中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

32 records (took 0.013 seconds)

    NANOSTRUCTURED APREPITANT COMPOSITIONS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    1.
    发明申请
    NANOSTRUCTURED APREPITANT COMPOSITIONS, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
    纳米结构的制剂组合物，其制备方法和含有它们的药物组合物

    公开(公告)号：WO2011158053A1

    公开(公告)日：2011-12-22

    申请号：PCT/HU2011/000057

    申请日：2011-06-17

    Applicant: NANOFORM CARDIOVASCULAR THERAPEUTICS LTD. ,  FILIPCSEI, Genovéva ,  ÖTVÖS, Zsolt ,  HELTOVICS, Gábor ,  DARVAS, Ferenc

    Inventor： FILIPCSEI, Genovéva ,  ÖTVÖS, Zsolt ,  HELTOVICS, Gábor ,  DARVAS, Ferenc

    IPC: C07D413/06 ,  A61P9/08 ,  A61K31/5377

    CPC classification number: A61K9/14 ,  A61K31/5377 ,  C07D413/06 ,  Y10T428/2982

    Abstract: The present invention is directed to nanostructured Aprepitant compositions, process for the preparation thereof and pharmaceutical compositions containing them. The nanoparticles of Aprepitant according to the invention have an average particle size of less than about 200 nm. The stable nanostructured particles of the invention are presented by increased solubility, dissolution rate, permeability and bioequivalent or enhanced biological performance characterized by significantly decreased fed/fasted effect compared to the reference and marketed drug. Aprepitant is a chemical compound that belongs to a class of drugs called substance P antagonists (SPA). It mediates its effect by acting on neurokinin 1 receptor. Aprepitant is manufactured by Merck & Co. under the brand name Emend for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and for prevention of postoperative nausea and vomiting.

    Abstract translation: 本发明涉及纳米结构的Aprepitant组合物，其制备方法和含有它们的药物组合物。 根据本发明的阿维地丁剂的纳米颗粒的平均粒度小于约200nm。 本发明的稳定的纳米结构颗粒通过增加的溶解度，溶解速率，渗透性和生物等效性或增强的生物学性能来表征，其特征在于与参考和市售药物相比显着降低进食/禁食效应。 阿维他啶是一种化合物，属于称为物质P拮抗剂（SPA）的一类药物。 它通过作用于神经激肽1受体介导其作用。 默克公司以默克公司制造，以防止急性和延迟化疗引起的恶心呕吐（CINV）和预防术后恶心呕吐的品牌名称。

    OZONE GENERATING ELECTROLYSIS CELL
    4.
    发明申请
    OZONE GENERATING ELECTROLYSIS CELL 审中-公开
    臭氧发生电解槽

    公开(公告)号：WO2007072098A2

    公开(公告)日：2007-06-28

    申请号：PCT/HU2006/000126

    申请日：2006-12-22

    Applicant: THALES NANOTECHNOLÓGIAI ZRT. ,  SZALAY, Dániel ,  VARGA, Norbert ,  BONCZ, Ferenc ,  DARVAS, Ferenc ,  KARANCSI, Tamás ,  GÖDÖRHÁZY, Lajos

    Inventor： SZALAY, Dániel ,  VARGA, Norbert ,  BONCZ, Ferenc ,  DARVAS, Ferenc ,  KARANCSI, Tamás ,  GÖDÖRHÁZY, Lajos

    CPC classification number: C25B1/13 ,  C25B9/08 ,  C25B11/04

    Abstract: The ozone generating electrolysis cell (10) according to the invention has a negative electrode (13) and an ozone generating positive electrode (16) comprising a mixture of lead dioxide and polytetrafluoroethylene (PTFE). A proton conducting solid electrolytic membrane (15) is arranged between the negative and positive electrodes (13, 16). The ozone generating electrolysis cell (10) also comprises an electrically conducting, liquid and gas permeable first electrode support (17) in contact with a side of the positive electrode (16) located opposite to the membrane (15), wherein said side of the electrode support (17) has a surface covered with a platinum-containing layer. The positive electrode (16) is made of a mixture prepared by the high-pressure compression of lead dioxide grains of colloid size and PTFE filaments having a dimension of at most 1 mm. Furthermore, the negative electrode (13) is adjoined to a side of the membrane (15) located opposite to the positive electrode (16) by a given compressing force and is formed on a surface of a porous second electrode support (12).

    Abstract translation: 根据本发明的臭氧发生电解槽（10）具有负极（13）和包含二氧化铅和聚四氟乙烯（PTFE）的混合物的产生臭氧的正极（16）。 质子传导固体电解质膜（15）设置在负极和正极（13,16）之间。 臭氧发生电解槽（10）还包括与位于与膜（15）相对的正电极（16）的一侧接触的导电，液体和气体可透过的第一电极支撑件（17），其中 电极支撑件（17）具有被含铂层覆盖的表面。 正极（16）由通过高压压缩胶体尺寸的二氧化铅颗粒和尺寸至多为1mm的PTFE细丝制成的混合物制成。 此外，负极（13）通过给定的压缩力与位于与正极（16）相对的膜（15）的一侧相邻，并形成在多孔第二电极支撑体（12）的表面上。

    CHROMATOGRAPHY PURIFICATION SYSTEM
    5.
    发明申请
    CHROMATOGRAPHY PURIFICATION SYSTEM 审中-公开
    色谱纯化系统

    公开(公告)号：WO2006000840A1

    公开(公告)日：2006-01-05

    申请号：PCT/HU2005/000068

    申请日：2005-06-27

    Applicant: COMGENEX RT. ,  DARVAS, Ferenc ,  GÖDÖRHÁZY, Lajos ,  KARANCSI, Tamás ,  SZALAY, Dániel ,  ÜRGE, László

    Inventor： DARVAS, Ferenc ,  GÖDÖRHÁZY, Lajos ,  KARANCSI, Tamás ,  SZALAY, Dániel ,  ÜRGE, László

    IPC: B01D15/08

    CPC classification number: G01N30/82

    Abstract: The chromatography purification system (10) for automated chromatography separation of a plurality of different components in a sample and collection the fraction of at least one target component comprises a fluid streaming unit (11), a chromatography column (12) for receiving a sample and separating the components of the sample, a sample injection valve (18) for injecting the sample, a detector (14) coupled to the chromatography column (12) for receiving the sample and outputting a signal indicating the presence of at least one component in the sample flowing through it, a waste reservoir (17), a fraction collector (16) for dispensing the collected fractions into fraction containers and a system controller (20) for controlling the operation of the fluid streaming unit (11) and the fraction collector (16). The system further comprises a selector (22) for receiving the sample from the detector (14), selecting a predetermined number of target components with a predetermined property from the at least one component of the sample, directing the fraction of the at least one selected target component to the fraction collector (16) and discharging the remaining part of the sample into the waste reservoir (17).

    Abstract translation: 用于自动色谱分离样品中多种不同组分并收集至少一种目标组分的级分的色谱纯化系统（10）包括流体流动单元（11），用于接收样品的色谱柱（12）和 分离样品的组分，用于注射样品的样品注入阀（18），耦合到色谱柱（12）的检测器（14），用于接收样品并输出指示存在至少一种组分的信号 流经其的样品，废液储存器（17），用于将收集的馏分分配到馏分容器中的馏分收集器（16）和用于控制流体流动单元（11）和馏分收集器 16）。 所述系统还包括用于从所述检测器（14）接收样品的选择器（22），从所述样品的所述至少一个组分中选择具有预定特性的预定数量的目标成分，引导所述至少一个选定的 将目标组分加入到馏分收集器（16）中并将剩余部分的样品排放到废物储存器（17）中。

    FLOW-TYPE LABORATORY OZONOLYSIS APPARATUS AND METHOD OF PERFORMING OZONOLYSIS REACTION
    9.
    发明申请
    FLOW-TYPE LABORATORY OZONOLYSIS APPARATUS AND METHOD OF PERFORMING OZONOLYSIS REACTION 审中-公开
    流动型实验室臭氧分析装置及其执行臭氧反应的方法

    公开(公告)号：WO2007072097A3

    公开(公告)日：2007-08-16

    申请号：PCT/HU2006000125

    申请日：2006-12-22

    Applicant: THALES NANOTECHNOLOGIAI ZRT ,  SZALAY DANIEL ,  VARGA NORBERT ,  BONCZ FERENC ,  DARVAS FERENC ,  KARANCSI TAMAS ,  GOEDOERHAZY LAJOS ,  UERGE LASZLO

    Inventor： SZALAY DANIEL ,  VARGA NORBERT ,  BONCZ FERENC ,  DARVAS FERENC ,  KARANCSI TAMAS ,  GOEDOERHAZY LAJOS ,  UERGE LASZLO

    IPC: B01J19/00 ,  B01L3/00

    CPC classification number: B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00788 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00891 ,  B01J2219/0095 ,  B01J2219/00986 ,  C07C29/48 ,  C07C231/10 ,  C25B1/13 ,  C25B9/08 ,  C25B11/04 ,  C07C233/25 ,  C07C33/22 ,  C07C33/24

    Abstract: A flow-type laboratory scale ozonolysis apparatus (100) according to the invention comprises a reservoir (104), a feed pump (102), a mixing element (120) with two inlets and an outlet, a reactor unit (110) and a pressure-adjusting means (160), all connected into a flow path. The ozonolysis apparatus (100) further comprises an ozone source (110), as well as a dispensing valve (112) transmitting a gas stream only in a single direction and installed between the ozone source (110) and one of the inlets of the mixing element (120). The feed pump (102) of the ozonolysis apparatus (100) according to the invention is a liquid pump generating a constant volume rate, the reservoir (104) contains at least the substance, as a solute, to be subjected to the ozonolysis reaction and the reactor unit consists of first and second reactor zones differing in function from one another. In the flow path, the outlet of the first reactor zone is connected to the inlet of the second reactor zone. Furthermore, an inlet for feeding in substances is inserted into the flow path between the reactor zones, and the pressure-adjusting means (160) is installed into the flow path after the reactor unit and is provided with an electrically governed control.

    Abstract translation: 根据本发明的流式实验室规模臭氧分解装置（100）包括储存器（104），进料泵（102），具有两个入口和出口的混合元件（120），反应器单元（110）和 压力调节装置（160），全部连接到流路中。 臭氧分解装置（100）还包括臭氧源（110）以及仅在单个方向上传输气流并且安装在臭氧源（110）和混合入口之一之间的分配阀（112） 元件（120）。 根据本发明的臭氧分解装置（100）的进料泵（102）是产生恒定体积比的液体泵，储存器（104）至少含有作为溶质的待进行臭氧分解反应的物质， 反应器单元由功能彼此不同的第一和第二反应器区组成。 在流动路径中，第一反应器区的出口连接到第二反应器区的入口。 此外，用于进料物质的入口插入在反应器区域之间的流动路径中，并且压力调节装置（160）安装在反应器单元之后的流动路径中并且被设置有电控制的控制。

Patent Agency Ranking