Abstract:
The present invention is directed to a lateral flow assay device for the monitoring and measuring of coagulation and method thereof. Ideally, the invention is directed to a lateral capillary flow device for the monitoring and/or measurement of coagulation in a liquid sample wherein the device comprises a non-porous substrate with a zone for receiving a sample and a defined flow path zone wherein a clotting agent is deposited on at least part of the defined flow path zone to accelerate the coagulation of the liquid sample, enable the formation of an evenly distributed clot along the defined flow path zone and to result in the change in flow rate or cessation of flow of the liquid sample along the defined flow path zone.
Abstract:
The invention comprises a polymeric microarray support (1) for an optical assay arrangement (2) comprising optical means (3, 4, 6) for detection of light emitted from the support. The microarray support is provided with microfeatures comprising a surface enlarging pattern (5), i.e. grooves having a selected depth (8). The depth is selected such that the sum of the depth and of the variations in the thickness (7) of the support substantially corresponds to the depth of focus of the optical means.
Abstract:
A nozzle chip (3') for ejecting a liquid such as in an electrospray device is built from a substrate chip having grooves (5, 7) on a top surface. A lid (25) is attached to the top surface closing the grooves to form channels one of which has an open outlet end (9). At the outlet end a nozzle is formed at or attached and it has an outlet opening from which the liquid is to be ejected. Alignment recesses (13, 15) are made at edges of the substrate chip and they are accurately positioned in relation to the outlet opening, the alignment recesses allowing an accurate mounting of nozzle chip giving the outlet opening of the nozzle a reproducible position in the device where it is to be used. At the outlet end a recess (17) in the substrate chip can be provided and the nozzle can then be located in the recess to mechanically protect it.
Abstract:
A microfluidic structure comprises first and second substantially planar form-stable base layers (1, 2), and an intermediate spacing layer (3) of elastic material, said spacing layer (3) being recessed to define a microcavity or channel system (4) with at least one of said first and second base layers. The structure is produced by moulding the spacing layer, optionally applied to or integral with a first base layer (2), against a planar mould, and the microcavity or channel system is completed by applying a second base layer (1), and optionally said first base layer (2), to the spacing layer (3).
Abstract:
A method of making a nozzle plate structure with miniature nozzles, said nozzles having an accurately defined geometry and an upper and a lower surface, and said nozzle plate structure comprising a stable base plate (14) provided with holes and each hole containing a moulded structure forming the miniature nozzles (22). The method comprising the steps of providing a positive lower half of a mould (10) having protrusions (12) defining the size and shape of the said miniature nozzle, in which the protrusion mate with the holes of the stable base plate, and inserting the stable base plate in the mould, closing the mould with a lid (16) and applying a curable polymer (18) to the mould and exposing the curable resin to curing conditions. A nozzle plate structure (20) made according to the method is also disclosed.
Abstract:
Objects, such as molecules, macormolecules, nanoparticles, cells and organelles are immobilised to a surface by covalent bonds and in a site-specific manner using an external source of energy, acting on the surface in the presence of said objects, when said surface and said objects have been chemically derivatised to present groups capable of forming reactive moieties when subjected to said source of energy. The exact location of the immobilisation is determined either by exposing the surface to said source of energy in a highly localised manner, or by creating site-specific defects or a pattern, to which groups capable of forming reactive moieties when subjected to said source of energy are first arranged. Said pattern may be in the form of electrodes, arranged on the surface.
Abstract:
In a method of forming a microchannel and/or microcavity structure by bonding together two elements (1, 2) having opposed plane surfaces of the same or different materials, one or both surfaces having open channels and/or cavities, bonding is effected by applying to one or both element surfaces (1, 2) a thin layer (3) of a solution of a material capable of fusing with and having a lower melting point than that of the material or materials of the two element surfaces (1, 2) in a solvent which substantially does not dissolve the element surface material or materials. The solvent is then removed, and the two elements (1, 2) are brought together and heated to a temperature where the dissolved material is caused to melt but not the element surface material or materials.
Abstract:
Manufacturing of miniaturised three-dimentional electric components are presented, as well as components manufactured by the methods. The manufacturing methods comprise micro replication of at least one master structure, e.g. via a mould structure, in at least one polymer layer onto which layer at least one conductive path is provided.
Abstract:
There is suggested according to the invention that when gluing together information-carrying disc substrates into an optical, data-storing disc, there be used an adhesive in which there is mixed an evenly distributed trace amount of a fluorophore. This makes it possible, by measuring the fluorescent light, to determine and check the thickness of the adhesive layer between the substrates.
Abstract:
The invention relates to a nozzle (28c) for simultaneous application of a string of glue on two facing adjacent disc surfaces, especially for gluing together two optical disc elements to form a DVD. In order to make possible higher glue application rates and smaller dimensions of the glue application nozzle, there is suggested according to the application a nozzle which in a suitable manner can steer the flow towards the facing disc elements. For this purpose, the nozzle according to the invention has a channel outlet opening which has upper and lower outlet areas (60) and therebetween a constricted outlet area (58, 62).