公开(公告)号：WO2004003558A1

公开(公告)日：2004-01-08

申请号：PCT/US2003/020567

申请日：2003-06-27

Applicant: GEORGIA TECH RESEARCH CORPORATION ,  DICKSON, Robert, Martin ,  ZHENG, Jie

Inventor： DICKSON, Robert, Martin ,  ZHENG, Jie

IPC: G01N33/543

CPC classification number: B82Y15/00 ,  G01N33/582 ,  G01N33/588 ,  Y10S436/805

Abstract: A composition is disclosed which is capable of being used for detection, comprising an encapsulated noble metal nanocluster. Methods for preparing the encapsulated noble metal nanoclusters, and methods of using the encapsulated noble metal nanoclusters are also disclosed. The noble metal nanoclusters are preferably encapsulated by a dendrimer or a peptide. The encapsulated noble metal nanoclusters have a characteristic spectral emission, wherein said spectral emission is varied by controlling the nature of the encapsulating material, such as by controlling the size of the nanocluster and/or the generation of the dendrimer, and wherein said emission is used to provide information about a biological state.

Abstract translation: 公开了能够用于检测的组合物，其包含包封的贵金属纳米簇。 还公开了制备包封的贵金属纳米簇的方法，以及使用包封的贵金属纳米团簇的方法。 贵金属纳米团簇优选被树枝状聚合物或肽包封。 封装的贵金属纳米团簇具有特征光谱发射，其中所述光谱发射通过控制封装材料的性质而变化，例如通过控制纳米簇的尺寸和/或树枝状聚合物的产生，并且其中使用所述发射 提供有关生物状态的信息。

公开(公告)号：WO2005086830A3

公开(公告)日：2005-12-29

申请号：PCT/US2005007649

申请日：2005-03-10

Applicant: GEORGIA TECH RES INST ,  DICKSON ROBERT MARTIN ,  ZHENG JIE ,  CAPADONA LYNN ANNE ,  PETTY JEFFREY THOMAS ,  PATEL SANDEEP AJIT ,  WECK MARCUS

Inventor： DICKSON ROBERT MARTIN ,  ZHENG JIE ,  CAPADONA LYNN ANNE ,  PETTY JEFFREY THOMAS ,  PATEL SANDEEP AJIT ,  WECK MARCUS

IPC: C07K1/00 ,  C12Q1/68 ,  G01N33/20 ,  G01N33/53 ,  G01N33/532 ,  G01N33/533 ,  G01N33/543 ,  G01N33/553 ,  G01N33/58

CPC classification number: G01N33/588 ,  A61K49/0065 ,  A61K49/0067 ,  A61K49/0093 ,  B82Y15/00 ,  G01N33/532 ,  G01N33/54346 ,  G01N33/5436 ,  G01N33/582 ,  Y10T436/107497

Abstract: A composition is disclosed which is capable of being used for detection, comprising an encapsulated noble metal nanocluster. Methods for preparing the encapsulated noble metal nanoclusters, and methods of using the encapsulated noble metal nanoclusters are also disclosed. In certain embodiments, the noble metal nanoclusters are encapsulated by a dendrimer, a peptide, a small organic or inorganic molecule, or an oligonucleotide. The encapsulated noble metal nanoclusters have a characteristic spectral emission, wherein said spectral emission is varied by controlling the nature of the encapsulating material, such as by controlling the size of the nanocluster, the generation of a dendrimer, the incorporation of a functional group, and wherein said emission is used to provide information about a biological state. The emission is selected from the group consisting of nanocluster fluorescence, multiphoton excited nanocluster fluorescence, Stokes or Anti-Stokes Raman emission from the encapsulating material, and second harmonic generation.

Abstract translation: 公开了能够用于检测的组合物，其包含包封的贵金属纳米簇。 还公开了制备包封的贵金属纳米簇的方法，以及使用包封的贵金属纳米团簇的方法。 在某些实施方案中，贵金属纳米簇被树枝状聚合物，肽，小有机或无机分子或寡核苷酸包封。 封装的贵金属纳米团簇具有特征光谱发射，其中通过控制封装材料的性质来改变所述光谱发射，例如通过控制纳米簇的尺寸，树枝状聚合物的产生，官能团的结合，和 其中所述发射用于提供关于生物学状态的信息。 发射选自纳米团簇荧光，多光子激发纳米团簇荧光，来自封装材料的斯托克斯或反斯托克斯拉曼发射以及二次谐波产生。

公开(公告)号：WO2005086830A2

公开(公告)日：2005-09-22

申请号：PCT/US2005/007649

申请日：2005-03-10

Applicant: GEORGIA TECH RESEARCH CORPORATION ,  DICKSON, Robert, Martin ,  ZHENG, Jie ,  CAPADONA, Lynn, Anne ,  PETTY, Jeffrey, Thomas ,  PATEL, Sandeep, Ajit ,  WECK, Marcus

Inventor： DICKSON, Robert, Martin ,  ZHENG, Jie ,  CAPADONA, Lynn, Anne ,  PETTY, Jeffrey, Thomas ,  PATEL, Sandeep, Ajit ,  WECK, Marcus

IPC: C07K1/00 ,  C12Q1/68 ,  G01N33/20 ,  G01N33/53 ,  G01N33/532 ,  G01N33/533 ,  G01N33/543 ,  G01N33/553 ,  G01N33/58

CPC classification number: G01N33/588 ,  A61K49/0065 ,  A61K49/0067 ,  A61K49/0093 ,  B82Y15/00 ,  G01N33/532 ,  G01N33/54346 ,  G01N33/5436 ,  G01N33/582 ,  Y10T436/107497

Abstract: A composition is disclosed which is capable of being used for detection, comprising an encapsulated noble metal nanocluster. Methods for preparing the encapsulated noble metal nanoclusters, and methods of using the encapsulated noble metal nanoclusters are also disclosed. In certain embodiments, the noble metal nanoclusters are encapsulated by a dendrimer, a peptide, a small organic or inorganic molecule, or an oligonucleotide. The encapsulated noble metal nanoclusters have a characteristic spectral emission, wherein said spectral emission is varied by controlling the nature of the encapsulating material, such as by controlling the size of the nanocluster, the generation of a dendrimer, the incorporation of a functional group, and wherein said emission is used to provide information about a biological state. The emission is selected from the group consisting of nanocluster fluorescence, multiphoton excited nanocluster fluorescence, Stokes or Anti-Stokes Raman emission from the encapsulating material, and second harmonic generation.

Abstract translation: 公开了一种能够用于检测的组合物，其包含包封的贵金属纳米簇。 还公开了制备包封的贵金属纳米团簇的方法以及使用包封的贵金属纳米团簇的方法。 在某些实施方案中，贵金属纳米簇被树枝状聚合物，肽，小有机或无机分子或寡核苷酸包封。 包封的贵金属纳米簇具有特征光谱发射，其中所述光谱发射通过控制包封材料的性质而改变，例如通过控制纳米团簇的尺寸，树枝状聚合物的生成，掺入官能团和 其中所述发射被用于提供关于生物状态的信息。 发射选自纳米团簇荧光，多光子激发的纳米团簇荧光，来自封装材料的斯托克斯或反斯托克斯拉曼发射以及二次谐波产生。