SENTINEL SIGNAL FOR ADAPTIVE RETENTION TIME IN TARGETED MS METHODS
    2.
    发明申请
    SENTINEL SIGNAL FOR ADAPTIVE RETENTION TIME IN TARGETED MS METHODS 审中-公开
    SENTINEL信号在靶向MS方法中的自适应保留时间

    公开(公告)号:WO2017093861A1

    公开(公告)日:2017-06-08

    申请号:PCT/IB2016/057083

    申请日:2016-11-24

    Inventor: LEMOINE, Jerome

    CPC classification number: H01J49/0045 H01J49/0031

    Abstract: A plurality of MRM transitions to be used to monitor a sample are received and divided into two or more contiguous groups. At least one sentinel transition is selected in each group that identifies a next group of the two or more contiguous groups that is to be monitored. A first group of the two or more contiguous groups is placed on a duty cycle list of the tandem mass spectrometer. One or more compounds are separated from the sample and ionized, producing an ion beam. A series of MRM transitions read from the duty cycle list are executed on the ion beam by the tandem mass spectrometer. When at least one sentinel transition of the first group is detected, a next group identified by the sentinel transition is placed on the list.

    Abstract translation: 接收用于监测样品的多个MRM转变并将其分成两个或更多个连续的组。 在每个组中选择至少一个标识转换,标识要被监视的两个或更多个连续组的下一个组。 两个或多个连续组的第一组被放置在串联质谱仪的占空比列表上。 从样品中分离出一种或多种化合物并电离,产生离子束。 通过串联质谱仪在离子束上执行从占空比列表中读取的一系列MRM跃迁。 当检测到第一组的至少一个哨兵转变时,由哨兵转变识别的下一组被放置在列表上。

    CONTROLLING GAS-PHASE ION INTERACTIONS
    3.
    发明申请
    CONTROLLING GAS-PHASE ION INTERACTIONS 审中-公开
    控制气相离子相互作用

    公开(公告)号:WO2015189552A8

    公开(公告)日:2017-03-02

    申请号:PCT/GB2015000184

    申请日:2015-06-15

    Applicant: MICROMASS LTD

    CPC classification number: G01N27/624 H01J49/0031 H01J49/0422 H01J49/421

    Abstract: A mass spectrometer or ion mobility spectrometer is disclosed comprising: a first device for separating ions or molecules according to a physicochemical property (3); an ion mobility separation device (4) for receiving and separating at least some of said ions or ions derived from said molecules according to their ion mobility; a gas supply (6-10) connected to said ion mobility separation device (4) for supplying gas into said ion mobility separation device (4); and a control system (11) configured to adjust said gas supply (6-10) so as to change the composition of gas within the ion mobility separation device (4) as a function of time.

    Abstract translation: 公开了质谱仪或离子迁移谱仪,其包括:用于根据物理化学性质(3)分离离子或分子的第一装置; 离子迁移率分离装置(4),用于根据其离子迁移率接收和分离衍生自所述分子的至少一些所述离子或离子; 连接到所述离子迁移率分离装置(4)的用于将气体供应到所述离子迁移率分离装置(4)中的气体供应装置(6-10); 以及控制系统(11),其被配置为调节所述气体供应(6-10),以便随着时间的推移改变离子迁移率分离装置(4)内的气体的组成。

    A METHOD OF MASS ANALYSIS USING ION FILTERING
    4.
    发明申请
    A METHOD OF MASS ANALYSIS USING ION FILTERING 审中-公开
    使用离子过滤的质量分析方法

    公开(公告)号:WO2016193699A1

    公开(公告)日:2016-12-08

    申请号:PCT/GB2016/051579

    申请日:2016-05-31

    Inventor: MOULDS, Richard

    Abstract: A method of mass spectrometry is disclosed comprising detecting the ions transmitted by a mass filter (4) with a detector (6); changing the RF and/or DC voltage applied to the mass filter (4) during a voltage transition period so as to change the mass to charge ratio capable of being transmitted by the mass filter (4); preventing ions from reaching the detector during the voltage transition period; and allowing ions to be transmitted to the detector (6) after the voltage transition period.

    Abstract translation: 公开了一种质谱方法,包括用检测器(6)检测由质量过滤器(4)传输的离子; 改变在电压过渡期间施加到质量过滤器(4)的RF和/或DC电压,以便改变能够被质量过滤器(4)传输的质量与电荷比; 在电压过渡期间防止离子到达检测器; 并且在电压转换周期之后允许离子被传输到检测器(6)。

    TRAP FILL TIME DYNAMIC RANGE ENHANCEMENT
    5.
    发明申请
    TRAP FILL TIME DYNAMIC RANGE ENHANCEMENT 审中-公开
    TRAP填充时间动态范围增强

    公开(公告)号:WO2016181167A1

    公开(公告)日:2016-11-17

    申请号:PCT/GB2016/051395

    申请日:2016-05-13

    CPC classification number: H01J49/025 H01J49/0031 H01J49/0036 H01J49/4265

    Abstract: A method of mass and/or ion mobility spectrometry is disclosed that comprises accumulating ions for a first period of time (T1) one or more times so as to form one or more first groups of ions, accumulating ions for a second period of time (T2) one or more times so as to form one or more second groups of ions, wherein the second period of time (T2) is less that the first period of time (T1), analysing the one or more first groups of ions to generate one or more first data sets, analysing the one or more second groups of ions to generate one or more second data sets, and determining whether the one or more first data sets comprise saturated and/or distorted data. If it is determined that the one or more first data sets comprise saturated and/or distorted data, then the method further comprises replacing the saturated and/or distorted data from the one or more first data sets with corresponding data from the one or more second data sets.

    Abstract translation: 公开了一种质量和/或离子迁移谱的方法,其包括将离子累积第一时间段(T1)一次或多次以形成一个或多个第一离子组,在第二时间段内积聚离子( T2)一次或多次以形成一个或多个第二组离子,其中第二时间段(T2)小于第一时间段(T1),分析一个或多个第一组离子以产生 一个或多个第一数据集,分析所述一个或多个第二组离子以生成一个或多个第二数据集,以及确定所述一个或多个第一数据集是否包括饱和和/或失真的数据。 如果确定一个或多个第一数据集包括饱和和/或失真的数据,则该方法还包括用来自一个或多个第二数据的相应数据从一个或多个第一数据集中替换饱和和/或失真的数据 数据集。

    VERFAHREN ZUR MASSENSPEKTROMETRISCHEN UNTERSUCHUNG EINES GASES UND MASSENSPEKTROMETER
    6.
    发明申请
    VERFAHREN ZUR MASSENSPEKTROMETRISCHEN UNTERSUCHUNG EINES GASES UND MASSENSPEKTROMETER 审中-公开
    方法质谱分析气体和质谱仪

    公开(公告)号:WO2016177503A1

    公开(公告)日:2016-11-10

    申请号:PCT/EP2016/055842

    申请日:2016-03-17

    Abstract: Die Erfindung betrifft ein Verfahren zur massenspektrometrischen Untersuchung eines Gases (4), umfassend: Ionisieren des Gases (4) zum Erzeugen von Ionen (4a, 4b), sowie Speichern, Anregen und Detektieren zumindest eines Teils der erzeugten Ionen (4a, 4b) in einer FT-Ionenfalle (2). Bei dem Verfahren umfasst das Erzeugen und Speichern der Ionen (4a, 4b) in der FT-Ionenfalle (2) und/oder das Anregen der Ionen (4a, 4b) vor dem Detektieren der Ionen (4a, 4b) in der FT-Ionenfalle (2) mindestens eine selektive, vom Masse-zu-Ladungsverhältnis (m/z) der Ionen (4a, 4b) abhängige IFT-Anregung, insbesondere eine SWIFT-Anregung (10). Die Erfindung betrifft auch ein Massenspektrometer (1).

    Abstract translation: 本发明涉及一种用于气体的质谱分析的方法(4),包括:离子化用于产生离子的气体(4)(4A,4B),并存储,刺激,至少检测产生的离子的一部分(图4a,4b)在 的FT-离子阱(2)。 在该方法中产生和离子存储包括(4A,4B)在FT-离子阱(2)和/或离子的激发(4A,4B)之前检测的离子的至(4A,4B)在FT-离子阱 (2)至少一种选择性的,从离子的质荷比(M / Z)(图4a,4b)依赖IFT激励,特别是SWIFT激励(10)。 本发明还涉及一种质谱仪(1)。

    网络化质量分析方法及装置
    7.
    发明申请

    公开(公告)号:WO2016177164A1

    公开(公告)日:2016-11-10

    申请号:PCT/CN2016/077114

    申请日:2016-03-23

    Abstract: 一种网络化质量分析方法及装置,涉及质谱仪、离子质量分析领域,该装置包括离子源,用于产生待测离子;离子传输器,用于传输所述待测离子;离子偏转器,用于控制待测离子进行偏转;多个质量分析器,用于对所述待测离子进行质量分析;其中所述离子传输器与多个所述质量分析器之一相连,多个所述质量分析器分别与所述离子偏转器相连,所述离子源产生所述待测离子,所述待测离子通过所述离子传输器进入与所述离子偏转器相连的任意所述质量分析器进行质量分析,通过所述离子偏转器将剩余的所述待测离子送入相应的所述质量分析器中进行质量分析。本装置能提高连续型离子源质量分析占空比,获得每个时间段内离子束内更多质荷比信息。

    MALDI-TOF MS METHOD AND APPARATUS FOR ASSAYING AN ANALYTE IN A BODILY FLUID FROM A SUBJECT
    8.
    发明申请
    MALDI-TOF MS METHOD AND APPARATUS FOR ASSAYING AN ANALYTE IN A BODILY FLUID FROM A SUBJECT 审中-公开
    MALDI-TOF MS方法和装置,用于测定来自主体的体液中的分析物

    公开(公告)号:WO2016160511A1

    公开(公告)日:2016-10-06

    申请号:PCT/US2016/024018

    申请日:2016-03-24

    CPC classification number: H01J49/164 H01J49/0031 H01J49/40

    Abstract: A method for assaying an analyte in a bodily fluid from a subject includes collecting a sample of the bodily fluid comprising an analyte of interest from a subject. A sample with the bodily fluid comprising the analyte of interest suitable for analysis by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF) is then prepared. Mass spectrometry is then performed to determine mass-to-charge ratios and ion abundances of the bodily fluid or its components. The mass-to-charge ratio values and the ion abundance of each of these ratios are then analyzed using calibration standards to interpret a resulting mass spectrum and to provide quantitative information.

    Abstract translation: 用于测定来自受试者的体液中的分析物的方法包括从受试者收集包含感兴趣分析物的体液样品。 然后制备包含适合于通过基质辅助激光解吸/电离飞行时间质谱(MALDI-TOF)分析的感兴趣分析物的体液样品。 然后进行质谱以测定体液或其组分的质荷比和离子丰度。 然后使用校准标准分析这些比率中的每一个的质荷比值和离子丰度,以解释所得质谱并提供定量信息。

    SYSTEM AND METHOD FOR CHARACTERIZING IONS USING A SUPERCONDUCTING TRANSMISSION LINE DETECTOR
    9.
    发明申请
    SYSTEM AND METHOD FOR CHARACTERIZING IONS USING A SUPERCONDUCTING TRANSMISSION LINE DETECTOR 审中-公开
    使用超导传输线检测器表征离子的系统和方法

    公开(公告)号:WO2016144628A1

    公开(公告)日:2016-09-15

    申请号:PCT/US2016/020340

    申请日:2016-03-02

    Abstract: A system and method for characterizing incident ions are provided. The method includes positioning a transmission line detector to receive incident ions, the transmission line detector comprising a superconducting meandering wire defining a detection area for incident ions, and applying a bias current to the transmission line detector. The method also includes detecting a first signal produced in the transmission line detector due to an ion impacting the detection area, and detecting a second signal produced in the transmission line detector due to the ion impacting the detection area. The method further includes analyzing the first signal and the second signal to characterize the ion. In some aspects, the method further includes identifying a delay between the first signal and the second signal to determine, using the identified delay, a location of the ion on the detection area.

    Abstract translation: 提供了表征入射离子的系统和方法。 该方法包括定位传输线检测器以接收入射离子,传输线检测器包括限定入射离子的检测区域的超导蜿蜒线,以及向传输线检测器施加偏置电流。 该方法还包括检测由于离子影响检测区域而在传输线检测器中产生的第一信号,以及检测由于离子影响检测区域而在传输线检测器中产生的第二信号。 该方法还包括分析第一信号和第二信号以表征离子。 在一些方面,所述方法还包括识别所述第一信号和所述第二信号之间的延迟,以使用所识别的延迟来确定所述检测区域上的所述离子的位置。

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