公开(公告)号：WO2011061469A1

公开(公告)日：2011-05-26

申请号：PCT/GB2010/001842

申请日：2010-09-30

Applicant: UNIVERSITY COLLEGE LONDON ,  POSADA, Cristina, Garcia ,  SELWOOD, David ,  GARTHWAITE, John ,  BAKER, David ,  CLUTTERBUCK, Lisa

Inventor： POSADA, Cristina, Garcia ,  SELWOOD, David ,  GARTHWAITE, John ,  BAKER, David ,  CLUTTERBUCK, Lisa

IPC: C07D413/14 ,  C07D417/14 ,  A61K31/4245 ,  A61P25/00 ,  A61P23/00

CPC classification number: C07D413/14 ,  C07D417/14

Abstract: The invention provides an indazole derivative of formula (1), or a pharmaceutically acceptable salt or N-oxide thereof, wherein R 1 , R 2 , R 3 and R 4 are as defined herein. The indazole derivatives are capable of blockading voltage dependent sodium channels and they are useful in the treatment or prevention of normal tension glaucoma, multiple sclerosis, a motorneurone disease, stroke, spinal cord injury, Alzheimer's disease, Parkinson's disease or pain.

Abstract translation: 本发明提供式（1）的吲唑衍生物或其药学上可接受的盐或N-氧化物，其中R 1，R 2，R 3和R 4如本文所定义。 吲唑衍生物能够阻断电压依赖性钠通道，并且它们可用于治疗或预防正常张力性青光眼，多发性硬化，运动神经元疾病，中风，脊髓损伤，阿尔茨海默病，帕金森病或疼痛。

公开(公告)号：WO0116359A3

公开(公告)日：2002-05-10

申请号：PCT/GB0003360

申请日：2000-08-31

Applicant: UNIV LONDON ,  GARTHWAITE GITI ,  GARTHWAITE JOHN

Inventor： GARTHWAITE GITI ,  GARTHWAITE JOHN

IPC: A61P25/00 ,  G01N33/50 ,  C12Q1/527 ,  G01N33/53

CPC classification number: G01N33/5058 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5088 ,  G01N33/5091 ,  G01N2800/52

Abstract: A method for determining the viability of an axon comprises: (i) contacting the axon with a substance that is capable of stimulating soluble guanylate cyclase (sGC); (ii) determining whether sGC is stimulated in the axon; and (iii) determining thereby whether the axon is viable.

Abstract translation: 用于确定轴突活力的方法包括：（i）使轴突与能够刺激可溶性鸟苷酸环化酶（sGC）的物质接触; （ii）确定在轴突中是否刺激sGC; 和（iii）确定轴突是否存活。

公开(公告)号：WO2008009935A1

公开(公告)日：2008-01-24

申请号：PCT/GB2007/002722

申请日：2007-07-19

Applicant: UCL BUSINESS PLC ,  SELWOOD, David ,  RIDDAL, Dieter ,  GRIFFITHS, Charmaine ,  KEYNES, Robert ,  BELLAMY, Tomas ,  GARTHWAITE, John

Inventor： SELWOOD, David ,  RIDDAL, Dieter ,  GRIFFITHS, Charmaine ,  KEYNES, Robert ,  BELLAMY, Tomas ,  GARTHWAITE, John

IPC: A61K31/5415 ,  A61P25/16 ,  A61P25/28 ,  A61P9/10 ,  A61P11/06

CPC classification number: A61K31/5415

Abstract: The invention relates to use of a phenothiazine derivative which is (a) a compound of formula (I) or a tautomer thereof, or (b) a pharmaceutically acceptable salt thereof, for the manufacture of a medicament for use in treating a disorder mediated by lipid peroxidation wherein R 1 , R 2 , R 3 , R 4 , R 5 , S’, m, n, p and q are as defined herein.

Abstract translation: 本发明涉及吩噻嗪衍生物的用途，其为（a）式（I）化合物或其互变异构体，或（b）其药学上可接受的盐，用于制备用于治疗由 脂质过氧化，其中R 1，R 2，R 3，R 4，R 5， SUP>，S'，m，n，p和q如本文所定义。