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    조골세포 분화를 촉진하며 지방세포 분화를 저해하는 벼 추출물 및 그 용도
    1.
    发明申请
    조골세포 분화를 촉진하며 지방세포 분화를 저해하는 벼 추출물 및 그 용도 审中-公开
    促进成骨细胞分化并抑制脂肪细胞分化的大米提取物及其用途

    公开(公告)号：WO2018008838A1

    公开(公告)日：2018-01-11

    申请号：PCT/KR2017/004973

    申请日：2017-05-12

    申请人： 주식회사 성균바이오텍

    发明人： 김현석 ,  박기문 ,  양희진 ,  윤형식

    IPC分类号： A23L33/105 ,  A61K36/899 ,  A61K31/34

    CPC分类号： A23L33/105 ,  A61K31/34 ,  A61K36/899

    摘要： 본 발명은 조골세포 분화를 촉진하며 지방세포 분화를 저해하는 활성을 갖는 벼 추출물에 관한 것으로, 본 발명의 벼 추출물은 조골세포의 분화에 관련된 유전자인 ALP, Osterix 및 Runx2의 발현을 증가시키고, 지방세포의 분화를 관여하는 유전자인 PPARγ, aP2 및 CD36의 발현을 감소하며, 난소절제 골다공증 동물모델에서 골밀도(BMD)를 증가시키며, 골수 속의 지방세포를 감소시켜, 골대사 질환 또는 비만에 유용한 의약품 또는 건강기능식품의 유효성분으로 이용될 수 있다.

    摘要翻译：

    本发明的促进成骨细胞分化和涉及具有抑制脂肪细胞分化，本发明的大米提取物，参与成骨细胞ALP，Osterix的分化基因和的活性的水稻植物提取物 增加Runx2的表达，参与脂肪细胞PPARγ的分化的基因，降低的aP2和CD36的表达，并且在去势骨质疏松动物模型中增加骨矿物密度（BMD），减少脂肪细胞的骨髓，骨 它可以用作药物或用于疾病或肥胖症的健康功能性食品中的有效成分。

    DETERMINATION OF SYNTHETIC LETHAL PARTNERS OF CANCER-SPECIFIC ALTERATIONS AND METHODS OF USE THEREOF
    2.
    发明申请
    DETERMINATION OF SYNTHETIC LETHAL PARTNERS OF CANCER-SPECIFIC ALTERATIONS AND METHODS OF USE THEREOF 审中-公开
    确定癌症特异性改变的全合成组成部分及其使用方法

    公开(公告)号：WO2017083716A3

    公开(公告)日：2017-07-13

    申请号：PCT/US2016061623

    申请日：2016-11-11

    申请人： UNIV LELAND STANFORD JUNIOR

    发明人： SINHA SUBARNAREKHA ,  DILL DAVID L ,  MAJETI RAVINDRA ,  THOMAS DANIEL

    IPC分类号： G06F19/12 ,  C12Q1/68 ,  G06F19/18

    CPC分类号： A61K31/34 ,  G06F19/18 ,  G06F19/20

    摘要： Analytic methods and systems for determining synthetic lethal (SL) partners of a gene of interest are provided. Identification of one or a set of candidate SL partners associated with a mutation in a gene of interest provides targeted therapies for precision oncology, provides targets for drug screening, enables repurposing of existing drugs, and for theranostic applications. An SL partner for a recurrent mutation in IDH1 is identified, which IDH1 mutation may be present in hematologic malignancies, such as acute myeloid leukemia (AML) cells and in solid tumors.

    摘要翻译： 提供了用于确定感兴趣基因的合成致死（SL）伴侣的分析方法和系统。 鉴定与感兴趣基因中的突变相关的一个或一组候选SL伙伴为精确肿瘤学提供靶向治疗，为药物筛选提供靶标，允许重新利用现有药物以及用于分类应用。 确定IDH1复发突变的SL合作伙伴，这种IDH1突变可能存在于血液恶性肿瘤，如急性髓性白血病（AML）细胞和实体瘤中。

    COUMESTROL-CONTAINING GERMINATED FERMENTED SOYBEAN EXTRACT HAVING HEPATOCYTE PROTECTIVE EFFECT AND BONE DENSITY INCREASE EFFECT AND COMPOSITION CONTAINING SAME
    3.
    发明申请
    COUMESTROL-CONTAINING GERMINATED FERMENTED SOYBEAN EXTRACT HAVING HEPATOCYTE PROTECTIVE EFFECT AND BONE DENSITY INCREASE EFFECT AND COMPOSITION CONTAINING SAME 审中-公开
    含有醋酸纤维素的发酵大豆提取物具有肝细胞保护作用和骨密度增加作用和含有该化合物的组合物

    公开(公告)号：WO2017074159A3

    公开(公告)日：2017-06-22

    申请号：PCT/KR2016012399

    申请日：2016-10-31

    申请人： HUBIO

    发明人： LEE DONG SUNG

    IPC分类号： A61K36/48 ,  A23L33/105 ,  A61K9/08 ,  A61K9/20 ,  A61K9/48 ,  A61K31/34 ,  A61K31/35 ,  A61K31/352

    CPC分类号： A23L33/105 ,  A61K9/08 ,  A61K9/20 ,  A61K9/48 ,  A61K31/34 ,  A61K31/35 ,  A61K31/352 ,  A61K36/48

    摘要： The present invention relates to a germinated fermented soybean extract containing coumestrol, a preparation method therefor, and a composition containing the germinated fermented soybean extract. It can be seen that the germinated fermented soybean extract of the present invention is effective in the hepatocyte protection against hepatotoxicity through in vitro antioxidative activity and cell viability, and hematological tests and MDA, GST, GSH, SOD, and CAT measurements in animal models. In addition, the germinated fermented soybean extract of the present invention increases the mineral content in bones, thereby significantly increasing the bone density, and has an effect of increasing the thickness and number of spongy bones. Furthermore, the germinated fermented soybean extract of the present invention has an effect of relieving symptoms of menopause.

    摘要翻译： 本发明涉及含有香豆雌酚的发芽的发酵大豆提取物，其制备方法和含有发芽的发酵大豆提取物的组合物。 可以看出，本发明的发芽的发酵大豆提取物通过体外抗氧化活性和细胞生存力以及血液学测试和MDA，GST，GSH，SOD和CAT测量在动物模型中在肝细胞对肝毒性的保护中是有效的。 此外，本发明发芽的发酵大豆提取物增加了骨骼中的矿物质含量，从而显着增加了骨密度，并且具有增加海绵骨厚度和数量的效果。 此外，本发明的发芽的发酵大豆提取物具有缓解更年期症状的作用。

    PHARMACEUTICAL COMPOSITION INCLUDING 5-{4-(AMINOSULFONYL)PHENYL}-2,2-DIMETHYL-4-(3-FLUOROPHENYL)-3(2H)-FURANONE AND CAPSULE FORMULATION INCLUDING THE PHARMACEUTICAL COMPOSITION
    10.
    发明申请
    PHARMACEUTICAL COMPOSITION INCLUDING 5-{4-(AMINOSULFONYL)PHENYL}-2,2-DIMETHYL-4-(3-FLUOROPHENYL)-3(2H)-FURANONE AND CAPSULE FORMULATION INCLUDING THE PHARMACEUTICAL COMPOSITION 审中-公开
    包括5- {4-（氨基甲酰基）苯基} -2,2-二甲基-4-（3-氟苯基）-3（2H） - 呋喃酮的药物组合物和包括药物组合物的胶囊制剂

    公开(公告)号：WO2015115853A1

    公开(公告)日：2015-08-06

    申请号：PCT/KR2015/001002

    申请日：2015-01-29

    申请人： CRYSTALGENOMICS, INC.

    发明人： KIM, Byung-Ha ,  AHN, Sik Il ,  PARK, Jae-Yeon ,  KIM, Tae Ryong ,  CHO, Joong Myung ,  RO, Seonggu

    IPC分类号： A61K31/34 ,  A61K31/255 ,  A61K9/48 ,  A61K47/38

    CPC分类号： A61K31/34 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/397 ,  A61K31/42

    摘要： The present invention relates to a pharmaceutical composition including (i) the compound of Formula 1 described in the specification or a pharmaceutically acceptable salt thereof, (ii) a pharmaceutically acceptable diluent, and (iii) a pharmaceutically acceptable lubricant. The compound of Formula 1 or pharmaceutically acceptable salt thereof has a 50% volume particle diameter (d (0.5) ) of 3 μm to 9 μm. The pharmaceutical composition of the present invention has the advantages of good stability, high dissolution rate, improved content uniformity, and excellent pharmacokinetic properties. Due to these advantages, the pharmaceutical composition of the present invention is effective in treating inflammation or pain.

    摘要翻译： 本发明涉及药物组合物，其包含（i）说明书中描述的式1的化合物或其药学上可接受的盐，（ii）药学上可接受的稀释剂，和（iii）药学上可接受的润滑剂。 式1的化合物或其药学上可接受的盐具有3μm至9μm的50体积体积粒径（d（0.5））。 本发明的药物组合物具有稳定性好，溶解速度快，含量均匀性提高，药代动力学优异的优点。 由于这些优点，本发明的药物组合物在治疗炎症或疼痛方面是有效的。