公开(公告)号：WO2023034928A1

公开(公告)日：2023-03-09

申请号：PCT/US2022/075854

申请日：2022-09-01

Applicant: THE COCA-COLA COMPANY ,  FRANCIS, Cynthia ,  REN, Haiyu ,  RUDAN, Brenda ,  SCHACHT, Raymond, W. ,  WANG, Bin

Inventor： FRANCIS, Cynthia ,  REN, Haiyu ,  RUDAN, Brenda ,  SCHACHT, Raymond, W. ,  WANG, Bin

IPC: A23L33/105 ,  A23F3/16 ,  A23F3/34 ,  A23F5/02 ,  A23F5/24 ,  A23F5/44 ,  A23L2/02 ,  A23L2/38 ,  A23L2/385 ,  A23L2/60

Abstract: The present disclosure presents compositions and methods for improving cognitive function and/or alertness of a human. In one embodiment, a method comprises: administering to the human in need of an improved condition an edible composition, wherein the composition comprises: caffeine and/or a derivative thereof; and a polyphenol, wherein the composition has a weight ratio of the total polyphenol to the total caffeine from about 1 : 10 to about 10: 1. In some embodiments, the polyphenol is a chlorogenic acid (CGA).

公开(公告)号：WO2008104953A2

公开(公告)日：2008-09-04

申请号：PCT/IB2008/050732

申请日：2008-02-28

Applicant: THE PROCTER & GAMBLE COMPANY ,  JUMP, Mary, Lynn ,  CLYMER, Jeffrey, Warren ,  HO, Begonia, Y. ,  WALANSKI, Amy, Ann ,  FRANCIS, Cynthia, E.

Inventor： JUMP, Mary, Lynn ,  CLYMER, Jeffrey, Warren ,  HO, Begonia, Y. ,  WALANSKI, Amy, Ann ,  FRANCIS, Cynthia, E.

IPC: G01N33/569

CPC classification number: G01N33/56983 ,  G01N2333/095 ,  G01N2500/00

Abstract: The present invention provides methods for identifying genes, expression regulators, receptors, protein product receptors, and proteins that may regulate rhinovirus infections. The genes identified may be used as markers for disease onset and progression and to measure efficacy of a therapeutic. The present invention also provides methods to screen agents that are capable of regulating rhinovirus infection. The present invention also provides methods of identifying therapeutic compounds that may treat various disorders by regulating the expression and activity of genes, expression regulators, receptors, protein product receptors, and proteins identified.

Abstract translation: 本发明提供了用于鉴定可调节鼻病毒感染的基因，表达调节剂，受体，蛋白质产物受体和蛋白质的方法。 所鉴定的基因可以用作疾病发作和进展的标志物并测量治疗剂的功效。 本发明还提供了筛选能够调节鼻病毒感染的药剂的方法。 本发明还提供了鉴定可通过调节基因，表达调节剂，受体，蛋白质产物受体和鉴定的蛋白质的表达和活性来治疗各种病症的治疗化合物的方法。

公开(公告)号：WO2008104953A3

公开(公告)日：2008-12-11

申请号：PCT/IB2008050732

申请日：2008-02-28

Applicant: PROCTER & GAMBLE ,  JUMP MARY LYNN ,  CLYMER JEFFREY WARREN ,  HO BEGONIA Y ,  WALANSKI AMY ANN ,  FRANCIS CYNTHIA E

Inventor： JUMP MARY LYNN ,  CLYMER JEFFREY WARREN ,  HO BEGONIA Y ,  WALANSKI AMY ANN ,  FRANCIS CYNTHIA E

IPC: G01N33/569

CPC classification number: G01N33/56983 ,  G01N2333/095 ,  G01N2500/00

Abstract: The present invention provides methods for identifying genes, expression regulators, receptors, protein product receptors, and proteins that may regulate rhinovirus infections. The genes identified may be used as markers for disease onset and progression and to measure efficacy of a therapeutic. The present invention also provides methods to screen agents that are capable of regulating rhinovirus infection. The present invention also provides methods of identifying therapeutic compounds that may treat various disorders by regulating the expression and activity of genes, expression regulators, receptors, protein product receptors, and proteins identified.

Abstract translation: 本发明提供了用于鉴定可能调节鼻病毒感染的基因，表达调节剂，受体，蛋白质产物受体和蛋白质的方法。 所鉴定的基因可用作疾病发病和进展的标志物，并用于测量治疗剂的功效。 本发明还提供了能够调节鼻病毒感染的筛选剂的方法。 本发明还提供了通过调节基因，表达调节剂，受体，蛋白质产物受体和鉴定的蛋白质的表达和活性来鉴定可治疗各种疾病的治疗化合物的方法。