公开(公告)号：WO2008057203A3

公开(公告)日：2008-05-15

申请号：PCT/US2007/022428

申请日：2007-10-23

Applicant: DURAMED PHARMACEUTICALS, INC. ,  CHOWDHURY, Tahseen, A. ,  GABRIELSKI, Edward, J. ,  BAKER, Christopher, H.

Inventor： CHOWDHURY, Tahseen, A. ,  GABRIELSKI, Edward, J. ,  BAKER, Christopher, H.

IPC: A23G3/12 ,  A61J3/00 ,  A61J7/00 ,  B29C65/64 ,  B30B11/02 ,  A61K9/20

Abstract: A method for attaching a handle to a tablet to form a lollipop utilizes a specific work holder. The work holder has a tooling pallet with a plurality of openings going from a top surface to a bottom surface. A bullet and a spring are located in each opening and held in place by a plate that slides through a groove in the bottom surface of the tooling pallet to block the openings in the bottom surface. Each spring is positioned between a bullet and the plate. A tablet is placed in a cavity of each bullet and a handle is placed in contact with each tablet. High frequency mechanical vibrations, such as ultrasonic vibrations, are applied to a joint interface between each tablet and bullet until the joint interface reaches a molten state. The joint interfaces are then allowed to cool, thereby attaching a handle to each tablet and forming a lollipop.

公开(公告)号：WO2008057203A2

公开(公告)日：2008-05-15

申请号：PCT/US2007022428

申请日：2007-10-23

Applicant: DURAMED PHARMACEUTICALS INC ,  CHOWDHURY TAHSEEN A ,  GABRIELSKI EDWARD J ,  BAKER CHRISTOPHER H

Inventor： CHOWDHURY TAHSEEN A ,  GABRIELSKI EDWARD J ,  BAKER CHRISTOPHER H

IPC: A23G3/12 ,  A61J7/00

CPC classification number: A23G3/125 ,  A61J7/003 ,  A61K9/0056 ,  A61K9/2031 ,  A61K9/2095 ,  B29C65/645 ,  B29C65/7841 ,  B29C66/126 ,  B29C66/534 ,  B29C66/71 ,  B29C66/73773 ,  B29C66/7392 ,  B29C66/7394 ,  B29C66/8161 ,  B29C66/8322 ,  B29C66/843 ,  B29K2021/00 ,  B29K2021/003 ,  B29K2023/00 ,  B29K2101/12 ,  B29K2995/004 ,  B29L2031/753 ,  Y10T29/49826 ,  Y10T29/49828 ,  Y10T29/49829 ,  Y10T29/49966 ,  Y10T29/53435 ,  B29K2067/00 ,  B29K2055/02

Abstract: A method for attaching a handle to a tablet to form a lollipop utilizes a specific work holder. The work holder has a tooling pallet with a plurality of openings going from a top surface to a bottom surface. A bullet and a spring are located in each opening and held in place by a plate that slides through a groove in the bottom surface of the tooling pallet to block the openings in the bottom surface. Each spring is positioned between a bullet and the plate. A tablet is placed in a cavity of each bullet and a handle is placed in contact with each tablet. High frequency mechanical vibrations, such as ultrasonic vibrations, are applied to a joint interface between each tablet and bullet until the joint interface reaches a molten state. The joint interfaces are then allowed to cool, thereby attaching a handle to each tablet and forming a lollipop.

Abstract translation: 用于将手柄附接至平板电脑以形成棒棒糖的方法利用特定的工作架。 工件夹具具有工具托盘，工具托盘具有从顶表面到底表面的多个开口。 子弹和弹簧位于每个开口中，并且通过滑动通过工具托盘底面中的凹槽的平板保持就位，以阻挡底面的开口。 每个弹簧都位于子弹和盘子之间。 将平板电脑置于每个子弹的空腔中，并将手柄放置成与每个平板电脑接触。 高频机械振动，例如超声波振动，被施加到每个片剂和子弹之间的接合界面处，直到接合界面达到熔融状态。 然后使接合界面冷却，由此将手柄附接到每个平板电脑并形成棒棒糖。

公开(公告)号：WO2006133047A1

公开(公告)日：2006-12-14

申请号：PCT/US2006/021658

申请日：2006-06-05

Applicant: DURAMED PHARMACEUTICALS, INC. ,  CHOWDHURY, Tahseen A. ,  GABRIELSKI, Edward J. ,  BAKER, Christopher H.

Inventor： CHOWDHURY, Tahseen A. ,  GABRIELSKI, Edward J. ,  BAKER, Christopher H.

IPC: A61J3/00 ,  A61K9/00

CPC classification number: A61K9/2027 ,  A61J3/00 ,  A61J7/003 ,  A61K9/0056 ,  A61K9/2009 ,  A61K9/2013 ,  B29C65/645 ,  B29C66/71 ,  B29C66/7392 ,  B29C66/7394 ,  B29L2031/753 ,  B29K2025/08 ,  B29K2023/00 ,  B29K2021/003 ,  B29K2005/00 ,  B29K2003/00

Abstract: The present invention relates to a method of making a solid oral dosage form attached to a handle, the method comprising attaching a handle to a solid oral dosage form by applying high frequency mechanical vibrations. In some embodiments, the present invention relates to a method of making a solid oral dosage form attached to a handle, the method comprising: (a) placing a handle in contact with a solid oral dosage form, wherein an area of contact between the handle and the solid oral dosage form forms a joint interface; (b) applying high frequency mechanical vibrations to the joint interface until the solid oral dosage form at the joint interface reaches a molten state; and (c) cooling the joint interface in a molten state to allow solidification, thereby attaching the solid oral dosage form to the handle.

Abstract translation: 本发明涉及一种制备固定口服剂型附着在手柄上的方法，所述方法包括通过施加高频机械振动将手柄附接到固体口服剂型。 在一些实施方案中，本发明涉及制备连接到手柄上的固体口服剂型的方法，所述方法包括：（a）将手柄放置成与固体口服剂型接触，其中手柄之间的接触区域 并且固体口服剂型形成接合界面; （b）将高频机械振动施加到接合界面，直到接合界面处的固体口服剂型达到熔融状态; 和（c）以熔融状态冷却接合界面以允许固化，从而将固体口服剂型附着到手柄上。