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1.发明申请METHODS OF MITIGATING EFFECTS OF RADIATION AND REDUCING THE RISK OF SYSTEMIC INFECTION 审中-公开减轻辐射效应并降低系统感染风险的方法
公开(公告)号：WO2011156729A2
公开(公告)日：2011-12-15
申请号：PCT/US2011040006
申请日：2011-06-10
Applicant: UNIV TEXAS , DARRELL CARNEY
Inventor： DARRELL CARNEY
IPC: A61K38/48
CPC classification number: A61K38/4833
Abstract: The present invention is directed to methods of reducing mortality in a subject exposed to a lethal dose of radiation comprising administering to the subject an effective amount of a thrombin peptide derivative described herein. Also included are methods of reducing the risk of developing bacterial, fungal or viral systemic infection a subject who is exposed or not exposed to radiation, methods of treating a subject with traumatic injury, dermal injury and/or bum injury who is also exposed to radiation, methods of reducing radiation related injury in a subject undergoing radiation therapy, methods of reducing the risk of developing a radiation induced illness, and methods of promoting the healing of a wound that is caused by radiation exposure and/or has been exposed to radiation. These methods comprising administering to the subject an effective amount of a thrombin peptide derivative described herein.
Abstract translation: 本发明涉及降低暴露于致死剂量的辐射的受试者的死亡率的方法，其包括向受试者施用有效量的本文所述的凝血酶肽衍生物。 还包括减少暴露于或不暴露于辐射的受试者的细菌，真菌或病毒全身感染的风险的方法，治疗受创伤性损伤的受试者的方法，还暴露于辐射的皮肤损伤和/或灼伤损伤 减少放射线治疗的受试者的辐射相关损伤的方法，降低辐射诱发疾病发展风险的方法，以及促进由放射线暴露引起的伤口愈合和/或暴露于辐射的方法。 这些方法包括向受试者施用有效量的本文所述的凝血酶肽衍生物。
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2.发明申请
公开(公告)号：WO2011156729A3
公开(公告)日：2011-12-15
申请号：PCT/US2011/040006
申请日：2011-06-10
Inventor： DARRELL, Carney
Abstract: The present invention is directed to methods of reducing mortality in a subject exposed to a lethal dose of radiation comprising administering to the subject an effective amount of a thrombin peptide derivative described herein. Also included are methods of reducing the risk of developing bacterial, fungal or viral systemic infection a subject who is exposed or not exposed to radiation, methods of treating a subject with traumatic injury, dermal injury and/or bum injury who is also exposed to radiation, methods of reducing radiation related injury in a subject undergoing radiation therapy, methods of reducing the risk of developing a radiation induced illness, and methods of promoting the healing of a wound that is caused by radiation exposure and/or has been exposed to radiation. These methods comprising administering to the subject an effective amount of a thrombin peptide derivative described herein.
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