Abstract:
Described herein are compositions for purging the GI tract of a subject together with methods of manufacture of said compositions. In various embodiments, compositions for purging the GI tract of a subject may comprise USP food ingredients and USP/NF grade chemicals mixed together to form homogeneous edible mixtures. Methods of manufacture of formulations for delivery laxatives may comprise a temperature controlled process.
Abstract:
Described herein are methods and compounds for aiding in the performance of capsule endoscopy on an individual. The efficacy of the capsule endoscopy procedure is limited in at least in part by the power provided by the battery within the capsule. The methods and compounds described herein provide improved capsule endoscopies yielding valuable clinical data. In addition, the methods and compounds described herein provide for a more satisfying experience for the individual undergoing a bowel preparation related to a capsule endoscopy and thus increase compliance with the bowel preparation.
Abstract:
Described herein are compositions and methods for treating constipation in an individual. In some embodiments, the composition and method for treating constipation comprises providing an individual with a therapeutic that comprises a food item and a laxative.
Abstract:
Described herein are compositions and methods for treating constipation in an individual. In some embodiments, the composition and method for treating constipation comprises providing an individual with a composition that comprises a food item comprising one or more ingredients and a concentrated amount of laxative.
Abstract:
Disclosed herein are compounds and methods for identifying and quantifying a metabolite or breakdown product of PEG. A sample may be assayed for PEG metabolites or breakdown products using liquid chromatography combined with mass spectrometry. Derivatization of the PEG metabolites or breakdown products within the sample with pentaflurobenzoyl chloride in conjunction with negative chemical ionization mode liquid chromatography optimizes the assay.
Abstract:
Described herein are compositions and methods that, in some embodiments, are specifically configured to treat different types of constipation. In particular, described herein are compositions and methods for treating IBS-C, opioid induced constipation, and chronic idiopathic constipation. In addition to treating the symptom of constipation, these embodiments of the compositions and methods described herein are configured to address specific etiologies and/or pathophysiologies associated with the constipation types of IBS-C, opioid induced constipation, and chronic idiopathic constipation.
Abstract:
Described herein are methods, compositions, systems, and kits that effectively deliver a laxative to a patient along with effective electrolyte replenishment by delivering both a laxative and electrolytes via a food item. The food item is prepared by either combining, mixing, or integrating the ingredients that form the food item together with one of or both of a laxative and electrolytes so that the ingredients in the food item either eliminate or significantly reduce the poor taste associated with either the electrolytes or the laxative. Eliminating or reducing the poor taste associated with either electrolytes or laxative, greatly improves patient satisfaction and compliance with ingesting these substances in order to, for example, prepare the GI tract of the patient for a medical or surgical procedure.
Abstract:
Described herein are compositions comprising one or more United States Pharmacopeial Convention (USP) grade food ingredients mixed together with a cannabinoid. In some embodiments of the compositions and methods described herein, the compositions comprises a mixture which comprises a food item or a meal containing cannabinoid.
Abstract:
Described herein are compositions, methods, and kits for treating hepatic encephalopathy. A composition for treating or preventing hepatic encephalopathy comprises one or more therapeutic agents and a delivery modality comprising an edible food, beverage, candy, or gum. The one or more therapeutic agents are mixed with one or more food ingredients so that the therapeutic agent is incorporated in the delivery modality.