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    PROCESS CONTROLS FOR MOLECULAR ASSAY
    1.
    发明申请
    PROCESS CONTROLS FOR MOLECULAR ASSAY 审中-公开
    用于分子测定的过程控制

    公开(公告)号：WO2012122525A1

    公开(公告)日：2012-09-13

    申请号：PCT/US2012/028603

    申请日：2012-03-09

    Applicant: GENEOHM SCIENCES, INC. ,  DORE, Benoit ,  MENARD, Christian ,  HELLYER, Tobin

    Inventor： DORE, Benoit ,  MENARD, Christian ,  HELLYER, Tobin

    IPC: C12N1/06 ,  C12N15/10 ,  C12Q1/68

    CPC classification number: C12Q1/689 ,  C12N1/06 ,  C12Q1/6806

    Abstract: A full process control for use with a molecular assay and a method of determine the efficacy of the molecular assay. A full process control can include a fixed cell, and specifically can include a fixed vegetative cell. A method of determining the efficacy of a molecular assay can include providing an internal control, mixing the internal control with a sample, lysing the internal control and the sample, and detecting the lysis product. The full process control and/or the internal control can be Bacillus subtilis cells.

    Abstract translation: 用于分子测定的全过程控制和确定分子测定的功效的方法。 完整的过程控制可以包括固定的细胞，并且具体可以包括固定的营养细胞。 确定分子测定的功效的方法可以包括提供内部对照，将内部对照与样品混合，裂解内部对照和样品，以及检测裂解产物。 完整的过程控制和/或内部控制可以是枯草芽孢杆菌细胞。

    METHODS FOR THE DETECTION AND IDENTIFICATION OF EXTENDED SPECTRUM BETA LACTAMASES
    3.
    发明申请
    METHODS FOR THE DETECTION AND IDENTIFICATION OF EXTENDED SPECTRUM BETA LACTAMASES 审中-公开
    用于检测和鉴定扩展的光谱分析仪的方法

    公开(公告)号：WO2010096723A1

    公开(公告)日：2010-08-26

    申请号：PCT/US2010/024832

    申请日：2010-02-19

    Applicant: GENEOHM SCIENCES, INC. ,  LIPPE, Catherine ,  DUTEAUD, Isabelle ,  ROGER-DALBERT, Celine

    Inventor： LIPPE, Catherine ,  DUTEAUD, Isabelle ,  ROGER-DALBERT, Celine

    IPC: C12Q1/68 ,  C12P19/34 ,  C07H21/04

    CPC classification number: C12Q1/689 ,  C12Q2600/156

    Abstract: Embodiments disclosed herein relate to compositions for the detection and/or identification of microbes that carry extended spectrum beta-lactamase genes. Specifically, provided herein are oligonucleotides, probes, and kits containing the same, for the detection of bacterial CTX-M sequences. Also provided are methods for the detection and/or amplification of microbes harboring extended spectrum beta-lactamase genes, including CTX-M type extended spectrum beta-lactamase genes.

    Abstract translation: 本文公开的实施方案涉及用于检测和/或鉴定携带扩展光谱β-内酰胺酶基因的微生物的组合物。 具体地，本文提供了用于检测细菌CTX-M序列的寡核苷酸，探针和含有该寡核苷酸的试剂盒。 还提供了用于检测和/或扩增含有广谱β-内酰胺酶基因的微生物的方法，包括CTX-M型扩展谱β-内酰胺酶基因。

    QUALITY CONTROL OF PROBE ATTACHMENT ON ELECTRODES
    5.
    发明申请
    QUALITY CONTROL OF PROBE ATTACHMENT ON ELECTRODES 审中-公开
    电极探针附件的质量控制

    公开(公告)号：WO2007055868A2

    公开(公告)日：2007-05-18

    申请号：PCT/US2006/040231

    申请日：2006-10-16

    Applicant: GENEOHM SCIENCES, INC. ,  YANG, Xing ,  ZHU, Qun

    Inventor： YANG, Xing ,  ZHU, Qun

    IPC: C12Q1/68

    CPC classification number: C12Q1/6837 ,  C12Q2563/113

    Abstract: The present disclosure relates to methods of quantifying nucleic acid molecules immobilized on an electrode of an electrochemical assay chip. Such quantification can be used in testing and quality control of assay chips. Materials and instrumentation useful in performing such techniques are also disclosed.

    Abstract translation: 本公开涉及定量固定在电化学测定芯片的电极上的核酸分子的方法。 这种定量可用于检测芯片的检测和质量控制。 还公开了用于执行这些技术的材料和仪器。

    FLUIDIC CARTRIDGES FOR ELECTROCHEMICAL DETECTION OF DNA
    8.
    发明申请
    FLUIDIC CARTRIDGES FOR ELECTROCHEMICAL DETECTION OF DNA 审中-公开
    用于电化学检测DNA的流体盒

    公开(公告)号：WO2006065598A3

    公开(公告)日：2007-07-26

    申请号：PCT/US2005044271

    申请日：2005-12-06

    Applicant: GENEOHM SCIENCES INC ,  YANG XING ,  HOLMLIN ROBERT ERIK

    Inventor： YANG XING ,  HOLMLIN ROBERT ERIK

    IPC: B01L3/00 ,  G01N33/543

    CPC classification number: B01L3/5027 ,  B01L7/52 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0877 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/049

    Abstract: A flow cell cartridge (100) for the detection of differences in nucleic acid sequences is disclosed. The flow cell cartridge has an electrode array (170) and two openings (130, 140), in which one opening (130) is for the entry and exit of sample, and the other opening (140) is for the control of the entry and exit of sample through the exertion of negative and positive pressure. The entire flow cell cartridge can be moved from sample to sample to allow different samples to be drawn into the cartridge into contact with an electrochemical electrode array, thus allowing reactions to occur in the chamber itself .

    Abstract translation: 公开了用于检测核酸序列差异的流动池盒（100）。 流动池盒具有电极阵列（170）和两个开口（130,140），其中一个开口（130）用于样品的进入和离开，另一个开口（140）用于控制入口 并通过消极和正压施加样品的出口。 整个流动池盒可以从样品移动到样品，以允许不同的样品被吸入到盒中与电化学电极阵列接触，从而允许反应发生在室本身中。

    NUCLEIC ACID HYBRIDIZATION METHODS
    9.
    发明申请
    NUCLEIC ACID HYBRIDIZATION METHODS 审中-公开
    核酸混合方法

    公开(公告)号：WO2005049848A3

    公开(公告)日：2007-06-14

    申请号：PCT/US2004037472

    申请日：2004-11-10

    Applicant: GENEOHM SCIENCES INC ,  CROTHERS DONALD M

    Inventor： CROTHERS DONALD M

    IPC: C12Q1/68 ,  C07H21/04 ,  C12P19/34 ,  C12Q20060101

    CPC classification number: C12Q1/6837 ,  C12Q2565/543 ,  C12Q2531/125 ,  C12Q2521/531

    Abstract: Disclosed herein are methods of destabilizing double-stranded nucleic acid hybridization using an enzyme comprising DNA N-glycosylase activity. Also disclosed herein is the detection of a double-stranded target DNA wherein the hybridization of duplex strands has been at least partially disrupted thereby permitting invasion of a probe strand. Also disclosed herein are methods of using an enzyme comprising DNA N-glycosylase activity to generate single-stranded circular nucleic acids.

    Abstract translation: 本文公开了使用包含DNA N-糖基化酶活性的酶使双链核酸杂交失稳的方法。 本文还公开了双链靶DNA的检测，其中双链体的杂交已被至少部分地破坏从而允许侵入探针链。 本文还公开了使用包含DNA N-糖基化酶活性的酶以产生单链环状核酸的方法。

    FLUIDIC CARTRIDGES FOR ELECTROCHEMICAL DETECTION OF DNA
    10.
    发明申请
    FLUIDIC CARTRIDGES FOR ELECTROCHEMICAL DETECTION OF DNA 审中-公开
    用于电化学检测DNA的流体盒

    公开(公告)号：WO2006065598A2

    公开(公告)日：2006-06-22

    申请号：PCT/US2005/044271

    申请日：2005-12-06

    Applicant: GENEOHM SCIENCES, INC. ,  YANG, Xing ,  HOLMLIN, Robert, Erik

    Inventor： YANG, Xing ,  HOLMLIN, Robert, Erik

    CPC classification number: B01L3/5027 ,  B01L7/52 ,  B01L2200/10 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0877 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/049

    Abstract: A flow cell cartridge for the detection of differences in nucleic acid sequences is disclosed. The flow cell cartridge has an electrode array and two openings, in which one opening is for the entry and exit of sample, and the other opening is for the control of the entry and exit of sample through the exertion of negative and positive pressure. The entire flow cell cartridge can be moved from sample to sample to allow different samples to be drawn into the cartridge into contact with an electrochemical electrode array, thus allowing reactions to occur in the chamber itself.

    Abstract translation: 公开了用于检测核酸序列差异的流动池盒。 流动池盒具有电极阵列和两个开口，其中一个开口用于样品的入口和出口，另一个开口用于通过施加负压和正压来控制样品的进出。 整个流动池盒可以从样品移动到样品，以允许不同的样品被吸入到与电化学电极阵列接触的盒中，从而允许反应发生在室本身中。

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