公开(公告)号：WO2011136911A3

公开(公告)日：2012-03-08

申请号：PCT/US2011031829

申请日：2011-04-08

Applicant: AVEO PHARMACEUTICALS INC ,  VINCENT SYLVIE ,  WINSTON WILLIAM M JR ,  WANG FANG ,  WEILER SOLLY ,  MEETZE KRISTAN ,  BREAULT LYNE ,  BOTEGA STEVE ,  CHEN TING ,  DEPRIMA MICHAEL ,  FLEET CHRISTINA ,  TYLER STEVEN ,  WOO JIN-KYEUNG ,  GYURIS JENO

Inventor： VINCENT SYLVIE ,  WINSTON WILLIAM M JR ,  WANG FANG ,  WEILER SOLLY ,  MEETZE KRISTAN ,  BREAULT LYNE ,  BOTEGA STEVE ,  CHEN TING ,  DEPRIMA MICHAEL ,  FLEET CHRISTINA ,  TYLER STEVEN ,  WOO JIN-KYEUNG ,  GYURIS JENO

IPC: C07K16/32 ,  A61K39/395 ,  A61P35/00 ,  C12N15/13

CPC classification number: C07K16/32 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB 3/HER3.

Abstract translation: 公开了结合并抑制表皮生长因子受体相关成分ErbB3 / HER3活化的单克隆抗体。 抗体可用于治疗与ErbB 3 / HER3的激活相关的细胞增殖性疾病和病症，包括某些形式的癌症。

公开(公告)号：WO2011136911A2

公开(公告)日：2011-11-03

申请号：PCT/US2011/031829

申请日：2011-04-08

Applicant: AVEO PHARMACEUTICALS, INC. ,  VINCENT, Sylvie ,  WINSTON, William, M., Jr. ,  WANG, Fang ,  WEILER, Solly ,  MEETZE, Kristan ,  BREAULT, Lyne ,  BOTEGA, Steve ,  CHEN, Ting ,  DEPRIMA, Michael ,  FLEET, Christina ,  TYLER, Steven ,  WOO, Jin-Kyeung ,  GYURIS, Jeno

Inventor： VINCENT, Sylvie ,  WINSTON, William, M., Jr. ,  WANG, Fang ,  WEILER, Solly ,  MEETZE, Kristan ,  BREAULT, Lyne ,  BOTEGA, Steve ,  CHEN, Ting ,  DEPRIMA, Michael ,  FLEET, Christina ,  TYLER, Steven ,  WOO, Jin-Kyeung ,  GYURIS, Jeno

IPC: C07K16/32

CPC classification number: C07K16/32 ,  A61K39/39558 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: Monoclonal antibodies that bind and inhibit activation of epidermal growth factor receptor related member ErbB3/HER3 are disclosed. The antibodies can be used to treat cell proliferative diseases and disorders, including certain forms of cancer, associated with activation of ErbB 3/HER3.

Abstract translation: 公开了结合并抑制表皮生长因子受体相关成分ErbB3 / HER3活化的单克隆抗体。 抗体可用于治疗与ErbB 3 / HER3的激活相关的细胞增殖性疾病和病症，包括某些形式的癌症。