公开(公告)号：WO2020011995A1

公开(公告)日：2020-01-16

申请号：PCT/EP2019/068859

申请日：2019-07-12

Applicant: FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA ,  INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS

Inventor： SÁNCHEZ ORDÓÑEZ, Samuel ,  PARMAR, Jemish ,  VILLA GÓMEZ, Katherine ,  VILELA GARCIA, Diana

IPC: C02F1/00 ,  C02F1/28 ,  C02F1/72 ,  C02F1/48 ,  C02F101/20 ,  C02F101/30

Abstract: A water treatment system (1) comprising a primary gastight treatment chamber (21) comprising: a closable water inlet (26), and a water outlet (29) closed by a membrane (5), wherein the membrane prevents a flow of water when the pressure in the chamber is below a predetermined threshold and allowing the flow of water therethrough and out of the chamber when the pressure in the chamber is above the predetermined threshold, and micromotors (3) inside the treatment chamber, wherein the micromotors comprise: a functional region (32) comprising a material functionalized to remove a pollutant (34) from the water, and a driving region (31) comprising a material for generating gas bubbles (33) and causing build-up of pressure inside the chamber. A water treatment method is also provided.

公开(公告)号：WO2021048250A1

公开(公告)日：2021-03-18

申请号：PCT/EP2020/075278

申请日：2020-09-10

Applicant: FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA

Inventor： RAMÓN AZCÓN, Javier ,  CLUA FERRÉ, Laura ,  VELASCO MALLORQUÍ, Ferran ,  ORTEGA MACHUCA, Maria Alejandra ,  DE CHIARA, Francesco

IPC: A61L27/24 ,  A61L27/38 ,  A61L27/50 ,  A61L27/52 ,  C12N5/00 ,  A61F2/02 ,  C12N5/071

Abstract: The present invention provides a hydrogel capsule comprising a cell, a protein, and a cross-linking agent; wherein the cell is within a first core layer comprising the protein; and wherein the first core layer is surrounded by a second layer comprising the protein and the cross-linking agent. The invention further provides the hydrogel capsule for use in therapy, prognosis and diagnosis, a method for culturing cells, a method for differentiating cells, and method for producing the hydrogel capsule. The hydrogel capsules of the invention are particularly useful for encapsulating pancreatic islets.

公开(公告)号：WO2022229107A1

公开(公告)日：2022-11-03

申请号：PCT/EP2022/060911

申请日：2022-04-25

Applicant: FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA ,  INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS

Inventor： MARCO RIUS, Irene ,  YESTE LOZANO, Jose ,  HERRERO GÓMEZ, Alba ,  AZAGRA RODRÍGUEZ, Marc ,  ORTEGA MACHUCA, Maria Alejandra ,  RAMÓN AZCÓN, Javier

IPC: G01R33/30 ,  G01N24/08 ,  G01R33/46 ,  G01R33/485 ,  G01R33/561 ,  G01R33/465

Abstract: The disclosure relates to a system and a method of analysing a physiological condition in an analyte. In particular, the disclosure pertains to systems, components of such systems, and methods of analysing a physiological condition in an analyte using hyperpolarization (HP) and magnetic resonance (MR) techniques.

公开(公告)号：WO2022023499A1

公开(公告)日：2022-02-03

申请号：PCT/EP2021/071340

申请日：2021-07-29

Applicant: FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA ,  UNIVERSITAT DE BARCELONA ,  CONSORCIO CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED, M.P.

Inventor： SAMITIER MARTÍ, Josep ,  MIR LLORENTE, Mònica ,  DULAY BACENA, Samuel ,  RIVAS TORCATES, Lourdes Josefina ,  MISERERE, Sandrine ,  PÉREZ LÓPEZ, Briza ,  LOPEZ DE MIGUEL, Manuel ,  PALACIO BONET, Francisco

IPC: G01N27/416 ,  G01N27/49

Abstract: An electrochemical sensor system for sensing analytical reactions and biological operations is provided. The electrochemical sensor system comprises: an amperometric sensor comprising two electrodes, wherein the electrodes comprise a working electrode and a reference electrode, wherein the amperometric sensor includes no other electrodes and a potentiometric sensor comprising a working electrode and a reference electrode, wherein the potentiometric sensor includes no other electrodes, wherein the reference electrode of the potentiometric sensor is coupled to ground, wherein the working electrode of the amperometric sensor is electrically coupled to the reference electrode of the potentiometric sensor, wherein the amperometric sensor is configured to receive an excitation voltage between the working electrode of the amperometric sensor and the reference electrode of the amperometric sensor such that the received excitation voltage is used as a reference voltage of the potentiometric sensor via the reference electrode of the potentiometric sensor.

公开(公告)号：WO2022003203A1

公开(公告)日：2022-01-06

申请号：PCT/EP2021/068502

申请日：2021-07-05

Applicant: FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA (IBEC) ,  INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS (ICREA)

Inventor： SÁNCHEZ ORDOÑEZ, Samuel ,  MESTRE CASTILLO, Rafael ,  GUIX NOGUERA, María ,  PATIÑO PADIAL, Tania

IPC: A61L27/20 ,  A61L27/22 ,  A61L27/24 ,  A61L27/26 ,  A61L27/34 ,  A61L27/36 ,  A61L27/38 ,  A61L27/52 ,  B33Y70/00 ,  B33Y80/00 ,  A61L2400/12 ,  A61L2400/16 ,  A61L2430/30 ,  A61L27/222 ,  A61L27/225 ,  A61L27/3633 ,  A61L27/3826 ,  A61L27/3873

Abstract: A method for obtaining one or more free-form individual fibers of biocompatible hydrogels with a predefined diameter, wherein said method comprises the use of a printing system comprising at least a first nozzle (110) and a second nozzle (120) surrounding the first nozzle, wherein said method comprises the following steps: a) providing a printable biocompatible hydrogel (130) in the first nozzle; b) providing a printable composition (140) comprising a non-toxic thermoreversible gelation polymer in the second nozzle; c) extruding the biocompatible hydrogel in a) and the composition in b) simultaneously through the nozzles, wherein the composition in b) in a gel state coats the extruded biocompatible hydrogel; d) optionally, submitting the obtained one or more individual fibers to a cross- linking treatment; e) optionally, removing the composition in b) from the external surface of the deposited one or more fibers.

公开(公告)号：WO2017158168A1

公开(公告)日：2017-09-21

申请号：PCT/EP2017/056410

申请日：2017-03-17

Applicant: FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA (IBEC) ,  UNIVERSITAT DE BARCELONA

Inventor： ROCA-CUSACHS SOULERE, Pere ,  ELÓSEGUI-ARTOLA, Alberto

IPC: A61K38/39

CPC classification number: C07K5/10 ,  A61K38/00 ,  C07K5/1016

Abstract: Inhibitors of talin-vinculin binding for the treatment of cancer The present invention provides a compound inhibiting the interaction between talin and vinculin for use in the treatment of a solid tumor.

Abstract translation: 结合talin-vinculin的抑制剂用于治疗癌症本发明提供了抑制talin和纽蛋白之间相互作用的化合物，用于治疗实体瘤。

公开(公告)号：WO2023067170A1

公开(公告)日：2023-04-27

申请号：PCT/EP2022/079438

申请日：2022-10-21

Applicant: FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA ,  FUNDACIÓN PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA ,  UNIVERSITAT DE BARCELONA

Inventor： FERNÀNDEZ BUSQUETS, Xavier ,  BIOSCA ROMANILLOS, Arnau ,  BOUZÓN ARNÁIZ, Inés ,  MUÑOZ-TORRERO LÓPEZ-IBARRA, Diego ,  MARTÍNEZ ARCE, Elsa ,  REOLID COLL, Pau

IPC: A61P33/06 ,  C07D213/38 ,  C07D401/14 ,  A61K31/4427

Abstract: Bis(aminostyrylpyridinium) compounds of formula (I) and pharmaceutical acceptable salts thereof are provided for use as a medicament. Additionally, multiple novel bis(aminostyrylpyridinium) compounds of formula (I) are provided. The present invention relates to compounds of formula (I) and compositions for use in the treatment of a disease whose etiology is based on protein aggregation. Particularly, compounds are useful in the treatment, prevention or amelioration of malaria, or symptoms, complications and/or sequelae thereof.

公开(公告)号：WO2022229490A1

公开(公告)日：2022-11-03

申请号：PCT/ES2022/070265

申请日：2022-04-29

Applicant: DEPURACIÓN DE AGUAS DEL MEDITERRÁNEO, S.L. ,  FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA (IBEC) ,  UNIVERSITAT DE BARCELONA

Inventor： DOÑATE HERNÁNDEZ, Silvia ,  ESCLAPEZ VICENTE, María Deseada ,  BURGUÉS CALDERÓN, Javier ,  MARCO COLÁS, Santiago ,  SAÚCO BOZIC, Lidia Clara

IPC: G01N1/22

Abstract: La presente invención es un dron para la medición de concentración de olor caracterizado por una configuración específica que permite la toma de muestras en localizaciones que de otra forma tendrían difícil acceso o no serían accesibles y, en unas condiciones en las que los medios de impulsión no afectan a la medida. Adicionalmente, la invención está caracterizada por el correcto marcado de la localización espacial de cada toma de muestra y medida aunque la toma de muestra y medida requiera un tiempo de transporte del aire aspirado.

公开(公告)号：WO2019193126A1

公开(公告)日：2019-10-10

申请号：PCT/EP2019/058570

申请日：2019-04-04

Applicant: FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA (IBEC) ,  UNIVERSITAT DE BARCELONA (UB)

Inventor： TORRENTS SERRA, Eduard ,  SAMITIER MARTÍ, Josep ,  LÓPEZ MARTÍNEZ, María José ,  BLANCO CABRA, Núria

IPC: B01L3/00

Abstract: Microfluidic structure (1) for carrying out biological assays, which comprises a first assay channel (C1) and a second assay channel (C2) coplanar, identical and arranged in parallel, a first inlet port (I1) for inserting a first fluid, a second inlet port (I2) for inserting a second fluid, a common outlet (O1), and a distributing channel system (D) comprising a common connection point or pre-chamber (V), a first supply channel (IP1) connecting the first inlet port (I1) with the common connection point (V), a second supply channel (IP2) connecting the second inlet port (I2) with the common connection point (V), a first distribution channel (PC1) connecting the common connection point (V) with the first assay channel (C1), a second distribution channel (PC2) separate from the first distribution channel (PC1) connecting the common connection point (V) with the second assay channel (C2), and a first outlet channel (CO1) connecting the first assay channel (C1) with the common outlet (O1) and a second outlet channel (CO2) separate from the first outlet channel (CO1) connecting the second assay channel (C2) with the common outlet (O1). The invention also relates to a chip (2) having two or more of such microfluidic structures (1) and a method wherein such microfluidic structure is used.

公开(公告)号：WO2019122151A1

公开(公告)日：2019-06-27

申请号：PCT/EP2018/086233

申请日：2018-12-20

Applicant: FUNDACIÓ INSTITUT DE BIOENGINYERIA DE CATALUNYA ,  UNIVERSITAT DE BARCELONA ,  CONSORCIO CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED, M.P. ,  INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS

Inventor： GOROSTIZA LANGA, Pablo Ignacio ,  SOLER PRAT, Concepció ,  MATERA, Carlo ,  CAMARERO PALAO, Nuria ,  LIBERGOLI, Michela ,  GOMILA JUANEDA, Alexandre

IPC: C07D239/94 ,  C07D487/04 ,  C07D333/52 ,  A61P17/06 ,  A61P35/00 ,  A61P19/02 ,  A61K31/519 ,  A61K31/522 ,  A61K31/381

CPC classification number: C07D239/94 ,  A61P17/06 ,  A61P19/02 ,  A61P35/00 ,  C07D333/52 ,  C07D487/04

Abstract: The present invention relates a compound of formula (I) in Z-isomer form (Z-(l)) or a compound of formula (I) in E-isomer form (E-(l)) wherein: R 2 is a radical of formula (II) and of formula (III); X 1 , X 2 , X 3 , X 4 and X 5 are CR 3 and N; Y 1 is NH, O and S; each R 1 , each R 3 and R 7 are H, halogen, -OH, -O-(C 1 -C 8 )alkyl, -N((C 1 -C 8 )alkyl) 3 , -NH((C 1 -C 8 )alkyl) 2 , and -NH 2 (C 1 -C 8 )alkyl; R 4 , R 5 and R 6 are H and (C 1 -C 8 )alkyl; - - - line indicates the position of R 2 radical by which R 2 is attached to the adjacent N; and the asterisk indicates a stereogenic carbon atom being in R -isomer, S -isomer and a mixture of R -isomer and S -isomer. It also relates to the compound Z-(l) for use as a medicament; and the compound E-(l) for use in the treatment of a disease or condition mediated by the dihydrofolate reductase, wherein the treatment comprises exposing a compound E-(I) to light irradiation to obtain the compound Z-(l).