公开(公告)号：WO2013001490A1

公开(公告)日：2013-01-03

申请号：PCT/IB2012/053294

申请日：2012-06-28

申请人： THE STATE OF ISRAEL - MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (ARO) (VOLCANI CENTER) ,  DEAD SEA & ARAVA SCIENCE CENTER ,  ELMANN, Anat ,  KASHMAN, Yoel ,  OFIR, Rivka

发明人： ELMANN, Anat ,  KASHMAN, Yoel ,  OFIR, Rivka

IPC分类号： C07C49/245 ,  C07C49/255 ,  A61K31/047 ,  A61K31/05 ,  A61K31/121 ,  A61P29/00 ,  A61P25/16 ,  A61P25/28

CPC分类号： C07C49/84 ,  C07C49/83

摘要： Disclosed are dihydrochaicone derivatives useful in the treatment of inflammatory and neuro-inflammatory diseases such as Alzheimer and Parkinson or conditions such as stroke. Both a and β carbons of the dihydrochaicone are hydroxylated. Also disclosed are methods of using such compounds in the treatment of inflammatory diseases in mammals and pharmaceutical compositions containing such compounds.

摘要翻译： 公开了可用于治疗炎性和神经炎症性疾病如阿尔茨海默病和帕金森病的二氢吖啶酮衍生物或诸如中风的病症。 二氢吖啶酮的a和ß碳都是羟基化的。 还公开了使用这些化合物治疗哺乳动物炎性疾病的方法和含有这些化合物的药物组合物。

公开(公告)号：WO2012104845A1

公开(公告)日：2012-08-09

申请号：PCT/IL2012/000065

申请日：2012-02-06

申请人： BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY ,  OFIR, Rivka ,  RACHMILEVICH, Shimon ,  Amiel, Eitan ,  DUDAI, Nativ ,  RABINSKI, Tattiana ,  THE VOLCANI CENTER- THE STATE OF ISRAEL MINISTRY OF AGRICULTURE & RURAL DEVELOPMENT, AGRICULTURAL RESEARCH ORGANIZATION (A.R.O.)

发明人： OFIR, Rivka ,  RACHMILEVICH, Shimon ,  Amiel, Eitan ,  DUDAI, Nativ ,  RABINSKI, Tattiana

IPC分类号： A61K36/00

CPC分类号： A61K31/015 ,  C12N5/0693

摘要： The invention provides compositions and methods for inducing apoptosis in a cancer cell or a cell transformed by Epstein-Barr virus (EBV). Specifically, the invention provides Beta-Caryophyllene or a composition thereof to induce apoptosis. The invention further provides treating lymphoma or Epstein-Barr virus (EBV) associated disease in a subject by administering Beta-Caryophyllene or a composition thereof.

摘要翻译： 本发明提供用于诱导癌细胞或由爱泼斯坦 - 巴尔病毒（EBV）转化的细胞的细胞凋亡的组合物和方法。 具体地，本发明提供了β-石竹烯或其组合物以诱导细胞凋亡。 本发明还通过给予β-石竹烯或其组合物来治疗受试者中的淋巴瘤或爱泼斯坦 - 巴尔病毒（EBV）相关疾病。

公开(公告)号：WO2007086070A2

公开(公告)日：2007-08-02

申请号：PCT/IL2007/000113

申请日：2007-01-30

申请人： BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY ,  MOR RESEARCH APPLICATIONS LTD. ,  BIRK, Ohad Shmuel ,  BIRNBAUM, Ramon Yossef ,  OFIR, Rivka

发明人： BIRK, Ohad Shmuel ,  BIRNBAUM, Ramon Yossef ,  OFIR, Rivka

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

摘要： The invention provides a method for diagnosing a skin disease that is associated with the ZNF750 gene in an individual, comprising determining an aberration in the sequence or expression of the ZNF750 gene and/or determining the identity of single nucleotide polymorphism of the ZNF750 gene, in a biological sample of said individual.

摘要翻译： 本发明提供一种用于诊断与个体中的ZNF750基因相关的皮肤疾病的方法，包括确定ZNF750基因的序列或表达中的像差和/或确定ZNF750基因的单核苷酸多态性的同一性， 所述个体的生物样品。

公开(公告)号：WO2010067352A1

公开(公告)日：2010-06-17

申请号：PCT/IL2009/001117

申请日：2009-11-26

申请人： BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY ,  HACOHEN, Zvi ,  KHOZIN GOLDBERG, Inna ,  OFIR, Rivka ,  UMIDJON, Iskandarov

发明人： HACOHEN, Zvi ,  KHOZIN GOLDBERG, Inna ,  OFIR, Rivka ,  UMIDJON, Iskandarov

IPC分类号： C12N9/10 ,  C12P7/64 ,  C12N15/82

CPC分类号： C12N9/1029 ,  C12N15/8247 ,  C12P7/6427 ,  C12P7/6463 ,  C12P7/6472

摘要： An isolated protein which is at least partially encoded by a polynucleotide sequence encoding a novel elongase is provided together with a composition which includes the isolated protein. A transgenic plant or a transgenic seed transformed by a polynucleotide encoding a protein which is at least partially encoded by a novel elongase is also provided. The invention also includes a process for making a very long-chain polyunsaturated fatty acid in a transformed cell or plant expressing the isolated protein which is at least partially encoded by a polynucleotide sequence encoding a novel elongase.

摘要翻译： 与包含分离的蛋白质的组合物一起提供至少部分由编码新的延伸酶的多核苷酸序列编码的分离的蛋白质。 还提供了转基因植物或由编码至少部分由新的延伸酶编码的蛋白质的多核苷酸转化的转基因种子。 本发明还包括在表达分离的蛋白质的转化细胞或植物中制备非常长链多不饱和脂肪酸的方法，其至少部分由编码新的延伸酶的多核苷酸序列编码。

公开(公告)号：WO2007086070A3

公开(公告)日：2009-04-09

申请号：PCT/IL2007000113

申请日：2007-01-30

申请人： UNIV BEN GURION ,  MOR RESEARCH APPLIC LTD ,  BIRK OHAD SHMUEL ,  BIRNBAUM RAMON YOSSEF ,  OFIR RIVKA

发明人： BIRK OHAD SHMUEL ,  BIRNBAUM RAMON YOSSEF ,  OFIR RIVKA

IPC分类号： C12Q1/68 ,  A01N43/04

CPC分类号： C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/172

摘要： The invention provides a method for diagnosing a skin disease that is associated with the ZNF750 gene in an individual, comprising determining an aberration in the sequence or expression of the ZNF750 gene and/or determining the identity of single nucleotide polymorphism of the ZNF750 gene, in a biological sample of said individual.

摘要翻译： 本发明提供一种用于诊断与个体中的ZNF750基因相关的皮肤疾病的方法，包括确定ZNF750基因的序列或表达中的像差和/或确定ZNF750基因的单核苷酸多态性的同一性， 所述个体的生物样品。