公开(公告)号：WO2021248133A1

公开(公告)日：2021-12-09

申请号：PCT/US2021/036234

申请日：2021-06-07

Applicant: CODIAK BIOSCIENCES, INC. ,  VERMA, Ajay ,  GAYDUKOV, Leonid

Inventor： XU, Ke ,  DOOLEY, Kevin P. ,  FINN, Jonathan

IPC: A61K31/00 ,  A61K35/12 ,  C07D417/10 ,  A61K31/713 ,  A61K45/06 ,  C07K17/00

Abstract: The present disclosure relates extracellular vesicles, e.g., exosomes, comprising an antigen-binding moeity, e.g., a single-domain antigen-binding moeity, e.g., a vNAR, a VHH, or a fragment thereof, that specifically binds transferrin receptor, and methods of making and using the same.

公开(公告)号：WO2008111062A1

公开(公告)日：2008-09-18

申请号：PCT/IL2008/000335

申请日：2008-03-11

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  GAYDUKOV, Leonid ,  KHERSONSKY, Olga ,  TAWFIK, Dan S.

Inventor： GAYDUKOV, Leonid ,  KHERSONSKY, Olga ,  TAWFIK, Dan S.

IPC: C12Q1/34 ,  C12Q1/42 ,  C12Q1/44

CPC classification number: C12Q1/34 ,  C12Q1/42 ,  C12Q1/44

Abstract: A method of determining an amount of total PON1 in a sample of a subject is disclosed. The method comprises: (a) contacting the sample with a compound being capable of generating at least one spectrophotometrically detectable moiety upon contact with PON1, under conditions wherein the generating is not dependent on a PON1 status; and (b) spectrophotometrically measuring a level of the moiety, thereby determining an amount of total PON1 in the sample. Kits for measuring total PON1 levels comprising the compounds are also disclosed.

Abstract translation: 公开了一种确定受检者样本中总PON1量的方法。 该方法包括：（a）在产生不依赖于PON1状态的条件下，使样品与能够与PON1接触时能够产生至少一种分光光度可检测部分的化合物接触; 和（b）分光光度测量该部分的水平，从而确定样品中总PON1的量。 还公开了用于测量包含化合物的总PON1水平的试剂盒。

公开(公告)号：WO2004078991A2

公开(公告)日：2004-09-16

申请号：PCT/IL2004/000216

申请日：2004-03-04

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  TAWFIK, Dan, S. ,  AHARONI, Amir ,  GAYDUKOV, Leonid ,  SUSSMAN, Joel, L. ,  SILMAN, Israel

Inventor： TAWFIK, Dan, S. ,  AHARONI, Amir ,  GAYDUKOV, Leonid ,  SUSSMAN, Joel, L. ,  SILMAN, Israel

IPC: C12Q

CPC classification number: C12N9/18 ,  A61K38/00 ,  C12N9/16 ,  Y02A50/473

Abstract: Isolated polynucleotides and polypeptides encoded therefrom are provided. These include mutated PON enzymes with increased, modified or substantially the same substrate specificity as compared to respective wild-type PON. Also provided are kits and methods using these enzymes.

Abstract translation: 提供分离的多核苷酸及其编码的多肽。 这些包括与相应的野生型PON相比具有增加的，修饰的或基本上相同的底物特异性的突变的PON酶。 还提供了使用这些酶的试剂盒和方法。

公开(公告)号：WO2007105223A3

公开(公告)日：2009-02-12

申请号：PCT/IL2007000345

申请日：2007-03-18

Applicant: YEDA RES & DEV ,  RAPPAPORT FAMILY INST FOR RES ,  GAYDUKOV LEONID ,  KHERSONSKY OLGA ,  TAWFIK DAN S ,  AVIRAM MICHAEL

Inventor： GAYDUKOV LEONID ,  KHERSONSKY OLGA ,  TAWFIK DAN S ,  AVIRAM MICHAEL

IPC: A61K38/46 ,  C12N9/16

CPC classification number: G01N33/92 ,  A61K38/1709 ,  C12Q1/6883

Abstract: Methods and kits for diagnosing a lipid-related disorder are disclosed. Methods and pharmaceutical compositions for treating lipid-related disorders are also disclosed.

Abstract translation: 公开了用于诊断脂质相关疾病的方法和试剂盒。 还公开了用于治疗脂质相关病症的方法和药物组合物。

公开(公告)号：WO2007105223A2

公开(公告)日：2007-09-20

申请号：PCT/IL2007/000345

申请日：2007-03-18

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SCIENCES ,  GAYDUKOV, Leonid ,  KHERSONSKY, Olga ,  TAWFIK, Dan, S. ,  AVIRAM, Michael

Inventor： GAYDUKOV, Leonid ,  KHERSONSKY, Olga ,  TAWFIK, Dan, S. ,  AVIRAM, Michael

IPC: C12Q1/68

CPC classification number: G01N33/92 ,  A61K38/1709 ,  C12Q1/6883

Abstract: Methods and kits for diagnosing a lipid-related disorder are disclosed. Methods and pharmaceutical compositions for treating lipid-related disorders are also disclosed.

Abstract translation: 公开了用于诊断脂质相关病症的方法和试剂盒。 还公开了用于治疗脂质相关病症的方法和药物组合物。

公开(公告)号：WO2004078991A3

公开(公告)日：2006-01-05

申请号：PCT/IL2004000216

申请日：2004-03-04

Applicant: YEDA RES & DEV ,  TAWFIK DAN S ,  AHARONI AMIR ,  GAYDUKOV LEONID ,  SUSSMAN JOEL L ,  SILMAN ISRAEL

Inventor： TAWFIK DAN S ,  AHARONI AMIR ,  GAYDUKOV LEONID ,  SUSSMAN JOEL L ,  SILMAN ISRAEL

IPC: C12N9/16 ,  C12Q20060101 ,  C12Q1/00 ,  C07H21/04

CPC classification number: C12N9/18 ,  A61K38/00 ,  C12N9/16

Abstract: Isolated polynucleotides and polypeptides encoded therefrom are provided. These include mutated PON enzymes with increased, modified or substantially the same substrate specificity as compared to respective wild-type PON. Also provided are kits and methods using these enzymes.

Abstract translation: 提供了分离的多核苷酸及其编码的多肽。 这些包括与相应的野生型PON相比具有增加的，修饰的或基本上相同的底物特异性的突变的PON酶。 还提供了使用这些酶的试剂盒和方法。