公开(公告)号：WO2007100643A2

公开(公告)日：2007-09-07

申请号：PCT/US2007/004692

申请日：2007-02-21

Applicant: WYETH ,  FOUSER, Lynette, A. ,  HEGEN, Martin ,  LUXENBERG, Deborah, P. ,  O'TOOLE, Margot

Inventor： FOUSER, Lynette, A. ,  HEGEN, Martin ,  LUXENBERG, Deborah, P. ,  O'TOOLE, Margot

IPC: A61K39/395 ,  C07K16/28 ,  A61P37/06 ,  A61P31/14 ,  A61P19/02 ,  A61P1/18

CPC classification number: C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  Y10S514/861

Abstract: The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22) and methods of using those antibodies, for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, septic shock, infectious disorders, transplant rejection, cancer, and other immune system disorders.

Abstract translation: 本申请提供了特异性结合人白细胞介素-22（IL-22）的人抗体及其抗原结合片段，以及使用这些抗体的方法，例如诊断，治疗或预防炎性疾病，自身免疫性疾病，过敏症，败血症 休克，感染性疾病，移植排斥，癌症和其他免疫系统疾病。

公开(公告)号：WO2002066647A3

公开(公告)日：2002-08-29

申请号：PCT/US2002/000986

申请日：2002-01-14

Applicant: GENETICS INSTITUTE, LLC. ,  FOUSER, Lynette ,  LIU, Wei ,  DENG, Bijia

Inventor： FOUSER, Lynette ,  LIU, Wei ,  DENG, Bijia

IPC: C12N15/12

Abstract: The present invention provides novel isolated CRF2-12 polynucleotides and polypeptides encoded by the CRF2-12 polynucleotides. Also provided are the antibodies that immunospecifically bind to a CRF2-12 polypeptide or any derivative (including fusion derivative), variant, mutant of the CRF2-12 polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the CRF2-12 polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.

公开(公告)号：WO2007100643A3

公开(公告)日：2008-03-06

申请号：PCT/US2007004692

申请日：2007-02-21

Applicant: WYETH CORP ,  FOUSER LYNETTE A ,  HEGEN MARTIN ,  LUXENBERG DEBORAH P ,  O'TOOLE MARGOT

Inventor： FOUSER LYNETTE A ,  HEGEN MARTIN ,  LUXENBERG DEBORAH P ,  O'TOOLE MARGOT

IPC: A61K39/395 ,  A61P1/18 ,  A61P19/02 ,  A61P31/14 ,  A61P37/06 ,  C07K16/28

CPC classification number: C07K16/244 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  Y10S514/861

Abstract: The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22) and methods of using those antibodies, for example, in diagnosing, treating or preventing inflammatory disorders, autoimmune diseases, allergies, septic shock, infectious disorders, transplant rejection, cancer, and other immune system disorders.

Abstract translation: 本申请提供了特异性结合人白细胞介素-22（IL-22）的人抗体及其抗原结合片段，以及使用这些抗体的方法，例如诊断，治疗或预防炎性疾病，自身免疫性疾病，过敏症，败血症 休克，感染性疾病，移植排斥，癌症和其他免疫系统疾病。

公开(公告)号：WO2005000897A2

公开(公告)日：2005-01-06

申请号：PCT/US2004020833

申请日：2004-06-22

Applicant: INST GENETICS LLC ,  LI JING ,  TAN XIANG-YANG ,  TOMKINSON KATHLEEN N ,  PITTMAN DEBRA D ,  VELDAN GEERTRUIDA M ,  FOUSER LYNETTE

Inventor： LI JING ,  TAN XIANG-YANG ,  TOMKINSON KATHLEEN N ,  PITTMAN DEBRA D ,  VELDAN GEERTRUIDA M ,  FOUSER LYNETTE

IPC: C07K16/24 ,  C07K16/00

CPC classification number: C07K16/244 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/76

Abstract: Antibodies and antigen-binding fragments thereof that bind interleukin-22 (IL­ 22), in particular, human IL-22, and their uses in regulating IL-22-associated immune responses are disclosed. The antibodies disclosed herein are useful in diagnosing, preventing, or treating IL-22-associated immune disorders, e.g., autoimmune disorders (e.g., arthritis).

Abstract translation: 公开了结合白细胞介素-22（IL22）（尤其是人IL-22）的抗体及其抗原结合片段及其在调节IL-22相关免疫应答中的用途。 本文公开的抗体可用于诊断，预防或治疗IL-22相关免疫病症，例如自身免疫病症（例如关节炎）。

公开(公告)号：WO2007149814A1

公开(公告)日：2007-12-27

申请号：PCT/US2007/071464

申请日：2007-06-18

Applicant: WYETH ,  LIANG, Spencer, C. ,  FOUSER, Lynette, A. ,  O'TOOLE, Margot

Inventor： LIANG, Spencer, C. ,  FOUSER, Lynette, A. ,  O'TOOLE, Margot

IPC: A61K39/395 ,  A61K38/20 ,  C07K16/24

CPC classification number: C07K16/244 ,  A61K38/1793 ,  A61K45/06 ,  A61K2039/507 ,  C07K2317/76 ,  G01N33/6869 ,  A61K2300/00

Abstract: The present application provides methods of modulating immune responses by using IL-22 in combination with at least one of IL-17A, IL-17F, or IL-23 or by using an IL-22 antagonist, such as an antibody or a soluble receptor or a binding protein, in combination with an antagonist of at least one of IL-17A, IL-17F, or IL-23

Abstract translation: 本申请提供了通过使用IL-22与IL-17A，IL-17F或IL-23中的至少一种或通过使用IL-22拮抗剂如抗体或可溶性受体结合来调节免疫应答的方法 或结合蛋白，与IL-17A，IL-17F或IL-23中的至少一种的拮抗剂组合

公开(公告)号：WO2005000897A3

公开(公告)日：2005-01-06

申请号：PCT/US2004/020833

申请日：2004-06-22

Applicant: GENETICS INSTITUTE, LLC ,  LI, Jing ,  TAN, Xiang-Yang ,  TOMKINSON, Kathleen, N. ,  PITTMAN, Debra, D. ,  VELDAN, Geertruida, M. ,  FOUSER, Lynette

Inventor： LI, Jing ,  TAN, Xiang-Yang ,  TOMKINSON, Kathleen, N. ,  PITTMAN, Debra, D. ,  VELDAN, Geertruida, M. ,  FOUSER, Lynette

IPC: C07K16/24

Abstract: Antibodies and antigen-binding fragments thereof that bind interleukin-22 (IL­ 22), in particular, human IL-22, and their uses in regulating IL-22-associated immune responses are disclosed. The antibodies disclosed herein are useful in diagnosing, preventing, or treating IL-22-associated immune disorders, e.g., autoimmune disorders (e.g., arthritis).

公开(公告)号：WO02068476A3

公开(公告)日：2003-08-07

申请号：PCT/US0205684

申请日：2002-02-25

Applicant: INST GENETICS LLC ,  JACOBS KENNETH ,  PITTMAN DEBRA ,  FOUSER LYNETTE ,  SPAULDING VIKKI ,  XUAN DEJUN

Inventor： JACOBS KENNETH ,  PITTMAN DEBRA ,  FOUSER LYNETTE ,  SPAULDING VIKKI ,  XUAN DEJUN

IPC: C12P21/08 ,  A61K38/20 ,  A61K39/395 ,  A61P1/04 ,  A61P3/04 ,  A61P3/10 ,  A61P9/10 ,  A61P17/02 ,  A61P17/06 ,  A61P19/04 ,  A61P21/04 ,  A61P25/00 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/08 ,  A61P39/06 ,  C07K14/54 ,  C07K16/24 ,  A61K38/00

CPC classification number: C07K16/244 ,  A61K38/20 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/5428 ,  C12N2710/10043 ,  C12N2799/022 ,  A61K2300/00

Abstract: Inhibitors of IL-22 are disclosed as well as pharmaceutical compositions and methods of using same. The inhibitors include IL-22 antibodies and are useful for treating inflammatory disorders.

Abstract translation: 公开了IL-22的抑制剂以及药物组合物及其使用方法。 抑制剂包括IL-22抗体，可用于治疗炎性疾病。

公开(公告)号：WO2003040345A3

公开(公告)日：2003-05-15

申请号：PCT/US2002/036316

申请日：2002-11-12

Applicant: WYETH ,  LIU, Wei ,  FOUSER, Lynette ,  SPAULDING, Vikki

Inventor： LIU, Wei ,  FOUSER, Lynette ,  SPAULDING, Vikki

IPC: C12N5/10

Abstract: The present invention provides novel isolated CRF2-13 polynucleotides and polypeptides encoded by the CRF2-13 polynucleotides. Also provided are the antibodies that immunospecifically bind to a CRF2-13 polypeptide or any derivative (including fusion derivative), variant, mutant or fragment of the CRF2-13 polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the CRF2-13 polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.

公开(公告)号：WO03040345A2

公开(公告)日：2003-05-15

申请号：PCT/US0236316

申请日：2002-11-12

Applicant: WYETH CORP ,  LIU WEI ,  FOUSER LYNETTE ,  SPAULDING VIKKI

Inventor： LIU WEI ,  FOUSER LYNETTE ,  SPAULDING VIKKI

IPC: C12N15/09 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P43/00 ,  C07K14/715 ,  C07K16/28 ,  C07K16/46 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12N

CPC classification number: C07K14/7155 ,  A61K38/00 ,  C07K14/7158 ,  C07K2319/00

Abstract: The present invention provides novel isolated CRF2-13 polynucleotides and polypeptides encoded by the CRF2-13 polynucleotides. Also provided are the antibodies that immunospecifically bind to a CRF2-13 polypeptide or any derivative (including fusion derivative), variant, mutant or fragment of the CRF2-13 polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the CRF2-13 polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.

Abstract translation: 本发明提供了由CRF2-13多核苷酸编码的新型分离的CRF2-13多核苷酸和多肽。 还提供免疫特异性结合CRF2-13多肽或CRF2-13多肽，多核苷酸或抗体的任何衍生物（包括融合衍生物），变体，突变体或片段的抗体。 本发明还提供了其中CRF2-13多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

公开(公告)号：WO2009117640A3

公开(公告)日：2009-09-24

申请号：PCT/US2009/037773

申请日：2009-03-20

Applicant: WYETH ,  FOUSER, Lynette, A. ,  LI, Jing ,  WU, Paul, W. ,  KODANGATTLI, Sreekumar, R.

Inventor： FOUSER, Lynette, A. ,  LI, Jing ,  WU, Paul, W. ,  KODANGATTLI, Sreekumar, R.

IPC: C07K14/54 ,  C07K16/24 ,  A61K39/395 ,  A61P29/00 ,  A61P37/02

Abstract: Specific binding fragments, antibodies, and antigen-binding fragments thereof that bind IL-10-like cytokines, including human interleukin-22 (IL-22) are provided. Methods of making and using such binding fragments, antibodies, and antigen-binding fragments are also provided. Kits containing such binding fragments, antibodies, and antigen-binding fragments are also provided.