公开(公告)号：WO2014197026A3

公开(公告)日：2015-01-29

申请号：PCT/US2014022602

申请日：2014-03-10

Applicant: COLORADO SEMINARY WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER ,  MOSES ALLISTAIR A ,  VALAVANIS KIMON P ,  RUTHERFORD MATTHEW J

Inventor： MOSES ALLISTAIR A ,  VALAVANIS KIMON P

IPC: G01S17/32 ,  G01S13/32

CPC classification number: G01S13/34 ,  G01S7/03 ,  G01S7/354 ,  G01S7/415 ,  G01S13/04 ,  G01S13/348 ,  G01S13/584 ,  G01S13/9303

Abstract: A RADAR apparatus may be used in target detection and/or avoidance. The RADAR apparatus may include a microwave front end configured to transmit and receive RF signals, an analog signal conditioning module coupled with the microwave front end module that conditions RF signals received at the microwave front end module, and a digital signal processing module coupled with the analog signal conditioning module that detects presence and range of one or more targets based on the filtered RF signals.

Abstract translation: RADAR装置可用于目标检测和/或回避。 RADAR装置可以包括被配置为发送和接收RF信号的微波前端，与微波前端模块耦合的模拟信号调节模块，其调节在微波前端模块处接收的RF信号，以及与该微波前端模块耦合的数字信号处理模块 模拟信号调节模块，其基于滤波的RF信号检测一个或多个目标的存在和范围。

公开(公告)号：WO2014043513A2

公开(公告)日：2014-03-20

申请号：PCT/US2013/059726

申请日：2013-09-13

Applicant: COLORADO SEMINARY, WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER

Inventor： EATON, Gareth, R. ,  TSEITLIN, Mark ,  QUINE, Richard, Quine

IPC: G01R11/06

CPC classification number: G01R33/0064 ,  G01R33/3607 ,  G01R33/3621 ,  G01R33/60

Abstract: Systems and methods are disclosed to simulate a Hall probe, provide EPR coil driver, and/or perform a time-domain full scan sinusoidal deconvolution of EPR signals. The simulated Hall probe can return a Hall Effect voltage from a coil current that creates a magnetic field within a coil magnet and the reference current that would be fed to an actual Hall probe. From these values, the Hall Effective voltage can be determined which can be used to determine the magnetic field flux, which can then be used to regulate the magnetic field. Embodiments of the invention also disclose a coil driver and a new technique for EPR deconvolution.

Abstract translation: 公开了模拟霍尔探针，提供EPR线圈驱动器和/或执行EPR信号的时域全扫描正弦反卷积的系统和方法。 模拟霍尔探头可以从线圈电流中返回一个霍尔效应电压，该线圈电流在线圈磁体内产生磁场，而参考电流将被馈送到实际的霍尔探头。 根据这些值，可以确定霍尔有效电压，其可以用来确定磁场通量，然后可以用它来调节磁场。 本发明的实施例还公开了用于EPR解卷积的线圈驱动器和新技术。

公开(公告)号：WO2014015219A3

公开(公告)日：2014-01-23

申请号：PCT/US2013/051219

申请日：2013-07-19

Applicant: COLORADO SEMINARY, WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER

Inventor： RINARD, George ,  EATON, Gareth

IPC: G01R33/60

Abstract: Embodiments of the invention are directed toward a crossed-loop electron paramagnetic resonance resonator comprising a first resonator having a first resonator axis; and a second resonator having a second resonator axis. The first resonator axis and the second resonator axis can be substantially perpendicular. Either or both the first resonator and the second resonator can be a ribbon resonator having a plurality of metallic ribbons formed in a loop. Each metallic ribbon can include a central axis. The plurality of metallic ribbons can be arranged parallel relative one to another.

公开(公告)号：WO2012064891A3

公开(公告)日：2012-07-12

申请号：PCT/US2011060056

申请日：2011-11-09

Applicant: COLORADO SEMINARY WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER ,  GODZDANKER ROY ,  VALAVANIS KIMON P ,  RUTHERFORD MATTHEW J

Inventor： GODZDANKER ROY ,  VALAVANIS KIMON P ,  RUTHERFORD MATTHEW J

IPC: B64F1/12 ,  B64F1/22 ,  B64F1/28

CPC classification number: B64F1/12 ,  B64C2201/024 ,  B64F1/125 ,  B64F1/22 ,  B64F1/28 ,  E01F3/00

Abstract: A docking system for an unmanned aerial vehicle (UAV) is described that provides a stable landing and take-off area as well as, in some embodiments, refueling and/or data transfer capabilities. The docking system may be portable to provide a ready docking area for a UAV in areas that may not otherwise be suitable for UAV operation. The docking system may include a landing surface, an orientation mechanism that adjusts the landing surface to provide a level landing area, and an alignment mechanism coupled with the landing surface that moves a UAV resting on the landing surface to a predetermined location on the landing surface for automated refueling of the UAV. A latching mechanism may secure the UAV to the landing surface when the UAV is located at the predetermined location.

Abstract translation: 描述了用于无人机（UAV）的对接系统，其提供稳定的着陆和起飞区域，以及在一些实施例中，加油和/或数据传输能力。 对接系统可以是便携式的，以便在可能不适合于UAV操作的区域中为UAV提供准备好的对接区域。 对接系统可以包括着陆表面，调整着陆表面以提供水平着陆区域的定向机构，以及与着陆表面联接的对准机构，其将搁置在着陆表面上的UAV移动到着陆面上的预定位置 用于无人机的自动加油。 当UAV位于预定位置时，闩锁机构可将UAV固定到着陆面。

公开(公告)号：WO2008058051A3

公开(公告)日：2008-05-15

申请号：PCT/US2007/083579

申请日：2007-11-05

Applicant: COLORADO SEMINARY, WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER ,  SHOURESHI, Rahmat A. ,  ALBERT, Stephen F.

Inventor： SHOURESHI, Rahmat A. ,  ALBERT, Stephen F.

IPC: A61B5/01

Abstract: This invention is a temperature-based smart insole capable of continuously or intermittently measuring the foot temperature of the patient at one or more locations of the foot while the insole is worn. The device provides feedback to the patient alerting the individual of risk based on his/her plantar temperatures. Benefits of this device include: its ability to free the patient from the clinical setting and increase patient's confidence to be mobile, thus enhancing circulation while at the same time allowing the patient to self-monitor their feet.

公开(公告)号：WO2008058048A2

公开(公告)日：2008-05-15

申请号：PCT/US2007/083575

申请日：2007-11-05

Applicant: COLORADO SEMINARY, WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER ,  LENGSFELD, Corinne, S. ,  SHOURESHI, Rahmat, A.

Inventor： LENGSFELD, Corinne, S. ,  SHOURESHI, Rahmat, A.

IPC: A61B5/103

CPC classification number: A61B5/1038

Abstract: Provided is a system for monitoring gait. More particularly, the system comprises: one or more pressure sensors; an algorithm which compares the data from the pressure sensor(s) to a stability profile, and provides a feedback value; means for communicating the feedback value; and a power source. Also provided is a method for gait analysis comprising: collecting signals from one or more pressure sensors located in pressure proximity to a foot, generating a test profile; comparing the test profile to a stability profile; generating a feedback signal; and communicating the feedback signal. The system may also comprise one or more accelerometers.

Abstract translation: 提供了一种用于监测步态的系统。 更具体地，该系统包括：一个或多个压力传感器; 将来自压力传感器的数据与稳定性曲线进行比较并提供反馈值的算法; 用于传达反馈值的手段; 和电源。 还提供了一种用于步态分析的方法，包括：收集位于压力靠近脚部的一个或多个压力传感器的信号，产生测试轮廓; 将测试轮廓与稳定性曲线进行比较; 产生反馈信号; 并传送反馈信号。 该系统还可以包括一个或多个加速度计。

公开(公告)号：WO2014182954A1

公开(公告)日：2014-11-13

申请号：PCT/US2014/037375

申请日：2014-05-08

Applicant: COLORADO SEMINARY, WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER ,  REGIS UNIVERSITY

Inventor： PEGAN, Scott Dusan ,  AHRENDT, Kateri ,  CAPODAGLI, Glenn C. ,  COWEN, Bryan

IPC: A61K31/535 ,  A01N43/42 ,  C07D413/00 ,  C07D215/00

CPC classification number: C07D215/48 ,  A01N43/42 ,  C07D401/04 ,  C07D413/04 ,  C07D417/04 ,  C12Q1/527 ,  G01N2333/988 ,  G01N2500/04

Abstract: This invention provides a family of compounds that inhibit Class II fructose 1,6-bisphosphate aldolase (FBA), which is implicated in the pathogenic activity of a broad range of bacterial and parasitic agents. The compounds were identified by empirical testing, and provide a basis for further derivatization and optimization of 8-hydroxyquinoline-2-carboxylic acid and related compounds. Crystal structure shows that the compounds don't bind directly to the catalytic site of the enzyme, and so are not defined simply as substrate analogs. Instead, they create a pocket by induced fit, resulting a powerful and specific inhibitory effect on FBA activity.

Abstract translation: 本发明提供一种抑制II型果糖1,6-二磷酸醛缩酶（FBA）的化合物家族，其涉及广泛的细菌和寄生虫的致病活性。 通过实验检验鉴定出化合物，为进一步的8-羟基喹啉-2-羧酸衍生化和优化提供依据。 晶体结构显示这些化合物不直接与酶的催化位点结合，因此不被简单地定义为底物类似物。 相反，他们通过诱导拟合创建口袋，从而对FBA活动产生强大而具体的抑制作用。

公开(公告)号：WO2014015219A2

公开(公告)日：2014-01-23

申请号：PCT/US2013051219

申请日：2013-07-19

Applicant: COLORADO SEMINARY WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER

Inventor： RINARD GEORGE ,  EATON GARETH

IPC: G01R33/20

CPC classification number: G01R33/34 ,  G01R33/34046 ,  G01R33/34053 ,  G01R33/34061 ,  G01R33/34092 ,  G01R33/345 ,  G01R33/3456 ,  G01R33/3657 ,  G01R33/60

Abstract: Embodiments of the invention are directed toward a crossed-loop electron paramagnetic resonance resonator comprising a first resonator having a first resonator axis; and a second resonator having a second resonator axis. The first resonator axis and the second resonator axis can be substantially perpendicular. Either or both the first resonator and the second resonator can be a ribbon resonator having a plurality of metallic ribbons formed in a loop. Each metallic ribbon can include a central axis. The plurality of metallic ribbons can be arranged parallel relative one to another.

Abstract translation: 本发明的实施例针对一种交叉环电子顺磁共振谐振器，其包括具有第一谐振器轴线的第一谐振器; 以及具有第二谐振器轴线的第二谐振器。 第一谐振器轴线和第二谐振器轴线可以基本垂直。 第一谐振器和第二谐振器中的任一个或两者可以是具有形成为环的多个金属带的带状谐振器。 每个金属带可以包括中心轴线。 多个金属带可以彼此平行布置。

公开(公告)号：WO2007070761A2

公开(公告)日：2007-06-21

申请号：PCT/US2006/061728

申请日：2006-12-07

Applicant: COLORADO SEMINARY, WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER ,  KUTATELADZE, Andrei G. ,  KOTTANI, Rudresha ,  VALIULIN, Roman ,  MAJJIGAPU, Janaki

Inventor： KUTATELADZE, Andrei G. ,  KOTTANI, Rudresha ,  VALIULIN, Roman ,  MAJJIGAPU, Janaki

IPC: C40B30/06

CPC classification number: C40B30/06

Abstract: A method of screening a library comprising: (i) providing either (a) a library comprising more than one copy of different library members, each copy of a different library member attached to a different releasable tag through a releasable covalent bond; where a plurality of tags uniquely encode each library member; or (b) a library comprising one or more copies of a library member attached to a support, with a plurality of tags uniquely encoding each library member; or (c) a library comprising different library members, each different library member attached to a plurality of tags uniquely encoding the different library member; (ii) providing a target compound with tethered sensitizer in specific binding proximity to the library, allowing specific binding of the target compound with tethered sensitizer to a selected library member; (iii) exciting the tethered sensitizer with excitation photoradiation, whereby the releasable tags attached to the selected library member are released; and (iv) detecting the releasable tags.

Abstract translation: 一种筛选文库的方法，包括：（i）提供（a）包含多于一个不同文库成员的文库的文库，通过可释放共价键连接到不同可释放标签的不同文库成员的每个拷贝; 其中多个标签唯一地编码每个库成员; 或（b）包括连接到支持的库成员的一个或多个副本的库，具有唯一编码每个库成员的多个标签; 或（c）包含不同库成员的库，每个不同的库成员附加到唯一编码不同库成员的多个标签; （ii）提供具有特异性结合到文库的具有束缚敏化剂的靶化合物，允许目标化合物与拴系的敏化剂特异性结合到选定的文库成员; （iii）通过激发光激发激发拴系的敏化剂，从而释放附着在所选文库构件上的可释放标签; 和（iv）检测可释放标签。

公开(公告)号：WO2015105831A1

公开(公告)日：2015-07-16

申请号：PCT/US2015/010418

申请日：2015-01-07

Applicant: COLORADO SEMINARY, WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER ,  HUFFMAN, Donald Ray

Inventor： HUFFMAN, Donald Ray ,  HUFFMAN, John Alexander

IPC: G01J3/28 ,  G01N21/63 ,  G01J3/44

CPC classification number: G01N21/6458 ,  G01J3/0208 ,  G01J3/14 ,  G01J3/18 ,  G01J3/4406 ,  G01J3/4412 ,  G01N15/1434 ,  G01N15/1456 ,  G01N15/1463 ,  G01N21/6428 ,  G01N21/65 ,  G01N21/718 ,  G01N21/85 ,  G01N2015/0065 ,  G01N2015/144 ,  G01N2015/1465 ,  G01N2021/6417 ,  G01N2021/6439 ,  G01N2201/0612 ,  G01N2201/062 ,  G02B21/16

Abstract: Provided are inexpensive devices and methods for obtaining emission or scattering spectra of multiple particles simultaneously and for characterizing the particles based on their emission or scattering spectra. The disclosed devices and methods are useful for analyzing multiple particles to determine one or more characteristics of the particles, such as size, type, elastic scattering, fluorescence and/or Raman characteristics, for distinguishing between biological and non-biological particles, and for biomedical assaying applications. Laboratory or research grade spectroscopic devices are described. Smartphone-based spectroscopic devices are also described, where various components of a smartphone are used for data collection and analysis purposes.

Abstract translation: 提供了用于同时获得多个颗粒的发射或散射光谱并用于基于其发射或散射光谱表征颗粒的便宜的装置和方法。 所公开的装置和方法可用于分析多个颗粒以确定颗粒的一个或多个特性，例如尺寸，类型，弹性散射，荧光和/或拉曼特性，用于区分生物和非生物颗粒，以及用于生物医学 测定应用。 描述实验室或研究级分光装置。 还描述了基于智能手机的光谱装置，其中智能手机的各种组件用于数据收集和分析目的。