公开(公告)号：WO2011119528A2

公开(公告)日：2011-09-29

申请号：PCT/US2011/029311

申请日：2011-03-22

Applicant: SCHLUMBERGER CANADA LIMITED ,  SCHLUMBERGER TECHNOLOGY B.V. ,  PRAD RESEARCH AND DEVELOPMENT LIMITED ,  SERVICES PETROLIERS SCHLUMBERGER ,  SCHLUMBERGER HOLDINGS LIMITED ,  ANAND, Vivek ,  FREEDMAN, Robert ,  DEMENTYEV, Anatoly ,  TABRIZI, Payam ,  CATINA, Daniel

Inventor： ANAND, Vivek ,  FREEDMAN, Robert ,  DEMENTYEV, Anatoly ,  TABRIZI, Payam ,  CATINA, Daniel

IPC: G01V3/32 ,  G01V3/34 ,  E21B47/00

CPC classification number: G01V3/32 ,  G01R33/4625

Abstract: The Larmor frequency for an in situ nuclear magnetic resonance (NMR) tool is determined and used to acquire NMR data. An NMR tool is provided and placed in situ, for example, in a wellbore. An initial estimate of the Larmor frequency for the in situ NMR tool is made and NMR data are acquired using the in situ NMR tool. A spectral analysis is performed on the NMR data, or optionally, the NMR data are digitized and a discrete Fourier transform (DFT) is performed on the digitized NMR data. The modal frequency of the spectral analysis or DFT is determined, and the Larmor frequency for the in situ NMR tool is determined using the modal frequency. The NMR tool is modified to transmit at the determined Larmor frequency and then used to acquire further NMR data.

Abstract translation: 确定原位核磁共振（NMR）工具的拉莫尔频率并用于获得NMR数据。 提供NMR工具并放置在例如井眼中。 进行原位NMR工具的拉莫尔频率的初步估算，并使用原位NMR工具获得NMR数据。 对NMR数据进行光谱分析，或者可选地，NMR数据被数字化，并且对数字化NMR数据进行离散傅里叶变换（DFT）。 确定光谱分析或DFT的模态频率，并使用模态频率确定原位NMR工具的拉莫尔频率。 NMR工具被修改为以确定的拉莫尔频率发射，然后用于获取进一步的NMR数据。

公开(公告)号：WO2007120220A3

公开(公告)日：2007-10-25

申请号：PCT/US2006/045707

申请日：2006-11-29

Applicant: WAYNE STATE UNIVERSITY, A CORPORATION OF THE STATE OF MICHIGAN ,  FREEDMAN, Robert, R. ,  WASSON, Samuel, L.

Inventor： FREEDMAN, Robert, R. ,  WASSON, Samuel, L.

IPC: A61B5/00 ,  G01N27/22

Abstract: A method of measuring hot flashes based on the sensing of skin moisture incorporates a chip for sensing humidity. The method incorporates a chip for sensing humidity, and a RISC micro-controller. A single tiny low-power device of about the size of a quarter is embedded into a reusable plastic housing. Inexpensive and reliable objective measurement of hot flashes is achieved, along with advantages in size, weight, and extended durations of recording and data analysis periods. Hot flashes are measured as a biomarker of the efficacy of clinical intervention in relieving symptoms of menopause.

公开(公告)号：WO1993025676A1

公开(公告)日：1993-12-23

申请号：PCT/US1993005318

申请日：1993-06-02

Applicant: MERCK & CO., INC. ,  UNIVERSITY OF KENT AT CANTERBURY ,  TUITE, Michael, F. ,  FREEDMAN, Robert, B. ,  SCHULTZ, Loren, D. ,  ELLIS, Ronald, W. ,  MARKUS, Henry, Z. ,  MONTGOMERY, Donna, L.

Inventor： MERCK & CO., INC. ,  UNIVERSITY OF KENT AT CANTERBURY

IPC: C12N15/09

CPC classification number: C12N9/90 ,  C07K14/811 ,  C07K14/815 ,  C12N15/81

Abstract: Disclosed is a process for increasing the yield of disulfide bonded recombinant proteins produced by yeast, especially recombinant secreted proteins. The enzyme protein disulfide isomerase (PDI) catalyzes the formation of disulfide bonds in secretory and cell-surface proteins. We disclose the construction of recombinant strains of the yeast Saccharomyces cerevisiae which overproduce either human PDI or yeast PDI in a regulated fashion. These strains show greatly increased secretion of disulfide bonded proteins of potential therapeutic significance. These strains have the potential to increase the production of various disulfide bonded proteins.

Abstract translation: 公开了一种增加由酵母，特别是重组分泌蛋白质产生的二硫键合重组蛋白的产率的方法。 酶蛋白二硫键异构酶（PDI）催化分泌和细胞表面蛋白中二硫键的形成。 我们公开了以规定的方式过量产生人PDI或酵母PDI的酵母酿酒酵母重组菌株的构建。 这些菌株显示出显着增加的二硫键合蛋白的分泌具有潜在的治疗意义。 这些菌株有可能增加各种二硫键合蛋白的产生。

公开(公告)号：WO2012078942A3

公开(公告)日：2012-06-14

申请号：PCT/US2011/064062

申请日：2011-12-09

Applicant: SCHLUMBERGER CANADA LIMITED ,  SERVICES PETROLIERS SCHLUMBERGER ,  SCHLUMBERGER HOLDINGS LIMITED ,  SCHLUMBERGER TECHNOLOGY B.V. ,  PRAD RESEARCH AND DEVELOPMENT LIMITED ,  ANAND, Vivek ,  FREEDMAN, Robert ,  ZHOU, Tong ,  ROSE, David ,  BEEKMAN, Sicco

Inventor： ANAND, Vivek ,  FREEDMAN, Robert ,  ZHOU, Tong ,  ROSE, David ,  BEEKMAN, Sicco

IPC: G01V5/10 ,  G01T3/00

Abstract: Disclosed is a model-independent method for accurate prediction of formation and borehole properties from neutron capture cross section measurements. A mapping function is constructed which maps the input measurements to the properties of interest. The mapping function is a linear combination of Gauss radial basis functions. The expansion coefficients and widths of the Gaussian functions are determined uniquely using a database populated with representative samples. For a sample not included in the original database, the desired properties can be estimated from the mapping function using the measurements made on the unknown sample.

公开(公告)号：WO2009067361A1

公开(公告)日：2009-05-28

申请号：PCT/US2008/083189

申请日：2008-11-12

Applicant: SCHLUMBERGER CANADA LIMITED ,  SCHLUMBERGER TECHNOLOGY B.V. ,  PRAD RESEARCH AND DEVELOPMENT LIMITED ,  SERVICES PETROLIERS SCHLUMBERGER ,  SCHLUMBERGER HOLDINGS LIMITED ,  FREEDMAN, Robert ,  GANESAN, Krishnamurthy ,  GRANT, Douglas, W.

Inventor： FREEDMAN, Robert ,  GANESAN, Krishnamurthy ,  GRANT, Douglas, W.

IPC: G01R33/34 ,  G01R33/563 ,  G01R33/30

CPC classification number: G01R33/34053 ,  G01N24/081 ,  G01R33/305 ,  G01R33/307 ,  G01R33/3806 ,  G01R33/383 ,  G01R33/60

Abstract: The present invention pertains to an apparatus and method for conducting magnetic resonance measurements on fluids at high pressures and/or high temperatures. The apparatus can be used in conjunction with or as part of a downhole fluid sampling tool to perform NMR measurements on fluids withdrawn from petroleum reservoirs, or can also be used for laboratory measurements on live reservoir fluids. The apparatus can perform all of the measurements made by modern NMR logging tools, including multi-dimensional distribution functions of spin-spin (T2) and spin-lattice relaxation (Ti) times and molecular diffusion coefficients. The spin densities of hydrogen and other NMR sensitive species can be computed from the distribution functions. The apparatus can also be used to predict the apparent conductivity of the fluids in the flowline from measurements of the quality factor ("Q") of the NMR circuit. The apparent conductivity can be used to predict water cut or water salinity.

Abstract translation: 本发明涉及用于在高压和/或高温下对流体进行磁共振测量的装置和方法。 该装置可以与井下流体采样工具结合使用或作为其一部分使用，以对从石油储存器中取出的流体进行NMR测量，或者也可用于实时储存液体的实验室测量。 该装置可以执行现代NMR测井工具进行的所有测量，包括自旋 - 自旋（T2）和自旋 - 晶格弛豫（Ti）时间的多维分布函数和分子扩散系数。 氢和其他NMR敏感物种的自旋密度可以从分布函数计算。 该装置还可以用于通过NMR电路的质量因子（“Q”）的测量来预测流线中的流体的表观电导率。 表观电导率可用于预测水分或水分盐度。

公开(公告)号：WO2007021343A3

公开(公告)日：2007-06-21

申请号：PCT/US2006018951

申请日：2006-05-17

Applicant: CORNELL RES FOUNDATION INC ,  BAXTER GREGORY T ,  FREEDMAN ROBERT

Inventor： BAXTER GREGORY T ,  FREEDMAN ROBERT

IPC: C12M3/06 ,  C12N5/08

CPC classification number: C12M23/16 ,  B01L3/5027 ,  C12M21/08 ,  C12M23/44 ,  C12M29/04

Abstract: Systems and methods are disclosed for microscale pharmacokinetics. Various organs and their interactions with drug compounds can be simulated in vitro by use of microscale compartments (3722, 3734, 3744) that can be interconnected by microscale channels. Cells or cellular materials associated with the organs can be cultured in such compartments to allow interactions with drug compounds in one or more fluidic flows. Such fluidic systems can include, by way of examples, gastrointestinal flow, blood flow, bile flow, urinary flow, and brain fluid flow. Interactions between fluidic systems can be simulated by a microscale permeable member (3430). In one example, blood-biliary interaction can be simulated by a microscale permeable material having hepatocytes (3434) bound to a permeable substrate (3432) via a binder.

Abstract translation: 公开了用于微量药代动力学的系统和方法。 各种器官及其与药物化合物的相互作用可以通过使用可通过微量通道相互连接的微小隔室（3722,3734,3744）在体外进行模拟。 与器官相关的细胞或细胞材料可以在这些隔室中培养以允许与一种或多种流体流中药物化合物的相互作用。 这样的流体系统可以包括例如胃肠道流动，血流量，胆汁流量，尿流量和脑液流量。 流体系统之间的相互作用可以通过微量可渗透构件（3430）进行模拟。 在一个实例中，可以通过具有通过粘合剂结合到可渗透基底（3432）的肝细胞（3434）的微量可渗透材料来模拟血液 - 胆汁相互作用。

公开(公告)号：WO2006036612A3

公开(公告)日：2007-03-01

申请号：PCT/US2005033302

申请日：2005-09-16

Applicant: LIFE RECOVERY SYSTEMS HD LLC ,  FREEDMAN ROBERT J JR ,  COTE MARC ,  OHLEY WILLIAM J ,  SCHOCK ROBERT B

Inventor： FREEDMAN ROBERT J JR ,  COTE MARC ,  OHLEY WILLIAM J ,  SCHOCK ROBERT B

IPC: A61F7/00 ,  A61H31/00 ,  A61B17/00 ,  A61M16/06

CPC classification number: A61F7/02 ,  A61B2017/00199 ,  A61F7/00 ,  A61F7/0053 ,  A61F2007/0001 ,  A61F2007/0054 ,  A61F2007/0056 ,  A61F2007/0091 ,  A61F2007/0093 ,  A61F2007/0296

Abstract: An apparatus for adjusting the body temperature of a patient comprises an enclosure defining an interior space for receiving at least a portion of a patient's body therein. The enclosure is adapted for substantially sealingly enclosing the portion of the patient's body within the interior space with the enclosure. Heat transfer liquid may then be circulated through the interior space of the enclosure via an inlet and an outlet for flow over the patient's body in direct liquid contact therewith to promote heat transfer between the patient's body and said heat transfer liquid. The heat transfer liquid may be either warmer or cooler than the patient's body temperature, to either warm or cool the portion. Controlled cooling may be employed to induce therapeutic hypothermia, while controlled warming may be employed to counteract unintended hypothermia. The apparatus further comprises a portable control unit that includes a liquid delivery system, a power source, a control system and a user interface for powering and controlling the liquid delivery system.

Abstract translation: 用于调节患者体温的装置包括限定内部空间的外壳，用于在其中接收患者身体的至少一部分。 外壳适于基本上密封地将外壳内的空间内的患者身体的部分封闭。 传热液体然后可以通过入口和出口循环通过外壳的内部空间，以便与患者的身体直接液体接触，以促进患者身体和所述传热液体之间的热传递。 传热液体可以比患者的体温更温暖或更冷，来加热或冷却部分。 可采用控制冷却来诱导治疗性低温，同时可采用可控制的温热来抵消非预期的低体温。 该装置还包括便携式控制单元，其包括液体输送系统，电源，控制系统和用于为液体输送系统供电和控制的用户界面。

公开(公告)号：WO2004006814A3

公开(公告)日：2004-04-22

申请号：PCT/US0321367

申请日：2003-07-09

Applicant: LIFE RECOVERY SYSTEMS HD LLC ,  SCHOCK ROBERT B ,  FREEDMAN ROBERT J JR ,  COTE MARC

Inventor： SCHOCK ROBERT B ,  FREEDMAN ROBERT J JR ,  COTE MARC

IPC: A61H31/00 ,  A61B17/00 ,  A61F7/00 ,  A61M16/06

CPC classification number: A61F7/00 ,  A61B2017/00199 ,  A61F2007/0054

Abstract: An apparatus for adjusting the body temperature of a patient comprises an enclosure defining an interior space for receiving at least a portion of a patient's body therein. The enclosure is adapted for substantially sealingly enclosing the portion of the patient's body within the interior space with the enclosure. Heat transfer liquid may then be circulated through the interior space of the enclosure via an inlet and an outlet for flow over the patient's body in direct liquid contact therewith to promote heat transfer between the patient's body and said heat transfer liquid. The heat transfer liquid may be either warmer or cooler than the patient's body temperature, to either warm or cool the portion. Controlled cooling may be employed to induce therapeutic hypothermia, while controlled warming may be employed to counteract unintended hypothermia. The apparatus further comprises a portable control unit that includes a liquid delivery system, a power source, a control system and a user interface for powering and controlling the liquid delivery system.

Abstract translation: 一种用于调节患者体温的装置包括：外壳，其限定用于在其中接收患者身体的至少一部分的内部空间。 外壳适合于用外壳将患者身体的一部分基本上密封地封闭在内部空间内。 然后，传热液体可以通过入口和出口循环通过外壳的内部空间，用于在患者身体上直接液体接触地流过患者身体，以促进患者身体和所述传热液体之间的热传递。 传热液体可以比患者体温高或低，以加热或冷却该部分。 受控冷却可用于诱导治疗性低温，而受控温热可用于抵消意外低温。 该设备还包括便携式控制单元，其包括液体输送系统，电源，控制系统和用于为液体输送系统供电和控制的用户界面。

公开(公告)号：WO2012068119A3

公开(公告)日：2012-08-09

申请号：PCT/US2011060802

申请日：2011-11-15

Applicant: SCHLUMBERGER TECHNOLOGY CORP ,  SCHLUMBERGER CA LTD ,  SCHLUMBERGER SERVICES PETROL ,  SCHLUMBERGER HOLDING LTD ,  PRAD RES & DEV LTD ,  SCHLUMBERGER TECHNOLOGY BV ,  FREEDMAN ROBERT

Inventor： FREEDMAN ROBERT

IPC: E21B47/02 ,  E21B7/04 ,  G01V3/20 ,  G01V3/26

CPC classification number: G01V3/26 ,  E21B7/04 ,  E21B47/02 ,  G01V3/24

Abstract: Methods and systems are provided for obtaining both magnetic and apparent resistivity ultra-deep reading electromagnetic measurements at the same time and/or by a single tool. The system can include a magnetometer, a current source electrode, a pair of voltage measuring electrodes, and a current return electrode. Using such a system can enable a lowering a tool into a relief well and obtaining both magnetic and apparent resistivity ultra-deep reading electromagnetic measurements in a single trip in order to provide a more accurate and faster determination of the distance and direction to a cased blown out well in order to shorten the time required to intersect and kill the blown out well.

Abstract translation: 提供的方法和系统用于同时和/或通过单个工具获得磁性和视电阻率超深读取电磁测量。 该系统可以包括磁力计，电流源电极，一对电压测量电极和电流返回电极。 使用这样的系统可以将工具降低到浮雕井中，并且在单次跳闸中获得磁性和视电阻率超深读取电磁测量结果，以便提供更准确和更快速地确定套管吹风的距离和方向 以便缩短交叉和杀死吹出井所需的时间。

公开(公告)号：WO2012078942A2

公开(公告)日：2012-06-14

申请号：PCT/US2011064062

申请日：2011-12-09

Applicant: SCHLUMBERGER CA LTD ,  SCHLUMBERGER SERVICES PETROL ,  SCHLUMBERGER HOLDINGS ,  SCHLUMBERGER TECHNOLOGY BV ,  PRAD RES & DEV LTD ,  ANAND VIVEK ,  FREEDMAN ROBERT ,  ZHOU TONG ,  ROSE DAVID ,  BEEKMAN SICCO

Inventor： ANAND VIVEK ,  FREEDMAN ROBERT ,  ZHOU TONG ,  ROSE DAVID ,  BEEKMAN SICCO

IPC: G01V5/10 ,  G01T3/00

CPC classification number: G01V5/102 ,  G01N33/24

Abstract: Disclosed is a model-independent method for accurate prediction of formation and borehole properties from neutron capture cross section measurements. A mapping function is constructed which maps the input measurements to the properties of interest. The mapping function is a linear combination of Gauss radial basis functions. The expansion coefficients and widths of the Gaussian functions are determined uniquely using a database populated with representative samples. For a sample not included in the original database, the desired properties can be estimated from the mapping function using the measurements made on the unknown sample.

Abstract translation: 公开了一种用于从中子捕获截面测量精确预测地层和钻孔性质的模型无关方法。 构建映射函数，将输入测量值映射到感兴趣的属性。 映射函数是高斯径向基函数的线性组合。 使用填充有代表性样本的数据库来唯一地确定高斯函数的扩展系数和宽度。 对于未包含在原始数据库中的样本，可以使用对未知样本进行的测量从映射函数估计所需的属性。