公开(公告)号：WO2023018972A1

公开(公告)日：2023-02-16

申请号：PCT/US2022/040227

申请日：2022-08-12

Applicant: MEZZION PHARMA CO., LTD. ,  GOLDBERG, David, J. ,  RUSSELL, Mark, W. ,  SCHUMACHER, Kurt, R. ,  YEAGER, James, L.

Inventor： GOLDBERG, David, J. ,  RUSSELL, Mark, W. ,  SCHUMACHER, Kurt, R. ,  YEAGER, James, L.

IPC: A61K31/519 ,  A61P1/16

Abstract: Various methods and compositions for using udenafil, or a pharmaceutical acceptable salt thereof, for improving enhanced liver fibrosis (ELF) score for improving, maintaining/stabilizing, preventing and/or reducing the rate of decline of fibrotic impaired liver function, transforming a fibrotic liver to a less fibrotic liver, maintaining fibrotic liver condition, and/or reversing fibrotic liver condition and function in patients who have fibrotic livers, especially patients having single ventricle heart disease (SVHD) who have undergone Fontan surgery and have Fontan physiology.

公开(公告)号：WO2015020982A3

公开(公告)日：2015-04-16

申请号：PCT/US2014049652

申请日：2014-08-04

Applicant: AQUAVIT PHARMACEUTICALS INC ,  CHANG SOBIN ,  GOLDBERG DAVID J ,  SHAFER DAVID ,  WEINSTEIN MICHAEL A

Inventor： CHANG SOBIN ,  GOLDBERG DAVID J ,  SHAFER DAVID ,  WEINSTEIN MICHAEL A

IPC: A61K38/45 ,  A61K38/47

CPC classification number: A61K39/08 ,  A61J1/065 ,  A61J1/1418 ,  A61J2205/60 ,  A61K8/99 ,  A61K9/0021 ,  A61K9/08 ,  A61K2800/91 ,  A61L27/20 ,  A61L27/54 ,  A61L2400/06 ,  A61M5/20 ,  A61M5/30 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2205/3553 ,  A61M2205/505 ,  A61M2205/6054 ,  A61Q19/08 ,  B65B3/003 ,  G06F19/3462 ,  G06F19/3468 ,  C08L5/08

Abstract: The embodiments relate to improved skin quality, health and appearance using a new delivery method and certain bioactive compositions and formulations. The system incorporates microneedle delivery technology with unique compositions and formulations. Such development allows for the pursuit of personalized medicine, or treatment delivery that can expand to remote controlled environment, immediate compounding and ultimate personalization with a state of the art longitudinal data predictive analytics. Certain formulations described herein are unique, combinatory and synergistic. Secured by high-tech proprietary system, there are unlimited potentials using AQT technology including but not limited to 3-D printing of a biodegradable micro chips that can be delivered via injection, AQT or any other possible route.

Abstract translation: 实施方案涉及使用新的递送方法和某些生物活性组合物和制剂来改善皮肤质量，健康和外观。 该系统采用具有独特组成和配方的微针输送技术。 这种发展允许追求个性化医学，或者通过最先进的纵向数据预测分析来扩展到远程控制环境，立即复合和最终个性化的治疗传递。 本文描述的某些制剂是独特的，组合的和协同的。 通过高科技专有系统保证，使用AQT技术具有无限的潜力，包括但不限于可通过注射，AQT或任何其他可能途径输送的可生物降解的微芯片的3-D印刷。

公开(公告)号：WO2015020982A2

公开(公告)日：2015-02-12

申请号：PCT/US2014/049652

申请日：2014-08-04

Applicant: AQUAVIT PHARMACEUTICALS, INC. ,  CHANG, Sobin ,  GOLDBERG, David, J. ,  SHAFER, David ,  WEINSTEIN, Michael, A.

Inventor： CHANG, Sobin ,  GOLDBERG, David, J. ,  SHAFER, David ,  WEINSTEIN, Michael, A.

IPC: A61K39/08

CPC classification number: A61K39/08 ,  A61J1/065 ,  A61J1/1418 ,  A61J2205/60 ,  A61K8/99 ,  A61K9/0021 ,  A61K9/08 ,  A61K2800/91 ,  A61L27/20 ,  A61L27/54 ,  A61L2400/06 ,  A61M5/20 ,  A61M5/30 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2205/3553 ,  A61M2205/505 ,  A61M2205/6054 ,  A61Q19/08 ,  B65B3/003 ,  G06F19/00 ,  G06F19/3462 ,  G06F19/3468 ,  C08L5/08

Abstract: The embodiments relate to improved skin quality, health and appearance using a new delivery method and certain bioactive compositions and formulations. The system incorporates microneedle delivery technology with unique compositions and formulations. Such development allows for the pursuit of personalized medicine, or treatment delivery that can expand to remote controlled environment, immediate compounding and ultimate personalization with a state of the art longitudinal data predictive analytics. Certain formulations described herein are unique, combinatory and synergistic. Secured by high-tech proprietary system, there are unlimited potentials using AQT technology including but not limited to 3-D printing of a biodegradable micro chips that can be delivered via injection, AQT or any other possible route.

Abstract translation: 实施方案涉及使用新的递送方法和某些生物活性组合物和制剂来改善皮肤质量，健康和外观。 该系统采用具有独特组成和配方的微针输送技术。 这种发展允许追求个性化医学，或者通过最先进的纵向数据预测分析来扩展到远程控制环境，立即复合和最终个性化的治疗传递。 本文描述的某些制剂是独特的，组合的和协同的。 通过高科技专有系统保证，使用AQT技术具有无限的潜力，包括但不限于可通过注射，AQT或任何其他可能途径输送的可生物降解的微芯片的3-D印刷。