公开(公告)号：WO2015089467A1

公开(公告)日：2015-06-18

申请号：PCT/US2014/070142

申请日：2014-12-12

Applicant: SIMPSON STRONG-TIE COMPANY, INC. ,  BUNDY, Gregory D. ,  MUHN, Dustin P. ,  EVANS, Thomas G. ,  GRAY, Daniel M.

Inventor： BUNDY, Gregory D. ,  MUHN, Dustin P. ,  EVANS, Thomas G. ,  GRAY, Daniel M.

IPC: E04B1/26 ,  E04B1/94 ,  E04B5/12

CPC classification number: E04B1/2612 ,  E04B1/26 ,  E04B1/94 ,  E04B5/12

Abstract: A connection utilizing a joist hanger to hang a substantially horizontal joist or beam from a wood structural support member such as a top plate or header in cooperation with a first plurality of fasteners such as screws and one or more substantially vertical fire-resistant panels such as drywall.

Abstract translation: 使用托梁悬挂器的连接器将诸如顶板或集管的木结构支撑构件的基本上水平的托梁或梁悬挂在与第一多个紧固件（例如螺钉）和一个或多个基本垂直的防火面板（例如， 石膏板。

公开(公告)号：WO2005021707A3

公开(公告)日：2006-11-30

申请号：PCT/US2004015512

申请日：2004-05-17

Applicant: VICAL INC ,  VILALTA ADRIAN ,  EVANS THOMAS G ,  QUONG MELANIE W ,  MANTHORPE MARSTON

Inventor： VILALTA ADRIAN ,  EVANS THOMAS G ,  QUONG MELANIE W ,  MANTHORPE MARSTON

IPC: A61K31/7088 ,  A61K39/215 ,  A61K39/395 ,  C07K14/165 ,  C07K16/10 ,  C12N20060101 ,  C12N15/50

CPC classification number: A61K39/215 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/70 ,  C07K14/005 ,  C12N2770/20022 ,  C12N2770/20034

Abstract: The present invention is directed to raising a detectable immune response in a vertebrate by administering in vivo, into a tissue of the vertebrate, at least one polynucleotide comprising one or more regions of nucleic acid encoding a SARS-CoV protein or a fragment, a variant, or a derivative thereof. The present invention is further directed to raising a detectable immune response in a vertebrate by administering, in vivo, into a tissue of the vertebrate, at least one SARS-CoV protein or a fragment, a variant, or derivative thereof. The SARS-CoV protein can be, for example, in purified form. The polynucleotide is incorporated into the cells of the vertebrate in vivo, and an immunologically effective amount of an immunogenic epitope of a SARS-CoV polypeptide, fragment, variant, or derivative thereof is produced in vivo.

Abstract translation: 本发明涉及通过在体内向脊椎动物的组织中施用至少一种包含一个或多个编码SARS-CoV蛋白或片段的核酸区域的多核苷酸来提高脊椎动物中的可检测的免疫应答，变体 ，或其衍生物。 本发明还涉及通过在体内施用脊椎动物组织，至少一种SARS-CoV蛋白或其片段，变体或衍生物来提高脊椎动物中的可检测的免疫应答。 SARS-CoV蛋白可以是例如纯化形式。 将多核苷酸体内掺入脊椎动物的细胞中，在体内产生免疫有效量的SARS-CoV多肽，片段，变体或衍生物的免疫原性表位。

公开(公告)号：WO02056828A2

公开(公告)日：2002-07-25

申请号：PCT/US0147808

申请日：2001-11-29

Applicant: UNIV ROCHESTER ,  FEDEROFF HOWARD J ,  BOWERS WILLIAM J ,  FRELINGER JOHN G ,  WILLIS RICHARD A ,  EVANS THOMAS G ,  DEWHURST STEPHEN ,  HOCKNELL PETER K

Inventor： FEDEROFF HOWARD J ,  BOWERS WILLIAM J ,  FRELINGER JOHN G ,  WILLIS RICHARD A ,  EVANS THOMAS G ,  DEWHURST STEPHEN ,  HOCKNELL PETER K

IPC: A61K39/00 ,  A61K48/00 ,  C07K14/035 ,  C07K14/705 ,  C12N7/04 ,  C12N15/869 ,  A61K

CPC classification number: C12N15/86 ,  A61K39/0011 ,  A61K48/00 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/5256 ,  A61K2039/5258 ,  A61K2039/54 ,  A61K2039/55522 ,  A61K2039/55561 ,  A61K2039/57 ,  C07K14/005 ,  C07K14/70575 ,  C12N7/00 ,  C12N2710/16622 ,  C12N2710/16643 ,  C12N2710/16662

Abstract: The invention features new helper virus-free methods for making herpesvirus amplicon particles that can be used in immunotherapies, including those for treating any number of infectious diseases and cancers (including chronic lymphocytic leukemia, other cancers in which blood cells become malignant, lymphomas (e.g. Hodgkin's lymphoma or non-Hodgkin's type lymphomas). Described herein are methods of making helper virus-free HSV amplicon particles; cells that contain those particles (e.g, packaging cell lines or patients' cells, infected in vivo or ex vivo; particles produced according to those methods; and methods of treating a patient with an hf-HSV particle made according to those methods.

Abstract translation: 本发明提供了用于制备可用于免疫疗法的疱疹病毒扩增子颗粒的新型无辅助病毒方法，所述免疫疗法包括用于治疗许多感染性疾病和癌症（包括慢性淋巴细胞白血病，其中血细胞恶变的其他癌症，淋巴瘤（例如， 霍奇金淋巴瘤或非何杰金氏淋巴瘤）本文描述了制备无辅助病毒的HSV扩增子颗粒的方法;含有那些颗粒的细胞（例如，包装细胞系或患者的细胞，在体内或离体感染;根据 这些方法;以及用根据这些方法制备的hf-HSV颗粒治疗患者的方法。

公开(公告)号：WO2005021707A2

公开(公告)日：2005-03-10

申请号：PCT/US2004/015512

申请日：2004-05-17

Applicant: VICAL INCORPORATED ,  VILALTA, Adrian ,  EVANS, Thomas, G. ,  QUONG, Melanie, W. ,  MANTHORPE, Marston

Inventor： VILALTA, Adrian ,  EVANS, Thomas, G. ,  QUONG, Melanie, W. ,  MANTHORPE, Marston

IPC: C12N

CPC classification number: A61K39/215 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/70 ,  C07K14/005 ,  C12N2770/20022 ,  C12N2770/20034

Abstract: The present invention is directed to raising a detectable immune response in a vertebrate by administering in vivo , into a tissue of the vertebrate, at least one polynucleotide comprising one or more regions of nucleic acid encoding a SARS-CoV protein or a fragment, a variant, or a derivative thereof. The present invention is further directed to raising a detectable immune response in a vertebrate by administering , in vivo , into a tissue of the vertebrate, at least one SARS-CoV protein or a fragment, a variant, or derivative thereof. The SARS-CoV protein can be, for example, in purified form. The polynucleotide is incorporated into the cells of the vertebrate in vivo , and an immunologically effective amount of an immunogenic epitope of a SARS-CoV polypeptide, fragment, variant, or derivative thereof is produced in vivo . The SARS-CoV protein is also administered in an immunologically effective amount.

Abstract translation: 本发明涉及通过在体内向脊椎动物的组织中施用至少一种包含一个或多个编码SARS-CoV蛋白或片段的核酸区域的多核苷酸来提高脊椎动物中的可检测的免疫应答，变体 ，或其衍生物。 本发明还涉及通过在体内施用脊椎动物组织，至少一种SARS-CoV蛋白或其片段，变体或衍生物来提高脊椎动物中的可检测的免疫应答。 SARS-CoV蛋白可以是例如纯化形式。 将多核苷酸体内掺入脊椎动物的细胞中，在体内产生免疫有效量的SARS-CoV多肽，片段，变体或衍生物的免疫原性表位。 SARS-CoV蛋白也以免疫有效量施用。

公开(公告)号：WO2002056828A3

公开(公告)日：2002-07-25

申请号：PCT/US2001/047808

申请日：2001-11-29

Applicant: UNIVERSITY OF ROCHESTER ,  FEDEROFF, Howard, J. ,  BOWERS, William, J. ,  FRELINGER, John, G. ,  WILLIS, Richard, A. ,  EVANS, Thomas, G. ,  DEWHURST, Stephen ,  HOCKNELL, Peter, K.

Inventor： FEDEROFF, Howard, J. ,  BOWERS, William, J. ,  FRELINGER, John, G. ,  WILLIS, Richard, A. ,  EVANS, Thomas, G. ,  DEWHURST, Stephen ,  HOCKNELL, Peter, K.

IPC: C12N15/00

Abstract: The invention features new helper virus-free methods for making herpesvirus amplicon particles that can be used in immunotherapies, including those for treating any number of infectious diseases and cancers (including chronic lymphocytic leukemia, other cancers in which blood cells become malignant, lymphomas ( e.g. Hodgkin's lymphoma or non-Hodgkin's type lymphomas). Described herein are methods of making helper virus-free HSV amplicon particles; cells that contain those particles ( e.g , packaging cell lines or patients' cells, infected in vivo or ex vivo ; particles produced according to those methods; and methods of treating a patient with an hf-HSV particle made according to those methods.

公开(公告)号：WO2005116270A3

公开(公告)日：2007-12-21

申请号：PCT/US2005017157

申请日：2005-05-18

Applicant: VICAL INC ,  LUKE CATHERINE ,  VILALTA ADRIAN ,  WLOCH MARY K ,  GEALL ANDREW ,  EVANS THOMAS G ,  JIMENEZ GRETCHEN S

Inventor： LUKE CATHERINE ,  VILALTA ADRIAN ,  WLOCH MARY K ,  GEALL ANDREW ,  EVANS THOMAS G ,  JIMENEZ GRETCHEN S

IPC: C12N15/44 ,  A61K31/711 ,  A61K39/145 ,  C07K16/10 ,  C12Q1/70

CPC classification number: C12N7/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/70 ,  C07K16/1018 ,  C07K2317/34 ,  C12N2760/16134 ,  C12N2760/16151

Abstract: The present invention is directed to enhancing the immune response of a human in need of protection against IV infection by administering in vivo, into a tissue of the human, at least one polynucleotide comprising one or more regions of nucleic acid encoding an IV protein or a fragment, a variant, or a derivative thereof. The present invention is further directed to enhancing the immune response of a human in need of protection against IV infection by administering, in vivo, into a tissue of the human, at least one IV protein or a fragment, a variant, or derivative thereof. The IV protein can be, for example, in purified form or can be an inactivated IV, such as those present in inactivated IV vaccines. The polynucleotide is incorporated into the cells of the human in vivo, and an immunologically effective amount of an immunogenic epitope of an IV, or a fragment, variant, or derivative thereof is produced in vivo. The IV protein (in purified form or in the form of an inactivated IV vaccine) is also administered in an immunologically effective amount.

Abstract translation: 本发明涉及通过在体内施用人体组织来增强需要防止IV感染的人的免疫应答，所述至少一种多核苷酸包含一个或多个编码IV蛋白的核酸区域或 片段，变体或其衍生物。 本发明进一步涉及通过在体内施用人体组织，至少一种IV蛋白或其片段，变体或衍生物来增强需要保护免受IV感染的人的免疫应答。 IV蛋白可以是例如纯化形式或可以是灭活的IV，例如存在于灭活IV疫苗中的那些。 将多核苷酸体内并入人的细胞中，并且在体内产生免疫有效量的IV或其片段，变体或衍生物的免疫原性表位。 IV蛋白（以纯化形式或灭活IV疫苗的形式）也以免疫有效量施用。

公开(公告)号：WO2006044591A3

公开(公告)日：2007-11-29

申请号：PCT/US2005036925

申请日：2005-10-13

Applicant: SIMPSON STRONG TIE CO INC ,  SIMONS TAWN ,  LIN JIN-JIE ,  EVANS THOMAS G

Inventor： SIMONS TAWN ,  LIN JIN-JIE ,  EVANS THOMAS G

IPC: E04B1/38 ,  E04C5/00

CPC classification number: E04B5/12 ,  E04B1/2612 ,  E04C3/125

Abstract: A structural connector for connecting first and second structural members has a substantially planar first flange and an embossment in the first flange, and the embossment in the first flange is formed with first and second sections, the first section generally extending uniformly to a first level above the top surface of the substantially planar first flange, that is different from a level to which the second section generally uniformly extends, the first and second sections being joined to each other at a distinct transition portion where the embossment sharply descends from the level of the first section to the level of the second section. The structural connector can be made with a bend that forms a first member adjacent the first flange and the embossment can extend through the bend into the first member.

Abstract translation: 用于连接第一和第二结构构件的结构连接器在第一凸缘中具有基本上平面的第一凸缘和凸起，并且第一凸缘中的凸起形成有第一和第二部分，第一部分通常均匀地延伸到上面的第一水平 基本上平面的第一凸缘的顶表面，其不同于第二部分大致均匀地延伸的水平，第一和第二部分在不同的过渡部分处彼此接合，其中压花从 第一部分到第二部分的级别。 结构连接器可以由弯曲形成，该弯曲形成邻近第一凸缘的第一构件，并且压花可以通过弯曲部延伸到第一构件中。

公开(公告)号：WO2006044591A2

公开(公告)日：2006-04-27

申请号：PCT/US2005/036925

申请日：2005-10-13

Applicant: SIMPSON STRONG-TIE COMPANY, INC. ,  SIMONS, Tawn ,  LIN, Jin-Jie ,  EVANS, Thomas, G.

Inventor： SIMONS, Tawn ,  LIN, Jin-Jie ,  EVANS, Thomas, G.

IPC: F21V21/00

CPC classification number: E04B5/12 ,  E04B1/2612 ,  E04C3/125

Abstract: A structural connector for connecting first and second structural members has a substantially planar first flange and an embossment in the first flange, and the embossment in the first flange is formed with first and second sections, the first section generally extending uniformly to a first level above the top surface of the substantially planar first flange, that is different from a level to which the second section generally uniformly extends, the first and second sections being joined to each other at a distinct transition portion where the embossment sharply descends from the level of the first section to the level of the second section. The structural connector can be made with a bend that forms a first member adjacent the first flange and the embossment can extend through the bend into the first member.

Abstract translation: 用于连接第一和第二结构构件的结构连接器在第一凸缘中具有基本上平面的第一凸缘和凸起，并且第一凸缘中的凸起形成有第一和第二部分，第一部分通常均匀地延伸到上面的第一级 基本上平面的第一凸缘的顶表面，其不同于第二部分大致均匀地延伸的水平，第一和第二部分在不同的过渡部分处彼此连接，其中凸起从 第一部分到第二部分的级别。 结构连接器可以用弯曲形成，该弯曲形成邻近第一凸缘的第一构件，并且压花可以延伸穿过弯头进入第一构件。

公开(公告)号：WO2005116270A2

公开(公告)日：2005-12-08

申请号：PCT/US2005/017157

申请日：2005-05-18

Applicant: VICAL INCORPORATED ,  LUKE, Catherine ,  VILALTA, Adrian ,  WLOCH, Mary, K. ,  GEALL, Andrew ,  EVANS, Thomas, G. ,  JIMENEZ, Gretchen, S.

Inventor： LUKE, Catherine ,  VILALTA, Adrian ,  WLOCH, Mary, K. ,  GEALL, Andrew ,  EVANS, Thomas, G. ,  JIMENEZ, Gretchen, S.

IPC: C12Q1/70

CPC classification number: C12N7/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55566 ,  A61K2039/70 ,  C07K16/1018 ,  C07K2317/34 ,  C12N2760/16134 ,  C12N2760/16151

Abstract: The present invention is directed to enhancing the immune response of a human in need of protection against IV infection by administering in vivo , into a tissue of the human, at least one polynucleotide comprising one or more regions of nucleic acid encoding an IV protein or a fragment, a variant, or a derivative thereof. The present invention is further directed to enhancing the immune response of a human in need of protection against IV infection by administering, in vivo , into a tissue of the human, at least one IV protein or a fragment, a variant, or derivative thereof. The IV protein can be, for example, in purified form or can be an inactivated IV, such as those present in inactivated IV vaccines. The polynucleotide is incorporated into the cells of the human in vivo , and an immunologically effective amount of an immunogenic epitope of an IV, or a fragment, variant, or derivative thereof is produced in vivo . The IV protein (in purified form or in the form of an inactivated IV vaccine) is also administered in an immunologically effective amount.

Abstract translation: 本发明涉及通过在体内施用人体组织来增强需要防止IV感染的人的免疫应答，所述至少一种多核苷酸包含一个或多个编码IV蛋白的核酸区域或 片段，变体或其衍生物。 本发明进一步涉及通过在体内施用人体组织，至少一种IV蛋白或其片段，变体或衍生物来增强需要保护免受IV感染的人的免疫应答。 IV蛋白可以是例如纯化形式或可以是灭活的IV，例如存在于灭活IV疫苗中的那些。 将多核苷酸体内并入人的细胞中，并且在体内产生免疫有效量的IV或其片段，变体或衍生物的免疫原性表位。 IV蛋白（以纯化形式或灭活IV疫苗的形式）也以免疫有效量施用。

公开(公告)号：WO2008002814A3

公开(公告)日：2008-06-12

申请号：PCT/US2007071727

申请日：2007-06-21

Applicant: SIMPSON STRONG TIE CO INC ,  EVANS THOMAS G ,  SIMONS TAWN ,  KNUDSON CALEB ,  OELLERICH PAUL ,  LIN JIN-JIE

Inventor： EVANS THOMAS G ,  SIMONS TAWN ,  KNUDSON CALEB ,  OELLERICH PAUL ,  LIN JIN-JIE

IPC: E04B1/38

CPC classification number: E04B1/2612

Abstract: A joist hanger used to attach a joist to a support member or header designed to minimize the noise caused by the rubbing of the members of the connection, during loading. The joist hanger includes a seat and a pair of side walls extending upwardly in spaced relationship therefrom to receive the end portion of a joist. The bottom of the joist rests on the seat, and the side faces of the joist extend upwardly therefrom in spaced relationship from the side walls of the hanger Inwardly projecting guides formed in the side walls of the hanger, hold the joist at selected points, maintaining the spaced relationship between the side walls of the hanger and the side faces of the joist. The inwardly projecting guides can be formed with embossed portions connected to the side walls of the joist.

Abstract translation: 托梁悬挂器用于将托梁附接到设计成在加载期间最小化由于连接件的摩擦而引起的噪音的支撑构件或插头。 托梁悬挂器包括一个座和一对侧壁，其间隔开地向上延伸以接收托梁的端部。 托梁的底部位于座椅上，托梁的侧面从悬挂架的侧壁间隔开地向上延伸，形成在衣架的侧壁中的向内突出的导向件将托梁保持在选定的位置，保持 悬架的侧壁和托梁的侧面之间的间隔关系。 向内突出的引导件可以形成有连接到托梁的侧壁的压花部分。