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公开(公告)号：WO2013027055A1
公开(公告)日：2013-02-28
申请号：PCT/GB2012/052054
申请日：2012-08-22
申请人： MICROMASS UK LIMITED , GILES, Kevin , GREEN, Martin Raymond , KENNY, Daniel James , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
发明人： GILES, Kevin , GREEN, Martin Raymond , KENNY, Daniel James , LANGRIDGE, David J. , WILDGOOSE, Jason Lee
IPC分类号： H01J49/42
CPC分类号： H01J49/4285 , H01J49/0031 , H01J49/062 , H01J49/063 , H01J49/40 , H01J49/422
摘要： A mass or mass to charge ratio selective ion trap is disclosed which directs ions into a small ejection region. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC or RF voltage acts to confine ions in a second (x) direction. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. The profile of the quadratic DC potential well progressively varies along the second (x) direction.
摘要翻译： 公开了将离子引导到小的喷射区域中的质量或质量比选择性离子阱。 RF电压用于将离子限制在离子阱内的第一（y）方向。 DC或RF电压用于将离子限制在第二（x）方向。 二次直流势阱用于将离子限制在离子阱内的第三（z）方向。 二次直流电势的曲线沿着第二（x）方向逐渐变化。
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公开(公告)号：WO2013027054A2
公开(公告)日：2013-02-28
申请号：PCT/GB2012052053
申请日：2012-08-22
申请人： MICROMASS LTD , GILES KEVIN , GREEN MARTIN RAYMOND , KENNY DANIEL JAMES , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
发明人： GILES KEVIN , GREEN MARTIN RAYMOND , KENNY DANIEL JAMES , LANGRIDGE DAVID J , WILDGOOSE JASON LEE
IPC分类号： H01J49/42
CPC分类号： H01J49/424 , H01J49/421 , H01J49/422 , H01J49/4285
摘要： A mass or mass to charge ratio selective ion trap is disclosed having an increased charge storage capacity. A RF voltage acts to confine ions in a first (y) direction within the ion trap. A DC voltage and/or an RF voltage acts to confine ions in a second (x) direction within the ion trap. A quadratic DC potential well acts to confine ions in a third (z) direction within the ion trap. Ions are excited in the third (z) direction and are caused to be mass or mass to charge ratio selectively ejected in the third (z) direction.
摘要翻译： 公开的具有增加的电荷存储容量的质量或质荷比选择离子阱。 RF电压用于在离子阱内的第一（y）方向上限制离子。 直流电压和/或RF电压用于在离子阱内的第二（x）方向上限制离子。 二次直流势阱用于在离子阱内的第三（z）方向上限制离子。 离子在第三（z）方向上被激发，并且导致质量或质荷比选择性地在第三（z）方向上喷射。
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公开(公告)号：WO2012123730A2
公开(公告)日：2012-09-20
申请号：PCT/GB2012/050545
申请日：2012-03-13
CPC分类号： H01J49/36 , G01N27/624 , H01J49/06 , H01J49/42 , H01J49/426
摘要： An ion mobility separator or spectrometer is disclosed comprising an inner cylinder (2) and an outer cylinder (1). The inner cylinder (2) and the outer cylinder (1) define an annular volume (3) through which ions are transmitted. One or more spiral electrodes a-f are arranged on a surface of the inner cylinder (2) and/or on a surface of the outer cylinder (1). A first device is arranged and adapted to maintain a DC electric field and/or a pseudo- potential force which acts to urge ions from a first end of the ion mobility separator or spectrometer to a second end of the ion mobility separator or spectrometer. A second device is arranged and adapted to apply one or more transient DC voltages to the one or more spiral electrodes in order to urge ions towards the first end of the ion mobility separator or spectrometer. The net effect is to extend the effective path length of the ion mobility separator.
摘要翻译： 公开了一种离子迁移率分离器或光谱仪，其包括内筒（2）和外筒（1）。 内筒（2）和外筒（1）限定了一个环形体积（3），离子通过该环体积传递。 一个或多个螺旋形电极a-f布置在内筒（2）的表面和/或外筒（1）的表面上。 第一装置被布置并适于维持DC电场和/或伪电势力，其作用是将离子从离子迁移率分离器或光谱仪的第一端促进到离子迁移率分离器或光谱仪的第二端。 第二装置被布置并适于将一个或多个瞬态DC电压施加到所述一个或多个螺旋电极，以促使离子朝向离子迁移率分离器或光谱仪的第一端。 净效应是延长离子迁移率分离器的有效路径长度。
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公开(公告)号：WO2012123729A2
公开(公告)日：2012-09-20
申请号：PCT/GB2012050544
申请日：2012-03-13
CPC分类号： H01J49/065 , G01N27/622 , H01J49/0031 , H01J49/022 , H01J49/062 , H01J49/063 , H01J49/36
摘要： A mass spectrometer is disclosed comprising a RF ion guide wherein in a mode of operation a continuous, quasi-continuous or pulsed beam of ions is orthogonally sampled from the ion guide and wherein the continuous, quasi-continuous or pulsed beam of ions is not axially trapped or otherwise axially confined within the RF ion guide. The ion guide is maintained, in use, at a pressure selected from the group consisting of: (i) 0.0001 -0.001 mbar; (ii) 0.001 -0.01 mbar; (iii) 0.01 -0.1 mbar; (iv) 0.1 -1 mbar; (v) 1 -10 mbar; (vi) 10-100 mbar; and (vii) > 100 mbar.
摘要翻译： 公开了一种质谱仪，其包括RF离子导向器，其中在操作模式中，连续的，准连续的或脉冲的离子束从离子导向器正交地采样，并且其中连续的，准连续的或脉冲的离子束不轴向 被捕获或以其它方式轴向限制在RF离子导向器内。 离子导向器在使用中以选自以下的压力保持：（i）0.0001 -0.001毫巴; （ii）0.001 -0.01毫巴; （iii）0.01 -0.1毫巴; （iv）0.1-1毫巴; （v）1 -10 mbar; （vi）10-100毫巴; 和（vii）> 100mbar。
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公开(公告)号：WO2012056239A1
公开(公告)日：2012-05-03
申请号：PCT/GB2011/052085
申请日：2011-10-26
CPC分类号： H01J49/04 , G01N27/622 , H01J49/0031 , H01J49/36 , H01J49/422
摘要： A linear ion trap is disclosed wherein an asymmetric voltage waveform is applied to electrodes forming the ion trap which causes ions to become radially separated according to their differential ion mobility. An axial potential barrier is arranged at the exit of the ion trap such that ions having a first differential ion mobility and a first radial displacement are retained axially within the ion trap but ions having a second differential ion mobility and a second radial displacement are ejected axially from the ion trap.
摘要翻译： 公开了一种线性离子阱，其中对形成离子阱的电极施加不对称电压波形，这导致离子根据其离子迁移率的差异而径向分离。 轴向势垒布置在离子阱的出口处，使得具有第一差分离子迁移率和第一径向位移的离子轴向保留在离子阱内，但具有第二差分离子迁移率和第二径向位移的离子被轴向地排出 离子阱。
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公开(公告)号：WO2009127808A8
公开(公告)日：2011-04-28
申请号：PCT/GB2009000902
申请日：2009-04-03
CPC分类号： H01J49/28 , H01J49/0072 , H01J49/065
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.
摘要翻译： 公开了一种质谱仪，其包括电子转移离解装置，其包括离子导向器。 控制系统确定离子导向器内的前体离子的碎裂和电荷减少的程度，并且改变离子通过离子导向器传输的速度，以便优化碎裂和电荷还原过程。
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公开(公告)号：WO2010136765A1
公开(公告)日：2010-12-02
申请号：PCT/GB2010/001052
申请日：2010-05-28
申请人： MICROMASS UK LIMITED , GREEN, Martin, Raymond , SCOTT, Garry, Michael , ST HILL, Nicholas, Lester
IPC分类号： H01J49/00
CPC分类号： H01J49/0036 , G06K9/0053 , H01J49/40
摘要： A method of processing mass spectral data is disclosed comprising digitising a first signal output from an ion detector to produce a first digitised signal. A first set of peaks in the first digitised signal is detected and the arrival time T o and peak area S o of one or more peaks in the first set of peaks are determined thereby forming a first list of data pairs, each data pair comprising an arrival time value and a peak area value. One or more data pairs from the first list are then filtered out thereby forming a second reduced list, wherein a data pair is filtered out, attenuated or otherwise rejected from the first list if the peak area value of a data pair in the first list is determined to be less than a threshold peak area.
摘要翻译： 公开了一种处理质谱数据的方法，包括数字化从离子检测器输出的第一信号以产生第一数字化信号。 检测第一数字化信号中的第一组峰值，并确定第一组峰值中的一个或多个峰值的到达时间To和峰值面积So，从而形成第一数据对列表，每个数据对包括到达时间 值和峰面积值。 然后将来自第一列表的一个或多个数据对过滤掉，从而形成第二缩减列表，其中如果第一列表中的数据对的峰值面积值是第一列表中的峰值面积值，则数据对被滤除，衰减或以其他方式从第一列表中被拒绝 确定为小于阈值峰面积。
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公开(公告)号：WO2009030900A3
公开(公告)日：2010-03-11
申请号：PCT/GB2008002981
申请日：2008-09-03
CPC分类号： H01J49/06 , H01J49/0031 , H01J49/004 , H01J49/025 , H01J49/26 , H01J49/4265 , H01J49/427
摘要： A mass spectrometer is disclosed comprising a first storage ion trap (2) arranged upstream of a high performance analytical ion trap (3). According to an embodiment ions are simultaneously scanned from both the first and second ion trap (2, 3). At any instant in time the quantity of charge present within the second ion trap (3) is limited or restricted so that the second ion trap (3) does not suffer from space charge saturation effects and hence the performance of the second ion trap (3) is not degraded.
摘要翻译： 公开了一种质谱仪，其包括设置在高性能分析离子阱（3）上游的第一存储离子阱（2）。 根据一个实施例，离子同时从第一和第二离子阱（2,3）扫描。 在任何时刻，存在于第二离子阱（3）内的电荷量被限制或限制，使得第二离子阱（3）不会受到空间电荷饱和效应的影响，因此第二离子阱（3）的性能 ）没有退化。
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公开(公告)号：WO2009066089A3
公开(公告)日：2009-11-26
申请号：PCT/GB2008003918
申请日：2008-11-24
IPC分类号： H01J49/00
CPC分类号： H01J49/065 , H01J49/0072
摘要： An ion-ion reaction cell is provided comprising a plurality of electrodes (1) forming an ion guide (2). One or more transient DC voltage waves (8, 9) are applied to the electrodes (2). Reagent anions and analyte cations are arranged to undergo ion-ion reactions within the reaction cell and the resulting fragment ions which are formed within the reaction cell are then subsequently translated out of the reaction cell by means of one or more transient DC voltage waves (8, 9).
摘要翻译： 提供离子离子反应池，其包括形成离子导向器（2）的多个电极（1）。 一个或多个瞬态DC电压波（8,9）被施加到电极（2）。 试剂阴离子和分析物阳离子排列成在反应池内进行离子 - 离子反应，然后在反应池内形成的所得碎片离子随后通过一个或多个瞬态直流电压波（8 ，9）。
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公开(公告)号：WO2009127808A2
公开(公告)日：2009-10-22
申请号：PCT/GB2009/000902
申请日：2009-04-03
CPC分类号： H01J49/28 , H01J49/0072 , H01J49/065
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation device comprising an ion guide. A control system determines the degree of fragmentation and charge reduction of precursor ions within the ion guide and varies the speed at which ions are transmitted through the ion guide in order to optimise the fragmentation and charge reduction process.
摘要翻译： 公开了一种质谱仪，其包括电子转移离解装置，其包括离子导向器。 控制系统确定离子导向器内的前体离子的碎裂和电荷减少的程度，并且改变离子通过离子导向器传输的速度，以便优化碎裂和电荷还原过程。
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