公开(公告)号：WO2010132765A9

公开(公告)日：2011-10-13

申请号：PCT/US2010034893

申请日：2010-05-14

Applicant: ACHAOGEN INC ,  DOZZO PAOLA ,  GOLDBLUM ADAM AARON ,  AGGEN JAMES BRADLEY ,  LINSELL MARTIN SHERINGHAM

Inventor： DOZZO PAOLA ,  GOLDBLUM ADAM AARON ,  AGGEN JAMES BRADLEY ,  LINSELL MARTIN SHERINGHAM

IPC: C07H15/236 ,  A61K31/7036 ,  A61P31/04

CPC classification number: C07H15/236

Abstract: Antibacterial compounds of structures (I) and (II) are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2, R3, R11 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了结构（I）和（II）的抗菌化合物，包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，Q3，R1，R2，R3，R11如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

公开(公告)号：WO2011044502A1

公开(公告)日：2011-04-14

申请号：PCT/US2010/052044

申请日：2010-10-08

Applicant: ACHAOGEN, INC. ,  DOZZO, Paola ,  GOLDBLUM, Adam Aaron ,  AGGEN, James Bradley

Inventor： DOZZO, Paola ,  GOLDBLUM, Adam Aaron ,  AGGEN, James Bradley

IPC: C07H15/232 ,  A61K31/7036 ,  A61P31/04

CPC classification number: C07H15/232

Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q 1 , Q 2 , R 1 , R 2 and R 3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，R1，R2和R3如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

公开(公告)号：WO2011031740A1

公开(公告)日：2011-03-17

申请号：PCT/US2010/048104

申请日：2010-09-08

Applicant: ACHAOGEN, INC. ,  WAGMAN, Allan, Scott ,  MOSER, Heinz, Ernst ,  MCENROE, Glenn, A. ,  AGGEN, James, Bradley ,  LINSELL, Martin, Sheringham ,  GOLDBLUM, Adam, Aaron ,  SIMONS, Lloyd, J. ,  BELLIOTTI, Thomas, R. ,  HARRIS, Christina, R. ,  POEL, Toni-Jo ,  MELNICK, Michael, J. ,  GASTON, Ricky, D. ,  GRIFFIN, John, H.

Inventor： WAGMAN, Allan, Scott ,  MOSER, Heinz, Ernst ,  MCENROE, Glenn, A. ,  AGGEN, James, Bradley ,  LINSELL, Martin, Sheringham ,  GOLDBLUM, Adam, Aaron ,  SIMONS, Lloyd, J. ,  BELLIOTTI, Thomas, R. ,  HARRIS, Christina, R. ,  POEL, Toni-Jo ,  MELNICK, Michael, J. ,  GASTON, Ricky, D. ,  GRIFFIN, John, H.

IPC: C07D471/14 ,  C07D491/14 ,  A61K31/4353 ,  A61P31/04

CPC classification number: C07D471/14 ,  C07D491/14

Abstract: Compounds having antibacterial activity are disclosed. The compounds have one of the following structures (I) or (II): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein A, B, D, E, G, W, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了具有抗菌活性的化合物。 所述化合物具有以下结构（I）或（II）之一：其包括立体异构体，其药学上可接受的盐和前药，其中A，B，D，E，G，W，R 1，R 2，R 3，R 4，R 5，R 6 和R7如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

公开(公告)号：WO2010132765A2

公开(公告)日：2010-11-18

申请号：PCT/US2010034893

申请日：2010-05-14

Applicant: ACHAOGEN INC ,  DOZZO PAOLA ,  GOLDBLUM ADAM AARON ,  AGGEN JAMES BRADLEY ,  LINSELL MARTIN SHERINGHAM

Inventor： DOZZO PAOLA ,  GOLDBLUM ADAM AARON ,  AGGEN JAMES BRADLEY ,  LINSELL MARTIN SHERINGHAM

IPC: C07H15/224

CPC classification number: C07H15/236

Abstract: Antibacterial compounds of structures (I) and (II) are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2, R3, R11 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了结构（I）和（II）的抗菌化合物，包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，Q3，R1，R2，R3，R11如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

公开(公告)号：WO2009067692A1

公开(公告)日：2009-05-28

申请号：PCT/US2008/084399

申请日：2008-11-21

Applicant: ACHAOGEN, INC. ,  AGGEN, James ,  GOLDBLUM, Adam, Aaron ,  LINSELL, Martin ,  DOZZO, Paola ,  MOSER, Heinz, Ernst ,  HILDEBRANDT, Darin ,  GLIEDT, Micah

Inventor： AGGEN, James ,  GOLDBLUM, Adam, Aaron ,  LINSELL, Martin ,  DOZZO, Paola ,  MOSER, Heinz, Ernst ,  HILDEBRANDT, Darin ,  GLIEDT, Micah

IPC: C07H15/222 ,  A61K31/7036 ,  A61P31/04

CPC classification number: C07H15/224 ,  A61K31/7036 ,  C07H15/222 ,  C07H15/236 ,  Y02A50/473

Abstract: Compounds of structure (I): having antibacterial activity are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q 1 , Q 2 , Q 3 , R 8 and R 9 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了具有抗菌活性的结构（I）的化合物，包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，Q3，R8和R9如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

公开(公告)号：WO2010132768A9

公开(公告)日：2011-09-15

申请号：PCT/US2010034896

申请日：2010-05-14

Applicant: ACHAOGEN INC ,  DOZZO PAOLA ,  GOLDBLUM ADAM AARON ,  AGGEN JAMES BRADLEY ,  LINSELL MARTIN SHERINGHAM

Inventor： DOZZO PAOLA ,  GOLDBLUM ADAM AARON ,  AGGEN JAMES BRADLEY ,  LINSELL MARTIN SHERINGHAM

IPC: C07H15/236 ,  A61K31/7036 ,  A61P31/04

CPC classification number: C07H15/236

Abstract: Antibacterial compounds of structure (I) are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R11 and R12 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了结构（I）的抗菌化合物，包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，Q3，R11和R12如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

公开(公告)号：WO2011044538A9

公开(公告)日：2011-04-14

申请号：PCT/US2010/052109

申请日：2010-10-08

Applicant: ACHAOGEN, INC. ,  AGGEN, James, Bradley ,  DOZZO, Paola ,  GOLDBLUM, Adam, Aaron ,  HILDEBRANDT, Darin, James ,  KANE, Timothy, Robert ,  GLIEDT, Micah, James ,  LINSELL, Martin, Sheringham

Inventor： AGGEN, James, Bradley ,  DOZZO, Paola ,  GOLDBLUM, Adam, Aaron ,  HILDEBRANDT, Darin, James ,  KANE, Timothy, Robert ,  GLIEDT, Micah, James ,  LINSELL, Martin, Sheringham

IPC: C07H15/232 ,  A61K31/7036 ,  A61P31/04

Abstract: Compounds having antibacterial activity are disclosed. The compounds have one of the following structures (I) or (II): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q 1 , Q 2 , R 1 , R 2 , R 3 and Z 1 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

公开(公告)号：WO2011044498A1

公开(公告)日：2011-04-14

申请号：PCT/US2010052040

申请日：2010-10-08

Applicant: ACHAOGEN INC ,  MAIANTI JUAN PABLO ,  AGGEN JAMES BRADLEY ,  DOZZO PAOLA ,  GOLDBLUM ADAM AARON ,  HILDEBRANDT DARIN JAMES ,  KANE TIMOTHY ROBERT ,  GLIEDT MICAH JAMES ,  LINSELL MARTIN SHERINGHAM ,  HANESSIAN STEPHEN ,  GIGUERE ALEXANDRE

Inventor： MAIANTI JUAN PABLO ,  AGGEN JAMES BRADLEY ,  DOZZO PAOLA ,  GOLDBLUM ADAM AARON ,  HILDEBRANDT DARIN JAMES ,  KANE TIMOTHY ROBERT ,  GLIEDT MICAH JAMES ,  LINSELL MARTIN SHERINGHAM ,  HANESSIAN STEPHEN ,  GIGUERE ALEXANDRE

IPC: C07H15/232 ,  A61K31/7036 ,  A61P31/04

CPC classification number: C07H15/232

Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I): (Formula (I)), including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了具有抗菌活性的化合物。 该化合物具有以下结构（I）：（式（I）），其包括立体异构体，其药学上可接受的盐和前药，其中Q1，Q2，R1，R2，R3，Z1和Z2如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。

公开(公告)号：WO2010132757A3

公开(公告)日：2011-02-24

申请号：PCT/US2010034884

申请日：2010-05-14

Applicant: ACHAOGEN INC ,  GOLDBLUM ADAM AARON ,  DOZZO PAOLA ,  AGGEN JAMES BRADLEY ,  LINSELL MARTIN SHERINGHAM

Inventor： GOLDBLUM ADAM AARON ,  DOZZO PAOLA ,  AGGEN JAMES BRADLEY ,  LINSELL MARTIN SHERINGHAM

IPC: C07D407/12 ,  A61K31/351 ,  A61K31/397 ,  A61P31/04 ,  C07D407/14

CPC classification number: C07H15/234

Abstract: Compounds having antibacterial activity are disclosed. The compounds have the following structure (I) or (II): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q3, R1, R2 and R3 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

Abstract translation: 公开了具有抗菌活性的化合物。 所述化合物具有以下结构（I）或（II）：包括其立体异构体，药学上可接受的盐和前药，其中Q1，Q2，Q3，R1，R2和R3如本文所定义。 还公开了与这些化合物的制备和使用有关的方法，以及包含这些化合物的药物组合物。

公开(公告)号：WO2010132765A3

公开(公告)日：2010-11-18

申请号：PCT/US2010/034893

申请日：2010-05-14

Applicant: ACHAOGEN, INC. ,  DOZZO, Paola ,  GOLDBLUM, Adam, Aaron ,  AGGEN, James, Bradley ,  LINSELL, Martin, Sheringham

Inventor： DOZZO, Paola ,  GOLDBLUM, Adam, Aaron ,  AGGEN, James, Bradley ,  LINSELL, Martin, Sheringham

IPC: C07H15/236 ,  A61K31/7036 ,  A61P31/04

Abstract: Antibacterial compounds of structures (I) and (II) are disclosed, including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q 1 , Q 2 , Q 3 , R 1 , R 2 , R 3 , R 11 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.