公开(公告)号：WO2013124492A1

公开(公告)日：2013-08-29

申请号：PCT/EP2013/053747

申请日：2013-02-25

Applicant: OPTINOSE AS

Inventor： DJUPESLAND, Per Gisle ,  GORDON, Joseph ,  LECLERC, Michael ,  MAHMOUD, Ramy A ,  SIWINSKI, Shane

IPC: A61M15/08

CPC classification number: A61M15/08 ,  A61M15/0021 ,  A61M15/0098 ,  A61M2202/064 ,  A61M2205/0216 ,  A61M2210/0618 ,  A61M2210/0625

Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject compries: a housing (15); a nosepiece (17) for fitting to a nasal cavity of the subject; a mouthpiece (19) through which the subject in use exhales; and a flexible coupling (20) which couples the mouthpiece to the housing, wherein the flexible coupling provides for asymmetric translation of the mouthpiece relative to the nosepiece.

Abstract translation: 用于将物质输送到受试者的鼻腔的鼻输送装置：壳体（15）; 用于装配到受试者的鼻腔的鼻梁（17）; 用于呼气的受试者的喉舌（19）; 以及将所述接口件连接到所述壳体的柔性联接器（20），其中所述柔性联接件提供所述接口件相对于所述鼻梁的不对称平移。

公开(公告)号：WO2013124491A1

公开(公告)日：2013-08-29

申请号：PCT/EP2013/053746

申请日：2013-02-25

Applicant: OPTINOSE AS

Inventor： DJUPESLAND, Per Gisle ,  LECLERC, Michael ,  MAHMOUD, Ramy A ,  SIWINSKI, Shane ,  GORDON, Joseph ,  FISK, Justin

IPC: A61M15/08 ,  A61M15/00

CPC classification number: A61M15/08 ,  A61M15/0018 ,  A61M15/002 ,  A61M15/0021 ,  A61M15/009 ,  A61M15/0098 ,  A61M2210/0618

Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.

Abstract translation: 一种用于将物质输送到受试者的鼻气道的鼻输送装置和方法，所述输送装置包括：鼻梁（117），用于装配到受试者的鼻腔; 使用者呼气的受试者（119）; 输送单元，其包括可手动地移动以致动输送单元以从物镜输送物质的致动部分; 以及阀组件（127），其流体地连接到所述喷嘴和所述接口管，其中所述阀组件包括主体元件（128）和阀元件（131），所述主体元件（128）和阀元件（131）通过 输送单元的致动部分的手动位移以提供与物质输送同时通过喷嘴的气流。

公开(公告)号：WO2008081327A3

公开(公告)日：2009-02-05

申请号：PCT/IB2007004355

申请日：2007-11-28

Applicant: OPTINOSE AS ,  DJUPESLAND PER GISLE

Inventor： DJUPESLAND PER GISLE

IPC: A61M15/00 ,  A61M15/08

CPC classification number: A61M15/0098 ,  A61M15/0021 ,  A61M15/0023 ,  A61M15/0028 ,  A61M15/0035 ,  A61M15/0041 ,  A61M15/08 ,  A61M2202/04 ,  A61M2202/064 ,  A61M2205/073 ,  A61M2206/16

Abstract: A delivery device for delivering a metered amount of substance, the delivery device comprising: a mouthpiece (17) through which a user in use exhales; an outlet (19) through which substance is in use delivered; a housing (21) fluidly connected to the mouthpiece and the outlet, such, that exhalation by the user through the mouthpiece creates an air flow through the housing and from the outlet; and a substance-dispensing unit (25) which is disposed within the housing and operative to dispense a metered amount of substance into an entraining air flow as created through the housing.

Abstract translation: 一种用于输送计量的物质的输送装置，所述输送装置包括：用口使用者呼气的吸嘴（17）; 出口（19），物质在其中使用; 流体连接到接口管和出口的壳体（21），使得使用者通过接口管呼出，产生通过壳体和出口的气流; 以及物质分配单元（25），其布置在所述壳体内并且用于将计量的物质分配到通过所述壳体产生的夹带空气流中。

公开(公告)号：WO2008122795A2

公开(公告)日：2008-10-16

申请号：PCT/GB2008001226

申请日：2008-04-07

Applicant: OPTINOSE AS ,  DJUPESLAND PER GISLE ,  HAFNER RODERICK PETER

Inventor： DJUPESLAND PER GISLE ,  HAFNER RODERICK PETER

IPC: A61M15/08

CPC classification number: A61M15/08 ,  A61K31/4045 ,  A61M15/0005 ,  A61M15/0008 ,  A61M15/0021 ,  A61M15/0028 ,  A61M15/003 ,  A61M15/0035 ,  A61M15/0041 ,  A61M15/0098 ,  A61M16/0808 ,  A61M16/1045 ,  A61M16/1055 ,  A61M16/1065 ,  A61M2202/064 ,  A61M2205/3606 ,  A61M2210/0618 ,  A61M2210/0625

Abstract: A delivery device for and method of delivering a powdered substance, in particular a triptan, such as sumatriptan, to the posterior region of a nasal cavity of a subject, in particular for the treatment of headaches, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece for insertion into a nasal cavity of a subject through which the powdered substance is delivered to the posterior region of the nasal cavity of the subject, in particular the upper posterior two thirds of the nasal cavity; and a substance supply unit which is operable to deliver the powdered substance through the nosepiece.

Abstract translation: 特别是用于治疗头痛，例如丛集性头痛和偏头痛的粉状物质，特别是曲坦类，如舒马曲坦的递送装置和方法， 神经性疼痛，所述递送装置包括：用于插入到受试者鼻腔中的鼻梁，通过所述鼻子将所述粉末物质输送到所述受试者的鼻腔的后部区域，特别是鼻腔的上后三分之二; 以及物质供给单元，其可操作以通过所述喷雾器输送所述粉末状物质。

公开(公告)号：WO2007125318A1

公开(公告)日：2007-11-08

申请号：PCT/GB2007/001515

申请日：2007-04-25

Applicant: OPTINOSE AS ,  HAFNER, Roderick, Peter

Inventor： HAFNER, Roderick, Peter

IPC: A61K31/485 ,  A61K47/44 ,  A61K9/12

CPC classification number: A61K9/0043 ,  A61K9/008 ,  A61K31/00 ,  A61K31/485 ,  A61K47/44

Abstract: A formulation for administration to a nasal or buccal cavity of a subject which comprises a non-aqueous liquid environment, preferably an emollient oil base, and at least one active molecule, preferably a dopamine agonist and especially apomorphine, in solution or suspension therein, wherein in one embodiment the formulation has such a viscosity as to be delivered as a liquid jet from a spray pump which is capable of delivering an aerosol spray of an aqueous formulation.

Abstract translation: 用于给予受试者鼻腔或口腔的制剂，其包含非水性液体环境，优选软化油基质，以及至少一种活性分子，优选多巴胺激动剂，尤其是阿扑吗啡，其中溶液或悬浮液中，其中 在一个实施方案中，制剂具有这样的粘度，以便能够从能够递送水性制剂的气溶胶喷雾的喷雾泵以液体射流的形式输送。

公开(公告)号：WO2007102089A2

公开(公告)日：2007-09-13

申请号：PCT/IB2007/001709

申请日：2007-03-06

Applicant: OPTINOSE AS ,  DJUPESLAND, Dr Per Gisle

Inventor： DJUPESLAND, Dr Per Gisle

CPC classification number: A61M15/08 ,  A61M11/00 ,  A61M15/0021 ,  A61M15/009 ,  A61M15/0091 ,  A61M15/0098 ,  A61M15/085 ,  A61M31/00 ,  A61M2202/064

Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece unit including a nosepiece for fitting to a nostril of a subject and a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasai cavity, wherein at least a tip element of the nosepiece has, at least in one configuration, an elongate lateral section which has a longer dimension in a first, sagittal direction than a second direction orthogonal to the sagittal direction, such that, when the nosepiece is inserted in the nasal cavity of the subject, the longer dimension of the nosepiece acts to engage lower and upper surfaces of the nasal cavity, preferably at the nasa! valve, and expand the same in the sagittal plane; and a delivery unit for delivering substance through the nozzle of the nosepiece.

Abstract translation: 一种用于将物质输送到被检体鼻腔的鼻输送装置和方法，所述输送装置包括：鼻梁单元，其包括用于装配到被检体的鼻孔的鼻梁和通过其使用物质的喷嘴，优选地基本上 轴向到鼻梁的纵向轴线到相应的鼻腔，其中鼻梁的至少一个尖端元件具有至少一个构造中的细长侧向部分，其在第一矢量方向上具有比第二矢量方向更长的尺寸 方向垂直于矢状方向，使得当鼻梁被插入到被检体的鼻腔中时，鼻梁的较长的尺寸用于接合鼻腔的下表面和上表面， 阀门，并在矢状面扩张; 以及用于通过喷嘴的喷嘴输送物质的输送单元。

公开(公告)号：WO2004060433A3

公开(公告)日：2005-04-28

申请号：PCT/IB2004000294

申请日：2004-01-02

Applicant: OPTINOSE AS ,  DJUPESLAND PER GISLE

Inventor： DJUPESLAND PER GISLE

IPC: A61M15/00 ,  A61M15/08

CPC classification number: A61M15/0091 ,  A61M15/0098 ,  A61M15/08 ,  A61M2202/064

Abstract: A delivery device for and method of delivering substance to a subject, in particular a nasal delivery device for delivering a substance to a subject through nasal mucosa in a nasal cavity of the subject, the delivery device comprising: a nozzle (25) for delivering a particulate aerosol containing a substance to nasal mucosa in the nasal cavity; and a substance supply unit (29) actuatable to supply substance to the nozzle(25); wherein at least a fraction of the particles of the aerosol has a dimension and velocity such as to penetrate through the nasal mucosa.

Abstract translation: 用于将物质递送到受试者的输送装置和方法，特别是用于通过被检体鼻腔中的鼻粘膜将物质递送到受试者的鼻输送装置，所述输送装置包括：喷嘴（25），用于输送物体 在鼻腔内含有物质至鼻粘膜的颗粒状气溶胶; 以及可致动以向所述喷嘴（25）供应物质的物质供应单元（29）; 其中所述气溶胶颗粒的至少一部分具有穿透鼻粘膜的尺寸和速度。

公开(公告)号：WO2004004814A2

公开(公告)日：2004-01-15

申请号：PCT/IB0303274

申请日：2003-07-02

Applicant: OPTINOSE AS ,  DJUPESLAND PER GISLE

Inventor： DJUPESLAND PER GISLE

IPC: A61M15/00 ,  A61M15/08

CPC classification number: A61M15/08 ,  A61M11/00 ,  A61M15/0021 ,  A61M15/0051 ,  A61M15/009 ,  A61M15/0091 ,  A61M15/0098 ,  A61M2202/04 ,  A61M2202/064 ,  A61M2202/30 ,  A61M2209/06 ,  A61M2209/088

Abstract: A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, in particular in the mass treatment, especially mass vaccination, of subjects, the delivery device comprising: an interface unit, as a replaceable unit, including at least one nosepiece unit for fitting to a respective nostril of a subject and including a nozzle from which substance is in use delivered, and at least one delivery unit including a substance supply unit for delivering substance to the nozzle of the at least one nosepiece unit; and an actuation unit for actuating the at least one delivery unit of the interface unit.

Abstract translation: 一种用于将物质递送到受试者的鼻气道的鼻输送装置和方法，特别是在受试者的大规模治疗，特别是大规模接种中，所述输送装置包括：作为可更换单元的界面单元，至少包括 一个鼻梁单元，用于装配到被检体的各个鼻孔，并且包括使用物质输送的喷嘴;以及至少一个输送单元，包括用于将物质输送到至少一个鼻甲单元的喷嘴的物质供应单元; 以及用于致动所述接口单元的所述至少一个传送单元的致动单元。

公开(公告)号：WO2003090812A2

公开(公告)日：2003-11-06

申请号：PCT/IB2003/002305

申请日：2003-04-25

Applicant: OPTINOSE AS ,  DJUPESLAND, Per, Gisle

Inventor： DJUPESLAND, Per, Gisle

IPC: A61M

CPC classification number: A61M15/08 ,  A61M15/0008 ,  A61M15/0086 ,  A61M15/009 ,  A61M15/0098 ,  A61M2206/14

Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject; a delivery unit comprising a substance supply unit and a nozzle unit including at least one nozzle fluidly connected to the substance supply unit for generating an aerosol spray for delivery to a nasal airway of the subject; and an aerosol interactor operable to interact with an aerosol spray as generated by the at least one nozzle.

Abstract translation: 一种用于将物质输送到受试者的鼻气道的鼻输送装置和方法，所述输送装置包括：鼻梁，用于装配到受试者的鼻孔; 输送单元，其包括物质供应单元和喷嘴单元，所述喷嘴单元包括流体连接到所述物质供应单元的至少一个喷嘴，用于产生用于输送到所述对象的鼻气道的气溶胶喷雾; 以及可操作地与由至少一个喷嘴产生的气溶胶喷雾相互作用的气溶胶相互作用器。

公开(公告)号：WO2002068030A3

公开(公告)日：2002-09-06

申请号：PCT/IB2002/001546

申请日：2002-02-26

Applicant: OPTINOSE AS ,  DJUPESLAND, Per, Gisle

Inventor： DJUPESLAND, Per, Gisle

IPC: A61M15/00

Abstract: A nasal delivery device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device including: a nosepiece for fitting to a nostril of a subject; a substance supply unit for supplying a substance for delivery through the nosepiece; and a delivery prevention mechanism for preventing delivery of a substance through the nosepiece until the nosepiece is properly fitted to the nostril of the subject.