公开(公告)号：WO2012025637A1

公开(公告)日：2012-03-01

申请号：PCT/EP2011/064841

申请日：2011-08-29

Applicant: DUBLIN CITY UNIVERSITY ,  KILLARD, Anthony Joseph ,  KENT, Nigel ,  DUDEK, Magdalena Maria

Inventor： KILLARD, Anthony Joseph ,  KENT, Nigel ,  DUDEK, Magdalena Maria

IPC: G01N33/543 ,  G01N33/86 ,  B01L3/00 ,  C12Q1/56

CPC classification number: G01N33/558 ,  B01L3/502746 ,  B01L2200/0647 ,  B01L2300/1827 ,  B01L2400/086 ,  G01N33/86 ,  G01N2333/4613

Abstract: The present invention is directed to a method and device for monitoring and measuring agglutination within a sample using a lateral flow assay device. In particular, the present invention is directed to a method for monitoring and measuring the onset of agglutination within a sample on a lateral flow assay device comprising micro-projections to define a lateral flow assay path wherein the method comprises combining the sample with at least one detectable marker and at least one agglutination marker or a combination thereof to form a labelled sample; subjecting the labelled sample to lateral flow; and monitoring the redistribution of the agglutination marker through the lateral flow assay path as agglutination occurs. The invention is also directed to a lateral flow assay device for carrying out the method and a kit comprising the lateral flow assay device and detection means.

Abstract translation: 本发明涉及用于使用侧流测定装置来监测和测量样品内的凝集的方法和装置。 特别地，本发明涉及一种用于监测和测量样品中在侧流测定装置上的凝集起始的方法，所述侧流测定装置包括微突起以限定侧流测定路径，其中所述方法包括将所述样品与至少一个 可检测标记和至少一种凝集标记或其组合以形成标记样品; 使标记的样品经受横向流动; 并且当凝集发生时，通过侧流测定路径监测凝集标记物的再分布。 本发明还涉及用于实施该方法的侧流测定装置和包括侧流分析装置和检测装置的试剂盒。

公开(公告)号：WO2012025637A9

公开(公告)日：2012-05-18

申请号：PCT/EP2011064841

申请日：2011-08-29

Applicant: UNIV DUBLIN CITY ,  KILLARD ANTHONY JOSEPH ,  KENT NIGEL ,  DUDEK MAGDALENA MARIA

Inventor： KILLARD ANTHONY JOSEPH ,  KENT NIGEL ,  DUDEK MAGDALENA MARIA

IPC: G01N33/543 ,  B01L3/00 ,  C12Q1/56 ,  G01N33/86

CPC classification number: G01N33/558 ,  B01L3/502746 ,  B01L2200/0647 ,  B01L2300/1827 ,  B01L2400/086 ,  G01N33/86 ,  G01N2333/4613

Abstract: The present invention is directed to a method and device for monitoring and measuring agglutination within a sample using a lateral flow assay device. In particular, the present invention is directed to a method for monitoring and measuring the onset of agglutination within a sample on a lateral flow assay device comprising micro-projections to define a lateral flow assay path wherein the method comprises combining the sample with at least one detectable marker and at least one agglutination marker or a combination thereof to form a labelled sample; subjecting the labelled sample to lateral flow; and monitoring the redistribution of the agglutination marker through the lateral flow assay path as agglutination occurs. The invention is also directed to a lateral flow assay device for carrying out the method and a kit comprising the lateral flow assay device and detection means.

Abstract translation: 本发明涉及使用侧流测定装置监测和测量样品内凝集的方法和装置。 特别地，本发明涉及一种用于监测和测量包括微突起的横向流动测定装置上的样品内的凝集发作的方法，以限定横向流动测定路径，其中所述方法包括将所述样品与至少一个 可检测标记和至少一个凝集标记或其组合以形成标记样品; 使标记的样品经受横向流动; 并在发生凝集时监测凝集标记物通过侧流测定路径的重新分布。 本发明还涉及一种用于执行该方法的侧流测定装置和一种包括该侧流测定装置和检测装置的套件。

公开(公告)号：WO2010122158A1

公开(公告)日：2010-10-28

申请号：PCT/EP2010/055470

申请日：2010-04-23

Applicant: DUBLIN CITY UNIVERSITY ,  ÅMIC AB ,  KILLARD, Anthony Joseph ,  DUDEK, Magdalena Maria ,  MACCRAITH, Brian ,  MENDEL-HARTVIG, Ib ,  ÖHMAN, Ove

Inventor： KILLARD, Anthony Joseph ,  DUDEK, Magdalena Maria ,  MACCRAITH, Brian ,  MENDEL-HARTVIG, Ib ,  ÖHMAN, Ove

IPC: B01L3/00 ,  G01N33/49 ,  G01N33/86

CPC classification number: G01N33/4905 ,  B01L3/502707 ,  B01L3/502753 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/086 ,  G01N33/54353 ,  G01N33/545 ,  G01N33/558 ,  G01N33/86

Abstract: The present invention is directed to a lateral flow assay device for the monitoring and measuring of coagulation and method thereof. Ideally, the invention is directed to a lateral capillary flow device for the monitoring and/or measurement of coagulation in a liquid sample wherein the device comprises a non-porous substrate with a zone for receiving a sample and a defined flow path zone wherein a clotting agent is deposited on at least part of the defined flow path zone to accelerate the coagulation of the liquid sample, enable the formation of an evenly distributed clot along the defined flow path zone and to result in the change in flow rate or cessation of flow of the liquid sample along the defined flow path zone.

Abstract translation: 本发明涉及一种用于监测和测量凝血的侧流测定装置及其方法。 理想地，本发明涉及用于监测和/或测量液体样品中的凝结的侧向毛细管流动装置，其中该装置包括具有用于接收样品的区域和限定的流动路径区域的无孔基材，其中凝固 试剂沉积在限定的流动路径区的至少部分上以加速液体样品的凝结，使得能够沿着限定的流动路径区形成均匀分布的凝块，并导致流速的变化或流动停止 液体样品沿着限定的流路区域。