公开(公告)号：WO2008030627A3

公开(公告)日：2008-03-13

申请号：PCT/US2007/019754

申请日：2007-09-10

申请人： UNIVERSITY OF CINCINNATI ,  DORN, Gerald, W. ,  LIGGETT, Stephen, B.

发明人： DORN, Gerald, W. ,  LIGGETT, Stephen, B.

IPC分类号： C12Q1/68

摘要： The present invention is directed to compositions and methods relating to a G-protein coupled receptor kinase-5 polymorphism. The methods include, for example: detecting enhanced desensitization of the beta adrenergic receptor signaling pathway in an individual, assessing partial protection against heart failure progression in an individual, and assessing an individual's response to beta-blocker therapy. The compositions include polynucleotides or fragments thereof of a nucleotide sequence encoding for a G-protein receptor kinase-5 molecule with a thymine at amino acid position 122 and oligonucleotide primers that hybridize thereto.

公开(公告)号：WO2008030627A2

公开(公告)日：2008-03-13

申请号：PCT/US2007019754

申请日：2007-09-10

申请人： UNIV CINCINNATI ,  DORN GERALD W ,  LIGGETT STEPHEN B

发明人： DORN GERALD W ,  LIGGETT STEPHEN B

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6827

摘要： The present invention is directed to compositions and methods relating to a G-protein coupled receptor kinase-5 polymorphism. The methods include, for example: detecting enhanced desensitization of the beta adrenergic receptor signaling pathway in an individual, assessing partial protection against heart failure progression in an individual, and assessing an individual's response to beta-blocker therapy. The compositions include polynucleotides or fragments thereof of a nucleotide sequence encoding for a G-protein receptor kinase-5 molecule with a thymine at amino acid position 122 and oligonucleotide primers that hybridize thereto.

摘要翻译： 本发明涉及涉及G蛋白偶联受体激酶-5多态性的组合物和方法。 该方法包括例如：检测个体中β肾上腺素能受体信号传导途径的增强的脱敏，评估个体对抗心力衰竭进展的部分保护，以及评估个体对β-阻滞剂治疗的反应。 该组合物包括编码在氨基酸位置122具有胸腺嘧啶的G-蛋白受体激酶-5分子的核苷酸序列的多核苷酸或其片段和与之杂交的寡核苷酸引物。

公开(公告)号：WO2022198139A1

公开(公告)日：2022-09-22

申请号：PCT/US2022/021210

申请日：2022-03-21

申请人： MITOCHONDRIA EMOTION, INC. ,  DORN, Gerald W.

发明人： DORN, Gerald W.

IPC分类号： C07C233/23 ,  C07C233/60 ,  C07C235/40 ,  C07C323/60 ,  A61P25/28 ,  A61K31/16

摘要： The present disclosure relates to compounds of Formula (I): (I) or pharmaceutically acceptable salts thereof. The present disclosure also relates to uses of the compounds, e.g., in treating or preventing diseases, disorders, or conditions (e.g., associated with mitochondria).

公开(公告)号：WO2009097080A1

公开(公告)日：2009-08-06

申请号：PCT/US2009/000208

申请日：2009-01-12

申请人： THE UNIVERSITY OF CINCINNATI ,  PATHAK, Anand ,  KRANIAS, Evangelia, G. ,  CHEN, Guoli ,  DORN, Gerald, W., II

发明人： PATHAK, Anand ,  KRANIAS, Evangelia, G. ,  CHEN, Guoli ,  DORN, Gerald, W., II

IPC分类号： G01N33/48 ,  G01N33/50

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2800/325 ,  G01N2800/52

摘要： A method for diagnosing the presence of a G147D polymorphism of human phosphatase- 1 inhibitor- 1 protein is provided, wherein the method involves determining the presence of the polymorphism in a biological sample from a human subject by means which detect the presence of the polymorphism, wherein the presence of the polymorphism is indicative of a predisposition to impaired functioning of the β- adrenergic signaling pathway.

摘要翻译： 提供了一种用于诊断人磷酸酶-1抑制剂-1蛋白的G147D多态性的存在的方法，其中所述方法包括通过检测多态性的存在的方式确定来自人受试者的生物样品中多态性的存在， 其中多态性的存在表明β-肾上腺素能信号通路功能受损的倾向。

公开(公告)号：WO2022204125A1

公开(公告)日：2022-09-29

申请号：PCT/US2022/021321

申请日：2022-03-22

申请人： MITOCHONDRIA EMOTION, INC. ,  DORN, Gerald, W.

发明人： DORN, Gerald, W.

IPC分类号： C07C213/10 ,  C07C215/42

摘要： The present disclosure relates to crystalline polymorphs of N-(trans-4-hydroxycyclohexyl)-6-phenylhexanamide, and to pharmaceutical compositions that may be prepared from the polymorphs. The present disclosure also relates to uses of the crystalline polymorphs, e.g., in treating or preventing a disease, disorder, or condition.