公开(公告)号：WO9611266A3

公开(公告)日：1996-12-12

申请号：PCT/US9512770

申请日：1995-10-03

Applicant: AMGEN INC ,  BURGESS TERESA L ,  FARRELL CATHERINE L ,  FISHER ERIC F

Inventor： BURGESS TERESA L ,  FARRELL CATHERINE L ,  FISHER ERIC F

IPC: A61K38/00 ,  C12N15/113 ,  C12N15/11 ,  A61K31/70 ,  C07H21/00 ,  C12Q1/68

CPC classification number: C12N15/1135 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/33

Abstract: The present invention provides multi-G oligonucleotides that are capable of inhibiting smooth muscle cell proliferation. The multi-G oligonucleotides of the present invention can be used as nucleic acid therapeutic compounds to inhibit smooth muscle cell proliferation in arteries ex vivo, and more particularly against restenosis. The present invention further provides pharmaceutical compositions containing the multi-G oligonucleotides. A method for screening oligonucleotides for their ability to inhibit smooth muscle cell proliferation ex vivo is also provided.

公开(公告)号：WO1998001555A2

公开(公告)日：1998-01-15

申请号：PCT/US1997012244

申请日：1997-07-09

Applicant: AMGEN INC. ,  FISHER, Eric, F. ,  EDWARDS, Carl, K. ,  KIEFT, Gary, L.

Inventor： AMGEN INC.

IPC: C12N15/12

CPC classification number: C07K14/7151 ,  A01K67/027 ,  A01K2217/05 ,  A01K2267/0325 ,  A61K38/00 ,  A61K47/60 ,  C07K14/705 ,  C07K2319/00 ,  Y10S530/815

Abstract: Disclosed are proteins, referred to as tumor necrosis factor binding proteins, that modulate the activity of tumor necrosis factor. Also disclosed are processes for obtaining the tumor necrosis binding proteins by recombinant genetic engineering techniques.

Abstract translation: 公开了调节肿瘤坏死因子活性的蛋白质，称为肿瘤坏死因子结合蛋白。 还公开了通过重组基因工程技术获得肿瘤坏死结合蛋白的方法。

公开(公告)号：WO1996011266A2

公开(公告)日：1996-04-18

申请号：PCT/US1995012770

申请日：1995-10-03

Applicant: AMGEN INC. ,  BURGESS, Teresa, L. ,  FARRELL, Catherine, L. ,  FISHER, Eric, F.

Inventor： AMGEN INC.

IPC: C12N15/11

CPC classification number: C12N15/1135 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/33

Abstract: The present invention provides multi-G oligonucleotides that are capable of inhibiting smooth muscle cell proliferation. The multi-G oligonucleotides of the present invention can be used as nucleic acid therapeutic compounds to inhibit smooth muscle cell proliferation in arteries ex vivo, and more particularly against restenosis. The present invention further provides pharmaceutical compositions containing the multi-G oligonucleotides. A method for screening oligonucleotides for their ability to inhibit smooth muscle cell proliferation ex vivo is also provided.

Abstract translation: 本发明提供能够抑制平滑肌细胞增殖的多-G寡核苷酸。 本发明的多G寡核苷酸可用作核酸治疗化合物，用于在体内离体动脉中抑制平滑肌细胞增殖，特别是针对再狭窄。 本发明还提供含有多G寡核苷酸的药物组合物。 还提供了一种用于筛选寡核苷酸以抑制其体外平滑肌细胞增殖的能力的方法。