公开(公告)号：WO2017186692A1

公开(公告)日：2017-11-02

申请号：PCT/EP2017/059747

申请日：2017-04-25

Applicant: PHARMACEUTICAL BUSINESS CONSULTANTS LIMITED ,  GIANNOUDIS, Peter V

Inventor： GIANNOUDIS, Peter V ,  O'SULLIVAN, Carol ,  INSLEY, Gerard Michael ,  BURKE, Paul ,  O'SULLIVAN, Regina

IPC: A61L27/12 ,  A61L27/24 ,  A61L27/36 ,  A61L27/56

CPC classification number: A61L27/365 ,  A61L27/12 ,  A61L27/24 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/3616 ,  A61L27/3691 ,  A61L27/52 ,  A61L27/56 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2430/02

Abstract: The present invention relates to an implantable device configured to deliver, to an injured bone site, components for revascularisation and bone repair, the device comprising: a first osteoconductive scaffold component adapted to hold and deliver to the injured bone site, growth factors for inducing cellular events that initiate healing; and comprising a second osteoconductive scaffold component adapted to hold and deliver to the injured bone site, viable autologous osteogenic and/or angiogenic cells, and wherein the device also comprises a third scaffold component adapted to promote bone cell proliferation and vascularity, whereby the scaffold components provide a stable mechanical environment for promoting bone cell proliferation and vascularity. The present invention also relates to a method of manufacture of the implantable device.

Abstract translation: 本发明涉及一种可植入装置，其被配置为将用于血管再生和骨修复的组件递送至受损的骨骼部位，所述装置包括：第一骨传导性支架部件，其适于保持并递送至受伤者 骨部位，诱导引发愈合的细胞事件的生长因子; 并且包含第二骨传导性支架部件，所述第二骨传导性支架部件适于容纳并递送至受损的骨骼部位的活的自体成骨细胞和/或血管生成细胞，并且其中所述装置还包含适于促进骨细胞增殖和血管分布的第三支架部件， 为促进骨细胞增殖和血管分布提供稳定的机械环境。 本发明还涉及制造可植入装置的方法。

公开(公告)号：WO2011028520A2

公开(公告)日：2011-03-10

申请号：PCT/US2010/046476

申请日：2010-08-24

Applicant: DEPUY PRODUCTS, INC. ,  METZINGER, Anthony, J. ,  GIANNOUDIS, Peter ,  HAIDUKEWYCH, George, J. ,  LIPORACE, Frank, A. ,  SEMS, Andrew ,  HORWITZ, Daniel, S.

Inventor： METZINGER, Anthony, J. ,  GIANNOUDIS, Peter ,  HAIDUKEWYCH, George, J. ,  LIPORACE, Frank, A. ,  SEMS, Andrew ,  HORWITZ, Daniel, S.

IPC: A61B17/17

CPC classification number: A61B17/1721 ,  A61B17/1703 ,  A61B17/175 ,  A61B17/72 ,  A61B17/744

Abstract: An instrument system is provided for positioning an internal fixation prosthesis and guiding a cannulated bone drill during a surgical, radioscopic procedure for the repair of a fractured bone of a patient. The instrument system includes a target wire, a handle formed from a radio translucent material having a target hole for guided passage of the target wire along a target axis. The target axis coincides with the intersection of a first plane and a second plane orthogonal to the first plane. The instrument system also includes a nose component attached to an end of the handle and removably connectable to the prosthesis. The nose component includes an alignment sight formed from a radio-opaque material. When the prosthesis is connected to the nose component and the target wire is positioned through the target hole along the target axis, the image of the guide wire may be radioscopically viewed along a first line of sight contained in the first plane to bisect the image of the alignment device, thereby providing a first visual reference to the user for directing the first guide wire into the desired portion of the bone while holding the prosthesis in a desired position relative to the bone.

Abstract translation: 提供了一种用于定位内固定假体并在用于修复患者骨折骨的外科手术放射学程序中引导插管骨钻的仪器系统。 仪器系统包括目标线，由无线电半透明材料形成的手柄，其具有用于目标线沿目标轴引导通过的目标孔。 目标轴与第一平面和与第一平面正交的第二平面的交点重合。 仪器系统还包括附接到手柄的端部并可拆卸地连接到假体的鼻部部件。 鼻部组件包括由不透射线材料形成的对准视线。 当假体连接到鼻部部件并且目标线沿着目标轴线定位穿过目标孔时，可以沿着包含在第一平面中的第一视线来放射线地观察导丝的图像，以将图像平均化 对准装置，从而为使用者提供第一视觉参考，用于将第一导丝引导到骨骼的期望部分中，同时将假体保持在相对于骨骼的期望位置。

公开(公告)号：WO2017066682A1

公开(公告)日：2017-04-20

申请号：PCT/US2016/057193

申请日：2016-10-14

Applicant: RICKER, Lauren ,  HORWITZ, Daniel ,  SANDERS, Roy ,  DZIADOSZ, Dan ,  GIANNOUDIS, Peter

Inventor： RICKER, Lauren ,  HORWITZ, Daniel ,  SANDERS, Roy ,  DZIADOSZ, Dan ,  GIANNOUDIS, Peter

IPC: A61B17/17 ,  A61B17/80

CPC classification number: A61B17/8061 ,  A61B17/1767 ,  A61B17/8085 ,  A61B2017/00831 ,  A61B2017/681

Abstract: Plates for patella fracture reduction and fracture reduction devices are described. More particularly plates and devices for patella reduction that are universally fit to a front surface or perimeter of a patella and include a plurality of attachment holes disposed therein for receiving a fastener. In some embodiments, the plates include removable tab members.

Abstract translation: 描述了用于髌骨骨折复位和骨折复位装置的板。 更具体地说，用于减少髌骨的板和装置普遍适合于髌骨的前表面或周边，并且包括设置在其中用于接收紧固件的多个附接孔。 在一些实施例中，板包括可移除的突片构件。

公开(公告)号：WO2010117677A1

公开(公告)日：2010-10-14

申请号：PCT/US2010/028816

申请日：2010-03-26

Applicant: DEPUY PRODUCTS, INC. ,  HAIDUKEWYCH, George, J. ,  HORWITZ, Daniel, S. ,  LIPORACE, Frank, A. ,  SEMS, Andrew ,  GIANNOUDIS, Peter ,  METZINGER, Anthony, J. ,  CHRISTIE, Charles, D. ,  BERTHUSEN, Andrew, H.

Inventor： HAIDUKEWYCH, George, J. ,  HORWITZ, Daniel, S. ,  LIPORACE, Frank, A. ,  SEMS, Andrew ,  GIANNOUDIS, Peter ,  METZINGER, Anthony, J. ,  CHRISTIE, Charles, D. ,  BERTHUSEN, Andrew, H.

IPC: A61B17/72

CPC classification number: A61B17/7241 ,  A61B17/725 ,  F16B39/06

Abstract: An intramedullary nail comprises longitudinal channel, a first transverse passage and a second transverse passage. A lag screw extends through the first transverse passage of the intramedullary nail. An anti-rotation shaft extends through the second transverse passage of the intramedullary nail. A cannulated lag screw lock is positioned in the intramedullary shaft and engages the lag screw. The anti-rotation shaft extends through a cross channel in the lag screw lock. A second shaft lock is positioned in the intramedullary nail with the second shaft lock engaging the anti-rotation shaft. In at least one embodiment, the lag screw lock includes a substantially cylindrical body portion rotatably connected to a threaded head portion. In at least one embodiment, the second shaft lock is provided as an end cap including a threaded upper portion and a lower post portion that extends into the lag screw lock.

Abstract translation: 髓内钉包括纵向通道，第一横向通道和第二横向通道。 拉力螺钉延伸穿过髓内钉的第一横向通道。 防旋转轴延伸穿过髓内钉的第二横向通道。 插管拉力螺钉锁定在髓内轴中并与拉力螺钉啮合。 防旋转轴延伸穿过拉杆螺丝锁中的十字槽。 第二轴锁定位于髓内钉中，第二轴锁与防旋转轴接合。 在至少一个实施例中，拉伸螺钉锁包括可旋转地连接到螺纹头部的基本上圆柱形的主体部分。 在至少一个实施例中，第二轴锁被设置为端盖，该端盖包括螺纹的上部和延伸到拉力螺钉锁中的下部柱部分。

公开(公告)号：WO2011028520A3

公开(公告)日：2011-06-30

申请号：PCT/US2010046476

申请日：2010-08-24

Applicant: DEPUY PRODUCTS INC ,  METZINGER ANTHONY J ,  GIANNOUDIS PETER ,  HAIDUKEWYCH GEORGE J ,  LIPORACE FRANK A ,  SEMS ANDREW ,  HORWITZ DANIEL S

Inventor： METZINGER ANTHONY J ,  GIANNOUDIS PETER ,  HAIDUKEWYCH GEORGE J ,  LIPORACE FRANK A ,  SEMS ANDREW ,  HORWITZ DANIEL S

IPC: A61B17/17

CPC classification number: A61B17/1721 ,  A61B17/1703 ,  A61B17/175 ,  A61B17/72 ,  A61B17/744

Abstract: An instrument system is provided for positioning an internal fixation prosthesis and guiding a cannulated bone drill during a surgical, radioscopic procedure for the repair of a fractured bone of a patient. The instrument system includes a target wire (180), a handle (106) formed from a radio translucent material having a target hole for guided passage of the target wire along a target axis. The target axis coincides with the intersection of a first plane and a second plane orthogonal to the first plane. The instrument system also includes a nose component (150) attached to an end of the handle and removably connectable to the prosthesis. The nose component includes an alignment sight formed from a radio-opaque material. When the prosthesis is connected to the nose component and the target wire is positioned through the target hole along the target axis, the image of the guide wire may be radioscopically viewed along a first line of sight contained in the first plane to bisect the image of the alignment device, thereby providing a first visual reference to the user for directing the first guide wire into the desired portion of the bone while holding the prosthesis in a desired position relative to the bone.

Abstract translation: 提供了一种用于定位内固定假体并在用于修复患者骨折骨的外科手术放射学程序中引导插管骨钻的仪器系统。 仪器系统包括目标线（180），由无线电半透明材料形成的手柄（106），其具有用于目标线沿着目标轴线引导通过的目标孔。 目标轴与第一平面和与第一平面正交的第二平面的交点重合。 仪器系统还包括附接到手柄的端部并可拆卸地连接到假体的鼻部部件（150）。 鼻部组件包括由不透射线材料形成的对准视线。 当假体连接到鼻部部件并且目标线沿着目标轴线定位穿过目标孔时，可以沿着包含在第一平面中的第一视线来放射线地观察导丝的图像，以将图像平均化 对准装置，从而为使用者提供第一视觉参考，用于将第一导丝引导到骨骼的期望部分中，同时将假体保持在相对于骨骼的期望位置。

公开(公告)号：WO2011039502A3

公开(公告)日：2011-04-07

申请号：PCT/GB2010/001808

申请日：2010-09-27

Applicant: GIANNOUDIS, Peter ,  ANASTOPOULOS, George

Inventor： GIANNOUDIS, Peter ,  ANASTOPOULOS, George

IPC: A61B17/17 ,  A61B17/72

Abstract: The invention relates to a surgical implant (10), and in particular, to a surgical implant for stabilising a bone fracture (20). The surgical implant (10) comprising a plate (14) and an elongate member (16) projecting from the plate (14). The elongate member (16) is provided for insertion into a bone (32) and the plate (14) is provided for attachment to a surface of a bone (24). Each of the elongate member (16) and the plate (14) are provided with at least one fastening region for fastening the surgical implant (10) to the bone (24, 32).

公开(公告)号：WO2011039502A2

公开(公告)日：2011-04-07

申请号：PCT/GB2010001808

申请日：2010-09-27

Applicant: GIANNOUDIS PETER ,  ANASTOPOULOS GEORGE

Inventor： GIANNOUDIS PETER ,  ANASTOPOULOS GEORGE

IPC: A61B17/17 ,  A61B17/72

CPC classification number: A61B17/1725 ,  A61B17/1764 ,  A61B17/1778 ,  A61B17/7233

Abstract: The invention relates to a surgical implant (10), and in particular, to a surgical implant for stabilising a bone fracture (20). The surgical implant (10) comprising a plate (14) and an elongate member (16) projecting from the plate (14). The elongate member (16) is provided for insertion into a bone (32) and the plate (14) is provided for attachment to a surface of a bone (24). Each of the elongate member (16) and the plate (14) are provided with at least one fastening region for fastening the surgical implant (10) to the bone (24, 32).

Abstract translation: 本发明涉及一种手术植入物（10），并且具体涉及用于稳定骨折（20）的手术植入物。 所述手术植入物（10）包括板（14）和从所述板（14）突出的细长构件（16）。 细长构件（16）被提供用于插入到骨（32）中，并且板（14）被提供用于附接到骨（24）的表面。 细长构件（16）和板（14）中的每一个设置有用于将外科植入物（10）紧固到骨（24,32）的至少一个紧固区域。