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公开(公告)号：WO2006052568A2
公开(公告)日：2006-05-18
申请号：PCT/US2005/039554
申请日：2005-11-02
申请人： ELI LILLY AND COMPANY , DIEFENBACHER, Clive, Gideon , ENGLER, Thomas, Albert , LI, Hong-yu , MALHOTRA, Sushant , SAWYER, Jason, Scott , WANG, Yan
发明人： DIEFENBACHER, Clive, Gideon , ENGLER, Thomas, Albert , LI, Hong-yu , MALHOTRA, Sushant , SAWYER, Jason, Scott , WANG, Yan
IPC分类号： C07D519/00 , A61K31/437 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： The present invention is directed to inhibitors of TGF-BETA of Formula (I).
摘要翻译： 本发明涉及式（I）的TGF-βA的抑制剂。
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公开(公告)号：WO2004050659A1
公开(公告)日：2004-06-17
申请号：PCT/US2003/035969
申请日：2003-11-24
申请人： ELI LILLY AND COMPANY , BEIGHT, Douglas, Wade , BURKHOLDER, Timothy, Paul , DECOLLO, Todd, Vincent , GODFREY, Alexander, Glenn , HEAP, Charles, Raymond , KING, Chi-Hsin, Richard , LI, Hong-Yu , MCMILLEN, William, Thomas , SAWYER, Jason, Scott , WANG, Yan , DIEFENBACHER, Clive, Gideon , ENGLER, Thomas, Albert , MALHOTRA, Sushant , MUNDLA, Sreenivasa, Reedy
发明人： BEIGHT, Douglas, Wade , BURKHOLDER, Timothy, Paul , DECOLLO, Todd, Vincent , GODFREY, Alexander, Glenn , HEAP, Charles, Raymond , KING, Chi-Hsin, Richard , LI, Hong-Yu , MCMILLEN, William, Thomas , SAWYER, Jason, Scott , WANG, Yan , DIEFENBACHER, Clive, Gideon , ENGLER, Thomas, Albert , MALHOTRA, Sushant , MUNDLA, Sreenivasa, Reedy
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The current invention relates to compounds of the formula:(Ia) and the pharmaceutically acceptable salts thereof and their use as TGF-beta signal transduction inhibitors for treating cancer and other diseases in a patient in need thereof by administration of said compounds.
摘要翻译： 本发明涉及式（Ia）化合物及其药学上可接受的盐及其作为TGF-β信号转导抑制剂的用途，其用于通过施用所述化合物治疗有需要的患者中的癌症和其它疾病。
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公开(公告)号：WO2003076442A1
公开(公告)日：2003-09-18
申请号：PCT/US2003/005050
申请日：2003-03-04
申请人： ELI LILLY AND COMPANY , CLAYTON, Joshua, Ryan , DIEFENBACHER, Clive, Gideon , ENGLER, Thomas, Albert , FURNESS, Kelly, Wayne , HENRY, James, Robert , MALHOTRA, Sushant , MARQUART, Angela, Lynn , MCLEAN, Johnathan, Alexander , MENDEL, David , BURKHOLDER, Timothy, Paul , LI, Yihong , REEL, Jon, Kevin
发明人： CLAYTON, Joshua, Ryan , DIEFENBACHER, Clive, Gideon , ENGLER, Thomas, Albert , FURNESS, Kelly, Wayne , HENRY, James, Robert , MALHOTRA, Sushant , MARQUART, Angela, Lynn , MCLEAN, Johnathan, Alexander , MENDEL, David , BURKHOLDER, Timothy, Paul , LI, Yihong , REEL, Jon, Kevin
IPC分类号： C07D487/06
CPC分类号： C07D471/06 , C07D487/06
摘要： The present invention provides kinase inhibitors of Formula I.
摘要翻译： 本发明提供式I的激酶抑制剂。
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公开(公告)号：WO2009006043A3
公开(公告)日：2009-01-08
申请号：PCT/US2008/067614
申请日：2008-06-20
申请人： ELI LILLY AND COMPANY , ABURUB, Aktham , CHEDID, Marcio , ENGLER, Thomas, Albert , VASUDEVAN, Venkatraghavan
IPC分类号： A61K31/4745 , A61K31/4985 , A61K31/513 , A61K31/5517 , A61K31/555 , A61K31/704 , A61K31/7068 , A61K31/724 , A61K33/24 , A61P35/00
摘要： A method for treating gastric cancer, ovarian cancer, non-small cell lung cancer, or colorectal cancer in a patient is described, as well as pharmaceutical compositions comprising 7-(2,5-dihydro-4-imidazo[1,2-a]pyridine-3-yl-2,5-dioxo-IH-pyrrol-3-yl)-9-fluoro-1,2,3,4-tetrahydro-2-(1-piperidinyl-carbonyl)-pyrrolo[3,2,1-jk][1,4] benzodiazepine, useful for the method and a process for preparing said compositions.
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公开(公告)号：WO2009006043A2
公开(公告)日：2009-01-08
申请号：PCT/US2008067614
申请日：2008-06-20
IPC分类号： A61K31/4745 , A61K31/4985 , A61K31/513 , A61K31/5517 , A61K31/555 , A61K31/704 , A61K31/7068 , A61K31/724 , A61K33/24 , A61P35/00
CPC分类号： A61K31/724 , A61K31/4745 , A61K31/4985 , A61K31/513 , A61K31/5517 , A61K31/555 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K2300/00
摘要： An improved method for treating gastric cancer, ovarian cancer, non-small cell lung cancer, or colorectal cancer in a patient is described, as well as pharmaceutical compositions useful for the method and a process for preparing said compositions.
摘要翻译： 描述了一种用于治疗患者的胃癌，卵巢癌，非小细胞肺癌或结肠直肠癌的改进方法，以及用于该方法和用于制备所述组合物的方法的药物组合物。
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公开(公告)号：WO2006052568A3
公开(公告)日：2006-07-06
申请号：PCT/US2005039554
申请日：2005-11-02
申请人： LILLY CO ELI , DIEFENBACHER CLIVE GIDEON , ENGLER THOMAS ALBERT , LI HONG-YU , MALHOTRA SUSHANT , SAWYER JASON SCOTT , WANG YAN
发明人： DIEFENBACHER CLIVE GIDEON , ENGLER THOMAS ALBERT , LI HONG-YU , MALHOTRA SUSHANT , SAWYER JASON SCOTT , WANG YAN
IPC分类号： C07D519/00 , A61K31/437 , A61P35/00
CPC分类号： C07D487/04 , C07D471/04 , C07D519/00
摘要： The present invention is directed to inhibitors of TGF-BETA of Formula (I).
摘要翻译： 本发明涉及式（I）的TGF-βB的抑制剂。
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公开(公告)号：WO03076398A2
公开(公告)日：2003-09-18
申请号：PCT/US0305052
申请日：2003-03-05
申请人： LILLY CO ELI , ALBAUGH PAMELA ANN , AMMENN JOCHEN , BURKHOLDER TIMOTHY PAUL , CLAYTON JOSHUA RYAN , CONNER SCOTT EUGENE , CUNNINGHAM BRIAN EUGENE , ENGLER THOMAS ALBERT , FURNESS KELLY WAYNE , HENRY JAMES ROBERT , LI YIHONG , MALHOTRA SUSHANT , TEBBE MARK JOSEPH , ZHU GUOXIN
发明人： ALBAUGH PAMELA ANN , AMMENN JOCHEN , BURKHOLDER TIMOTHY PAUL , CLAYTON JOSHUA RYAN , CONNER SCOTT EUGENE , CUNNINGHAM BRIAN EUGENE , ENGLER THOMAS ALBERT , FURNESS KELLY WAYNE , HENRY JAMES ROBERT , LI YIHONG , MALHOTRA SUSHANT , TEBBE MARK JOSEPH , ZHU GUOXIN
IPC分类号： C07D491/052 , A61K31/404 , A61K31/405 , A61K31/4355 , A61K31/437 , A61K31/438 , A61K31/439 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/4741 , A61K31/4745 , A61K31/496 , A61K31/506 , A61P3/10 , A61P5/50 , A61P25/28 , A61P43/00 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D451/04 , C07D471/02 , C07D471/04 , C07D491/04 , C07D209/00
CPC分类号： C07D451/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D471/04 , C07D491/04
摘要： The present invention provides kinase inhibitors of Formula (I)
摘要翻译： 本发明提供式（I）的激酶抑制剂，
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公开(公告)号：WO0228861A8
公开(公告)日：2003-11-20
申请号：PCT/US0127728
申请日：2001-09-24
申请人： LILLY CO ELI , ENGLER THOMAS ALBERT , FURNESS KELLY WAYNE , MALHOTRA SUSHANT , BRIGGS STEPHEN LYLE , BROOKS HAROLD BURNS , CLAWSON DAVID KEYES , SANCHEZ-MARTINEZ CONCEPCION , ZHANG FAMING , ZHU GUOXIN
发明人： ENGLER THOMAS ALBERT , FURNESS KELLY WAYNE , MALHOTRA SUSHANT , BRIGGS STEPHEN LYLE , BROOKS HAROLD BURNS , CLAWSON DAVID KEYES , SANCHEZ-MARTINEZ CONCEPCION , ZHANG FAMING , ZHU GUOXIN
IPC分类号： A61P35/00 , C07D403/14 , C07D487/14 , A61K31/407
CPC分类号： C07D403/14 , C07D487/14
摘要： The compounds disclosed herein are indolocarbazoles of Formula (I), which are potent CDK4 inhibitors, and are useful in the treatment of cell proliferative disorders, including cancer. Formula (I).
摘要翻译： 本文公开的化合物是式（I）的吲哚并唑，其是有效的CDK4抑制剂，并且可用于治疗包括癌症的细胞增殖性疾病。 式（I）。
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公开(公告)号：WO2003076398A3
公开(公告)日：2003-09-18
申请号：PCT/US2003/005052
申请日：2003-03-05
申请人： ELI LILLY AND COMPANY , ALBAUGH, Pamela, Ann , AMMENN, Jochen , BURKHOLDER, Timothy, Paul , CLAYTON, Joshua, Ryan , CONNER, Scott, Eugene , CUNNINGHAM, Brian, Eugene , ENGLER, Thomas, Albert , FURNESS, Kelly, Wayne , HENRY, James, Robert , LI, YiHong , MALHOTRA, Sushant , TEBBE, Mark, Joseph , ZHU, Guoxin
发明人： ALBAUGH, Pamela, Ann , AMMENN, Jochen , BURKHOLDER, Timothy, Paul , CLAYTON, Joshua, Ryan , CONNER, Scott, Eugene , CUNNINGHAM, Brian, Eugene , ENGLER, Thomas, Albert , FURNESS, Kelly, Wayne , HENRY, James, Robert , LI, YiHong , MALHOTRA, Sushant , TEBBE, Mark, Joseph , ZHU, Guoxin
IPC分类号： C07D401/14
摘要： The present invention provides kinase inhibitors of Formula (I)
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公开(公告)号：WO0228861A3
公开(公告)日：2002-08-01
申请号：PCT/US0127728
申请日：2001-09-24
申请人： LILLY CO ELI , ENGLER THOMAS ALBERT , FURNESS KELLY WAYNE , MALHOTRA SUSHANT , BRIGGS STEPHEN LYLE , BROOKS HAROLD BURNS , CLAWSON DAVID KEYES , SANCHEZ-MARTINEZ CONCEPCION , ZHANG FAMING , ZHU GUOXIN
发明人： ENGLER THOMAS ALBERT , FURNESS KELLY WAYNE , MALHOTRA SUSHANT , BRIGGS STEPHEN LYLE , BROOKS HAROLD BURNS , CLAWSON DAVID KEYES , SANCHEZ-MARTINEZ CONCEPCION , ZHANG FAMING , ZHU GUOXIN
IPC分类号： A61P35/00 , C07D403/14 , C07D487/14 , A61K31/407
CPC分类号： C07D403/14 , C07D487/14
摘要： The compounds disclosed herein are indolocarbazoles of Formula (I), which are potent CDK4 inhibitors, and are useful in the treatment of cell proliferative disorders, including cancer. Formula (I).
摘要翻译： 本文公开的化合物是式（I）的吲哚并唑，其是有效的CDK4抑制剂，并且可用于治疗包括癌症的细胞增殖性疾病。 式（I）。
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