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    A PROCESS FOR EFFICIENT CROSS-LINKING OF HYALURONIC ACID
    2.
    发明申请
    A PROCESS FOR EFFICIENT CROSS-LINKING OF HYALURONIC ACID 审中-公开
    一种有效交联羟丙酸的方法

    公开(公告)号：WO2017016917A1

    公开(公告)日：2017-02-02

    申请号：PCT/EP2016/067072

    申请日：2016-07-18

    申请人： GALDERMA SA

    发明人： KARLSSON, Morgan

    IPC分类号： A61K8/73 ,  C08B37/08 ,  A61K31/728 ,  A61K47/36 ,  C08L5/08

    CPC分类号： A61K31/728 ,  A61K8/735 ,  A61K9/06 ,  A61K47/36 ,  A61K2800/91 ,  A61Q19/08 ,  C08B37/0072 ,  C08L5/08

    摘要： A process for manufacturing a cross-linked hyaluronic acid (HA) gel product is comprising the steps of: (a) preparing an aqueous mixture of HA and a cross-linking agent selected from multiepoxides and diepoxides; wherein the HA is dissolved in an aqueous solution containing 1-10 % (w/w) inorganic hydroxide; and wherein the dissolved HA constitutes more than 10 % (w/w) of the final mixture; and (b) subjecting the aqueous mixture to cross-linking conditions to allow the dissolved HA to react with the cross-linking agent so as to obtain a cross-linked HA gel product.

    摘要翻译： 制备交联透明质酸（HA）凝胶产品的方法包括以下步骤：（a）制备HA和选自多环氧化物和二环氧化物的交联剂的水性混合物; 其中HA溶解在含有1-10％（w / w）无机氢氧化物的水溶液中; 并且其中所述溶解的HA构成所述最终混合物的10％（w / w）以上; 和（b）使含水混合物进行交联条件以使溶解的HA与交联剂反应，以获得交联的HA凝胶产物。

    PROCESS FOR PREPARING HYDROGELS
    4.
    发明申请
    PROCESS FOR PREPARING HYDROGELS 审中-公开
    制备水凝胶的方法

    公开(公告)号：WO2016096920A1

    公开(公告)日：2016-06-23

    申请号：PCT/EP2015/079889

    申请日：2015-12-15

    申请人： TEOXANE

    发明人： BOURDON, François ,  MEUNIER, Stéphane

    IPC分类号： A61K8/73 ,  A61L27/20 ,  A61K8/04 ,  C08B37/08 ,  C08L5/08 ,  A61Q19/08 ,  A61K31/728

    CPC分类号： A61L27/52 ,  A61K8/042 ,  A61K8/24 ,  A61K8/735 ,  A61K9/06 ,  A61K31/728 ,  A61K2800/91 ,  A61L27/20 ,  A61L2400/06 ,  A61L2430/16 ,  A61L2430/24 ,  A61Q11/00 ,  A61Q19/08 ,  C08B37/0072 ,  C08L5/08

    摘要： The present invention relates to a process for preparing a crosslinked gel of at least one polysaccharide or a salt thereof, comprising at least the steps consisting in: a) providing a solution formed from an aqueous medium comprising at least said polysaccharide(s) or a salt thereof in a non-crosslinked form, at least one difunctional or multifunctional epoxide crosslinking agent chosen from butanediol diglycidyl ether, diepoxyoctane, l,2-bis(2,3-epoxypropyl)-2,3-ethylene, and mixtures thereof, and at least one phosphate salt; b) crosslinking the solution from step a) and, where appropriate; c) recovering said crosslinked gel formed.

    摘要翻译： 本发明涉及一种制备至少一种多糖或其盐的交联凝胶的方法，至少包括以下步骤：a）提供由包含至少所述多糖的水性介质形成的溶液或 非交联形式的盐，至少一种选自丁二醇二缩水甘油醚，二环氧辛烷，1,2-双（2,3-环氧丙基）-2,3-亚乙基及其混合物的二官能或多官能环氧交联剂，以及 至少一种磷酸盐; b）使来自步骤a）的溶液交联，并在适当的情况下交联; c）回收形成的所述交联凝胶。

    COMPOSITION FOR IMPROVING THE APPEARANCE OF AGEING SKIN
    7.
    发明申请
    COMPOSITION FOR IMPROVING THE APPEARANCE OF AGEING SKIN 审中-公开
    用于改善老化皮肤外观的组合物

    公开(公告)号：WO2015158815A2

    公开(公告)日：2015-10-22

    申请号：PCT/EP2015/058254

    申请日：2015-04-16

    申请人： MERZ PHARMA GMBH & CO. KGAA

    发明人： OTTO, Sabine ,  POOTH, Rainer

    IPC分类号： A61K8/24

    CPC分类号： A61K8/735 ,  A61K8/19 ,  A61K8/24 ,  A61K8/42 ,  A61K8/60 ,  A61K8/731 ,  A61K8/85 ,  A61K8/965 ,  A61K2800/41 ,  A61K2800/91 ,  A61Q19/08

    摘要： A liquid composition for improving the facial contour and shape of the human or animal face by injection, the liquid composition comprising water and at least one of the following components A, B and C: at least one component A, which leads to an osmotic concentration in the range from 500 to 5000 mOsm in the liquid composition, at least one high viscosity component B, which leads to a viscosity of the liquid composition in the range from 10 to 1500 mPas, at least one micro-particles component C, comprising micro-particles with an average particle size not larger than 0.25 mm, preferably in the range of 0.001 mm to 0.25 mm, and optionally comprising a local anesthetic compound D.

    摘要翻译： 一种用于通过注射改善人或动物面部的面部轮廓和形状的液体组合物，所述液体组合物包含水和至少一种以下组分A，B和C：至少一种组分A，其导致渗透浓度 在液体组合物中在500至5000mOsm范围内的至少一种高粘度组分B，其导致液体组合物的粘度在10至1500mPas的范围内，至少一种微粒组分C包含微量 平均粒径不大于0.25mm，优选在0.001mm至0.25mm范围内的颗粒，并且任选地包含局部麻醉剂化合物D.

    METHODS AND COMPOSITIONS FOR ENHANCING AND EXTENDING THE COSMETIC EFFECTS OF NON-SURGICAL DERMAL INTERVENTIONS
    8.
    发明申请
    METHODS AND COMPOSITIONS FOR ENHANCING AND EXTENDING THE COSMETIC EFFECTS OF NON-SURGICAL DERMAL INTERVENTIONS 审中-公开
    用于增强和延长非手术干预措施的化妆效果的方法和组合

    公开(公告)号：WO2015153377A1

    公开(公告)日：2015-10-08

    申请号：PCT/US2015/023183

    申请日：2015-03-27

    申请人： HACK, Gary, D. ,  ENHANCE SKIN PRODUCTS, INC.

    发明人： HACK, Gary, D. ,  ASCULAI, Samuel, S.

    IPC分类号： A61K31/728

    CPC分类号： A61K8/25 ,  A61K8/0241 ,  A61K8/64 ,  A61K8/735 ,  A61K2800/413 ,  A61K2800/91 ,  A61Q19/08

    摘要： The present invention relates to methods for enhancing, extending and accelerating the cosmetic benefits certain non-surgical dermal interventions, examples of which include treatment with aesthetic injectables such as botulinum toxin and dermal fillers, as well as intense pulsed light (IPL) treatments, particularly cosmetic treatments characterized by the injection of botulinum toxin compositions, such as Botox® and Dysport®, and/or dermal fillers, such as Restylane® and Juviderm®. More particularly, the present invention relates to the unexpected discovery that the combination of micron-sized particulate bioactive glass and medical grade hyaluronic acid yields a cosmetic composition that is capable of improving and prolonging the anti-wrinkle effects of such cosmetic therapies as well as to afford enhanced and improved healing and anti-microbial benefits at the site(s) of injection.

    摘要翻译： 本发明涉及用于增强，延伸和加速美容效果的某些非手术皮肤干预的方法，其实例包括用美容注射剂如肉毒毒素和皮肤填充剂的治疗以及强烈的脉冲光（IPL）治疗，特别是 其特征在于注射肉毒杆菌毒素组合物，例如Botox和Dysport，和/或皮肤填充剂如Restylane和Juviderm。 更具体地，本发明涉及意想不到的发现，即微米级颗粒生物活性玻璃和医用级透明质酸的组合产生能够改善和延长这种美容治疗的抗皱作用的化妆品组合物，以及 在注射部位提供增强和改善的愈合和抗微生物益处。

    필러의 효능 유지용 조성물
    10.
    发明申请
    필러의 효능 유지용 조성물 审中-公开
    维持填料效率的组合物

    公开(公告)号：WO2015141978A1

    公开(公告)日：2015-09-24

    申请号：PCT/KR2015/002294

    申请日：2015-03-10

    申请人： (주)아모레퍼시픽

    发明人： 신현정 ,  최진규 ,  김병규 ,  서대방

    IPC分类号： A61L27/24 ,  A61K38/39 ,  A61K8/65

    CPC分类号： A61K8/65 ,  A61K2800/91 ,  A61L27/26 ,  A61L27/50 ,  A61L2400/06 ,  A61L2430/34 ,  A61Q19/08 ,  C08L5/08 ,  C08L89/06

    摘要： 본 발명은 콜라겐 가수분해물을 유효성분으로 포함하여 필러의 효능을 장기간 유지시키는 비경구 조성물에 관한 것이다. 본 발명에 의한 조성물은 히알루론산 필러 효능을 보다 장시간 유지시킬 수 있으므로, 보다 적은 횟수로 필러를 시술하여도 그 효과가 유지될 수 있어서 피부 자극 역시 줄어든다는 장점이 있다. 아울러 비경구 투여로 투여 방법이 간단하고 피부에 직접적으로 침투할 수 있어서, 즉각적인 효과가 가능하다는 장점이 있다.

    摘要翻译： 本发明涉及一种肠胃外组合物，其用于长期维持填充剂的功效，其含有胶原蛋白水解产物作为活性成分。 根据本发明的组合物可以保持更长时间的透明质酸填充剂的功效，从而能够保持其效果，而不管填充剂操作的频率更小，因此还具有还可以减少皮肤的优点 刺激。 此外，由于施用方法作为肠胃外给药是简单的并且能够直接渗透到皮肤中，因此具有即时效果的优点。