公开(公告)号：WO02068476A3

公开(公告)日：2003-08-07

申请号：PCT/US0205684

申请日：2002-02-25

Applicant: INST GENETICS LLC ,  JACOBS KENNETH ,  PITTMAN DEBRA ,  FOUSER LYNETTE ,  SPAULDING VIKKI ,  XUAN DEJUN

Inventor： JACOBS KENNETH ,  PITTMAN DEBRA ,  FOUSER LYNETTE ,  SPAULDING VIKKI ,  XUAN DEJUN

IPC: C12P21/08 ,  A61K38/20 ,  A61K39/395 ,  A61P1/04 ,  A61P3/04 ,  A61P3/10 ,  A61P9/10 ,  A61P17/02 ,  A61P17/06 ,  A61P19/04 ,  A61P21/04 ,  A61P25/00 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/08 ,  A61P39/06 ,  C07K14/54 ,  C07K16/24 ,  A61K38/00

CPC classification number: C07K16/244 ,  A61K38/20 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/5428 ,  C12N2710/10043 ,  C12N2799/022 ,  A61K2300/00

Abstract: Inhibitors of IL-22 are disclosed as well as pharmaceutical compositions and methods of using same. The inhibitors include IL-22 antibodies and are useful for treating inflammatory disorders.

Abstract translation: 公开了IL-22的抑制剂以及药物组合物及其使用方法。 抑制剂包括IL-22抗体，可用于治疗炎性疾病。

公开(公告)号：WO2003040345A3

公开(公告)日：2003-05-15

申请号：PCT/US2002/036316

申请日：2002-11-12

Applicant: WYETH ,  LIU, Wei ,  FOUSER, Lynette ,  SPAULDING, Vikki

Inventor： LIU, Wei ,  FOUSER, Lynette ,  SPAULDING, Vikki

IPC: C12N5/10

Abstract: The present invention provides novel isolated CRF2-13 polynucleotides and polypeptides encoded by the CRF2-13 polynucleotides. Also provided are the antibodies that immunospecifically bind to a CRF2-13 polypeptide or any derivative (including fusion derivative), variant, mutant or fragment of the CRF2-13 polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the CRF2-13 polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.

公开(公告)号：WO03040345A2

公开(公告)日：2003-05-15

申请号：PCT/US0236316

申请日：2002-11-12

Applicant: WYETH CORP ,  LIU WEI ,  FOUSER LYNETTE ,  SPAULDING VIKKI

Inventor： LIU WEI ,  FOUSER LYNETTE ,  SPAULDING VIKKI

IPC: C12N15/09 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P19/02 ,  A61P25/00 ,  A61P29/00 ,  A61P43/00 ,  C07K14/715 ,  C07K16/28 ,  C07K16/46 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12P21/02 ,  C12P21/08 ,  C12Q1/68 ,  C12N

CPC classification number: C07K14/7155 ,  A61K38/00 ,  C07K14/7158 ,  C07K2319/00

Abstract: The present invention provides novel isolated CRF2-13 polynucleotides and polypeptides encoded by the CRF2-13 polynucleotides. Also provided are the antibodies that immunospecifically bind to a CRF2-13 polypeptide or any derivative (including fusion derivative), variant, mutant or fragment of the CRF2-13 polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the CRF2-13 polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states, as well as to other uses.

Abstract translation: 本发明提供了由CRF2-13多核苷酸编码的新型分离的CRF2-13多核苷酸和多肽。 还提供免疫特异性结合CRF2-13多肽或CRF2-13多肽，多核苷酸或抗体的任何衍生物（包括融合衍生物），变体，突变体或片段的抗体。 本发明还提供了其中CRF2-13多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

公开(公告)号：WO2002068476A2

公开(公告)日：2002-09-06

申请号：PCT/US2002/005684

申请日：2002-02-25

Applicant: GENETICS INSTITUTE, LLC ,  JACOBS, Kenneth ,  PITTMAN, Debra ,  FOUSER, Lynette ,  SPAULDING, Vikki ,  XUAN, Dejun

Inventor： JACOBS, Kenneth ,  PITTMAN, Debra ,  FOUSER, Lynette ,  SPAULDING, Vikki ,  XUAN, Dejun

IPC: C07K16/24

CPC classification number: C07K16/244 ,  A61K38/20 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/5428 ,  C12N2710/10043 ,  C12N2799/022 ,  A61K2300/00

Abstract: Inhibitors of IL-22 are disclosed as well as pharmaceutical compositions and methods of using same. The inhibitors include IL-22 antibodies and are useful for treating inflammatory disorders.

Abstract translation: 公开了IL-22的抑制剂以及药物组合物及其使用方法。 抑制剂包括IL-22抗体，可用于治疗炎性疾病。