100) includes an elongated tubular segment (130) extending toward the bladder from a kidney end region for placement in the renal cavity to a bladder end region. A central lumen (260) connects at least one opening (127) at the first end region to at least one opening in the bladder end region. At least one flexible tail (110) is attached to the bladder end region of the tubular segment (130) at a point outside the bladder so as to receive urine from the opening in the bladder end region of the tubular segment (130) and to transport urine from there across the ureter/bladder junction and into the bladder. The tail (110) includes an elongated external urine transport surface sized and configured to transport urine along the ureter. The urine transporting surface is sized and configured to extend along at least part of the ureter, across the ureter/bladder junction, and from there into the bladder.

Abstract translation: 本发明是一种输尿管支架（100），用于辅助尿液沿着患者输尿管运动并进入患者膀胱。 支架（100）包括从肾端部区域向膀胱延伸的细长管状区段（130），用于放置在肾腔中至膀胱端部区域。 中心腔（260）将第一端部区域处的至少一个开口（127）连接到膀胱端部区域中的至少一个开口。 至少一个柔性尾部（110）在囊状物外部的点处附接到管状区段（130）的膀胱端部区域，以便从管状区段（130）的膀胱端部区域中的开口接收尿液，并且 从那里输尿管输尿管/膀胱交界处并进入膀胱。 尾部（110）包括细长的外部尿液输送表面，其大小和构造成沿着输尿管输送尿液。 尿液输送表面的尺寸和构造尺寸沿着输尿管的至少一部分延伸穿过输尿管/膀胱结，并从那里进入膀胱。

公开(公告)号：WO2022201161A1

公开(公告)日：2022-09-29

申请号：PCT/IL2022/050327

申请日：2022-03-24

Applicant: CLAYMAN, Ralph V. ,  JIANG, Pengbo ,  SCHOENBERG, Mark ,  TSIPORI, Omer

Inventor： CLAYMAN, Ralph V. ,  JIANG, Pengbo ,  SCHOENBERG, Mark ,  TSIPORI, Omer

IPC: A61K31/722 ,  A61K9/00 ,  A61P13/04 ,  A61L24/00 ,  A61B17/22 ,  A61K47/10

Abstract: Provided herein are methods for treating nephrolithiasis and protecting the urothelium and inner lining of the kidney from thermal damage during lithotripsy by use of a thermosensitive bio-adhesive hydrogel. The described method dramatically improved the efficiency and effectiveness of stone clearance compared to conventional techniques while providing protection to the urothelium from potentially damaging temperature spikes.

公开(公告)号：WO2004006989A2

公开(公告)日：2004-01-22

申请号：PCT/US2003/022161

申请日：2003-07-15

Applicant: APPLIED MEDICAL RESOURCES CORPORATION ,  DULAK, Gary, R. ,  CLAYMAN, Ralph, V.

Inventor： DULAK, Gary, R. ,  CLAYMAN, Ralph, V.

IPC: A61M

CPC classification number: A61M25/0662 ,  A61M25/0009 ,  A61M25/0017

Abstract: A ureteral access sheath adapted for insertion into a urethra includes an elongate tube extending between a proximal end and a distal end. A handle assembly is disposed at the proximal end and includes enlarged portions which inhibit migration of the sheath into the urethra. The enlarged portions are shaped like the bell of a horn with a concave, distally-facing outer surface and a convex, proximally-facing inner surface. The inner surface functions as a funnel while the outer surface is sized and configured to receive adjacent fingers of a user's hand held in its natural position. In an associated method, this shape of the handle assembly facilitates maintaining the sheath in a stationary position during insertion and removal of instrumentation. The handle assembly can be movable on the tube to facilitate variation of the sheath link in situ .

Abstract translation: 适于插入尿道的输尿管通路护套包括在近端和远端之间延伸的细长管。 手柄组件设置在近端处，并且包括抑制鞘进入尿道的迁移的扩大部分。 扩大部分的形状像喇叭的钟形，具有凹面的朝向外侧的外表面和朝向内侧的凸面的内表面。 内表面用作漏斗，而外表面的尺寸和构造适于接纳保持在其自然位置的用户手的相邻手指。 在相关联的方法中，手柄组件的这种形状便于在插入和移除仪器时将护套保持在静止位置。 手柄组件可以在管上移动以便于原位将护套连接件变化。

公开(公告)号：WO03033044A3

公开(公告)日：2003-10-09

申请号：PCT/US0218975

申请日：2002-06-14

Applicant: APPLIED MED RESOURCES ,  CLAYMAN RALPH V ,  HILAL NABIL ,  PINGLETON EDWARD D ,  EWERS RICHARD C

Inventor： CLAYMAN RALPH V ,  HILAL NABIL ,  PINGLETON EDWARD D ,  EWERS RICHARD C

IPC: A61B17/221 ,  A61B1/00 ,  A61B1/018 ,  A61B17/22 ,  A61M20060101 ,  A61M1/00

CPC classification number: A61B1/018 ,  A61B17/221 ,  A61B2017/22072 ,  A61B2017/2212

Abstract: A medical device for viewing inside a body and for retrieving an object from a location within the body, the medical device comprising an endoscope (32) having a tube defining a working channel (36) and a basket (48) engageable with the object. In one embodiment of the invention, the basket (48) does not require a sheath and is disposed through the working channel such that the endoscope operates to contain or activate the sheathless basket. In another embodiment of the invention, a single push wire (66) with a collar (64) at its end is used in place of a sheath to control the opening and closing of the basket. In another embodiment of the invention, a tapered and funnel-shaped sheath (70) surrounding the basket is used to contain or activate the basket. The invention minimizes the basket crossing profile so as to improve fluid flow in the working channel.

Abstract translation: 一种用于在体内观察并用于从身体内的位置检索物体的医疗装置，所述医疗装置包括内窥镜（32），所述内窥镜具有限定工作通道（36）的管和与物体接合的筐（48）。 在本发明的一个实施例中，筐（48）不需要护套并且通过工作通道设置，使得内窥镜操作以容纳或激活无鞘筐。 在本发明的另一个实施例中，使用在其端部具有套环（64）的单个推进线（66）代替护套来控制篮子的打开和关闭。 在本发明的另一个实施例中，围绕篮子的锥形和漏斗形护套（70）用于容纳或激活筐。 本发明使筐横向轮廓最小化，以便改善工作通道中的流体流动。

公开(公告)号：WO2003033050A1

公开(公告)日：2003-04-24

申请号：PCT/US2002/027923

申请日：2002-08-29

Applicant: APPLIED MEDICAL RESOURCES CORPORATION ,  LANDMAN, Jaime ,  CLAYMAN, Ralph, V. ,  EWERS, Richard, C.

Inventor： LANDMAN, Jaime ,  CLAYMAN, Ralph, V. ,  EWERS, Richard, C.

IPC: A61M1/00

CPC classification number: A61M25/007 ,  A61M25/0032 ,  A61M25/0041 ,  A61M25/0068 ,  A61M27/008 ,  A61M31/00 ,  A61M2025/0004 ,  A61M2025/0034 ,  A61M2025/0073 ,  A61M2025/0681 ,  A61M2205/3331 ,  A61M2210/1082

Abstract: A high-flow low-pressure irrigation system (10) for directing a fluid to and recovering the fluid from an area within a body, the irrigation system (10) comprising a sheath (37) and a flexible catheter (20) disposed in the sheath (37). The catheter (20) comprises a plurality of apertures (26) at a distal pigtail portion (28). The fluid is directed through the apertures (26) and recovered through the sheath (37). Renal applications include alkaline irrigation for dissolution of uric acid stones, chemo-dissolution of cystine stones, irrigation with chemotherapy drugs after ureteroscopic tumor management, antibiotic irrigation for severe infection (e.g., fungal and bacterial), and irrigation of thrombotic agents (Alum or direct delivery of Amicar for renal bleeding).

Abstract translation: 一种用于将流体引导到身体内的区域并从其中回收流体的高流量低压灌溉系统（10），所述灌溉系统（10）包括护套（37）和柔性导管（20），所述柔性导管 护套（37）。 导管（20）包括在远端猪尾部分（28）处的多个孔（26）。 流体被引导通过孔（26）并通过护套（37）回收。 肾脏应用包括尿液结石的碱性灌洗，胱氨酸结石的化学溶解，输尿管镜肿瘤治疗后的化学药物灌注，严重感染的抗生素灌注（例如真菌和细菌）以及血栓形成剂的灌注（Alum或直接 交付Amicar用于肾脏出血）。

公开(公告)号：WO2003033044A2

公开(公告)日：2003-04-24

申请号：PCT/US2002/018975

申请日：2002-06-14

Applicant: APPLIED MEDICAL RESOURCES CORPORATION ,  CLAYMAN, Ralph, V. ,  HILAL, Nabil ,  PINGLETON, Edward, D. ,  EWERS, Richard, C.

Inventor： CLAYMAN, Ralph, V. ,  HILAL, Nabil ,  PINGLETON, Edward, D. ,  EWERS, Richard, C.

IPC: A61M

CPC classification number: A61B1/018 ,  A61B17/221 ,  A61B2017/22072 ,  A61B2017/2212

Abstract: A medical device for viewing inside a body and for retrieving an object from a location within the body, the medical device comprising an endoscope having a tube defining a working channel and a basket engageable with the object. In one embodiment of the invention, the basket does not require a sheath and is disposed through the working channel such that the endoscope operates to contain or activate the sheathless basket. In another embodiment of the invention, a single push wire with a collar at its end is used in place of a sheath to control the opening and closing of the basket. In another embodiment of the invention, a tapered and funnel-shaped sheath surrounding the basket is used to contain or activate the basket. The invention minimizes the basket crossing profile so as to improve fluid flow in the working channel.

Abstract translation: 一种用于在体内观察并用于从身体内的位置检索物体的医疗装置，所述医疗装置包括具有限定工作通道的管和可与所述物体接合的篮的内窥镜。 在本发明的一个实施例中，篮子不需要护套并且通过工作通道设置，使得内窥镜操作以容纳或激活无鞘篮。 在本发明的另一个实施例中，使用在其端部具有套环的单个推动线代替护套来控制筐的打开和关闭。 在本发明的另一个实施例中，围绕篮子的锥形和漏斗形护套用于容纳或激活筐。 本发明使筐横向轮廓最小化，以便改善工作通道中的流体流动。