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    DETERMINATION OF LYMPHOCYTE ABUNDANCE IN MIXED SAMPLES
    2.
    发明申请
    DETERMINATION OF LYMPHOCYTE ABUNDANCE IN MIXED SAMPLES 审中-公开

    公开(公告)号：WO2023002046A1

    公开(公告)日：2023-01-26

    申请号：PCT/EP2022/070694

    申请日：2022-07-22

    Applicant: THE FRANCIS CRICK INSTITUTE ,  UNIVERSITY COLLEGE LONDON

    Inventor： BENTHAM, Robert ,  WATKINS, Thomas Benjamin Kingdon ,  MCGRANAHAN, Nicholas ,  SWANTON, Charles

    IPC: G16B20/00 ,  G16B30/00 ,  C12Q1/6869

    Abstract: Methods for determining the fraction of lymphocytes in a mixed sample comprising genomic material from multiple cell types are described. The methods comprise obtaining a read depth profile for the sample along a predetermined genomic region of interest including at least a portion of a genomic locus that undergoes VDJ recombination; obtaining a plurality of read depth ratios (ri) by normalising the read depths by reference to a baseline read depth derived from a subset of the region of interest; obtaining a summarised read depth ratio value (rVDJ) for a subset of the region of interest that is likely to be deleted through VDJ recombination; and determining the fraction of lymphocytes (f) in the sample as a function of the summarised read depth ratio value (rVDJ). Methods of providing a diagnosis or prognosis based on the lymphocyte fraction are also described, as well as related systems and products.

    A METHOD OF HYPERPOLARISING A MAGNETIC RESONANCE AGENT
    7.
    发明申请
    A METHOD OF HYPERPOLARISING A MAGNETIC RESONANCE AGENT 审中-公开
    高分子磁共振剂的方法

    公开(公告)号：WO2009004357A2

    公开(公告)日：2009-01-08

    申请号：PCT/GB2008/002323

    申请日：2008-07-07

    Applicant: UNIVERSITY COLLEGE LONDON ,  GADIAN, David, Geoffrey

    Inventor： GADIAN, David, Geoffrey

    IPC: A61K49/06

    CPC classification number: G01R33/5601 ,  A61K49/103 ,  G01R33/282

    Abstract: The invention provides a method of hyperpolarising a magnetic resonance (MR) agent suitable for use in magnetic resonance imaging (MRI) or magnetic resonance spectroscopy (MRS) comprising the steps of: a. providing a solution comprising the MR agent suitable for use in MRI or MRS and at least one relaxation agent, the relaxation agent being a paramagnetic metal ion having an electron spin relaxation time of less than 1 x 10 -10 seconds at 20°C; and b. exposing the solution to a temperature of less than 5 K and a magnetic field of at least 1 T. The relaxation agent may, for example, be dysprosium.

    Abstract translation: 本发明提供了一种适用于磁共振成像（MRI）或磁共振光谱（MRS）的磁共振（MR）剂的超极化方法，包括以下步骤：a。 提供包含适合用于MRI或MRS和至少一种松弛剂的MR试剂的溶液，所述松弛剂是在20℃时电子自旋弛豫时间小于1×10-10秒的顺磁金属离子; 和b。 将溶液暴露于小于5K的温度和至少1T的磁场。松弛剂可以是例如镝。

    HISTONE DEACETYLASE INHIBITORS
    8.
    发明申请
    HISTONE DEACETYLASE INHIBITORS 审中-公开
    HISTONE脱乙酰酶抑制剂

    公开(公告)号：WO2008047138A2

    公开(公告)日：2008-04-24

    申请号：PCT/GB2007/004000

    申请日：2007-10-19

    Applicant: UNIVERSITY COLLEGE LONDON ,  BARTS AND THE LONDON NHS TRUST ,  JOEL, Simon, Peter ,  MARSON, Charles, Michael

    Inventor： JOEL, Simon, Peter ,  MARSON, Charles, Michael

    CPC classification number: C07D285/08 ,  C07C233/07 ,  C07C259/06

    Abstract: The present invention provides histone deacetylase inhibitors of general formula (I), a process for the preparation of such compounds and uses of the compounds in medicine, especially in the treatment of cancers: in which R 1 is an optionally substituted aryl, arylalkyl, heteroaryl, heterocycloalkenyl, cycloalkene ring, cycloalkyl, heterocycloalkyl or a combination of such rings to form a linked or fused ring system, R 2 and R 3 is each independently hydrogen, optionally substituted saturated or unsaturated alkyl, optionally substituted aryl or heteroaryl, or a combination thereof to form a linked or fused ring system, alkoxy, thioalkoxy, hydroxyl, hydroxyalkyl, halo, haloalkyl, cyano, nitro, amino, amido, alkylamino, alkylcarbonyloxy, alkoxycarbonyl, alkylcarbonyl, alkylthiocarbonyl, alkylsulfonylamino, aminosulfonyl, alkylsulfinyl, or alkylsulfonyl, or R 3 is absent when Y stands for O or S, or R 2 and R 3 may be linked together and such that, together with the intervening atoms, they form a 5, 6 or 7-membered ring containing one or more heteroatoms, which may be a heteroaryl ring, heterocycloalkenyl ring, or heterocycloalkyl ring, optionally containing up to 4 heteroatoms, e.g. oxygen, nitrogen or sulphur, which ring may be fused to further rings as part of a fused ring system, and which may bear 1, 2 or 3 substituents, which substituents independently have the same meaning as R 2 on any or all of those rings, Q stands for an (alkyl, which may be unsaturated; aryl, arylalkyl, alkylaryl or alkylarylalkyl, all of which may be optionally substituted; and may be optionally interrupted by O, S, NR, CO, C(N=R), where R may be independently hydrogen, alkyl, alkenyl, alkynyl, or alkoxy; V is OH, SH, SR, OR, NH2, NHR, NRR, NROH, NHOR, NROR where R may independently be hydrogen or (C 1 -C 6 ) alkyl, Y is oxygen, or sulphur or N, and Z is O, S, S(=O), S(O)2, NR 4 , -N=, CR 4 R 5 , or -C(R4)=, where R 4 and R 5 independently have the same meaning as R 2 .

    Abstract translation: 本发明提供了通式（I）的组蛋白脱乙酰酶抑制剂，这种化合物的制备方法和该药物在药物中的用途，特别是在治疗癌症中的用途：其中R 1是 任选取代的芳基，芳基烷基，杂芳基，杂环烯基，环烯烃环，环烷基，杂环烷基或这些环的组合以形成连接或稠合的环体系，R 2和R 3， 各自独立地为氢，任选取代的饱和或不饱和烷基，任选取代的芳基或杂芳基，或其组合以形成连接或稠合的环体系，烷氧基，硫代烷氧基，羟基，羟基烷基，卤素，卤代烷基，氰基，硝基，氨基，酰氨基 当Y代表O或S或R 2时，不存在烷基氨基，烷基羰基氧基，烷氧基羰基，烷基羰基，烷硫基羰基，烷基磺酰基氨基，氨基磺酰基，烷基亚磺酰基或烷基磺酰基或R 3， 和R 3可以连接至 并且使得它们与插入的原子一起形成含有一个或多个杂原子的5,6或7元环，杂原子可以是杂芳基环，杂环烯基环或杂环烷基环，任选地含有至多4个杂原子，例如。 氧，氮或硫，该环可以作为稠环系统的一部分与另外的环稠合，并且其可以带有1,2或3个取代基，该取代基独立地具有与R 2相同的含义， 在任何或所有这些环上，Q表示（烷基，其可以是不饱和的;芳基，芳基烷基，烷基芳基或烷基芳基烷基，其全部可以被任选取代;并且可以任选地被O，S，NR，CO， C（N = R），其中R可以独立地是氢，烷基，烯基，炔基或烷氧基; V是OH，SH，SR，OR，NH 2，NHR，NRR，NROH，NHOR，NROR，其中R可以独立地是氢 或（C 1 -C 6）烷基，Y是氧或硫或N，并且Z是O，S，S（= O），S（O） 2，NR 4，-N =，CR 4 R 5或-C（R 4）=，其中R 4， / SUP>和R 5独立地具有与R 2相同的含义。

    INTERVENTIONAL DEVICE LOCATION METHOD AND APPARATUS
    9.
    发明申请
    INTERVENTIONAL DEVICE LOCATION METHOD AND APPARATUS 审中-公开
    传统装置定位方法和装置

    公开(公告)号：WO2007066096A2

    公开(公告)日：2007-06-14

    申请号：PCT/GB2006/004543

    申请日：2006-12-05

    Applicant: KING'S COLLEGE LONDON ,  UNIVERSITY COLLEGE LONDON ,  HILL, Derek ,  RAZAVI, Raza ,  RHODE, Kawal

    Inventor： HILL, Derek ,  RAZAVI, Raza ,  RHODE, Kawal

    IPC: A61B5/055 ,  A61B6/12 ,  A61B8/08

    CPC classification number: A61B6/12 ,  A61B5/061 ,  A61B8/0833 ,  A61B8/4416

    Abstract: The position of an interventional device, such as a catheter, introduced into a human body is determined by producing an image of a region of the body into which the device is to be introduced, using 3-dimensional imaging apparatus; displaying the 3-dimensional image on a two-dimensional display screen; detecting the device in the body using a single-plane detecting apparatus, thereby to determine the position of the device substantially in two dimensions; superimposing the image of the region of the body onto an image of the detected device on the display screen in registration therewith; detecting the movement of the device in response to internal movement of the body, thereby to determine the position of the device in said two dimensions; and displaying the position of the device on the image on the display screen.

    Abstract translation: 通过使用三维成像装置产生要引入装置的身体的区域的图像来确定引入人体的介入装置（例如导管）的位置; 在二维显示屏上显示三维图像; 使用单平面检测装置检测身体中的装置，从而基本上确定装置的位置; 将身体的区域的图像叠加在与其对准的显示屏上的检测到的装置的图像上; 响应于身体的内部运动来检测装置的运动，从而确定装置在所述两个维度中的位置; 并在显示屏幕上显示设备在图像上的位置。

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