中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

19 records (took 0.011 seconds)

    PHOSPHORSÄUREDIESTERAMIDE
    1.
    发明申请
    PHOSPHORSÄUREDIESTERAMIDE 审中-公开

    公开(公告)号：WO2007147644A2

    公开(公告)日：2007-12-27

    申请号：PCT/EP2007/005615

    申请日：2007-06-25

    Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. ,  EIBL, Hansjörg

    Inventor： EIBL, Hansjörg

    IPC: A61P35/00

    CPC classification number: C07F9/091 ,  C07F9/222

    Abstract: Die vorliegende Erfindung betrifft lipidanaloge Phosphorsäureverbindungen und insbesondere Phosphorsäuretriester, Phosphorsäurediesteramide sowie Phosphorsäurediester. Bevorzugt handelt es sich um kationische Phospholipide, welche vorzugsweise wenigstens eine freie Hydroxylgruppe aufweisen.

    Abstract translation: 本发明涉及脂质类似磷酸化合物，特别磷酸三酯，磷酸和Phosphorsäurediesteramide。 优选地，它是阳离子的磷脂，其优选具有至少一个游离羟基。

    PHOSPHATIDYL-OLIGO-GLYCERINE UND STRUKTURANALOGA
    2.
    发明申请
    PHOSPHATIDYL-OLIGO-GLYCERINE UND STRUKTURANALOGA 审中-公开
    磷脂OLIGO甘油和结构类似物

    公开(公告)号：WO2003095464A1

    公开(公告)日：2003-11-20

    申请号：PCT/EP2003/004942

    申请日：2003-05-12

    Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V. ,  EIBL, Hansjörg

    Inventor： EIBL, Hansjörg

    IPC: C07F9/10

    CPC classification number: C08G65/3353 ,  A61K9/127 ,  C07F9/091 ,  C07F9/10

    Abstract: Die Erfindung betrifft neue Strukturanaloga zu Phosphatidyloligoglycerinen. Diese Verbindungen können insbesondere zur Herstellung von Liposomen mit langer Zirkulationszeit mit oder ohne Thermolabilität eingesetzt werden. Die Erfindung betrifft weiterhin solche Verbindungen enthaltende Liposome sowie Arzneimittelzusammensetzungen.

    Abstract translation: 本发明涉及一种新颖的结构类似物来phosphatidyloligoglycerols。 这些化合物可以特别地用于具有长的循环时间有或没有热敏性脂质体的制备。 本发明还涉及含有这些化合物以及药物组合物的脂质体。

    NEW D-MANNITE DERIVATIVES AS STARTING PRODUCTS FOR THE SYNTHESIS OF PHOSPHOLIPIDS
    8.
    发明申请
    NEW D-MANNITE DERIVATIVES AS STARTING PRODUCTS FOR THE SYNTHESIS OF PHOSPHOLIPIDS 审中-公开
    新型D-MANNITE衍生物作为合成磷脂的产品

    公开(公告)号：WO1984000362A2

    公开(公告)日：1984-02-02

    申请号：PCT/DE1983000123

    申请日：1983-07-06

    Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER ... ,  EIBL, Hansjörg

    Inventor： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER ...

    IPC: C07C43/13

    CPC classification number: C07F9/091 ,  C07C43/135 ,  C07C43/178 ,  C07C43/1785 ,  C07F9/14 ,  C07F9/2408 ,  C07F9/2458

    Abstract: The mannite derivatives have the formula (I) wherein R and R , identical or different, represent when they are identical a straight or branched alkyl, alkenyl or alkynyl group containing from 6 to 24 atoms of carbon which may be substituted by a cycloalkyl rest having from 3 to 6 atoms of carbon, an aryl, benzyloxy, allyloxy, mesyloxy rest and/or halogen atoms and when R and R are different, they represent a straight or branched alkyl group with 1 to 24 atoms of carbon, which may be substituted by a cycloalkyl rest having from 3 to 6 atoms of carbon, an aryl, benzyloxy, allyloxy, mesyloxy rest and/or halogen atoms, with the possibility for R of being also a trityl group. From said mannite derivatives, it is possible to obtain in a simple way and with good yields the phospholipids in the form of their optical stereo isomers.

    Abstract translation: 所述甘露醇衍生物具有式（I），其中R 1和R 2相同或不同，表示当其含有6至24个碳原子的直链或支链烷基，烯基或炔基时，其可以是 被具有3至6个碳原子，芳基，苄氧基，烯丙氧基，甲磺酰氧基和/或卤素原子的环烷基取代，当R 1和R 2不同时，它们表示直链或支链烷基 具有1至24个碳原子，其可以被具有3至6个碳原子的芳基，芳基，苄氧基，烯丙氧基，甲磺酰基休止和/或卤素原子的环烷基取代，其中R 1为 也是一个三位一体的小组。 从所述的甘露醇衍生物，可以以简单的方式获得磷光体的良好的光学立体异构体的形式。

    LIPOSOMES WITH EXCESS NEGATIVE CHARGE
    9.
    发明申请
    LIPOSOMES WITH EXCESS NEGATIVE CHARGE 审中-公开
    具有超额负担的脂肪

    公开(公告)号：WO1993018749A1

    公开(公告)日：1993-09-30

    申请号：PCT/EP1993000605

    申请日：1993-03-16

    Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER ... ,  EIBL, Hansjörg ,  KAUFMANN-KOLLE, Petra ,  KRANICH, Anneliese ,  UNGER, Clemens

    Inventor： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER ...

    IPC: A61K09/127

    CPC classification number: A61K9/127 ,  Y02A50/409 ,  Y02A50/411

    Abstract: PCT No. PCT/EP93/00605 Sec. 371 Date Feb. 15, 1995 Sec. 102(e) Date Feb. 15, 1995 PCT Filed Mar. 16, 1993 PCT Pub. No. WO93/18749 PCT Pub. Date Sep. 30, 1993The present invention concerns liposomes with a negative excess charge and pharmaceutical compositions produced therefrom. The liposomes contain 30 to 50 mol % cholesterol, 49 to 56 mol % phospholipids and 1 to 14 mol % of one or several compounds of the general formula I (I) or salts thereof in relation to the total lipid components of the liposomes, in which R1 and R2 are the same or different and represent hydrogen, C1-C4 alkyl groups or saturated or unsaturated C8-C24 acyl groups which are unbranched or branched or/and unsubstituted or substituted, provided that at least one of the residues R1 and R2 is an acyl group as defined above. A process for the production of the liposomes in accordance with the invention is also provided.

    LIPOSOMES WITH POSITIVE EXCESS CHARGE
    10.
    发明申请
    LIPOSOMES WITH POSITIVE EXCESS CHARGE 审中-公开
    具有积极超额收费的脂肪

    公开(公告)号：WO1991016880A1

    公开(公告)日：1991-11-14

    申请号：PCT/EP1991000796

    申请日：1991-04-25

    Applicant: MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER ... ,  EIBL, Hansjörg ,  KAUFMANN-KOLLE, Petra ,  UNGER, Clemens

    Inventor： MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER ...

    IPC: A61K09/127

    CPC classification number: A61K9/1271 ,  A61K9/1272 ,  Y02A50/411

    Abstract: A b s t r a c t New liposome structures are described which are characterized in that they contain at least 1 mol-% of a compound having the general formula (I) with an excess positive charge (I) in which R1 denotes alkoyl or alkyl each with 14 to 18 C atoms, oleoyl or oleyl, R2 denotes the group PNN R3 = -O-R1, -O-PNN, -O-Gly, NH3+, NH2CH3+, NH(CH3)2 or N(CH3)3+, R has one of the meanings stated for R1, R2 or R3 and n denotes a whole number from 0 to 3, and preferably denotes 0, provided that the molecule contains one of the said groups with a positive charge. Due to their organ-specific characteristics the liposomes according to the present invention are especially suitable as pharmaceutical carriers in a pharmaceutical preparation for the treatment of diseases in the liver organ which contains one or several active substances which are active in the liver enclosed in the liposomes according to the present invention.

    Abstract translation: 描述了一种新的脂质体结构，其特征在于它们含有至少1mol-具有通式（I）的化合物，其具有过量的正电荷（IMG）（I），其中R 1表示烷酰基或烷基，各自具有 14至18个碳原子，油酰基或油基，R 2表示基团PNN R 3 = -O-R 1，-O-PNN，-O-Gly，NH 3 +，NH 2 CH 3 +，NH（CH 3）2或N（CH 3）3 +，R具有对于R 1，R 2或R 3表示的含义之一，n表示0至3的整数，并且优选表示0，条件是分子含有正电荷的所述基团之一。 由于它们的器官特异性特征，根据本发明的脂质体特别适合作为用于治疗肝器官疾病的药物制剂中的药物载体，所述药物载体含有在脂质体中封闭的肝中有活性的一种或多种活性物质 根据本发明。

Patent Agency Ranking