公开(公告)号：WO2020011770A1

公开(公告)日：2020-01-16

申请号：PCT/EP2019/068365

申请日：2019-07-09

Applicant: DUBLIN CITY UNIVERSITY

Inventor： COLLINS, Denis ,  GAYNOR, Nicola ,  CROWN, John ,  O'DONOVAN, Norma

IPC: G01N33/574

Abstract: A method of predicting response to chemotherapy in a patient with cancer is described. The method comprises the steps of incubating an ADCC-capable molecule, an immune response modulator, a cancer cell line that expresses a target of the ADCC-capable molecule, and a sample of the patient's blood, for a period of time, determining an ADCC response of the cancer cell line, comparing the ADCC response with a reference ADCC response, and predicting the patient's response to chemotherapy based on the comparison. In one aspect, the cancer is a HER2+ cancer, the ADCC-capable molecule is an antibody targeting HER2, and the cancer cell lines is a HER2+ cancer cell line.

公开(公告)号：WO2019206894A1

公开(公告)日：2019-10-31

申请号：PCT/EP2019/060350

申请日：2019-04-23

Applicant: DUBLIN CITY UNIVERSITY

Inventor： O'BOYLE, Paddy ,  TRAINOR, Martin

IPC: G08B5/36 ,  G08B6/00 ,  G08B7/06

Abstract: The invention provides a navigation device comprising a docking portion configured to securely adhere to a surface and a unit having at least one of a visual, an audio or tactile indicator. The present invention provides a device which the user attaches to a wall or door or ground surface entered on the way into a building. A number of fixed devices then assist the user to retrace their route out of the building. In addition, the device can be configured to transmit essential information to a user located outside the building. The devices can also be configured to form a novel navigation communication system.

公开(公告)号：WO2018184957A1

公开(公告)日：2018-10-11

申请号：PCT/EP2018/057997

申请日：2018-03-28

Applicant: DUBLIN CITY UNIVERSITY

Inventor： FORSTER, Robert ,  SPAIN, Elaine ,  ADAMSON, Kellie ,  CARTHY, Eadaoin ,  BOYLE, David

IPC: B01L3/00 ,  G01N27/02 ,  G01N27/04 ,  G01N27/26 ,  G01N27/60 ,  G01N33/543 ,  G01N33/58 ,  G01N35/00

Abstract: A microfluidic device for detection of an analyte in a fluid is described. The microfluidic device comprises a substrate having a first surface defining entrances to one or more chambers defined in the substrate, surfaces of the chambers defining a second surface of the substrate, the first surface being modified for selective targeting and capture of at least one analyte to operably effect a blocking of the entrance to at least one of the chambers, and wherein a response characteristic of the microfluidic device is operably varied by the blocking of the entrance to the at least one of the chambers, thereby providing an indication of the presence of the analyte within the fluid.

公开(公告)号：WO2015097087A1

公开(公告)日：2015-07-02

申请号：PCT/EP2014/078732

申请日：2014-12-19

Applicant: DUBLIN CITY UNIVERSITY

Inventor： DOLLY, James Oliver ,  WANG, Jiafu ,  MENG, Jianghui

IPC: C07K14/33

CPC classification number: C12N9/52 ,  A61K38/00 ,  A61K38/4893 ,  C07K14/33 ,  C07K2319/00 ,  C07K2319/50 ,  C12Y304/24069 ,  Y02A50/469

Abstract: The invention includes Clostridial neurotoxin derivatives containing at least two light chain endopeptidase domains, and nucleic acids encoding such Clostridial neurotoxin derivatives. In preferred embodiments, the invention includes methods and compositions for the treatment of inflammatory disorders(such as arthritis); chronic pain, such as neuropathic painand inflammatory pain through the use of such Clostridial neurotoxin derivatives, including those derived from an intact BoNT/A having an LC/E- derived endopeptidase joined to the LC/A endopeptidase.

Abstract translation: 本发明包括含有至少两个轻链内肽酶结构域的梭菌神经毒素衍生物和编码这种梭菌神经毒素衍生物的核酸。 在优选的实施方案中，本发明包括用于治疗炎症性疾病（例如关节炎）的方法和组合物; 包括通过使用这种梭菌神经毒素衍生物的神经性疼痛和炎性疼痛的慢性疼痛，包括衍生自具有连接到LC / A内肽酶的LC / E-衍生内肽酶的完整BoNT / A的那些。

公开(公告)号：WO2014166818A1

公开(公告)日：2014-10-16

申请号：PCT/EP2014/056749

申请日：2014-04-03

Applicant: DUBLIN CITY UNIVERSITY

Inventor： YOUNG, Paul Samuel Fleming ,  BYRNE, Francis Anthony ,  MURPHY, Alexander Philip ,  BREEN, Sean

IPC: B62D61/06 ,  B60P1/04

CPC classification number: B60P1/34 ,  B60K1/02 ,  B60L11/1877 ,  B60L2200/40 ,  B60L2220/42 ,  B60L2220/44 ,  B60L2260/28 ,  B60L2270/12 ,  B60L2270/142 ,  B60P1/16 ,  B62D61/065 ,  Y02P90/60 ,  Y02T10/646 ,  Y02T10/7005 ,  Y02T10/705

Abstract: The present teaching provides a three wheel zero emission dumper vehicle (100), the vehicle comprising a chassis (150), the chassis supporting: two fixed front wheels (180), a single steering rear wheel (190), and a load carrying assembly, wherein the vehicle is configured such that a distribution of weight supported by the chassis is such that a centre of gravity of the vehicle is maintained within a triangle formed by the contact of the wheels on the ground in both loaded and unloaded states of the load carrying assembly.

Abstract translation: 本实施例提供一种三轮零排放自卸车（100），该车辆包括底盘（150），底架支撑：两个固定前轮（180），单个转向后轮（190）和承载组件 其特征在于，所述车辆被构造成使得由所述底盘支撑的重量的分布使得所述车辆的重心保持在由所述载荷和所述载荷的负载状态下的地面上的所述车轮接触形成的三角形内 携带组件。

公开(公告)号：WO2011045394A1

公开(公告)日：2011-04-21

申请号：PCT/EP2010/065469

申请日：2010-10-14

Applicant: DUBLIN CITY UNIVERSITY ,  GUBALA, Vladimir ,  LE GUEVEL, Xavier ,  NOONEY, Robert

Inventor： GUBALA, Vladimir ,  LE GUEVEL, Xavier ,  NOONEY, Robert

IPC: G01N33/58 ,  G01N33/543

CPC classification number: B82Y15/00 ,  G01N33/587

Abstract: A label comprising: a nanoparticle wherein the nanoparticle surface is functionalised to comprise at least one dendrimer having at least one activatable functional group for conjugating a target analyte to the functionalised nanoparticle, wherein the dendrimer has a stabilizing effect on the zeta potential at the nanoparticle surface. Such a label is desirable since the stabilizing effect results from an increase in the zeta potential at the nanoparticle surface. The dendrimer functionalised nanoparticle may be conjugated to a detection molecule which detects a target analyte. Use of the labels in bioassays allow detection of ultralow LODs.

Abstract translation: 一种标签，包括：纳米颗粒，其中纳米颗粒表面被官能化以包含至少一个具有至少一个可激活官能团的树状聚合物，用于将目标分析物与功能化的纳米颗粒共轭，其中树枝状聚合物对纳米颗粒表面上的ζ电位具有稳定作用 。 这种标签是期望的，因为稳定效应是由纳米颗粒表面的ζ电位的增加引起的。 树枝状大分子官能化纳米颗粒可以与检测目标分析物的检测分子缀合。 在生物测定中使用标签可以检测超低LOD。

公开(公告)号：WO2010146153A1

公开(公告)日：2010-12-23

申请号：PCT/EP2010/058631

申请日：2010-06-18

Applicant: DUBLIN CITY UNIVERSITY ,  GANDHIRAMAN, Ram Prasad ,  BASABE-DESMONTS, Lourdes ,  RIAZ, Asif ,  LEE, Luke ,  DIMOV, Ivan ,  DUCREE, Jens ,  DANIELS, Stephen Michael

Inventor： GANDHIRAMAN, Ram Prasad ,  BASABE-DESMONTS, Lourdes ,  RIAZ, Asif ,  LEE, Luke ,  DIMOV, Ivan ,  DUCREE, Jens ,  DANIELS, Stephen Michael

IPC: B01L3/00 ,  B05D7/22 ,  C23C16/04 ,  C23C16/505

CPC classification number: C23C16/045 ,  B01L3/502707 ,  B01L2300/161 ,  B05D1/62 ,  B05D5/08 ,  B05D7/22 ,  B05D2201/00 ,  C23C16/505

Abstract: The formation of a barrier layer within individual channels or cavities of a microfluidic device is described. The barrier layer is effected through a gas phase deposition process, desirably implemented in a plasma environment.

Abstract translation: 描述了在微流体装置的各个通道或空腔内形成阻挡层。 阻挡层通过气相沉积工艺实现，期望地在等离子体环境中实现。

公开(公告)号：WO2010122158A1

公开(公告)日：2010-10-28

申请号：PCT/EP2010/055470

申请日：2010-04-23

Applicant: DUBLIN CITY UNIVERSITY ,  ÅMIC AB ,  KILLARD, Anthony Joseph ,  DUDEK, Magdalena Maria ,  MACCRAITH, Brian ,  MENDEL-HARTVIG, Ib ,  ÖHMAN, Ove

Inventor： KILLARD, Anthony Joseph ,  DUDEK, Magdalena Maria ,  MACCRAITH, Brian ,  MENDEL-HARTVIG, Ib ,  ÖHMAN, Ove

IPC: B01L3/00 ,  G01N33/49 ,  G01N33/86

CPC classification number: G01N33/4905 ,  B01L3/502707 ,  B01L3/502753 ,  B01L2300/161 ,  B01L2400/0406 ,  B01L2400/086 ,  G01N33/54353 ,  G01N33/545 ,  G01N33/558 ,  G01N33/86

Abstract: The present invention is directed to a lateral flow assay device for the monitoring and measuring of coagulation and method thereof. Ideally, the invention is directed to a lateral capillary flow device for the monitoring and/or measurement of coagulation in a liquid sample wherein the device comprises a non-porous substrate with a zone for receiving a sample and a defined flow path zone wherein a clotting agent is deposited on at least part of the defined flow path zone to accelerate the coagulation of the liquid sample, enable the formation of an evenly distributed clot along the defined flow path zone and to result in the change in flow rate or cessation of flow of the liquid sample along the defined flow path zone.

Abstract translation: 本发明涉及一种用于监测和测量凝血的侧流测定装置及其方法。 理想地，本发明涉及用于监测和/或测量液体样品中的凝结的侧向毛细管流动装置，其中该装置包括具有用于接收样品的区域和限定的流动路径区域的无孔基材，其中凝固 试剂沉积在限定的流动路径区的至少部分上以加速液体样品的凝结，使得能够沿着限定的流动路径区形成均匀分布的凝块，并导致流速的变化或流动停止 液体样品沿着限定的流路区域。

公开(公告)号：WO2010044083A3

公开(公告)日：2010-04-22

申请号：PCT/IE2009/000072

申请日：2009-10-14

Applicant: DUBLIN CITY UNIVERSITY ,  VASHIST, Sandeep, Kumar ,  O'SULLIVAN, Stephen, A. ,  O'NEILL, Feidhlim, T. ,  HOLTHOFER, Harry ,  O'REILLY, Brian ,  DIXIT, Chandra, Kumar

Inventor： VASHIST, Sandeep, Kumar ,  O'SULLIVAN, Stephen, A. ,  O'NEILL, Feidhlim, T. ,  HOLTHOFER, Harry ,  O'REILLY, Brian ,  DIXIT, Chandra, Kumar

IPC: B01L3/00 ,  G01N21/75

Abstract: A multi-well plate (1) for a biological assay comprising a plate frame (4) attached to a support substrate (7) through a gasket (5) wherein the plate frame (4) defines side walls for a plurality of wells (2) and the gasket (5) comprises a plurality of holes (6), whereby the holes (6) of the gasket (5) are substantially aligned with the wells (2) defined by the plate frame (4) such that the support substrate (7) forms a base for the wells (2) and wherein the side walls of the wells (2) comprise an absorbed layer of blocking agent. The substrate (7) may comprise functional surface amine groups for binding to a protein.

公开(公告)号：WO2009098272A3

公开(公告)日：2009-08-13

申请号：PCT/EP2009/051346

申请日：2009-02-05

Applicant: DUBLIN CITY UNIVERSITY ,  KENT - KAYLE, Nigel ,  LINCOLN, Bryan ,  BASABE-DESMONTS, Lourdes ,  RICCO, Antonio ,  KENNY, Dermot ,  MEADE, Gerardene ,  CORCORAN, Brian ,  ROYAL COLLEGE OF SURGEONS IN IRELAND

Inventor： KENT - KAYLE, Nigel ,  LINCOLN, Bryan ,  BASABE-DESMONTS, Lourdes ,  RICCO, Antonio ,  KENNY, Dermot ,  MEADE, Gerardene ,  CORCORAN, Brian

IPC: G06T7/20 ,  B01L3/00 ,  G01N33/49

Abstract: An object/test material interaction microti iridic device comprising a sample inlet adapted to receive a fluid sample comprising a plurality of objects, an outlet adapted to output the fluid sample from the device, at least one internal surface defining a flow cavity within the device, wherein the flow cavity extends between and is connected to the sample inlet and the outlet for flow of the fluid sample through the flow cavity, the flow cavity comprises a test area to which at least one test material is attached and which is situated in the flow cavity for flow of the fluid sample over the test area, and the flow cavity has an aspect ratio which, when the flow cavity is substantially filled by the fluid sample, provides a substantially constant shear force between the test area and the fluid sample flowing over the test area. The invention further comprises a system incorporating the device, methods of use of the device and system, and methods of analysing interactions.