公开(公告)号：WO2023067170A1

公开(公告)日：2023-04-27

申请号：PCT/EP2022/079438

申请日：2022-10-21

Applicant: FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA ,  FUNDACIÓN PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA ,  UNIVERSITAT DE BARCELONA

Inventor： FERNÀNDEZ BUSQUETS, Xavier ,  BIOSCA ROMANILLOS, Arnau ,  BOUZÓN ARNÁIZ, Inés ,  MUÑOZ-TORRERO LÓPEZ-IBARRA, Diego ,  MARTÍNEZ ARCE, Elsa ,  REOLID COLL, Pau

IPC: A61P33/06 ,  C07D213/38 ,  C07D401/14 ,  A61K31/4427

Abstract: Bis(aminostyrylpyridinium) compounds of formula (I) and pharmaceutical acceptable salts thereof are provided for use as a medicament. Additionally, multiple novel bis(aminostyrylpyridinium) compounds of formula (I) are provided. The present invention relates to compounds of formula (I) and compositions for use in the treatment of a disease whose etiology is based on protein aggregation. Particularly, compounds are useful in the treatment, prevention or amelioration of malaria, or symptoms, complications and/or sequelae thereof.