公开(公告)号：WO2010145035A1

公开(公告)日：2010-12-23

申请号：PCT/CA2010/000946

申请日：2010-06-18

Applicant: SIU, K.W. Michael ,  DE SOUZA, Leroi V. ,  YOUSEF, George M. ,  ROMASCHIN, Alexander D.

Inventor： SIU, K.W. Michael ,  DE SOUZA, Leroi V. ,  YOUSEF, George M. ,  ROMASCHIN, Alexander D.

IPC: C40B40/06 ,  A61K45/00 ,  A61K49/00 ,  A61P35/00 ,  C12Q1/68 ,  C40B30/04 ,  C40B40/10 ,  G01N33/574 ,  G01N33/68

CPC classification number: G01N33/57438 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N2500/00 ,  G01N2800/52 ,  G01N2800/56

Abstract: The invention provides markers for renal cancer, polynucleotides encoding same, and precursors thereof. The invention also provides methods for detecting, diagnosing, screening for, monitoring, assessing, and treating renal cancers and related disease conditions in a subject. The invention further provides a method of selecting for or assessing efficacy of agents against renal cancer, and a method for assessing renal cancer cell carcinogenic potential of a compound. The invention further provides localization and imaging methods for renal cancers. Also provided are diagnostic compositions and kits for carrying out methods of the invention. In addition, the invention provides therapeutic applications for renal cancers which employ protein renal cancer markers and polynucleotides encoding same, miRNA renal cancer markers and precursors thereof, and binding agents for the markers.

Abstract translation: 本发明提供肾癌标记物，编码其的多核苷酸及其前体。 本发明还提供用于检测，诊断，筛选，监测，评估和治疗受试者中的肾癌和相关疾病状况的方法。 本发明进一步提供了选择或评估药物对肾癌的功效的方法，以及评估化合物的肾癌细胞致癌潜力的方法。 本发明还提供了肾癌的定位和成像方法。 还提供了用于实施本发明方法的诊断组合物和试剂盒。 此外，本发明提供了使用蛋白质肾癌标记物和编码其的多核苷酸，miRNA肾癌标记物及其前体以及用于标记物的结合剂的肾癌的治疗应用。

公开(公告)号：WO2009097692A1

公开(公告)日：2009-08-13

申请号：PCT/CA2009/000154

申请日：2009-02-06

Applicant: SIU, K.W. Michael ,  RALHAN, Ranju ,  MATTA, Ajay ,  DE SOUZA, Leroi V.

Inventor： SIU, K.W. Michael ,  RALHAN, Ranju ,  MATTA, Ajay ,  DE SOUZA, Leroi V.

IPC: C40B40/10 ,  A61K45/00 ,  A61K49/00 ,  C07K14/47 ,  C12Q1/68 ,  C40B30/04 ,  G01N33/53 ,  G01N33/574 ,  G01N33/68

CPC classification number: G01N33/57407 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N33/57484

Abstract: The invention provides markers and methods for detecting head-and-neck precancers, (including OPLs), cancers, and related disease conditions in a subject. The invention also provides localization and imaging methods for head-and-neck precancers (including OPLs) and cancers, along with kits for carrying out methods of the invention. The invention further provides therapeutic applications for head-and-neck precancers (including OPLs) and cancers which employ head-and-neck precancer and cancer markers, polynucleotides encoding the markers, and binding agents for the markers.

Abstract translation: 本发明提供用于检测受试者的头颈部预处理剂（包括OPL），癌症和相关疾病状况的标记物和方法。 本发明还提供了头颈部预干燥剂（包括OPL）和癌症的定位和成像方法，以及用于实施本发明方法的试剂盒。 本发明进一步提供了用于头颈部预处理剂（包括OPL）和使用头颈前体癌症和癌症标志物的癌症，编码标记物的多核苷酸和用于标记物的结合剂的治疗应用。

公开(公告)号：WO2008049239A1

公开(公告)日：2008-05-02

申请号：PCT/CA2007/001935

申请日：2007-10-26

Applicant: MOUNT SINAI HOSPITAL ,  UNIVERSITY HEALTH NETWORK ,  SIU, Michael, K., W. ,  COLGAN, Terence, J. ,  ROMASCHIN, Alexander, D. ,  DE SOUZA, Leroi, V.

Inventor： SIU, Michael, K., W. ,  COLGAN, Terence, J. ,  ROMASCHIN, Alexander, D. ,  DE SOUZA, Leroi, V.

IPC: C40B40/10 ,  A61K49/00 ,  C07K14/47 ,  C07K14/52 ,  C07K14/705 ,  C07K14/775 ,  C07K14/81 ,  C12N9/12 ,  C12Q1/00 ,  C12Q1/68 ,  C40B30/00 ,  C40B30/04 ,  G01N33/53 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/16 ,  G01N33/57442 ,  G01N33/6893 ,  G01N2500/10

Abstract: Methods for detecting endometrial diseases or an endometrium phase in a subject are described comprising measuring endometrial markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for endometrial diseases, and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for endometrial diseases employing endometrial markers, polynucleotides encoding the markers, and/or binding agents for the markers.

Abstract translation: 描述了检测受试者子宫内膜疾病或子宫内膜期的方法，其包括测量子宫内膜标志物或编码来自受试者的样品中的标记物的多核苷酸。 本发明还提供子宫内膜疾病的定位或成像方法以及用于实施本发明方法的试剂盒。 本发明还考虑了使用子宫内膜标志物，编码标记物的多核苷酸和/或用于标记物的结合剂的子宫内膜疾病的治疗应用。