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    CHROMATOGRAPHY PURIFICATION SYSTEM
    2.
    发明申请
    CHROMATOGRAPHY PURIFICATION SYSTEM 审中-公开
    色谱纯化系统

    公开(公告)号：WO2006000840A1

    公开(公告)日：2006-01-05

    申请号：PCT/HU2005/000068

    申请日：2005-06-27

    Applicant: COMGENEX RT. ,  DARVAS, Ferenc ,  GÖDÖRHÁZY, Lajos ,  KARANCSI, Tamás ,  SZALAY, Dániel ,  ÜRGE, László

    Inventor： DARVAS, Ferenc ,  GÖDÖRHÁZY, Lajos ,  KARANCSI, Tamás ,  SZALAY, Dániel ,  ÜRGE, László

    IPC: B01D15/08

    CPC classification number: G01N30/82

    Abstract: The chromatography purification system (10) for automated chromatography separation of a plurality of different components in a sample and collection the fraction of at least one target component comprises a fluid streaming unit (11), a chromatography column (12) for receiving a sample and separating the components of the sample, a sample injection valve (18) for injecting the sample, a detector (14) coupled to the chromatography column (12) for receiving the sample and outputting a signal indicating the presence of at least one component in the sample flowing through it, a waste reservoir (17), a fraction collector (16) for dispensing the collected fractions into fraction containers and a system controller (20) for controlling the operation of the fluid streaming unit (11) and the fraction collector (16). The system further comprises a selector (22) for receiving the sample from the detector (14), selecting a predetermined number of target components with a predetermined property from the at least one component of the sample, directing the fraction of the at least one selected target component to the fraction collector (16) and discharging the remaining part of the sample into the waste reservoir (17).

    Abstract translation: 用于自动色谱分离样品中多种不同组分并收集至少一种目标组分的级分的色谱纯化系统（10）包括流体流动单元（11），用于接收样品的色谱柱（12）和 分离样品的组分，用于注射样品的样品注入阀（18），耦合到色谱柱（12）的检测器（14），用于接收样品并输出指示存在至少一种组分的信号 流经其的样品，废液储存器（17），用于将收集的馏分分配到馏分容器中的馏分收集器（16）和用于控制流体流动单元（11）和馏分收集器 16）。 所述系统还包括用于从所述检测器（14）接收样品的选择器（22），从所述样品的所述至少一个组分中选择具有预定特性的预定数量的目标成分，引导所述至少一个选定的 将目标组分加入到馏分收集器（16）中并将剩余部分的样品排放到废物储存器（17）中。

    NEW COMBINATORIAL PROTEIN MARKER COMPOUND LIBRARIES AND METHODS FOR THEIR PREPARATION AND UTILIZATION
    4.
    发明申请
    NEW COMBINATORIAL PROTEIN MARKER COMPOUND LIBRARIES AND METHODS FOR THEIR PREPARATION AND UTILIZATION 审中-公开
    新型组合蛋白标记化合物图谱及其制备和利用方法

    公开(公告)号：WO2004008151A2

    公开(公告)日：2004-01-22

    申请号：PCT/HU0300056

    申请日：2003-07-09

    Applicant: COMGENEX RT ,  DARVAS FERENC ,  UERGE LASZLO ,  DORMAN GYOERGY ,  KRAJCSI PETER ,  SZALAY DANIEL ,  BERES MARIANN ,  BUCSAI AGOTA ,  NAGY TAMAS ,  KALMAN FERENC

    Inventor： DARVAS FERENC ,  UERGE LASZLO ,  DORMAN GYOERGY ,  KRAJCSI PETER ,  SZALAY DANIEL ,  BERES MARIANN ,  BUCSAI AGOTA ,  NAGY TAMAS ,  KALMAN FERENC

    IPC: C40B30/04 ,  G01N33/58 ,  G01N33/68

    CPC classification number: C40B30/04 ,  G01N33/582 ,  G01N2500/04

    Abstract: The invention consists substantially of combinatorial, protein-marker molecule libraries, having groups that may be chemically and photochemically activated, with or without reporter groups, connected in different diversity points or spatial arrangements via side chains around a common molecular core. The invention consists furthermore of combinatorial libraries of marker units having chemically or photochemically reactive marker groups, reporter groups, and various other types of side chains attached variably to a common molecular, preferably lysine-based, structural core. The invention consists furthermore of a method for combinatorial chemical tethering, where a side chain having a terminal functional group, preferably an amino group, and to which a marker group is optionally attached, is introduced in optimal position ensuring structural diversity and protein binding effectiveness. The invention contributes to simplifying complexity of proteome in different tissues and to the identification of protein markers for diagnosis by alternating different labeling pattern in healthy and diseased tissues.

    Abstract translation: 本发明基本上由组合的蛋白质标记分子文库组成，其具有化学和光化学活化的基团，具有或不具有报告基团，通过在共同分子核心周围的侧链连接在不同的分化点或空间排列。 本发明还包括具有化学或光化学反应性标记物组，报道基团和可变地连接到共同分子，优选赖氨酸结构核心的各种其它类型侧链的标记单元的组合文库。 本发明还包括一种用于组合化学结合的方法，其中具有末端官能团，优选氨基的侧链，并且可选地连接有标记基团的侧链以确保结构多样性和蛋白质结合效力的最佳位置引入。 本发明有助于简化不同组织中蛋白质组的复杂性，并通过在健康和患病组织中交替不同的标记模式来确定用于诊断的蛋白质标记物。

    HYBRID CHIP FOR THE MINIATURIZATION OF CHEMICAL, BIOMEDICAL, AND BIOLOGICAL PROCESSES AND METHOD OF APPLICATION
    7.
    发明申请
    HYBRID CHIP FOR THE MINIATURIZATION OF CHEMICAL, BIOMEDICAL, AND BIOLOGICAL PROCESSES AND METHOD OF APPLICATION 审中-公开
    用于化学，生物医学和生物过程的微型化的混合芯片及其应用方法

    公开(公告)号：WO2004012856A1

    公开(公告)日：2004-02-12

    申请号：PCT/HU2003/000063

    申请日：2003-07-30

    Applicant: COMGENEX RT. ,  DARVAS, Ferenc ,  ÜRGE, László ,  DORMÁN, György ,  KARANCSI, Tamás ,  GÖDÖRHÁZY, Lajos ,  SZALAY, Dániel

    Inventor： DARVAS, Ferenc ,  ÜRGE, László ,  DORMÁN, György ,  KARANCSI, Tamás ,  GÖDÖRHÁZY, Lajos ,  SZALAY, Dániel

    IPC: B01J19/00

    CPC classification number: C40B50/08 ,  B01J19/0093 ,  B01J2219/00418 ,  B01J2219/00599 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/007 ,  B01J2219/0072 ,  B01J2219/00822 ,  B01J2219/00871 ,  B01J2219/00986 ,  B01L3/5027 ,  B01L2200/14 ,  B01L2300/02 ,  C40B30/10 ,  C40B60/14

    Abstract: This invention involves a small hybrid sheet (chip), used to miniaturize chemical, biochemical, and biological processes, characterized by that it consists of mono or multilayer sheet (chip) comprising the following directly connected units: a) a unit used for synthesis and work-up of compounds and the transport of raw materials, reagents, and final products; b) a unit used for the analysis of compounds and transport of raw materials, reagents, and final products; c) a unit used for execution of biological assays of compounds and the transport of raw materials, reagents, and final products; and d) preferably an electronic unit, more preferably a semi conductor chip into which the following have been burnt: (i) the software source code of at least one computer program for the realization of a function algorithm between biological activity and the chemical structure of compounds; whose input is the chemical structure and biological activity of one or more compounds, and whose output is the chemical structure(s) of one or more further compounds likely to display the desired degree of biological activity, (ii) the software source code of a synthesis program whose input is the chemical formula(e) of one or more compounds obtained as the output of part (i), and whose output provides the laboratory synthesis protocols for these compounds (iii) the software source code of a control program whose input is the one or more laboratory synthesis protocols obtained as the output of the previous step (ii), and whose output provides the control program for the unit described in subsection a). (iv) and finally, preferably the software source code of a control program that controls the operation of the units described under subsections (a) through (d), including launch, shut down, and optimization of these units, preferably the software source code of a control program that controls the biological assay by means of a threshold to be attained during the assay. The small hybrid sheet (chip) may be applied to the production, analysis, and assay of biologically active compounds, and to the measurement of their metabolism, toxicity, and other adaptable biological interactions.

    Abstract translation: 本发明涉及用于使化学，生化和生物过程小型化的小型混合片（芯片），其特征在于它由包括以下直接连接的单元的单层或多层板（芯片）组成：a）用于合成和 化合物的处理以及原材料，试剂和最终产品的运输; b）用于分析化合物和原料，试剂和最终产品运输的单位; c）用于执行化合物的生物测定的单位和原料，试剂和最终产品的运输; 以及d）优选地，用于分析和控制的软件源代码已被烧录的电子单元。 小型杂交片（芯片）可用于生物活性化合物的生产，分析和测定，以及其代谢，毒性和其他适应性相互作用的测量。

    ACTIVE SOLID SUPPORT AND METHOD FOR SURFACE IMMOBILIZATION OF COMBINATORIAL COMPOUNDS OR LIBRARIES
    9.
    发明申请
    ACTIVE SOLID SUPPORT AND METHOD FOR SURFACE IMMOBILIZATION OF COMBINATORIAL COMPOUNDS OR LIBRARIES 审中-公开

    公开(公告)号：WO2003083477A3

    公开(公告)日：2003-10-09

    申请号：PCT/HU2003/000025

    申请日：2003-03-28

    Applicant: COMGENEX RT. ,  MTA SZEGEDI BIOLÓGIAI KUTATÓKÖZPONT ,  DARVAS, Ferenc ,  ÜRGE, László ,  BUCSAI, Ágota ,  BÉRES, Mariann ,  DORMÁN, György ,  KRAJCSI, Péter ,  GÖDÖRHÁZY, Lajos ,  BÁGYI, István ,  PUSKÁS, László ,  HACKLER, László ,  ZVARA, Ágnes

    Inventor： DARVAS, Ferenc ,  ÜRGE, László ,  BUCSAI, Ágota ,  BÉRES, Mariann ,  DORMÁN, György ,  KRAJCSI, Péter ,  GÖDÖRHÁZY, Lajos ,  BÁGYI, István ,  PUSKÁS, László ,  HACKLER, László ,  ZVARA, Ágnes

    IPC: G01N33/543

    Abstract: The subject of the invention is a method for production of an active solid support suitable for anchoring drug molecules through covalent bonds, using the following methods a.) a solid support prepared in advance, preferably by pre-treatment in the presence of strong bases or acids, then reacted with a polyamine-functionalized alcoxy-silane derivative, preferably 3-[2-(2-aminoethylamino)ethylamino]propyl trimethoxy-silane, followed by washing and drying, b1) the solid support obtained in the procedure described above in Section a.) will be reacted with (I) where Z: = bond or a -CO or -CNR 1 group and group 121 is an alkyl, aralkyl or aryl group; B: = bond or a - (CH 2 ) n - or -(CH 2 ) n O-(CH 2 ) n or O - (CH 2 ) n - or -NH(CH 2 ) n - group; A: = a branched or unbranched alkyl or substituted aryl or aralkyl group containing 1-5 carbon atoms; D: = a halogen or -O-A group and n = 0, 1, 2, ... integer - with a bi-functional reagent, preferably reacted with acryloyl/chloride or 1,4-butanediol diacrylate in the presence of an organic or inorganic scavenger or b2) the support prepared using the method described in part (a) is reacted with a bi-functional reagent, preferably 1,4-butanediol diglicidyl-ether or epichlorohydrin, in the presence of an organic or inorganic scavenger containing terminal epoxy groups and an amino-group reactive functional subgroup. The invention also includes the active solid support produced using the several methods described above, as well as application of the active solid support described above for production of chemical microarrays and combinatorial chemical microarrays. The invention further comprises a method for immobilization of what have been termed organic molecules of low molecular weight, having a size less than 1500 Da, preferably between 250 and 750 Da. This is achieved by anchoring an unmodified drug or drug candidate molecule to the active solid support described above by adding the appropriate functional groups of the drug or drug candidate molecule, preferably executed using a micron-sized robotized binding technique.

    NEW ACTIVE SOLID SUPPORT AND METHOD FOR SURFACE IMMOBILIZATION OF COMBINATORIAL COMPOUNDS OR LIBRARIES
    10.
    发明申请
    NEW ACTIVE SOLID SUPPORT AND METHOD FOR SURFACE IMMOBILIZATION OF COMBINATORIAL COMPOUNDS OR LIBRARIES 审中-公开
    新型活性固体支持和组合化合物或文库的表面固化方法

    公开(公告)号：WO2003083477A2

    公开(公告)日：2003-10-09

    申请号：PCT/HU2003/000025

    申请日：2003-03-28

    Applicant: COMGENEX RT. ,  MTA SZEGEDI BIOLÓGIAI KUTATÓKÖZPONT ,  DARVAS, Ferenc ,  ÜRGE, László ,  BUCSAI, Ágota ,  BÉRES, Mariann ,  DORMÁN, György ,  KRAJCSI, Péter ,  GÖDÖRHÁZY, Lajos ,  BÁGYI, István ,  PUSKÁS, László ,  HACKLER, László ,  ZVARA, Ágnes

    Inventor： DARVAS, Ferenc ,  ÜRGE, László ,  BUCSAI, Ágota ,  BÉRES, Mariann ,  DORMÁN, György ,  KRAJCSI, Péter ,  GÖDÖRHÁZY, Lajos ,  BÁGYI, István ,  PUSKÁS, László ,  HACKLER, László ,  ZVARA, Ágnes

    IPC: G01N33/543

    CPC classification number: G01N33/54353

    Abstract: The subject of the invention is a method for production of an active solid support suitable for anchoring drug molecules through covalent bonds, using the following methods a.) a solid support prepared in advance, preferably by pre-treatment in the presence of strong bases or acids, then reacted with a polyamine-functionalized alcoxy-silane derivative, preferably 3-[2-(2-aminoethylamino)ethylamino]propyl trimethoxy-silane, followed by washing and drying, b1) the solid support obtained in the procedure described above in Section a.) will be reacted with (I) where Z: = bond or a -CO or -CNR 1 group and group 121 is an alkyl, aralkyl or aryl group; B: = bond or a - (CH 2 ) n - or -(CH 2 ) n O-(CH 2 ) n or O - (CH 2 ) n - or -NH(CH 2 ) n - group; A: = a branched or unbranched alkyl or substituted aryl or aralkyl group containing 1-5 carbon atoms; D: = a halogen or -O-A group and n = 0, 1, 2, ... integer - with a bi-functional reagent, preferably reacted with acryloyl/chloride or 1,4-butanediol diacrylate in the presence of an organic or inorganic scavenger or b2) the support prepared using the method described in part (a) is reacted with a bi-functional reagent, preferably 1,4-butanediol diglicidyl-ether or epichlorohydrin, in the presence of an organic or inorganic scavenger containing terminal epoxy groups and an amino-group reactive functional subgroup. The invention also includes the active solid support produced using the several methods described above, as well as application of the active solid support described above for production of chemical microarrays and combinatorial chemical microarrays. The invention further comprises a method for immobilization of what have been termed organic molecules of low molecular weight, having a size less than 1500 Da, preferably between 250 and 750 Da. This is achieved by anchoring an unmodified drug or drug candidate molecule to the active solid support described above by adding the appropriate functional groups of the drug or drug candidate molecule, preferably executed using a micron-sized robotized binding technique.

    Abstract translation: 本发明的主题是制备适用于通过共价键锚定药物分子的活性固体支持物的方法，使用以下方法a）预先制备的固体支持物，优选通过在强碱存在下预处理或 然后与多胺官能化的烷氧基硅烷衍生物，优选3- [2-（2-氨基乙基氨基）乙基氨基]丙基三甲氧基硅烷反应，然后洗涤和干燥，b1）以上述方法获得的固体支持物 部分a。）将与（I）反应，其中Z：=键或-CO或-CNR 1基团，基团121是烷基，芳烷基或芳基; B：=键或 - （CH 2）n - 或 - （CH 2）n O-（CH 2）n或O - （CH 2）n - 或-NH（CH 2）n - A：=含1-5个碳原子的支链或非支链烷基或取代的芳基或芳烷基; D：=卤素或-OA基团，n = 0,1,2，...整数 - 与双官能试剂反应，优选与丙烯酰氯/ 1,4-丁二醇二丙烯酸酯在有机或 无机清除剂或b2）使用部分（a）中描述的方法制备的载体与双功能试剂，优选1,4-丁二醇二缩水甘油醚或表氯醇在含有末端环氧基的有机或无机清除剂存在下反应 基团和氨基反应性功能亚组。 本发明还包括使用上述几种方法制备的活性固体支持物，以及上述用于生产化学微阵列和组合化学微阵列的活性固体支持物的应用。 本发明还包括一种固定所谓的低分子量有机分子的方法，其具有小于1500Da，优选250至750Da的尺寸。 这是通过将未修饰的药物或药物候选分子锚定到上述活性固体支持物上，通过加入药物或药物候选分子的适当官能团，优选使用微米级的自动化装订技术进行的。

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