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公开(公告)号：WO2019088367A1
公开(公告)日：2019-05-09
申请号：PCT/KR2018/001147
申请日：2018-01-26
Inventor： LYOO, In Kyoon , CHO, Han Byul , HONG, Ga Hae
IPC: A61B5/00
Abstract: Provided is a method and apparatus for predicting a posttraumatic behavior problem that may predict a posttraumatic violent behavior problem of an individual, in detail, that may determine a biological phenotype of an individual experiencing a traumatic event within a predetermined period after the individual is exposed to the traumatic event, predict a violent symptom presentation probability of the individual based on the biological phenotype of the individual, and suggest an objective basis for preventive intervention in a development of posttraumatic stress disorder (PTSD) of the individual based on a prediction result.
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公开(公告)号：WO2016129890A1
公开(公告)日：2016-08-18
申请号：PCT/KR2016/001301
申请日：2016-02-05
Inventor： KANG, Sang Won , KANG, Dong Hoon
IPC: G01N33/68
CPC classification number: G01N33/6869 , C07K16/2866 , G01N33/5023 , G01N33/5061 , G01N33/6842 , G01N2333/5434 , G01N2500/10 , G01N2570/00 , G01N2800/32
Abstract: Provided are a composition for diagnosing vascular disease including an agent measuring a level of interleukin 12 receptor β2 protein in the blood, and a kit for diagnosing vascular disease including the same. Further, provided is a method of providing information for diagnosing vascular disease, the method including the step of measuring a level of interleukin 12 receptor β2 protein in a blood sample separated from an individual suspected of having vascular disease. Furthermore, provided are a composition for preventing or treating vascular disease including an interleukin 12 receptor β2 activity inhibitor, and a method of screening a therapeutic agent for vascular disease, the method including the step of treating smooth muscle cells with a test agent for vascular disease treatment and measuring an expression level of interleukin 12 receptor β2. According to the present invention, when interleukin 12 receptor β2 is used as a biomarker for vascular disease, in particular, myocardial infarction or unstable angina, vascular disease, of which diagnosis has been performed only by angiography, can be diagnosed using blood in a rapid non-invasive economic manner. Accordingly, the early diagnosis of vascular disease is possible, since the disease has been diagnosed based on subjective symptoms after the appearance of ischemic symptoms with development of the disease. The promise of early diagnosis, prevention and treatment is realized.
Abstract translation: 提供了用于诊断血管疾病的组合物，包括测量血液中白细胞介素12受体β2蛋白水平的试剂，以及用于诊断包括其的血管疾病的试剂盒。 此外，提供了提供用于诊断血管疾病的信息的方法，所述方法包括测量从怀疑患有血管疾病的个体分离的血液样品中的白细胞介素12受体β2蛋白的水平的步骤。 此外，提供了用于预防或治疗包括白细胞介素12受体β2活性抑制剂的血管疾病的组合物和筛选血管疾病治疗剂的方法，所述方法包括用血管病变试剂治疗平滑肌细胞的步骤 治疗和测量白细胞介素12受体β2的表达水平。 根据本发明，当白细胞介素12受体β2用作血管疾病的生物标志物时，特别是心肌梗塞或不稳定性心绞痛，血管病变（其诊断仅通过血管造影术进行）可以使用血液快速诊断 无创经济方式。 因此，血管疾病的早期诊断是可能的，因为该疾病已经基于发生该疾病的缺血性症状出现后的主观症状被诊断。 实现早期诊断，预防和治疗的承诺。
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公开(公告)号：WO2012011740A2
公开(公告)日：2012-01-26
申请号：PCT/KR2011/005347
申请日：2011-07-20
Applicant: SK CHEMICALS CO., LTD. , EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION , SAH, Hong Kee , LEE, Bong-Yong , UM, Key-An , OH, Joon-gyo , HWANG, Yong Youn , KIM, Hong-Kee , LEE, Kyu Ho , HONG, Seok Hyun , LEE, Yoon-Jung
Inventor： SAH, Hong Kee , LEE, Bong-Yong , UM, Key-An , OH, Joon-gyo , HWANG, Yong Youn , KIM, Hong-Kee , LEE, Kyu Ho , HONG, Seok Hyun , LEE, Yoon-Jung
CPC classification number: A61K9/1694 , A61K9/16 , A61K9/1647 , A61K31/4196 , A61K31/551 , C08J3/05 , C08J3/12 , C08J3/16 , C08J2367/04
Abstract: The present invention relates to a method for preparing microsphere1- and microspheres produced by thereby. More particularly, the present invention relates to a method for preparing a polymeric microsphere comprising the steps of: mixing a water-insoluble organic solvent with a dispersion solvent; mixing a polymer compound, a drug and a water-insoluble organic solvent so as to prepare a dispersed phase; mixing the dispersed phase with the dispersion solvent mixed with the water-insoluble organic solvent so as to prepare an emulsion; and adding a base or an acid to the prepared emulsion so as to remove the water-insoluble organic solvent from the emulsion and a polymeric microsphere thereby, and a composition for drug delivery comprising the microspheres. In the inventive preparation method, it is possible to conveniently prepare a drug-containing polymeric microsphere within a short time using a small amount of water, with the generation of a minimized amount of waste solution without a requirement of a conventional solvent-evaporation or solvent-extract ion process. Also, since a low concentration of remaining solvent within a prepared polymeric microsphere can be maintained, it is effective in preparation in sustained-release type medicines.
Abstract translation: 本发明涉及由此制备的微球和微球的制备方法。 更具体地，本发明涉及一种制备聚合物微球的方法，包括以下步骤：将水不溶性有机溶剂与分散溶剂混合; 混合高分子化合物，药物和水不溶性有机溶剂以制备分散相; 将分散相与与水不溶性有机溶剂混合的分散溶剂混合以制备乳液; 并向制备的乳液中加入碱或酸，从而从乳液和聚合物微球中除去水不溶性有机溶剂，以及用于药物递送的组合物，其包含微球。 在本发明的制备方法中，可以使用少量的水在短时间内方便地制备含药聚合物微球体，同时产生最少量的废溶液，而不需要常规的溶剂蒸发或溶剂 - 提取离子过程。 此外，由于可以保持制备的聚合物微球体内的低浓度剩余溶剂，因此在缓释型药物的制备中是有效的。
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公开(公告)号：WO2010056065A2
公开(公告)日：2010-05-20
申请号：PCT/KR2009/006690
申请日：2009-11-13
Applicant: EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION , SK CHEMICALS CO., LTD. , SAH, Hong Kee
Inventor： SAH, Hong Kee
CPC classification number: A61K9/1694 , A61K9/1635 , A61K9/1647 , A61K31/137 , A61K31/27 , A61K31/337 , A61K31/40 , A61K31/496 , A61K31/519 , A61K31/54 , A61K31/551 , A61K31/5513 , A61K31/57
Abstract: The present invention relates to a method for preparing microspheres and microspheres prepared thereby, more particularly to a method for preparing a polymeric microsphere, including preparing an emulsion including a polymer compound, a drug, a water- insoluble organic solvent and a dispersion solvent and adding to the prepared emulsion a base or an acid to remove the water-insoluble organic solvent from the emulsion, a polymeric microsphere prepared thereby, and a composition for drug delivery including the microsphere. According to the present invention, a drug-containing polymer microsphere may be prepared quickly and simply without the solvent evaporation or solvent extraction process, thereby reducing water consumption and minimizing wastewater generation.
Abstract translation: 本发明涉及一种制备由此制备的微球和微球的方法，更具体地涉及一种制备聚合物微球的方法，包括制备包括高分子化合物，药物，水不溶性有机溶剂和分散溶剂的乳液，并加入 向所制备的乳液中加入碱或酸以从乳液中除去水不溶性有机溶剂，由此制备的聚合物微球，和用于药物递送的组合物，包括微球。 根据本发明，可以在没有溶剂蒸发或溶剂萃取过程的情况下快速且简单地制备含药聚合物微球体，从而减少耗水量并最小化废水产生。
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公开(公告)号：WO2009104851A1
公开(公告)日：2009-08-27
申请号：PCT/KR2008/005568
申请日：2008-09-19
Applicant: EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION , SHIN, Hyungsoon , LEE, Seungyeon , LEE, Hyunjoo , LEE, Gamyoung
Inventor： SHIN, Hyungsoon , LEE, Seungyeon , LEE, Hyunjoo , LEE, Gamyoung
IPC: H01L29/768
CPC classification number: G11C11/1675 , G11C11/1673
Abstract: The present invention relates to an XOR logic operation apparatus using a spin torque transfer-based MTJ device. The XOR logic operation apparatus includes two parallel-connected magnetic memory cells (100, 200), and a sense amplifier (300) connected to first ends of the two magnetic memory cells. Each of the magnetic memory cells includes an MTJ device (10) and a current control circuit (50). Each magnetic memory cell includes a top electrode (11) and a bottom electrode (13) configured to allow current to flow therethrough, an insulating layer (19) configured to electrically insulate the top electrode from the bottom electrode, and a free magnetic layer (17) and a pinned magnetic layer (15) respectively formed on a top and a bottom of the insulating layer. The current control circuit controls flow of current passing between the top electrode and the bottom electrode, and changes a magnetization direction of the free magnetic layer.
Abstract translation: 本发明涉及使用基于自旋转矩传输的MTJ装置的异或逻辑运算装置。 XOR逻辑运算装置包括两个并联的磁存储单元（100,200）和连接到两个磁存储单元的第一端的读出放大器（300）。 每个磁存储单元包括MTJ装置（10）和电流控制电路（50）。 每个磁存储单元包括被配置为允许电流流过其中的顶部电极（11）和底部电极（13），被配置为使顶部电极与底部电极电绝缘的绝缘层（19）和自由磁性层 17）和分别形成在绝缘层的顶部和底部上的钉扎磁性层（15）。 电流控制电路控制在顶部电极和底部电极之间流动的电流，并且改变自由磁性层的磁化方向。
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Patent Agency Ranking6.发明申请FIBROUS 3-DIMENSIONAL SCAFFOLD VIA ELECTROSPINNING FOR TISSUE REGENERATION AND METHOD FOR PREPARING THE SAME 审中-公开通过用于组织再生的电纺丝的三维三维扫描方法及其制备方法
公开(公告)号：WO2007024125A1
公开(公告)日：2007-03-01
申请号：PCT/KR2006/003390
申请日：2006-08-28
Applicant: EWHA UNIVERSITY-INDUSTRY COLLABORATION FOUNDATION , LEE, Seung Jin , HAN, Sol , SHIM, In Kyong
Inventor： LEE, Seung Jin , HAN, Sol , SHIM, In Kyong
IPC: A61L27/14
Abstract: The present invention relates to a fibrous 3-dimensional porous scaffold via electrospinning for tissue regeneration and a method for preparing the same. The fibrous porous scaffold for tissue regeneration of the present invention characteristically has a biomimetic structure established by using electrospinning which is efficient without wasting materials and simple in handling techniques. The fibrous porous scaffold for tissue regeneration of the present invention has the size of between nanofiber and microfiber and regular form and strength, so that it facilitates 3-dimensional tissue regeneration and improves porosity at the same time with making the surface area contacting to a cell large. Therefore, the scaffold of the invention can be effectively used as a support for the cell adhesion, growth and regeneration.
Abstract translation: 本发明涉及用于组织再生的静电纺丝的纤维状三维多孔支架及其制备方法。 本发明的组织再生用纤维多孔支架特征在于具有通过使用静电纺丝而建立的仿生结构，其在不浪费材料和操作技术简单的情况下是有效的。 本发明的组织再生用纤维多孔支架具有纳米纤维与超细纤维之间的尺寸和规则的形状和强度，使得其有助于三维组织再生，同时在使表面积接触细胞的同时改善孔隙率 大。 因此，本发明的支架可以有效地用作细胞粘附，生长和再生的载体。
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公开(公告)号：WO2019031869A1
公开(公告)日：2019-02-14
申请号：PCT/KR2018/009091
申请日：2018-08-09
Inventor： JO, Il Hyun , KIM, Youn Joo , OH, Ye Ji , KIM, Jeong Hyun
Abstract: A learning situation determining method and apparatus is disclosed. The learning situation determining method includes collecting psychophysiological response information of a learner on a first learning image, collecting stimulated recall response information of the learner based on a stimulated recall of the learner in response to a second learning image including a same learning content as the first learning image, determining cognitive load in the leaner that is recalled in each learning interval of the second learning image based on the psychophysiological response information and the stimulated recall response information. Alternatively, the learning situation determining method includes determining cognitive load in a learner learning a learning image for each learning interval of the learning image using psychophysiological response information of the learner based on prior knowledge possessed by the learner and task complexity of the learning image. Alternatively, the learning situation determining method includes determining a learning level of a learner based on an achievement level and a tension level of the learner.
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8.发明申请COMPOUND AND COMPOSITION FOR DETECTING PHOSGENE AND DIETHYL CHLOROPHOSPHATE 审中-公开用于检测磷酸和二乙基氯磷酸酯的化合物和组合物
公开(公告)号：WO2017146400A1
公开(公告)日：2017-08-31
申请号：PCT/KR2017/001389
申请日：2017-02-08
Inventor： YOON, Juyoung , ZHOU, Xin , HU, Ying , CHEN, Liyan
IPC: C07D311/82 , C07D221/14 , C07D271/12 , C07D209/08 , G01N33/00 , G01N21/64
CPC classification number: C07D221/14 , C07D209/14 , C07D271/12 , C07D311/88 , C07D491/107 , G01N21/77 , G01N21/783 , G01N33/0049 , G01N2021/7786
Abstract: The present invention relates to a compound for detecting phosgene and DCP (diethyl chlorophosphate) and a composition for detecting phosgene and DCP (diethyl chlorophosphate) comprising the said compound. More precisely, the compound for detecting phosgene and DCP of the present invention can selectively detect phosgene and DCP either in the liquid phase of gas phase by detecting the changes of fluorescence and color development very quickly within a few seconds with nM sensitivity. Therefore, the compound can also be effectively used as an ingredient for the composition and kit for the detection of one or more materials selected from the group consisting of phosgene and DCP.
Abstract translation: 本发明涉及用于检测光气和DCP（氯磷酸二乙酯）的化合物和用于检测光气的组合物以及包含所述化合物的DCP（氯磷酸二乙酯）。 更确切地说，本发明的用于检测光气和DCP的化合物可以通过在nM灵敏度的几秒内非常快速地检测荧光的变化和显色而在气相的液相中选择性地检测光气和DCP。 因此，所述化合物也可以有效地用作用于检测选自光气和DCP的一种或多种材料的组合物和试剂盒的成分。
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公开(公告)号：WO2009028796A1
公开(公告)日：2009-03-05
申请号：PCT/KR2008/004233
申请日：2008-07-19
Inventor： PARK, IL HUNG
CPC classification number: G02B26/0816
Abstract: An optical module is disclosed. The optical module includes: (1) a mirror part for controlling its reflection angle in an analog method; (2) an aperture for controlling an amount of light incident to the mirror part, the aperture being installed facing the mirror part; (3) a detector for detecting an optical signal from a light transmitted from the mirror part; (4) a beam emitter for emitting a beam, the beam emitter being adjacently installed to the optical signal detector; and (5) a controller for controlling the mirror part so as to locate an object, detected by the optical signal detector, at the center portion of the optical signal detector, and for controlling the beam emitter and the mirror part so as to emit a beam from the beam emitter to the object detected by the optical signal detector. The optical module can observe an object both in a wide field of view (FOV) and in detail, effectively track a rapidly moving object, and emit a beam to the object.
Abstract translation: 公开了一种光学模块。 光模块包括：（1）以模拟方式控制其反射角的反射镜部分; （2）用于控制入射到反射镜部分的光量的光圈，所述光圈被安装成面向镜部分; （3）检测器，用于从从镜部发射的光检测光信号; （4）用于发射光束的光束发射器，所述光束发射器被相邻地安装到所述光信号检测器; 以及（5）控制器，用于控制镜部分，以将由光信号检测器检测到的物体定位在光信号检测器的中心部分，并用于控制光束发射器和镜部分，以便发射 从光束发射器到由光信号检测器检测到的物体的光束。 光学模块可以在宽视野（FOV）中观察物体，并且具体地，可以有效地跟踪快速移动的物体，并向物体发射光束。
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公开(公告)号：WO2009011484A1
公开(公告)日：2009-01-22
申请号：PCT/KR2008/001276
申请日：2008-03-06
Inventor： SHIN, Hyungsoon
IPC: G11C11/15
CPC classification number: G11C11/1697 , G11C11/1675
Abstract: The present invention relates to a magnetic memory cell, which controls the magnetization direction of the free magnetic layer of a Magnetic Tunnel Junction (MTJ) device using a spin torque transfer, and enables the implementation of a magnetic logic circuit, in which memory and logic circuit functions are integrated. The magnetic memory cell includes an MTJ device (10) including a top electrode (11) and a bottom electrode (13), which are provided to allow current to flow therethrough, and a fixed layer (15) and a free layer (17), which are magnetic layers respectively deposited on a top and a bottom of an insulating layer (19), required to insulate the top and bottom electrodes from each other. A current control circuit (50) controls a flow of current flowing between the top and bottom electrodes, and changes a magnetization direction of the free layer according to an input logic level.
Abstract translation: 本发明涉及一种磁存储单元，其使用自旋转矩传递来控制磁隧道结（MTJ）装置的自由磁化层的磁化方向，并且能够实现磁逻辑电路，其中存储器和逻辑 电路功能集成。 磁存储单元包括MTJ装置（10），其包括顶电极（11）和底电极（13），其设置成允许电流流过其中;以及固定层（15）和自由层（17） ，它们是分别沉积在绝缘层（19）的顶部和底部上的磁性层，需要使顶部和底部电极彼此绝缘。 电流控制电路（50）控制在顶部和底部电极之间流动的电流，并根据输入逻辑电平改变自由层的磁化方向。
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