公开(公告)号：WO2020161720A1

公开(公告)日：2020-08-13

申请号：PCT/IL2020/050150

申请日：2020-02-06

Applicant: ARIEL SCIENTIFIC INNOVATIONS LTD. ,  THE DEAD-SEA & ARAVA SCIENCE CENTER

Inventor： BEN-VALID, Shoshana ,  COHEN, Guy

IPC: A61K8/00 ,  A61Q19/00

Abstract: Described herein is a process for obtaining a UV-absorbing material, optionally 1,2,3,4,6-pentagalloyl glucose, from sumac leaves and/or budding fruits, as well as a UV-absorbing material obtained according to said process, and compositions comprising such a UV-absorbing material. The process comprises contacting sumac leaves and/or budding fruits with a water miscible organic solvent, and removing the water-miscible organic solvent. Compositions described herein sunscreen compositions wherein a concentration of the UV-absorbing material is at least 0.005 mg/ml, as well as pharmaceutical and/or cosmetic compositions.

公开(公告)号：WO2013001490A1

公开(公告)日：2013-01-03

申请号：PCT/IB2012/053294

申请日：2012-06-28

Applicant: THE STATE OF ISRAEL - MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (ARO) (VOLCANI CENTER) ,  DEAD SEA & ARAVA SCIENCE CENTER ,  ELMANN, Anat ,  KASHMAN, Yoel ,  OFIR, Rivka

Inventor： ELMANN, Anat ,  KASHMAN, Yoel ,  OFIR, Rivka

IPC: C07C49/245 ,  C07C49/255 ,  A61K31/047 ,  A61K31/05 ,  A61K31/121 ,  A61P29/00 ,  A61P25/16 ,  A61P25/28

CPC classification number: C07C49/84 ,  C07C49/83

Abstract: Disclosed are dihydrochaicone derivatives useful in the treatment of inflammatory and neuro-inflammatory diseases such as Alzheimer and Parkinson or conditions such as stroke. Both a and β carbons of the dihydrochaicone are hydroxylated. Also disclosed are methods of using such compounds in the treatment of inflammatory diseases in mammals and pharmaceutical compositions containing such compounds.

Abstract translation: 公开了可用于治疗炎性和神经炎症性疾病如阿尔茨海默病和帕金森病的二氢吖啶酮衍生物或诸如中风的病症。 二氢吖啶酮的a和ß碳都是羟基化的。 还公开了使用这些化合物治疗哺乳动物炎性疾病的方法和含有这些化合物的药物组合物。