公开(公告)号：WO2009110655A1

公开(公告)日：2009-09-11

申请号：PCT/KR2008/002379

申请日：2008-04-25

Applicant: SUNGKYUNKWAN UNIVERSITY FOUNDATION FOR CORPORATE COLLABORATION ,  INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY ,  KOREA BASIC SCIENCE INSTITUTE ,  FOOD SCIENCE CO., LTD. ,  RYU, Do Hyun ,  HWANG, Geum Sook ,  KIM, Kun Hong ,  PARK, Jin Hyun ,  KIM, Hwa Jin

Inventor： RYU, Do Hyun ,  HWANG, Geum Sook ,  KIM, Kun Hong ,  PARK, Jin Hyun ,  KIM, Hwa Jin

IPC: C07C69/52

CPC classification number: C07C67/31 ,  C07B2200/09 ,  C07C67/343 ,  C07C69/73 ,  C07C69/732 ,  C07C69/738 ,  C07C255/57 ,  C07C311/19 ,  C07F7/1852

Abstract: Provided are β-substituted Morita-Baylis-Hillman (MBH) derivatives, pharmaceutically acceptable salts, hydrates, solvates and stereoisomers thereof. The derivatives may be prepared by preparing β-iodo-MBH esters from a variety of carbonyl compounds such as aldehydes and ketones, or imines in the presence of a Lewis acid as a basic backbone, and substituting iodide on a vinyl position with a variety of substituents. In addition, the β-substituted MBH derivatives have an excellent pharmaceutical effect in preventing and treating cancer.

Abstract translation: 提供的是取代的Morita-Baylis-Hillman（MBH）衍生物，其药学上可接受的盐，水合物，溶剂化物和立体异构体。 衍生物可以通过在路易斯酸作为碱性主链的存在下由各种羰基化合物如醛和酮或亚胺制备β-碘-MBH酯来制备，并且在乙烯基位置用各种各样的 取代。 此外，β取代的MBH衍生物在预防和治疗癌症中具有优异的药物作用。

公开(公告)号：WO2006004377A1

公开(公告)日：2006-01-12

申请号：PCT/KR2005/002155

申请日：2005-07-06

Applicant: PNI INC. ,  FOOD SCIENCE CO., LTD. ,  POSTECH FOUNDATION ,  PARK, Jin-Hyun ,  KIM, Kun-Hong ,  KIM, Hwa-Jin

Inventor： PARK, Jin-Hyun ,  KIM, Kun-Hong ,  KIM, Hwa-Jin

IPC: A61K38/17

CPC classification number: A61K35/60

Abstract: Provided is a polypeptide extract containing a polypeptide with a molecular weight of 1 ,000 to 3,000 Da, obtained by adding detoxified swellfish to water in a ratio of 50-1 ,500 g :1 L, followed by distillation.

Abstract translation: 本发明提供了含有分子量为1,000〜3000Da的多肽的多肽提取物，其通过以50-1,500g:1L的比例向水中加入解毒的sw鱼，然后蒸馏而获得。

公开(公告)号：WO2008140150A1

公开(公告)日：2008-11-20

申请号：PCT/KR2007/003576

申请日：2007-07-25

Applicant: FOOD SCIENCE CO., LTD. ,  KOREA BASIC SCIENCE INSTITUTE ,  KIM, Hwa-Jin ,  RYU, Do-Hyun ,  HWANG, Geum-Sook ,  KIM, Kun-Hong ,  PARK, Jin-Hyun ,  KIM, Kyung-Hwa ,  SIM, Jae-Yi ,  LEE, Mi-Young

Inventor： KIM, Hwa-Jin ,  RYU, Do-Hyun ,  HWANG, Geum-Sook ,  KIM, Kun-Hong ,  PARK, Jin-Hyun ,  KIM, Kyung-Hwa ,  SIM, Jae-Yi ,  LEE, Mi-Young

IPC: C07D307/93 ,  C07D307/77 ,  C07D493/10

CPC classification number: C07D307/93 ,  C07D493/10 ,  C07D519/00

Abstract: The present invention relates to novel octahydro indeno derivatives, pharmaceutically acceptable salts, hydrates, solvates and stereoisomers thereof, and pharmaceutical compositions for treating or preventing cancer comprising the same. Since the compounds according to the present invention have high cytotoxicity against cancer cells, they may be usefully used as medical uses such as anticancer agents or antibiotics.

Abstract translation: 本发明涉及新颖的八氢茚并衍生物，其药学上可接受的盐，水合物，溶剂化物和立体异构体，以及用于治疗或预防包含其的癌症的药物组合物。 由于根据本发明的化合物对癌细胞具有高的细胞毒性，所以它们可以有用地用作抗癌剂或抗生素等医疗用途。