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公开(公告)号：WO2022067052A8
公开(公告)日：2022-03-31
申请号：PCT/US2021/051973
申请日：2021-09-24
Applicant: ELANCO US INC.
Inventor： GANGAIAH, Dharanesh Mahimapura , KUMAR, Arvind , MANE, Shrinivasrao Peerajirao , SUSANTI, Dwi , VOLLAND, Alyssa
IPC: A23K10/18 , A61K35/742 , C12N1/20
Abstract: The present invention relates to probiotic compositions and methods for improving animal health and animal production. The probiotic compositions include one, two, three, or more isolated strains of novel bacillus strains which are capable of colonizing the gastrointestinal tract to improve the health of an animal. The probiotic compositions include a combination of at least one Bacillus amyloliquefaciens strain and a Bacillus subtilis strain.
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公开(公告)号：WO2022020585A1
公开(公告)日：2022-01-27
申请号：PCT/US2021/042769
申请日：2021-07-22
Applicant: ELANCO US INC.
Inventor： DEFAUW, Jean Marie , WU, Guanmin , HU, Jingdan , CHEN, Jing , ZHANG, Xin , HUANG, Ping
IPC: C07D413/04
Abstract: The present disclosure provides processes for making enantiomerically pure isoxazoline compounds of formula (1), (1). The present disclosure also provides processes for making enantiomerically pure isoxazoline compounds of formula (1) characterized by improving the enantiomeric purity of 3-methyl-5-[(5S)-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]thiophene-2-carboxylic acid by crystallization.
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公开(公告)号：WO2022271976A1
公开(公告)日：2022-12-29
申请号：PCT/US2022/034769
申请日：2022-06-23
Applicant: ELANCO US INC.
Inventor： BHOWMIK, Bijit, Kumar , GANGAIAH, Dharanesh, Mahimapura , KUMAR, Arvind , SNYDER, Jonathan, Earl
IPC: C07K14/255 , C12N1/36 , C12N15/87 , A61P31/00 , A61P31/04
Abstract: The present invention provides an intracellular delivery platform comprising an attenuated bacterium carrying a self-amplifying nucleic acid encoding a therapeutic biomolecule. The therapeutic biomolecule has a desired activity or effect such as treating or preventing an infection, disease or disorder, or eliciting protective immunity against a pathogenic or parasitic organism. Genetically modified and attenuated bacteria, particularly Salmonella bacteria, are provided. Methods for intracellular and systemic delivery of one or more therapeutic biomolecule are provided. Self-amplifying nucleic acids are provided.
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公开(公告)号：WO2022140235A1
公开(公告)日：2022-06-30
申请号：PCT/US2021/064308
申请日：2021-12-20
Applicant: ELANCO US INC.
Inventor： SPEIDEL, Gudrun , FREITAG, Klaus , REITZ, Claudia , RENNER, Maike
Abstract: The disclosed embodiments include a system for administration of medicament. The system includes at least a magnet and a dosing unit. The magnet is configured to generate a magnetic field. The dosage unit includes an excipient and an active ingredient. The excipient includes a magnetic substance that receives external agitation from the magnetic field of the magnet
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公开(公告)号：WO2021127189A1
公开(公告)日：2021-06-24
申请号：PCT/US2020/065625
申请日：2020-12-17
Applicant: ELANCO TIERGESUNDHEIT AG , ELANCO US INC.
Inventor： ROLFE, Peter , GEORGE, Sarah , TAHTAOUI, Chouaib
IPC: A61K31/167 , A61K31/609 , A61P33/10
Abstract: The present invention provides a method of treating liver fluke infections in a mammal in need of such treatment comprising administering an effective amount of diamphenethide in combination with an effective amount of closantel.
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Patent Agency Ranking
公开(公告)号：WO2021127188A1
公开(公告)日：2021-06-24
申请号：PCT/US2020/065624
申请日：2020-12-17
Applicant: ELANCO TIERGESUNDHEIT AG , ELANCO US INC.
Inventor： DUCRAY, Pierre , RAGEOT, Denise
IPC: C07D261/08 , A01N43/80 , C07D413/04 , C07D413/12 , C07D413/14 , C07D491/107 , A01N43/76 , A01N43/90 , C07D261/04
Abstract: The present invention provides compounds of formula (I): which are useful for long-lasting treatment and control of pests, for example fleas and ticks, in companion animals and livestock, and pharmaceutical compositions and methods of using the same.
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公开(公告)号：WO2020072343A1
公开(公告)日：2020-04-09
申请号：PCT/US2019/053750
申请日：2019-09-30
Applicant: ELANCO TIERGESUNDHEIT AG , ELANCO US INC
Inventor： GEORGE, Sarah , ROLFE, Peter , TAHTAOUI, Chouaib
IPC: A61K31/167 , A61K31/63 , A61P33/10
Abstract: The present invention provides a method of treating liver fluke infections in a mammal in need of such treatment comprising administering an effective amount of diamphenethide in combination with an effective amount of clorsulon.
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公开(公告)号：WO2023049747A1
公开(公告)日：2023-03-30
申请号：PCT/US2022/076781
申请日：2022-09-21
Applicant: ELANCO US INC.
Inventor： LI, Yong-Fu
Abstract: The present disclosure provides veterinary compositions comprising PlySs2, along with methods of using, making, or producing the PlySs2-containing veterinary composition, which exhibits desirable properties and provide benefits for the treatment of disease in animals.
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公开(公告)号：WO2022266244A1
公开(公告)日：2022-12-22
申请号：PCT/US2022/033662
申请日：2022-06-15
Applicant: ELANCO US, INC.
Inventor： HAN, Lili , JIN, Qiaowen , ROBIN, Jennifer , DE PAUL, Susan Margaret , WU, Guanmin , HU, Jingdan , STIRM, Stephen
IPC: C07D261/04 , A01N43/80
Abstract: The present disclosure provides crystalline forms of 2-methyl-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-4-[(5S)-5-[3-chloro-2-fluoro-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-4H-isoxazol-3-yl]benzamide, methods of preparing the same, and pharmaceutical compositions comprising the same.
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公开(公告)号：WO2022067052A1
公开(公告)日：2022-03-31
申请号：PCT/US2021/051973
申请日：2021-09-24
Applicant: ELANCO US INC.
Inventor： GANGAIAK, Dharanesh Mahimapura , KUMAR, Arvind , MANE, Shrinivasrao Peerajirao , SUSANTI, Dwi , VOLLAND, Alyssa
IPC: A23K10/18 , A61K35/742 , C12N1/20
Abstract: The present invention relates to probiotic compositions and methods for improving animal health and animal production. The probiotic compositions include one, two, three, or more isolated strains of novel bacillus strains which are capable of colonizing the gastrointestinal tract to improve the health of an animal. The probiotic compositions include a combination of at least one Bacillus amyloliquefaciens strain and a Bacillus subtilis strain.
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