中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

18 records (took 0.012 seconds)

    SYSTEM AND METHOD FOR ASSAY
    1.
    发明申请
    SYSTEM AND METHOD FOR ASSAY 审中-公开
    用于测定的系统和方法

    公开(公告)号：WO2010086772A1

    公开(公告)日：2010-08-05

    申请号：PCT/IB2010/050289

    申请日：2010-01-22

    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  DITTMER, Wendy, U. ,  HARDEMAN, Wilhelmina, M.

    Inventor： DITTMER, Wendy, U. ,  HARDEMAN, Wilhelmina, M.

    IPC: G01N33/543

    CPC classification number: G01N33/54333 ,  G01N21/552 ,  G01N27/745

    Abstract: The invention relates to a biosensor system for performing biological binding assays, comprising a reaction chamber with two opposing surfaces. Herein, the first surface comprises a sensor region, and immobilized thereto an analyte-specific probe, an analyte or an analyte-analogue. The second surface comprises a reagent region, opposite of the sensor region, the reagent region comprising, prior to the use of said system, magnetic particles in dry form, disposed on said reagent region (31).

    Abstract translation: 本发明涉及用于进行生物结合测定的生物传感器系统，其包括具有两个相对表面的反应室。 这里，第一表面包括传感器区域，并将其固定在分析物特异性探针，分析物或分析物类似物上。 第二表面包括与传感器区域相对的试剂区域，试剂区域在使用所述系统之前包括设置在所述试剂区域（31）上的干燥形式的磁性颗粒。

    MAGNETIC SENSOR DEVICE
    2.
    发明申请
    MAGNETIC SENSOR DEVICE 审中-公开
    磁传感器装置

    公开(公告)号：WO2009013662A1

    公开(公告)日：2009-01-29

    申请号：PCT/IB2008/052818

    申请日：2008-07-14

    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  PRINS, Menno, W., J. ,  DITTMER, Wendy, U. ,  NIEUWENHUIS, Jeroen, H.

    Inventor： PRINS, Menno, W., J. ,  DITTMER, Wendy, U. ,  NIEUWENHUIS, Jeroen, H.

    IPC: G01N33/543

    CPC classification number: G01N33/54333 ,  G01N27/745

    Abstract: The present invention provides a sensor device (20) and a method for determining the presence and/or amount of target moieties (22) in a sample fluid (27), the target moieties (22) being labeled with magnetic or magnetizable objects (23). The sensor device (20) comprises a magnetic field generating means adapted for applying a retention field for retaining the labeled target moieties (22, 23) to the sensor surface (24) during fluid manipulations. Through this the binding between the labeled target moieties (22, 23) and the sensor surface (24) and/or the magnetic particles (23) and the target moieties (22) is substantially not disturbed during these fluid manipulations. This leads to a reliable and accurate sensor device (20).

    Abstract translation: 本发明提供一种传感器装置（20）和用于确定样品流体（27）中目标部分（22）的存在和/或数量的方法，目标部分（22）用磁性或可磁化物体（23）标记 ）。 传感器装置（20）包括磁场产生装置，其适于在流体操纵期间施加用于将标记的目标部分（22,23）保持到传感器表面（24）的保持场。 通过这一点，标记的目标部分（22,23）和传感器表面（24）和/或磁性颗粒（23）和目标部分（22）之间的结合在这些流体操纵过程中基本上不受干扰。 这导致可靠且准确的传感器装置（20）。

    MAGNETIC SENSOR DEVICE, METHOD OF OPERATING SUCH A DEVICE AND SAMPLE
    5.
    发明申请
    MAGNETIC SENSOR DEVICE, METHOD OF OPERATING SUCH A DEVICE AND SAMPLE 审中-公开
    磁传感器装置，操作这种装置和样品的方法

    公开(公告)号：WO2011001337A1

    公开(公告)日：2011-01-06

    申请号：PCT/IB2010/052880

    申请日：2010-06-24

    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N. V. ,  DITTMER, Wendy, U. ,  DE THEIJE, Femke, K. ,  IMMINK, Albert, H., J. ,  NIEWENHUIS, Jeroen, H. ,  VAN LANKVELT, Petrus, J., W.

    Inventor： DITTMER, Wendy, U. ,  DE THEIJE, Femke, K. ,  IMMINK, Albert, H., J. ,  NIEWENHUIS, Jeroen, H.

    IPC: G01N33/543

    CPC classification number: G01N33/54326 ,  G01N21/552 ,  G01N27/745 ,  G01N33/54366 ,  G01N33/54386

    Abstract: A sensor device (1) for detecting the presence of a target molecule (20) in a sample, is disclosed. The sensor device comprises a measurement sensor (2) comprising a first moiety (16) for forming a binding couple with a first further moiety comprising the target molecule (20) and a detectable label (40) and a reference sensor (3) comprising a second moiety (50) for forming a further binding couple with a second further moiety comprising a further detectable label (40'). The sensor device is adapted to generate a first detection signal (14) from the detection of the detectable label (40) in the first further moiety bound to the first moiety (16) and to generate a second detection signal (14') from the detection of the further detectable label (40') in the second further moiety bound to the second moiety (50), wherein at least during operation of the sensor device the second further moiety is expected to be present in a predefined amount such that the value of the second detection signal (14') falls within an expected signal value window when the binding reaction of the second further moiety to the second moiety takes place as expected. An apparatus comprising such a sensor device, methods of operating the sensor device and apparatus and a sample for use with the sensor device are also disclosed.

    Abstract translation: 公开了一种用于检测样品中目标分子（20）的存在的传感器装置（1）。 所述传感器装置包括测量传感器（2），所述测量传感器（2）包括用于与包含所述目标分子（20）和可检测标记（40）的第一另外部分形成结合对的第一部分（16）和包括 用于与包含另外可检测标记物（40'）的第二另外部分形成另外的结合对的第二部分（50）。 所述传感器装置适于从与所述第一部分（16）结合的所述第一另外部分中的所述可检测标记（40）的检测产生第一检测信号（14），并且从所述第一检测信号（14'）产生第二检测信号 在第二另外部分结合到第二部分（50）上的另外可检测标记物（40'）的检测，其中至少在传感器装置的操作期间预期第二另外的部分以预定量存在，使得值 当第二另外部分与第二部分的结合反应按预期进行时，第二检测信号（14'）落入预期信号值窗口内。 还公开了一种包括这种传感器装置的装置，操作传感器装置和装置的方法以及与传感器装置一起使用的样本。

    SENSOR CARTRIDGE
    7.
    发明申请
    SENSOR CARTRIDGE 审中-公开
    传感器盒

    公开(公告)号：WO2009013668A2

    公开(公告)日：2009-01-29

    申请号：PCT/IB2008/052844

    申请日：2008-07-16

    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  IMMINK, Albert, H., J. ,  DE THEIJE, Femke, K. ,  PRINS, Menno, W., J. ,  DITTMER, Wendy, U. ,  NIEUWENHUIS, Jeroen, H.

    Inventor： IMMINK, Albert, H., J. ,  DE THEIJE, Femke, K. ,  PRINS, Menno, W., J. ,  DITTMER, Wendy, U. ,  NIEUWENHUIS, Jeroen, H.

    IPC: G01R33/09

    CPC classification number: G01R33/1269

    Abstract: The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).

    Abstract translation: 本发明提供一种用于区别地确定流体样品中至少两个不同靶部分的传感器盒（10）。 传感器盒（10）包括反应室（1）和至少彼此不同的第一和第二区域（2,3）。 第一区域（2）包括用第一类型的探针标记的磁性或可磁化物体（4a），用于特异性地结合第一类型的靶部分，第二区域（3）包括用第二类型标记的磁性或可磁化物体（4b） 的用于特异性结合第二类型的靶部分的探针，第一和第二区域（2,3）中的磁性或可磁化物体（4a，4b）可由样品流体直接接触。 本发明还提供了用于制造这种传感器装置（10）的方法以及使用这种传感器盒（10）确定样品流体中至少两种不同靶部分的存在和/或量的方法。

    MAGNETIC AND/OR ELECTRIC LABEL ASSISTED DETECTION SYSTEM AND METHOD
    8.
    发明申请
    MAGNETIC AND/OR ELECTRIC LABEL ASSISTED DETECTION SYSTEM AND METHOD 审中-公开
    磁性和/或电子标签辅助检测系统及方法

    公开(公告)号：WO2008044174A1

    公开(公告)日：2008-04-17

    申请号：PCT/IB2007/054055

    申请日：2007-10-05

    Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  DITTMER, Wendy, U. ,  PRINS, Menno, W., J.

    Inventor： DITTMER, Wendy, U. ,  PRINS, Menno, W., J.

    IPC: G01N33/543

    CPC classification number: G01N33/54326 ,  G01N27/745 ,  G01N35/0098

    Abstract: A detection system (100) is described for detecting analytes in a fluid sample. The detection system (100) comprises a transporting means (6) for transporting magnetic and/or electric labels (5) after interaction between the sample fluid and the reagents towards a detection receptacle (1). The detection receptacle (1) is initially substantially magnetic and/or electric label (5) free. By transporting the magnetic and/or electric labels (5) after reaction, interference between unreacted reagents and magnetic and/or electric label-assisted detection can be reduced.

    Abstract translation: 描述了用于检测流体样品中的分析物的检测系统（100）。 检测系统（100）包括用于在样品流体和试剂相互作用后朝向检测容器（1）传送磁性和/或电气标签（5）的传送装置（6）。 检测容器（1）最初基本上是磁性和/或电子标签（5）。 通过在反应后传送磁性和/或电子标签（5），可以减少未反应试剂与磁性和/或电标签辅助检测之间的干扰。

    SENSOR CARTRIDGE
    9.
    发明申请
    SENSOR CARTRIDGE 审中-公开
    传感器盒

    公开(公告)号：WO2009013668A3

    公开(公告)日：2010-07-15

    申请号：PCT/IB2008052844

    申请日：2008-07-16

    Applicant: KONINKL PHILIPS ELECTRONICS NV ,  IMMINK ALBERT H J ,  DE THEIJE FEMKE K ,  PRINS MENNO W J ,  DITTMER WENDY U ,  NIEUWENHUIS JEROEN H

    Inventor： IMMINK ALBERT H J ,  DE THEIJE FEMKE K ,  PRINS MENNO W J ,  DITTMER WENDY U ,  NIEUWENHUIS JEROEN H

    IPC: G01R33/09

    CPC classification number: G01R33/1269

    Abstract: The present invention provides a sensor cartridge (10) for distinctively determining at least two different target moieties in a fluid sample. The sensor cartridge (10) comprises a reaction chamber (1) and at least a first and second region (2, 3) distinct from each other. The first region (2) comprises magnetic or magnetizable objects (4a) labelled with a first type of probes for specifically binding a first type of target moieties and the second region (3) comprises magnetic or magnetizable objects (4b) labelled with a second type of probes for specifically binding a second type of target moieties, the magnetic or magnetizable objects (4a, 4b) in the first and second region (2, 3) being directly contactable by the sample fluid. The present invention also provides a method for the manufacturing of such sensor devices (10) and a method for determining the presence and/or amount of at least two different target moieties in a sample fluid using such sensor cartridge (10).

    Abstract translation: 本发明提供一种用于区别地确定流体样品中至少两个不同靶部分的传感器盒（10）。 传感器盒（10）包括反应室（1）和至少彼此不同的第一和第二区域（2,3）。 第一区域（2）包括用第一类型的探针标记的磁性或可磁化物体（4a），用于特异性地结合第一类型的靶部分，第二区域（3）包括用第二类型标记的磁性或可磁化物体（4b） 的用于特异性结合第二类型的靶部分的探针，第一和第二区域（2,3）中的磁性或可磁化物体（4a，4b）可由样品流体直接接触。 本发明还提供了用于制造这种传感器装置（10）的方法以及使用这种传感器盒（10）确定样品流体中至少两种不同靶部分的存在和/或量的方法。

Patent Agency Ranking