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23 条记录 (耗时 0.015 秒)

    C-TERMINAL AMIDATION OF POLYPEPTIDES
    1.
    发明申请
    C-TERMINAL AMIDATION OF POLYPEPTIDES 审中-公开
    聚氨酯的C-末端氨基化

    公开(公告)号：WO2012036962A2

    公开(公告)日：2012-03-22

    申请号：PCT/US2011/050754

    申请日：2011-09-08

    申请人： AMYLIN PHARMACEUTICALS, INC. ,  SUN, Chengzao ,  FOROOD, Behrouz, Bruce ,  LUO, Gary ,  GHOSH, Soumitra, S.

    发明人： SUN, Chengzao ,  FOROOD, Behrouz, Bruce ,  LUO, Gary ,  GHOSH, Soumitra, S.

    IPC分类号： C07K1/107

    CPC分类号： C07K1/003 ,  C07C211/27 ,  C07D311/88 ,  C07K1/107

    摘要： There are provided compounds and methods for amidating the C-terminus of a polypeptide. The method include reacting a polypeptide which includes a C-terminal thioester or C-terminal selenoester with any one of a defined set of auxiliary molecules under conditions suitable to produce a polypeptide adduct which includes the auxiliary molecule chemically bound at the C- terminal of the polypeptide. In the subsequent step, the auxiliary molecule is removed from the C-terminal of the polypeptide adduct under conditions suitable to produce an amidated polypeptide.

    摘要翻译： 提供了用于酰胺化多肽的C末端的化合物和方法。 该方法包括在适于产生多肽加合物的条件下使包含C-末端硫酯或C-末端硒酸酯的多肽与定义的一组辅助分子中的任何一种反应，所述多肽加合物包括在所述辅助分子的C-末端化学结合的辅助分子 多肽。 在随后的步骤中，辅助分子在适于产生酰胺化多肽的条件下从多肽加合物的C-末端去除。

    ACTIVATED LABELING REAGENTS AND METHODS FOR PREPARING AND USING THE SAME
    2.
    发明申请
    ACTIVATED LABELING REAGENTS AND METHODS FOR PREPARING AND USING THE SAME 审中-公开
    活性标记试剂及其制备和使用方法

    公开(公告)号：WO2006054310A1

    公开(公告)日：2006-05-26

    申请号：PCT/IL2005/001238

    申请日：2005-11-22

    申请人： BIOSIGHT LTD. ,  GENGRINOVITCH, Stela

    发明人： GENGRINOVITCH, Stela

    IPC分类号： C07K14/47

    CPC分类号： G01N33/532 ,  C07D311/88 ,  C07D495/04 ,  C07K1/13

    摘要： The present invention relates in general to labeling reagents useful for labeling biomolecules. In particular, the invention provides activated labeling reagents, methods of preparing same, methods of using the labeling reagents for synthesizing a labeled biomolecule, kits comprising the reagents for labeling a biomolecule and kits containing labeled biomolecules.

    摘要翻译： 本发明一般涉及可用于标记生物分子的标记试剂。 特别地，本发明提供活化标记试剂，其制备方法，使用标记试剂合成标记的生物分子的方法，包括用于标记生物分子的试剂和包含标记的生物分子的试剂盒的试剂盒。

    NOVEL MAGENTA COLORANTS FOR USE WITHIN INK SYSTEMS
    5.
    发明申请
    NOVEL MAGENTA COLORANTS FOR USE WITHIN INK SYSTEMS 审中-公开
    在墨水系统中使用的新颖的色料

    公开(公告)号：WO2002096900A1

    公开(公告)日：2002-12-05

    申请号：PCT/US2002/010781

    申请日：2002-04-04

    申请人： MILLIKEN & COMPANY

    发明人： BATLAW, Rajnish ,  MOORE, Patrick D.

    IPC分类号： C07D311/88

    CPC分类号： C07D311/88 ,  C09B69/103

    摘要： Novel addition products of isocyanates with oxyalkylene-substituted aminophenol compounds as intermediates for the production of urethane-substituted xanthene colorants, particularly triphenylmethane derivatives such as rhodamines, are provided. The xanthene colorants exhibit improved wax and/or oil solubility and high purity. The urethane-substituted xanthene colorant features very good wax and/or oil solubility, and is believed to be relatively nontoxic. A method for producing this novel colorant is also provided.

    摘要翻译： 提供具有氧化烯取代的氨基苯酚化合物的异氰酸酯作为生产氨基甲酸酯取代的呫吨着色剂，特别是三苯甲烷衍生物如罗丹明的中间体的新型加成产物。 呫吨着色剂表现出改善的蜡和/或油溶性和高纯度。 氨基甲酸酯取代的呫吨着色剂具有非常好的蜡和/或油溶性，并且被认为是相对无毒的。 还提供了生产这种新型着色剂的方法。

    CYTOTOXIC COMPOUNDS
    6.
    发明申请
    CYTOTOXIC COMPOUNDS 审中-公开
    CYTOTOXIC化合物

    公开(公告)号：WO1994005276A1

    公开(公告)日：1994-03-17

    申请号：PCT/US1993008427

    申请日：1993-09-08

    申请人： MORGAN, Lee, Roy

    IPC分类号： A61K31/15

    CPC分类号： C07D335/18 ,  C07D219/10 ,  C07D237/26 ,  C07D311/88

    摘要： Compounds are disclosed which display cytotoxic effects against estrogen-independent tumors. These compounds may be represented by the formula X-R1 wherein X is a phenyl ring which may be substituted with one or more nitro, methyl or trihalomethyl groups and R1 is a benzophenone hydrazone, a xanthone hydrazone, a thioxanthone hydrazone, a fluoren hydrazone, an anthraquinone hydrazone, an anthraquinone phenylhydrazone, an indano (1,2,3-(de))-2(H)-phtalazinone, a tetralin (1,2,3-(de))-2(H)-phtalazinone, an acridone hydrazone, or a dibenzosuberenone hydrazone. The R1 moiety may be substituted with one or more hydroxy, methoxy or halogen groups. These compounds are useful as chemotherapeutic antineoplastic agents.

    摘要翻译： 公开了显示针对雌激素非依赖性肿瘤的细胞毒性作用的化合物。 这些化合物可以由式X-R1表示，其中X是可以被一个或多个硝基，甲基或三卤代甲基取代的苯环，R 1是二苯甲酮腙，呫吨酮腙，噻吨酮腙，芴腙， 蒽醌腙，蒽醌苯腙，茚满（1,2,3-（de））-2（H） - 对乙炔基酮，四氢化萘（1,2,3-（de））-2（H） 吖啶酮腙或二苯并苯并one酮腙。 R1部分可以被一个或多个羟基，甲氧基或卤素基团取代。 这些化合物可用作化疗抗肿瘤剂。

    COMPOUND AND COMPOSITION FOR DETECTING PHOSGENE AND DIETHYL CHLOROPHOSPHATE
    7.
    发明申请
    COMPOUND AND COMPOSITION FOR DETECTING PHOSGENE AND DIETHYL CHLOROPHOSPHATE 审中-公开
    用于检测磷酸和二乙基氯磷酸酯的化合物和组合物

    公开(公告)号：WO2017146400A1

    公开(公告)日：2017-08-31

    申请号：PCT/KR2017/001389

    申请日：2017-02-08

    申请人： EWHA UNIVERSITY - INDUSTRY COLLABORATION FOUNDATION

    发明人： YOON, Juyoung ,  ZHOU, Xin ,  HU, Ying ,  CHEN, Liyan

    IPC分类号： C07D311/82 ,  C07D221/14 ,  C07D271/12 ,  C07D209/08 ,  G01N33/00 ,  G01N21/64

    CPC分类号： C07D221/14 ,  C07D209/14 ,  C07D271/12 ,  C07D311/88 ,  C07D491/107 ,  G01N21/77 ,  G01N21/783 ,  G01N33/0049 ,  G01N2021/7786

    摘要： The present invention relates to a compound for detecting phosgene and DCP (diethyl chlorophosphate) and a composition for detecting phosgene and DCP (diethyl chlorophosphate) comprising the said compound. More precisely, the compound for detecting phosgene and DCP of the present invention can selectively detect phosgene and DCP either in the liquid phase of gas phase by detecting the changes of fluorescence and color development very quickly within a few seconds with nM sensitivity. Therefore, the compound can also be effectively used as an ingredient for the composition and kit for the detection of one or more materials selected from the group consisting of phosgene and DCP.

    摘要翻译： 本发明涉及用于检测光气和DCP（氯磷酸二乙酯）的化合物和用于检测光气的组合物以及包含所述化合物的DCP（氯磷酸二乙酯）。 更确切地说，本发明的用于检测光气和DCP的化合物可以通过在nM灵敏度的几秒内非常快速地检测荧光的变化和显色而在气相的液相中选择性地检测光气和DCP。 因此，所述化合物也可以有效地用作用于检测选自光气和DCP的一种或多种材料的组合物和试剂盒的成分。

    NEW FUNCTIONALIZED POLYMERIC REAGENTS
    9.
    发明申请
    NEW FUNCTIONALIZED POLYMERIC REAGENTS 审中-公开
    新功能聚合物试剂

    公开(公告)号：WO01037983A1

    公开(公告)日：2001-05-31

    申请号：PCT/SE2000/002263

    申请日：2000-11-16

    IPC分类号： C07B61/00 ,  C07C233/13 ,  C07C233/18 ,  C07C291/10 ,  C07D311/88 ,  C08F8/30 ,  B01J19/00 ,  C07C265/08

    CPC分类号： C40B40/04 ,  C07B2200/11 ,  C07C291/10 ,  C07D311/88 ,  C08F8/30 ,  C40B20/04 ,  C40B30/04 ,  C40B50/14

    摘要： The present invention relates to functionalized polymeric reagents useful in solution and solid-phase synthesis. It relates more specifically to functionlized polymeric reagent, comprising an acid labile isonitrile moiety. In further aspects the present invention also relates to use of such functionalized polymeric reagent in solution and solid-phase synthesis, a method for preparing an organic compound by solution and solid-phase synthesis using such functionalized polymeric reagent, a method for preparing such functionalized polymeric reagent and to kits comprising the functionalized polymeric reagent of the invention. The present invention also relates to new intermediates for use in the preparation of the novel functionalized polymeric reagent. In one aspect, the present invention provides a functionalized polymeric reagent for use in solution and solid-phase synthesis, e.g. multicomponent reactions. The functionalized polymeric reagent comprises a linker, and said linker comprises an acid labile isonitrile moiety. The linker is covalently attached to the polymeric support.

    摘要翻译： 本发明涉及可用于溶液和固相合成的官能化聚合物试剂。 它更具体地涉及功能化的聚合物试剂，其包含酸不稳定的异腈部分。 在另外的方面，本发明还涉及这样的官能化聚合物试剂在溶液和固相合成中的用途，通过使用这种官能化聚合物试剂的溶液和固相合成制备有机化合物的方法，制备这种官能化聚合物的方法 试剂和包含本发明的官能化聚合物试剂的试剂盒。 本发明还涉及用于制备新型官能化聚合物试剂的新中间体。 在一个方面，本发明提供了用于溶液和固相合成的官能化聚合物试剂，例如。 多组分反应。 官能化聚合试剂包含接头，所述接头包含酸不稳定的异腈部分。 连接体共价连接到聚合物载体上。