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    ULTRASMALL NANOPARTICLES AND METHODS OF MAKING AND USING SAME
    1.
    发明申请
    ULTRASMALL NANOPARTICLES AND METHODS OF MAKING AND USING SAME 审中-公开
    超声波纳米粒子及其制备方法和使用方法

    公开(公告)号：WO2016179260A1

    公开(公告)日：2016-11-10

    申请号：PCT/US2016/030752

    申请日：2016-05-04

    申请人： CORNELL UNIVERSITY

    发明人： WIESNER, Ulrich B. ,  MA, Kai ,  MENDOZA, Carlie

    IPC分类号： A61K47/48 ,  A61K9/14 ,  A61K9/16 ,  A61K47/02 ,  A61K47/30

    CPC分类号： A61K49/0093 ,  A61B5/0071 ,  A61K9/141 ,  A61K9/5115 ,  A61K9/5146 ,  A61K9/5192 ,  A61K49/0032 ,  A61P35/00

    摘要： An aqueous synthesis methodology for the preparation of silica nanoparticles (SNPs), core-shell SNPs having, for example, a size of 2 to 15 nm and narrow size-dispersion with size control below 1 nm, i.e. at the level of a single atomic layer. Different types of dyes, including near infrared (NIR) emitters, can be covalently encapsulated within and brightness can be enhanced via addition of extra silica shells. The surface may be functionalized with polyethylene glycol (PEG) groups and, optionally, specific surface ligands. This aqueous synthesis methodology also enables synthesis of 2 to 15 nm sized fluorescent core and core- shell aluminosilicate nanoparticles (ASNPs) which may also be surface functionalized. Encapsulation efficiency and brightness of highly negatively charged NIR fluorophores is enhanced relative to the corresponding SNPs without aluminum.

    摘要翻译： 用于制备二氧化硅纳米颗粒（SNP）的水合成方法，具有例如2至15nm的尺寸和尺寸小于1nm的窄尺寸分散的核 - 壳SNP，即单原子水平 层。 包括近红外（NIR）发射体在内的不同类型的染料可以被共价地包封，并且可以通过加入额外的二氧化硅壳来增强亮度。 表面可以用聚乙二醇（PEG）基团和任选的特定表面配体官能化。 这种水性合成方法还能够合成2-15nm大小的荧光核心和核壳铝硅酸盐纳米颗粒（ASNP），其也可以被表面官能化。 相对于没有铝的相应SNP，高度负电荷的NIR荧光团的封装效率和亮度得到增强。

    CONJUGATED POLYMER NANODOTS AS LONG-TERM STEM CELL TRACKERS
    2.
    发明申请
    CONJUGATED POLYMER NANODOTS AS LONG-TERM STEM CELL TRACKERS 审中-公开
    作为长期干细胞跟踪器的聚合聚合物纳米粒子

    公开(公告)号：WO2016133462A1

    公开(公告)日：2016-08-25

    申请号：PCT/SG2016/050081

    申请日：2016-02-16

    申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    发明人： LI, Kai ,  JIN, Guorui ,  LIU, Bin

    IPC分类号： G01N33/52 ,  G01N33/58 ,  C09K11/06 ,  A61K49/00 ,  A61K35/12

    CPC分类号： A61K49/0097 ,  A61K35/00 ,  A61K49/0093 ,  C09K11/06 ,  C09K2211/1416 ,  C09K2211/1475 ,  G01N33/5005 ,  G01N33/5073 ,  G01N33/582 ,  G01N33/588

    摘要： This invention relates to a method for tracking stem cells characterized in that the stems cells are labelled with at least one fluorescent conjugated polymer nanodot and the fluorescence of the labelled cells is detected. The fluorescent conjugated polymer nanodot comprises a conjugated polymer such as poly(9,9-dihexylfluorene-alt-2,1,3-benzoxadiazole) (PFBD) capped with an amphiphilic co-polymer such as DSPE-PEG2000 (1,2-distearoyl-sn-glycero-3-phosphoethanolamine (DSPE)-conjugated polyethylene glycol) and DSPE-PEG 2000 maleimide. The method allows for the tracking of stem cells over long periods of time after transplantation exceeding 25 days. The stem cells are not compromised in their behaviours of proliferation, migration, differentiation and secretome by the labelling method of the invention. The method may be useful as a research tool in regenerative stem cell medicine. Corresponding stem cell tracking kits are also disclosed as well as stem cells labelled with the fluorescent conjugated polymer nanodots.

    摘要翻译： 本发明涉及一种跟踪干细胞的方法，其特征在于茎细胞用至少一个荧光共轭聚合物纳米点标记，并检测标记细胞的荧光。 荧光共轭聚合物纳米点包含共轭聚合物，例如用两亲共聚物封端的聚（9,9-二己基芴-2,2,3-苯并恶二唑）（PFBD），如DSPE-PEG2000（1,2-二硬脂酰基 -sn-甘油-3-磷酸乙醇胺（DSPE） - 共轭聚乙二醇）和DSPE-PEG2000马来酰亚胺。 该方法允许在移植超过25天后长时间跟踪干细胞。 通过本发明的标记方法，干细胞的增殖，迁移，分化和分泌的行为不受损害。 该方法可用作再生干细胞医学中的研究工具。 还公开了相应的干细胞跟踪试剂盒以及用荧光共轭聚合物纳米点标记的干细胞。

    PHARMACEUTICAL FORMULATION HAVING REVERSE THERMAL GELATION PROPERTIES FOR LOCAL DELIVERY OF NANOPARTICLES
    3.
    发明申请
    PHARMACEUTICAL FORMULATION HAVING REVERSE THERMAL GELATION PROPERTIES FOR LOCAL DELIVERY OF NANOPARTICLES 审中-公开
    具有反向热凝性能的药物制剂，用于局部递送纳米颗粒

    公开(公告)号：WO2016087674A1

    公开(公告)日：2016-06-09

    申请号：PCT/EP2015/078741

    申请日：2015-12-06

    申请人： EXCHANGE IMAGING TECHNOLOGIES GMBH

    发明人： GREB, Wolfgang ,  BELEKE, Jean Philip

    IPC分类号： A61K49/00 ,  A61K41/00 ,  A61K31/00

    CPC分类号： A61K49/0067 ,  A61K9/0019 ,  A61K9/501 ,  A61K9/5031 ,  A61K9/5115 ,  A61K31/77 ,  A61K47/10 ,  A61K49/0006 ,  A61K49/0093 ,  A61K2300/00

    摘要： The present invention refers to a pharmaceutical formulation for injection comprising fluorescent nanoparticles as in vivo diagnostics. The present invention relates to an injectable pharmaceutical formulation for human medicine and/or veterinary use, comprising 17% to 20% per weight of poloxamer 407 and 3% - 15% per weight of poloxamer 188, 0.10 nM to 10.0 μΜ fluorescent nanoparticles and water or an aqueous buffer, wherein the pharmaceutical formulation is liquid at 4°C - 32°C and forms a gel at about 37°C, their use as an in vivo marker and methods of their preparation. The inventive formulation is useful for local control and prevention of spreading/diffusion of nanoparticles, and thus allows full utilization of their quantum physics properties for example as a tool to enable surgical precision of tumor removal; even without tumor specific epitope binding antibodies.

    摘要翻译： 本发明涉及用于注射的药物制剂，其包含作为体内诊断的荧光纳米颗粒。 本发明涉及用于人类药物和/或兽医用途的可注射药物制剂，其包含17重量％至20重量％泊洛沙姆407和3重量％-15重量％泊洛沙姆188,10.1nM至10.0微米荧光纳米颗粒和水 或水性缓冲液，其中药物制剂在4℃至32℃下为液体，并在约37℃下形成凝胶，其用作体内标记物及其制备方法。 本发明的制剂可用于局部控制和防止纳米颗粒的扩散/扩散，因此允许充分利用其量子物理性质，例如作为使手术切除肿瘤精确度的工具; 即使没有肿瘤特异性表位结合抗体。

    IN-VIVO REACTIVE SPECIES IMAGING
    6.
    发明申请
    IN-VIVO REACTIVE SPECIES IMAGING 审中-公开
    INVIVO反应物种成像

    公开(公告)号：WO2015042256A1

    公开(公告)日：2015-03-26

    申请号：PCT/US2014/056292

    申请日：2014-09-18

    申请人： CALIPER LIFE SCIENCES ,  RAY, Sunetra ,  ANSALDI, Daniel ,  SINGH, Rajendra

    发明人： RAY, Sunetra ,  ANSALDI, Daniel ,  SINGH, Rajendra

    IPC分类号： A61K49/00

    CPC分类号： A61K49/0052 ,  A61K49/0019 ,  A61K49/0058 ,  A61K49/0093

    摘要： The disclosure features methods that include: administering to a subject a composition that includes particles, where each one of the particles features at least one targeting group that binds to a structural entity in the subject and at least one reacting group that reacts chemically with a reactive oxygen species in the subject, and where the particle emits luminescence when the reaction occurs; detecting the luminescence emission from the particles; and displaying an image of the subject showing locations of at least some reactive oxygen species in the subject based on the detected luminescence.

    摘要翻译： 本发明的特征在于方法，其包括：向受试者施用包括颗粒的组合物，其中每个颗粒的特征在于与受试者中的结构实体结合的至少一个靶向基团和至少一个与反应性化学反应的反应基团 受试者中的氧物质，当发生反应时颗粒发射发光的地方; 检测来自颗粒的发光发射; 以及基于检测到的发光显示受试者中至少一些活性氧的位置的图像。