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    NOVEL TASHINONE DRUGS FOR ALZHEIMER DISEASE
    1.
    发明申请
    NOVEL TASHINONE DRUGS FOR ALZHEIMER DISEASE 审中-公开
    新泽西州药物阿尔茨海默病

    公开(公告)号：WO2014138357A1

    公开(公告)日：2014-09-12

    申请号：PCT/US2014/021083

    申请日：2014-03-06

    Applicant: ZHENG, Jie ,  YU, Xiang ,  WANG, Qiuming ,  THE UNIVERSITY OF AKRON

    Inventor： ZHENG, Jie ,  YU, Xiang ,  WANG, Qiuming

    IPC: A61K31/343 ,  A61K31/122

    CPC classification number: A61K31/343

    Abstract: A method for disaggregating amyloid peptide aggregates the method comprising administering a tanshinone or a tanshinone derivatives to an amyloid peptide aggregate. The method may be useful for disaggregating amyloid peptide aggregates in a patient in need of such treatment, such as patients with Alzheimer's disease.

    Abstract translation: 分解淀粉样肽聚集体的方法包括将丹参酮或丹参酮衍生物施用于淀粉样肽聚集体。 该方法可用于在需要这种治疗的患者（例如阿尔茨海默病患者）中分解淀粉样肽聚集体。

    A MEDICAL IMAGE TRANSFER METHOD AND ITS SYSTEM
    3.
    发明申请
    A MEDICAL IMAGE TRANSFER METHOD AND ITS SYSTEM 审中-公开
    医学图像传输方法及其系统

    公开(公告)号：WO2011051103A1

    公开(公告)日：2011-05-05

    申请号：PCT/EP2010/065322

    申请日：2010-10-13

    Applicant: SIEMENS AKTIENGESELLSCHAFT ,  LIU, Ning ,  ZHENG, Jie

    Inventor： LIU, Ning ,  ZHENG, Jie

    IPC: G06F19/00

    CPC classification number: G06F19/321 ,  G06F19/00

    Abstract: The invention provides a medical image transfer method and system, wherein the source Picture Archiving and Communication System (PACS) side and the determination PACS side are respectively provided with a transfer client end and a transfer server; the transfer client end receives the medical image data from the source PACS according to the Digital Imaging and Communications in Medicine (DICOM) standard, sets the transfer server address as the destination address of the medical image data, compresses the medical image data, and sends the compressed medical image data to the Internet by way of broken-point continuous transfer when the network status of the Internet is monitored to satisfy the transfer requirements of medical image data; the transfer server receives via the Internet the medical image data, whose destination address is the address of the transfer server, decompresses the medical image data, and sends the decompressed image data by DICOM standard to the destination PACS.

    Abstract translation: 本发明提供一种医疗图像传送方法和系统，其中源图像存档和通信系统（PACS）侧和确定PACS侧分别设置有传送客户端和传送服务器; 转移客户端根据数字影像和通信医学（DICOM）标准从源PACS接收医学图像数据，将传输服务器地址设置为医学图像数据的目的地地址，压缩医学图像数据，并发送 当互联网的网络状态被监视以满足医学图像数据的传送要求时，通过断点连续传输将压缩的医学图像数据传送到因特网; 传送服务器经由因特网接收目的地址为传送服务器的地址的医疗图像数据，解压缩医学图像数据，并通过DICOM标准将解压缩的图像数据发送到目的地PACS。

    A METHOD FOR MANUFACTURING A DIAMOND COMPOSITE
    5.
    发明申请
    A METHOD FOR MANUFACTURING A DIAMOND COMPOSITE 审中-公开
    一种制造金刚石复合材料的方法

    公开(公告)号：WO2004089850A2

    公开(公告)日：2004-10-21

    申请号：PCT/EP2004/050367

    申请日：2004-03-26

    Applicant: SKELETON TECHNOLOGIES AG ,  SVENDSEN, Lena ,  ZHENG, Jie ,  MEURLING, Fredrik ,  ROSTVALL, Tomas

    Inventor： SVENDSEN, Lena ,  ZHENG, Jie ,  MEURLING, Fredrik ,  ROSTVALL, Tomas

    IPC: C04B35/573

    CPC classification number: C04B35/52 ,  C04B35/6316 ,  C04B2235/3821 ,  C04B2235/3826 ,  C04B2235/3843 ,  C04B2235/40 ,  C04B2235/404 ,  C04B2235/405 ,  C04B2235/407 ,  C04B2235/408 ,  C04B2235/421 ,  C04B2235/425 ,  C04B2235/427 ,  C04B2235/428 ,  C04B2235/5436 ,  C04B2235/80

    Abstract: The present invention relates to a method for manufacturing a diamond composite, comprising the steps of: a) mixing diamonds with additives, the mixture comprising at least 50 wt% and less than 95 wt% of diamonds and more than 5 wt% additives; b) forming a work piece from the mixture using a pressure of at least 100 Mpa; c) heating the formed work piece to at least 300°C for removing possible water and wholly or partially removing additives; d) heating the work piece and controlling the heating temperature and heatin time so that a certain desired amount of graphite is created by graphitization of diamonds, wherein the amount of graphite created by graphitization is 3-50 wt% of the amount of diamond; e) infiltrating silicon or silicon alloy into the work piece, the infiltration of silicon or silicon alloy being performed at a temperature below 1900°C and a pressure less than 50 bars; and f) heating the infiltrated work piece to form silicon carbide, or other carbides, (and silicides), thereby creating a final diamond composite.

    Abstract translation: 金刚石复合材料的制造方法技术领域本发明涉及金刚石复合材料的制造方法，包括以下步骤：a）将金刚石与添加剂混合，所述混合物包含至少50wt％且小于95wt％的金刚石和5wt％以上的添加剂; b）使用至少100Mpa的压力从混合物形成工件; c）将形成的工件加热至至少300℃，以除去可能的水并全部或部分除去添加剂; d）加热工件并控制加热温度和加热时间，使得通过石墨化石墨化产生一定的所需量的石墨，其中由石墨化产生的石墨的量为金刚石量的3-50wt％; e）将硅或硅合金渗透到工件中，在低于1900℃的温度和低于50巴的压力下进行硅或硅合金的渗透; 和f）加热渗透的工件以形成碳化硅或其他碳化物（和硅化物），从而形成最终的金刚石复合材料。

    LUMINESCENT NANOPARTICLE COMPOSITIONS
    7.
    发明申请
    LUMINESCENT NANOPARTICLE COMPOSITIONS 审中-公开
    发光纳米颗粒组合物

    公开(公告)号：WO2012174287A1

    公开(公告)日：2012-12-20

    申请号：PCT/US2012/042525

    申请日：2012-06-14

    Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM ,  ZHENG, Jie

    Inventor： ZHENG, Jie

    IPC: G01N21/62

    CPC classification number: G01N33/587 ,  A61K49/0065 ,  B82Y5/00 ,  B82Y15/00 ,  C09K2211/188 ,  G01N33/54346 ,  Y10S977/773 ,  Y10S977/92

    Abstract: A composition is disclosed which is capable of being used for detection, comprising a noble metal nanoparticle. The inventive compositions exhibit little interaction with serum proteins while exhibiting pH-dependent adsorption onto live cell membranes. The nanoparticles of the claimed invention are capable of interacting with cell membranes, which in turn permits the advantages of nanoparticle bio-imaging to be extended to many pH dependent biological processes such as targeting acidic tumor microenvironment.

    Abstract translation: 公开了能够用于检测的组合物，其包含贵金属纳米颗粒。 本发明的组合物与血清蛋白质几乎没有相互作用，同时在活细胞膜上显示pH依赖性吸附。 所要求保护的发明的纳米颗粒能够与细胞膜相互作用，这反过来允许纳米颗粒生物成像的优点扩展到许多pH依赖性生物过程，例如靶向酸性肿瘤微环境。

    GRANULAR NANOPARTICLES HAVING BRIGHT FLUORESCENCE AND GIANT RAMAN ENHANCEMENTS
    10.
    发明申请
    GRANULAR NANOPARTICLES HAVING BRIGHT FLUORESCENCE AND GIANT RAMAN ENHANCEMENTS 审中-公开
    具有明亮的荧光和巨大的拉曼增强的颗粒纳米颗粒

    公开(公告)号：WO2009064987A1

    公开(公告)日：2009-05-22

    申请号：PCT/US2008/083560

    申请日：2008-11-14

    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  ZHENG, Jie ,  ZHUANG, Xiaowei

    Inventor： ZHENG, Jie ,  ZHUANG, Xiaowei

    IPC: A61K9/14

    CPC classification number: G01N21/6428 ,  A61K49/0017 ,  A61K49/0065 ,  G01N21/658

    Abstract: The present invention provides nanoparticles having bright fluorescence, where the total number of photons emitted from a single nanoparticle upon excitation with an excitation wavelength of the nanoparticle is at least 107, and giant Raman enhancements, where Raman signal for a molecule near a single nanoparticle increases at least 107 times. The nanoparticles of the invention comprise a plurality of crystallites that are each about 0.6 nm to about 10 nm in size. The present invention also provides methods for making the nanoparticles, which include mixing a matrix material with a reactant capable of being thermally reduced to form the nanoparticle; forming a mixed solid phase; and thermally reducing the mixed solid phase to form the nanoparticle.

    Abstract translation: 本发明提供了具有明亮荧光的纳米颗粒，其中在用纳米颗粒的激发波长激发时从单个纳米颗粒发射的光子的总数至少为107，并且巨大的拉曼增强，其中单个纳米颗粒附近的分子的拉曼信号增加 至少107次。 本发明的纳米颗粒包括大小约0.6nm至约10nm的多个微晶。 本发明还提供了制备纳米颗粒的方法，其包括将基质材料与能够热还原形成纳米颗粒的反应物混合; 形成混合固相; 并且热还原混合的固相以形成纳米颗粒。

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