公开(公告)号：WO2012170766A1

公开(公告)日：2012-12-13

申请号：PCT/US2012/041476

申请日：2012-06-08

Applicant: IRONWOOD PHARMACEUTICALS, INC. ,  CURRIE, Mark, G. ,  ZIMMER, Daniel, P. ,  FRETZEN, Angelika ,  KESSLER, Marco ,  CALI, Brian, M.

Inventor： CURRIE, Mark, G. ,  ZIMMER, Daniel, P. ,  FRETZEN, Angelika ,  KESSLER, Marco ,  CALI, Brian, M.

IPC: A61K38/10 ,  A61P1/00

CPC classification number: C07K7/08 ,  A61K38/10 ,  A61K45/06

Abstract: The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including irritable bowel syndrome and constipation.

Abstract translation: 本发明提供了治疗较低胃肠道疾病（包括肠易激综合征和便秘）的药物组合物和方法。

公开(公告)号：WO2012155114A1

公开(公告)日：2012-11-15

申请号：PCT/US2012/037663

申请日：2012-05-11

Applicant: IRONWOOD PHARMACEUTICALS, INC. ,  CURRIE, Mark G. ,  ZIMMER, Daniel P. ,  KESSLER, Marco

Inventor： CURRIE, Mark G. ,  ZIMMER, Daniel P. ,  KESSLER, Marco

IPC: C07K7/08 ,  A61K38/04

CPC classification number: C07K7/08 ,  A61K38/04

Abstract: The present invention provides new uroguanylin derivatives that are useful for the treatment of gastrointestinal disorders. The present invention also provides compositions and methods of treating gastrointestinal disorders and pharmaceutical compositions for accomplishing the same. In some embodiments, these pharmaceutical compositions include oral dosage forms.

Abstract translation: 本发明提供了可用于治疗胃肠道疾病的新的尿路鸟苷衍生物。 本发明还提供了治疗胃肠疾病的组合物和方法以及用于实现其的药物组合物。 在一些实施方案中，这些药物组合物包括口服剂型。

公开(公告)号：WO2011123719A2

公开(公告)日：2011-10-06

申请号：PCT/US2011/030835

申请日：2011-03-31

Applicant: IRONWOOD PHARMACEUTICALS, INC. ,  UNITED STATE OF AMERICA SECRETARY OF THE DEPARTMENT OF VETERANS AFFAIRS ,  PEARSON, James Philip ,  CURRIE, Mark ,  TACHE, Yvette ,  LARAUCHE, Muriel

Inventor： PEARSON, James Philip ,  CURRIE, Mark ,  TACHE, Yvette ,  LARAUCHE, Muriel

IPC: A61K31/00 ,  A61K31/40 ,  A61K31/404 ,  A61P25/04

CPC classification number: A61K31/404 ,  A61K31/00 ,  A61K31/325 ,  A61K31/40 ,  A61K31/4439 ,  A61K45/06 ,  C07D209/22 ,  C07D401/12

Abstract: The present disclosure relates to methods of using fatty acid amide hydrolase (FAAH) inhibitors alone or in combination for the treatment or prevention of abdominal, visceral or pelvic pain. Also described herein are pharmaceutical compositions comprising a FAAH inhibitor, alone or in combination with an additional therapeutic agent for the treatment of abdominal, visceral or pelvic pain.

Abstract translation: 本公开涉及单独或组合使用脂肪酸酰胺水解酶（FAAH）抑制剂用于治疗或预防腹部，内脏或骨盆疼痛的方法。 本文还描述了包含FAAH抑制剂的药物组合物，其单独或与用于治疗腹部，内脏或骨盆疼痛的另外的治疗剂组合。

公开(公告)号：WO2008124505A3

公开(公告)日：2009-08-20

申请号：PCT/US2008059272

申请日：2008-04-03

Applicant: IRONWOOD PHARMACEUTICALS INC ,  CURRIE MARK G ,  ZIMMER DANIEL P

Inventor： CURRIE MARK G ,  ZIMMER DANIEL P

IPC: A61K31/04 ,  A61K31/165 ,  A61K31/192 ,  A61K31/21 ,  A61K31/34 ,  A61K31/40 ,  A61K31/407 ,  A61K31/5377 ,  A61K31/541 ,  A61P9/00

CPC classification number: A61K31/34 ,  A61K31/04 ,  A61K31/165 ,  A61K31/192 ,  A61K31/21 ,  A61K31/40 ,  A61K31/407 ,  A61K31/5377 ,  A61K31/541

Abstract: Disclosed herein are novel compositions and methods for treating or preventing a variety of disorders and conditions associated with lipid metabolism. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising one or more sGC modulators alone or in combination with one or more lipid altering agents and/or PDE inhibitors.

Abstract translation: 本文公开了用于治疗或预防与脂质代谢相关的多种病症和病症的新型组合物和方法。 所述方法通常包括向有需要的患者施用治疗有效量的药物组合物，其包含单独一种或多种sGC调节剂或与一种或多种脂质改变剂和/或PDE抑制剂组合。

公开(公告)号：WO2008157537A3

公开(公告)日：2009-04-02

申请号：PCT/US2008067204

申请日：2008-06-17

Applicant: IRONWOOD PHARMACEUTICALS INC ,  CURRIE MARK ,  TALLEY JOHN ,  CALI BRIAN

Inventor： CURRIE MARK ,  TALLEY JOHN ,  CALI BRIAN

IPC: C07D207/22 ,  A61K31/33 ,  C07C59/70 ,  C07C69/017 ,  C07C69/612 ,  C07C203/00 ,  C07C203/04 ,  C07D207/34 ,  C07D209/24 ,  C07D239/42 ,  C07D257/06 ,  C07D263/28 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12

CPC classification number: C07D257/06 ,  C07C69/712 ,  C07C69/732 ,  C07C203/04 ,  C07C235/30 ,  C07C259/06 ,  C07C279/12 ,  C07C279/14 ,  C07C279/22 ,  C07C281/16 ,  C07C291/02 ,  C07C2602/10 ,  C07C2602/28 ,  C07D207/22 ,  C07D207/34 ,  C07D209/24 ,  C07D239/42 ,  C07D263/28 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12

Abstract: Disclosed herein are novel compositions and methods for treating or preventing a variety of disorders and conditions associated with lipid metabolism. The methods generally include administering to a patient in need thereof a therapeutically effective amount of a pharmaceutical composition comprising one or more fibric acid or statin derivative compositions alone or in combination with one or more lipid altering agents and/or PDE inhibitors.

Abstract translation: 本文公开了用于治疗或预防与脂质代谢相关的多种病症和病症的新型组合物和方法。 所述方法通常包括向有需要的患者施用治疗有效量的药物组合物，其包含单独一种或多种纤维酸或他汀类衍生物组合物或与一种或多种脂质改变剂和/或PDE抑制剂组合。

公开(公告)号：WO2008002971A3

公开(公告)日：2008-08-28

申请号：PCT/US2007072223

申请日：2007-06-27

Applicant: MICROBIA INC ,  CURRIE MARK G ,  ZIMMER DANIEL P

Inventor： CURRIE MARK G ,  ZIMMER DANIEL P

IPC: A01N37/18 ,  A61K38/00

CPC classification number: C07K14/4705 ,  A61K38/00

Abstract: Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders and disorders and conditions associated with excess fluid and/or salt retention as well as other conditions and disorders are described. The compositions feature polypeptides that activate the guanylate cyclase C (GC-C) receptor.

Abstract translation: （例如胃肠动力障碍，功能性胃肠病症，胃食管反流病（GERD），十二指肠胃反流，克罗恩氏病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括胃肠动力障碍， 功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假梗阻），与便秘相关的病症和病症，例如与使用阿片剂止痛药有关的便秘，手术后便秘和与神经病性病症相关的便秘; 描述了与过量的液体和/或盐潴留以及其他病症和病症相关的病症和病症。所述组合物的特征在于活化鸟苷酸环化酶C（GC-C）受体的多肽。

公开(公告)号：WO2007062168A3

公开(公告)日：2007-05-31

申请号：PCT/US2006/045289

申请日：2006-11-22

Applicant: MICROBIA, INC. ,  CURRIE, Mark G.

Inventor： CURRIE, Mark G.

IPC: C07H19/00 ,  C07F9/02

Abstract: The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis employing. The methods and compositions employ guanosine 3', 5'-cyclic monophosphate pharmaceutically acceptable salt thereof.

公开(公告)号：WO2007022501A2

公开(公告)日：2007-02-22

申请号：PCT/US2006032573

申请日：2006-08-18

Applicant: MICROBIA INC ,  BARTOLINI WILMIN ,  CALI BRIAN M ,  CHEN BARBARA ,  CHIEN YUEH-TYNG ,  CURRIE MARK G ,  MILNE G TODD ,  PEARSON JAMES PHILIP ,  TALLEY JOHN JEFFREY ,  YANG JING JING ,  ZIMMERMAN CRAIG ,  MONREAL ALEX W

Inventor： BARTOLINI WILMIN ,  CALI BRIAN M ,  CHEN BARBARA ,  CHIEN YUEH-TYNG ,  CURRIE MARK G ,  MILNE G TODD ,  PEARSON JAMES PHILIP ,  TALLEY JOHN JEFFREY ,  YANG JING JING ,  ZIMMERMAN CRAIG ,  MONREAL ALEX W

IPC: A61K31/428

CPC classification number: C07D409/06 ,  A61K31/33 ,  A61K31/404 ,  C07D209/18 ,  C07D417/06

Abstract: Indoles having various activities, including indoles that are CRTH2 are described. The compounds are useful for treating asthma, neuropathic pain, allegic rhinitis and other disorders.

Abstract translation: 描述了具有各种活性的吲哚，包括CRTH2的吲哚。 该化合物可用于治疗哮喘，神经性疼痛，应激性鼻炎和其他疾病。

公开(公告)号：WO2006050120A2

公开(公告)日：2006-05-11

申请号：PCT/US2005/038978

申请日：2005-10-27

Applicant: MICROBIA, INC. ,  BARTOLINI, Wilmin ,  CALI, Brian, M. ,  CHEN, Barbara ,  CHIEN, Yueh-tyng ,  CURRIE, Mark, G. ,  MILNE, G., Todd ,  PEARSON, James, Philip ,  TALLEY, John, Jeffrey ,  ZIMMERMAN, Craig

Inventor： BARTOLINI, Wilmin ,  CALI, Brian, M. ,  CHEN, Barbara ,  CHIEN, Yueh-tyng ,  CURRIE, Mark, G. ,  MILNE, G., Todd ,  PEARSON, James, Philip ,  TALLEY, John, Jeffrey ,  ZIMMERMAN, Craig

IPC: C07D209/18

CPC classification number: C07D209/18 ,  C07D209/26 ,  C07D209/28 ,  C07D409/06

Abstract: Methods for preparing indoles that are useful COX-2 inhibitors and intermediates useful in such methods are described.

Abstract translation: 描述了制备有用的COX-2抑制剂和可用于这些方法的中间体的吲哚的方法。

公开(公告)号：WO2006036994A3

公开(公告)日：2006-04-06

申请号：PCT/US2005/034702

申请日：2005-09-27

Applicant: MICROBIA, INC. ,  BARTOLINI, Wilmin ,  CALI, Brian, M. ,  CHEN, Barbara ,  CHEN, Yueh-Tyng ,  CURRIE, Mark, G. ,  MILNE, G., Todd ,  PEARSON, James, Philip ,  TALLEY, John, Jeffrey ,  YANG, Jing Jing ,  ZIMMERMAN, Craig

Inventor： BARTOLINI, Wilmin ,  CALI, Brian, M. ,  CHEN, Barbara ,  CHEN, Yueh-Tyng ,  CURRIE, Mark, G. ,  MILNE, G., Todd ,  PEARSON, James, Philip ,  TALLEY, John, Jeffrey ,  YANG, Jing Jing ,  ZIMMERMAN, Craig

IPC: A61K31/405 ,  C07D209/12

Abstract: Certain substituted indoles that are modulators of one or more or of CRTH2, COX-2 AND FAAH are described. The compounds are useful for treatment of pain and/or inflammation as well as other disorders.