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    NASAL DELIVERY
    1.
    发明申请
    NASAL DELIVERY 审中-公开
    NASAL交货

    公开(公告)号：WO2010029441A2

    公开(公告)日：2010-03-18

    申请号：PCT/IB2009/007108

    申请日：2009-09-15

    Applicant: OPTINOSE AS ,  DJUPESLAND, Per, Gisle

    Inventor： DJUPESLAND, Per, Gisle

    IPC: A61K9/00

    CPC classification number: A61K9/0043

    Abstract: substances and the nasal administration thereof, in particular as one of a liquid, as a suspension or solution, or a powder, to the nasal airway of a subject, in particular the posterior region of the nasal airway, and in particular the upper posterior region of the nasal airway, which includes the olfactory bulb, in particular in the treatment of neurological conditions and disorders.

    Abstract translation: 特别是作为受试者的鼻气道，特别是鼻气道的后部区域的液体，作为悬浮液或溶液或粉末的药物，特别是鼻后管区域，特别是上后路区域 的鼻气道，其包括嗅球，特别是在治疗神经疾病和病症中。

    DELIVERY DEVICE AND METHOD
    3.
    发明申请
    DELIVERY DEVICE AND METHOD 审中-公开
    交付设备和方法

    公开(公告)号：WO2007093791A2

    公开(公告)日：2007-08-23

    申请号：PCT/GB2007/000516

    申请日：2007-02-14

    Applicant: OPTINOSE AS ,  DJUPESLAND, Per, Gisle ,  SHELDRAKE, Colin, David ,  HAFNER, Roderick, Peter

    Inventor： DJUPESLAND, Per, Gisle ,  SHELDRAKE, Colin, David ,  HAFNER, Roderick, Peter

    IPC: A61M15/08

    CPC classification number: A61M15/0098 ,  A61M11/00 ,  A61M15/0021 ,  A61M15/009 ,  A61M15/0091 ,  A61M15/08 ,  A61M2210/0681

    Abstract: A nasal delivery device for and method of delivering substance to the middle meatus in a nasal cavity of a subject in the treatment of a condition, in particular an inflammatory or infectious condition, thereof, the delivery device comprising : a nosepiece unit including a nosepiece for fitting to a nostril of a subject and a nozzle through which substance is in use delivered to the respective nasal cavity; and a delivery unit for delivering substance through the nozzle of the nosepiece; wherein the delivery device is configured to provide for deposition of a significant fraction of the delivered dose on, around and in the vicinity of the middle meatus.

    Abstract translation: 一种用于在物体的鼻腔中向物体递送物质的鼻输送装置和方法，用于治疗患者的病症，特别是炎症或感染状况，所述输送装置包括：鼻梁单元，其包括用于 配合到被检体的鼻孔和通过其使用物质的喷嘴输送到相应的鼻腔; 以及用于通过喷嘴的喷嘴输送物质的输送单元; 其中所述递送装置被配置为提供在所述中间口的周围和附近沉积大部分所递送的剂量。

    NASAL DELIVERY DEVICE
    4.
    发明申请
    NASAL DELIVERY DEVICE 审中-公开

    公开(公告)号：WO2006090149A3

    公开(公告)日：2006-08-31

    申请号：PCT/GB2006/000631

    申请日：2006-02-23

    Applicant: OPTINOSE AS ,  DJUPESLAND, Per, Gisle ,  SHELDRAKE, Colin, David ,  HAFNER, Roderick, Peter

    Inventor： DJUPESLAND, Per, Gisle ,  SHELDRAKE, Colin, David ,  HAFNER, Roderick, Peter

    IPC: A61M15/08 ,  A61M15/00 ,  A61K9/48 ,  A61J3/07

    Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit (3) for supplying a dose of substance to be delivered to the nasal cavity of the subject, the substance supply unit including an inlet (17) and an outlet (19); a nosepiece unit (15) including a nosepiece (30) for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit,- and a mouthpiece unit (11) including a mouthpiece (25) in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber (5) and deliver the same through the nosepiece, and at least one temperature modifier (27) for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.

    DELIVERY DEVICES
    5.
    发明申请
    DELIVERY DEVICES 审中-公开
    递送设备

    公开(公告)号：WO2005016423A3

    公开(公告)日：2005-07-07

    申请号：PCT/IB2004002751

    申请日：2004-08-16

    Applicant: OPTINOSE AS ,  DJUPESLAND PER GISLE

    Inventor： DJUPESLAND PER GISLE

    IPC: A61M15/00

    CPC classification number: A61M15/0098 ,  A61M11/02 ,  A61M15/00 ,  A61M15/0018 ,  A61M15/0021 ,  A61M15/0091 ,  A61M15/08

    Abstract: A delivery device, in particular a breath-actuated nasal delivery device, for delivering substance, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject.

    Abstract translation: 递送装置，特别是呼吸致动的鼻输送装置，用于输送物质，特别是一种液体，作为悬浮液或溶液，或含有药物，特别是全身或局部药物或鼻腔疫苗的粉末 主题的气道。

    DELIVERY DEVICES
    6.
    发明申请
    DELIVERY DEVICES 审中-公开
    递送设备

    公开(公告)号：WO2004060433A2

    公开(公告)日：2004-07-22

    申请号：PCT/IB2004/000294

    申请日：2004-01-02

    Applicant: OPTINOSE AS ,  DJUPESLAND, Per, Gisle

    Inventor： DJUPESLAND, Per, Gisle

    IPC: A61M

    CPC classification number: A61M15/0091 ,  A61M15/0098 ,  A61M15/08 ,  A61M2202/064

    Abstract: A delivery device for and method of delivering substance to a subject, in particular a nasal delivery device for delivering a substance to a subject through nasal mucosa in a nasal cavity of the subject, the delivery device comprising: a nozzle for delivering a particulate aerosol containing a substance to nasal mucosa in the nasal cavity; and a substance supply unit actuatable to supply substance to the nozzle; wherein at least a fraction of the particles of the aerosol has a dimension and velocity such as to penetrate through the nasal mucosa.

    Abstract translation: 用于将物质递送到受试者的递送装置，特别是用于通过受试者鼻腔中的鼻腔中的鼻粘膜将物质递送到受试者的鼻输送装置，所述输送装置包括：用于输送含有 鼻腔粘膜的物质; 以及可致动以向所述喷嘴供应物质的物质供应单元; 其中所述气溶胶颗粒的至少一部分具有穿透鼻粘膜的尺寸和速度。

    NASAL DELIVERY DEVICE
    7.
    发明申请
    NASAL DELIVERY DEVICE 审中-公开
    NASAL交付设备

    公开(公告)号：WO2003020350A1

    公开(公告)日：2003-03-13

    申请号：PCT/IB2002/003849

    申请日：2002-09-06

    Applicant: OPTINOSE AS ,  DJUPESLAND, Per, Gisle

    Inventor： DJUPESLAND, Per, Gisle

    IPC: A61M15/00

    CPC classification number: A61M15/0091 ,  A61M15/0065 ,  A61M15/009 ,  A61M15/0095 ,  A61M15/0098 ,  A61M15/08 ,  A61M2210/0618 ,  A61M2210/0625

    Abstract: A breath-actuated nasal delivery device, comprising: a mouthpiece through which a user in use exhales to actuate the delivery device; a nosepiece for fitting to a nostril of the user through which a substance is in use delivered; a substance supply unit actuatable to deliver a dose of a substance through the nosepiece; a loading unit operable to load the substance supply unit with an actuation force; and a release mechanism for enabling actuation of the substance supply unit in response to exhalation by the user through the mouthpiece; wherein the release mechanism comprises a locking unit which is movable : between a locking configuration in which the substance supply unit is locked in a non- actuated position when loaded by the loading unit and a release configuration in which the substance supply unit is actuatable by the loading unit, and a trigger member for releasing the locking unit from the locking configuration to the release configuration in response to exhalation by the user through the mouthpiece and thereby enabling actuation of the substance supply unit.

    Abstract translation: 一种呼吸致动的鼻腔输送装置，包括：口部，使用者通过所述吸口呼气以致动所述输送装置; 用于装配用户使用物质的鼻孔的鼻梁; 物质供应单元，可致动以通过物镜传送一定剂量的物质; 装载单元，其可操作以用致动力装载物质供应单元; 以及释放机构，用于响应于使用者通过所述嘴件的呼出而使得所述物质供应单元能够致动; 其中所述释放机构包括锁定单元，所述锁定单元可移动：在由所述装载单元加载时所述物质供应单元被锁定在非致动位置的锁定构造和其中所述物质供应单元可被所述装载单元致动的释放构造之间 以及触发构件，用于响应于使用者通过接口进行呼出，从而使物质供应单元的致动，将锁定单元从锁定构型释放到释放构造。

    DELIVERY DEVICES
    10.
    发明申请
    DELIVERY DEVICES 审中-公开
    递送设备

    公开(公告)号：WO2008081327A3

    公开(公告)日：2009-02-05

    申请号：PCT/IB2007004355

    申请日：2007-11-28

    Applicant: OPTINOSE AS ,  DJUPESLAND PER GISLE

    Inventor： DJUPESLAND PER GISLE

    IPC: A61M15/00 ,  A61M15/08

    CPC classification number: A61M15/0098 ,  A61M15/0021 ,  A61M15/0023 ,  A61M15/0028 ,  A61M15/0035 ,  A61M15/0041 ,  A61M15/08 ,  A61M2202/04 ,  A61M2202/064 ,  A61M2205/073 ,  A61M2206/16

    Abstract: A delivery device for delivering a metered amount of substance, the delivery device comprising: a mouthpiece (17) through which a user in use exhales; an outlet (19) through which substance is in use delivered; a housing (21) fluidly connected to the mouthpiece and the outlet, such, that exhalation by the user through the mouthpiece creates an air flow through the housing and from the outlet; and a substance-dispensing unit (25) which is disposed within the housing and operative to dispense a metered amount of substance into an entraining air flow as created through the housing.

    Abstract translation: 一种用于输送计量的物质的输送装置，所述输送装置包括：用口使用者呼气的吸嘴（17）; 出口（19），物质在其中使用; 流体连接到接口管和出口的壳体（21），使得使用者通过接口管呼出，产生通过壳体和出口的气流; 以及物质分配单元（25），其布置在所述壳体内并且用于将计量的物质分配到通过所述壳体产生的夹带空气流中。

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