公开(公告)号：WO2019104208A1

公开(公告)日：2019-05-31

申请号：PCT/US2018/062300

申请日：2018-11-21

Applicant: INSTITUTE FOR MUSCULOSKELETAL SCIENCE AND EDUCATION, LTD. ,  SACK, James, A.

Inventor： SACK, James, A.

IPC: A61F2/44 ,  A61F2/02

CPC classification number: A61F2/4455 ,  A61B17/68 ,  A61F2/2846 ,  A61F2/30767 ,  A61F2002/30062 ,  A61F2002/30156 ,  A61F2002/30224 ,  A61F2002/30289 ,  A61F2002/30593 ,  A61F2002/3093 ,  A61F2002/30985 ,  A61F2002/4475 ,  A61F2002/4495 ,  A61F2002/4629 ,  A61F2250/0026 ,  A61L27/3608

Abstract: An intervertebral implant includes a body formed as an open lattice structure by a plurality of struts. Some of the struts of the plurality of struts intersect at nodes. The nodes can include an enlarged contact member that extends over the node and at least a portion of the width of some of the struts. Enlarged contact members may have an asymmetrical shape with respect to the intersection of struts. The enlarged contact members can provide improved bone contact for the implant. The plurality of struts can have a cross-sectional shape that includes a flattened portion. The flattened portion of the plurality of struts can provide improved bone contact for the implant. An additive manufacturing process can be used to build the implant in a substantially vertical direction.

公开(公告)号：WO2017186692A1

公开(公告)日：2017-11-02

申请号：PCT/EP2017/059747

申请日：2017-04-25

Applicant: PHARMACEUTICAL BUSINESS CONSULTANTS LIMITED ,  GIANNOUDIS, Peter V

Inventor： GIANNOUDIS, Peter V ,  O'SULLIVAN, Carol ,  INSLEY, Gerard Michael ,  BURKE, Paul ,  O'SULLIVAN, Regina

IPC: A61L27/12 ,  A61L27/24 ,  A61L27/36 ,  A61L27/56

CPC classification number: A61L27/365 ,  A61L27/12 ,  A61L27/24 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/3616 ,  A61L27/3691 ,  A61L27/52 ,  A61L27/56 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2430/02

Abstract: The present invention relates to an implantable device configured to deliver, to an injured bone site, components for revascularisation and bone repair, the device comprising: a first osteoconductive scaffold component adapted to hold and deliver to the injured bone site, growth factors for inducing cellular events that initiate healing; and comprising a second osteoconductive scaffold component adapted to hold and deliver to the injured bone site, viable autologous osteogenic and/or angiogenic cells, and wherein the device also comprises a third scaffold component adapted to promote bone cell proliferation and vascularity, whereby the scaffold components provide a stable mechanical environment for promoting bone cell proliferation and vascularity. The present invention also relates to a method of manufacture of the implantable device.

Abstract translation: 本发明涉及一种可植入装置，其被配置为将用于血管再生和骨修复的组件递送至受损的骨骼部位，所述装置包括：第一骨传导性支架部件，其适于保持并递送至受伤者 骨部位，诱导引发愈合的细胞事件的生长因子; 并且包含第二骨传导性支架部件，所述第二骨传导性支架部件适于容纳并递送至受损的骨骼部位的活的自体成骨细胞和/或血管生成细胞，并且其中所述装置还包含适于促进骨细胞增殖和血管分布的第三支架部件， 为促进骨细胞增殖和血管分布提供稳定的机械环境。 本发明还涉及制造可植入装置的方法。

公开(公告)号：WO2017181164A1

公开(公告)日：2017-10-19

申请号：PCT/US2017/027861

申请日：2017-04-17

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： ORAL, Ebru ,  SUHARDI, Jeremy ,  MURATOGLU, Orhun

IPC: A61F2/02 ,  A61F2/28 ,  A61K35/32

CPC classification number: A61L27/54 ,  A61K35/32 ,  A61L27/3608 ,  A61L27/3683 ,  A61L27/3687 ,  A61L27/3691 ,  A61L27/3821 ,  A61L2300/428 ,  A61L2430/02

Abstract: Systems and methods of protecting allograft against radiation damage are disclosed. Systems and methods of incorporating additives such as radioprotectants into allograft tissue are also disclosed. The systems and methods comprise providing an allograft; cleaning the allograft; contacting the allograft with at least one radioprotectant, thereby obtaining a radioprotectant-doped allograft; contacting the radioprotectant-doped allograft with a supercritical fluid, thereby obtaining a radioprotectant doped and homogenized allograft.

Abstract translation: 公开了保护同种异体移植免受辐射损伤的系统和方法。 还公开了将添加剂如辐射防护剂掺入同种异体移植组织的系统和方法。 该系统和方法包括提供同种异体移植物; 清洗同种异体移植物; 使同种异体移植物与至少一种防辐射剂接触，由此获得辐射防护剂掺杂的同种异体移植物; 使辐射防护剂掺杂的同种异体移植物与超临界流体接触，由此获得辐射防护剂掺杂和同质化的同种异体移植物。

公开(公告)号：WO2017147117A1

公开(公告)日：2017-08-31

申请号：PCT/US2017/018814

申请日：2017-02-22

Applicant: WARSAW ORTHOPEDIC, INC.

Inventor： VICKERS, Scott M.

IPC: A61F2/28 ,  A61B17/70

CPC classification number: A61F2/2846 ,  A61L27/14 ,  A61L27/3608 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/414 ,  A61L2430/38

Abstract: A delivery system comprising an agent and a foldable covering including a first surface disposed with the agent and a second surface connectable with the first surface to intra-operatively dispose the covering in a selected configuration.

Abstract translation: 输送系统包括药剂和可折叠覆盖物，所述覆盖物包括与药剂一起放置的第一表面和可与第一表面连接的第二表面，以手术方式将覆盖物置于选定构型。

公开(公告)号：WO2017066306A1

公开(公告)日：2017-04-20

申请号：PCT/US2016/056617

申请日：2016-10-12

Applicant: BIOLOGICA TECHNOLOGIES

Inventor： GOVIL, Amit, Prakash ,  CHOI, Bryan ,  JALOTA, Sahil

IPC: A61P19/00 ,  A61K38/18 ,  A61F2/18

CPC classification number: A61L27/3834 ,  A61K38/18 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/3683 ,  A61L27/3895 ,  A61L27/54 ,  A61L2300/414 ,  A61L2430/02 ,  A61L2430/38

Abstract: Provided herein are soluble bioactive factor solutions, grafting scaffolds containing the bioactive factor solutions, and methods of making and using the same.

Abstract translation: 本文提供了可溶性生物活性因子溶液，包含生物活性因子溶液的移植支架，以及制备和使用它们的方法。

公开(公告)号：WO2016201185A1

公开(公告)日：2016-12-15

申请号：PCT/US2016/036824

申请日：2016-06-10

Applicant: GLOBUS MEDICAL, INC.

Inventor： KLIMEK, Jennifer ,  BHAT, Archana ,  KUNJACHAN, Vipin ,  GEISLER, Chris ,  ADAMS, Allison ,  GRIMES, Christine

IPC: A61L27/36 ,  A61L27/12

CPC classification number: A61L27/3608 ,  A61F2/28 ,  A61F2/2846 ,  A61F2/4455 ,  A61F2002/2835 ,  A61F2002/4475 ,  A61L27/10 ,  A61L27/12 ,  A61L27/427 ,  A61L27/50 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/412 ,  A61L2430/02 ,  A61L2430/38

Abstract: Biomaterials, implants made therefrom, methods of making the biomaterial and implants, methods of promoting bone or wound healing in a mammal by administering the biomaterial or implant to the mammal, and kits that include such biomaterials, implants, or components thereof. The biomaterials may be designed to exhibit osteogenic, osteoinductive, ostcoconductive, and/or ostcostimulative properties.

Abstract translation: 生物材料，由其制成的植入物，制备生物材料和植入物的方法，通过向哺乳动物施用生物材料或植入物来促进哺乳动物中的骨骼或伤口愈合的方法，以及包括这种生物材料，植入物或其组分的试剂盒。 生物材料可以设计成显示成骨，骨诱导，骨诱导和/或骨刺性质。

公开(公告)号：WO2016187413A1

公开(公告)日：2016-11-24

申请号：PCT/US2016/033246

申请日：2016-05-19

Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATION

Inventor： WANG, David ,  McALLISTER, Michele ,  BUBEAR, Michelle ,  CANALES, Joed ,  CHANG, Amy ,  SHIKHANOVICH, Roman ,  SPILKER, Mark ,  SEMLER, Eric

IPC: A61L27/36

CPC classification number: A61F2/28 ,  A61F2240/001 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/3683 ,  A61L2400/18 ,  A61L2430/02 ,  A61L2430/38

Abstract: Surgical grafts for the repair of bone defects, more particularly, surgical grafts that include demineralized bone fibers, are disclosed. Methods for making such grafts and for increasing their wettability and ensuring uniform density are also disclosed.

Abstract translation: 公开了用于修复骨缺损的手术移植物，更具体地，涉及包括软化骨纤维的手术移植物。 还公开了制备这种移植物并提高其润湿性并确保均匀密度的方法。

公开(公告)号：WO2016175891A1

公开(公告)日：2016-11-03

申请号：PCT/US2015/057839

申请日：2015-10-28

Applicant: CORENMAN, Donald, Steven

Inventor： CORENMAN, Donald, Steven

IPC: A61F2/44 ,  A61L2/07 ,  A61L27/56

CPC classification number: A61F2/4455 ,  A61F2/4644 ,  A61F2002/30476 ,  A61F2002/4646 ,  A61F2310/00359 ,  A61L27/3608 ,  A61L27/3612 ,  A61L27/3658 ,  A61L27/3687 ,  A61L27/3691 ,  A61L2430/24 ,  A61L2430/38

Abstract: The invention provides a method of making a biological disc graft. In one embodiment, the biological disc graft is useful for treating back or neck pain. In one embodiment, the biological disc graft is useful for treating any joint pain. The invention also provides a method of implanting said biological disc graft in a way that is minimally invasive and less dangerous.

Abstract translation: 本发明提供一种制造生物盘移植物的方法。 在一个实施方案中，生物盘移植物可用于治疗背部或颈部疼痛。 在一个实施方案中，生物盘移植物可用于治疗任何关节疼痛。 本发明还提供了一种以最小侵入性和危险性较低的方式植入所述生物盘移植物的方法。

公开(公告)号：WO2016123583A1

公开(公告)日：2016-08-04

申请号：PCT/US2016/015845

申请日：2016-01-29

Applicant: THERACELL, INC.

Inventor： CARTER, Andrew, J. ,  SCARBOROUGH, Nelson, L. ,  SCARBOROUGH, Oliver

IPC: A61B17/86 ,  A61F2/28 ,  A61F2/30 ,  A61F2/46 ,  A61L27/00

CPC classification number: A61F2/30965 ,  A61F2/28 ,  A61F2/3094 ,  A61F2/4601 ,  A61F2002/2835 ,  A61F2002/4627 ,  A61L27/3608 ,  A61L27/365 ,  A61L2430/02

Abstract: A bone repair composition and methods thereof include bone fibers made from cortical bone in which a plurality of bone fibers are made into various implant shapes conducive to introduction into a patient through minimally invasive surgery. The bone fiber compositions may be in the form of a pellet or cylinder. A method includes producing the bone fiber graft efficiently with control of key parameters of cohesiveness, rehydration and swelling of the bone fiber graft. Another method includes introducing the bone fiber graft into the cannula efficiently. A method is also provided to allow introduction of a bone graft into a patient by placing the implant in a tube and expelling it through the action of a plunger.

Abstract translation: 骨修复组合物及其方法包括由皮质骨制成的骨纤维，其中多个骨纤维通过微创手术制成有助于引入患者的各种种植体形状。 骨纤维组合物可以是丸粒或圆柱体的形式。 一种方法包括通过控制骨纤维移植物的内聚性，补液和肿胀的关键参数来有效地生产骨纤维移植物。 另一种方法包括有效地将骨纤维移植物引入套管。 还提供了一种方法，以通过将植入物放置在管中并通过柱塞的作用将骨移植物引入患者体内。

公开(公告)号：WO2016048657A1

公开(公告)日：2016-03-31

申请号：PCT/US2015/049138

申请日：2015-09-09

Applicant: WARSAW ORTHOPEDIC, INC.

Inventor： MCKAY, William F.

IPC: A61F2/28

CPC classification number: A61L27/56 ,  A61L27/10 ,  A61L27/12 ,  A61L27/24 ,  A61L27/3608 ,  A61L27/446 ,  A61L27/46 ,  A61L27/54 ,  A61L2430/02 ,  C08L89/06

Abstract: Osteoinductive and osteoconductive compositions for bone graft which utilize less allograft tissue, and methods for their production, are provided. The compositions and methods contain a combination of fibers of demineralized bone matrix from allograft bone and fibers of non-allograft bone material. The fibers of non-allograft bone material comprise non-fibrous demineralized bone matrix particles embedded within or disposed on the fibers of non-allograft bone material. The non-allograft fibers of the composition contain a bone void filler of collagen and one or more ceramics embedded with demineralized bone matrix particles. In some embodiments, the composition also contains a bioactive agent.

Abstract translation: 提供了利用较少同种异体移植组织的骨移植物的骨诱导和骨传导性组合物及其生产方法。 组合物和方法包含来自同种异体移植骨的脱矿质骨基质纤维和非同种异体骨材料的纤维的组合。 非同种异体移植骨材料的纤维包括非纤维脱矿骨基质颗粒，其嵌入或设置在非同种异体移植骨材料的纤维上。 该组合物的非同种异体移植纤维含有胶原蛋白的骨空隙填充物和一个或多个嵌有软化骨基质颗粒的陶瓷。 在一些实施方案中，组合物还含有生物活性剂。