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公开(公告)号：WO2007063133A2
公开(公告)日：2007-06-07
申请号：PCT/EP2006/069218
申请日：2006-12-01
Applicant: DSM IP ASSETS B.V. , BAUWELEERS, Hugo Marc Karel , GROESENEKEN, Dominique Robert , PEIJ, VAN, Noël Nicolaas Maria Elisabeth
Inventor： BAUWELEERS, Hugo Marc Karel , GROESENEKEN, Dominique Robert , PEIJ, VAN, Noël Nicolaas Maria Elisabeth
Abstract: The present invention relates to newly identified genes that encode proteins that are involved in the (bio)synthesis of citric acid. The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of citric acid from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for production of citric acid.
Abstract translation: 本发明涉及编码参与柠檬酸（生物）合成的蛋白质的新鉴定的基因。 本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。 本发明还涉及所述多核苷酸和多肽作为生物技术工具在从微生物生产柠檬酸中的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或 所述微生物中发酵产物的生产效率。 还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。 本发明还涉及基因工程微生物及其生产柠檬酸的用途。
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公开(公告)号：WO2007063133A3
公开(公告)日：2007-09-13
申请号：PCT/EP2006069218
申请日：2006-12-01
Applicant: DSM IP ASSETS BV , BAUWELEERS HUGO MARC KAREL , GROESENEKEN DOMINIQUE ROBERT , PEIJ VAN NOEL NICOLAAS MARIA E
Inventor： BAUWELEERS HUGO MARC KAREL , GROESENEKEN DOMINIQUE ROBERT , PEIJ VAN NOEL NICOLAAS MARIA E
Abstract: The present invention relates to newly identified genes that encode proteins that are involved in the (bio)synthesis of citric acid. The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of citric acid from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for production of citric acid.
Abstract translation: 本发明涉及编码参与柠檬酸（生物）合成的蛋白质的新鉴定的基因。 本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。 本发明还涉及所述多核苷酸和多肽作为生物技术工具在从微生物生产柠檬酸中的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或 所述微生物中发酵产物的生产效率。 还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。 本发明还涉及基因工程微生物及其生产柠檬酸的用途。
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公开(公告)号：WO2008107472A2
公开(公告)日：2008-09-12
申请号：PCT/EP2008/052717
申请日：2008-03-06
CPC classification number: C12P7/48 , C07C29/88 , C07C31/225
Abstract: The present invention relates to a method for producing citric acid from glycerol with a yield of more than 70%. The method comprises fermenting a filamentous fungus on a substrate which comprises glycerol. The advantage of the method according to the invention is that a widely available substrate, i.e. glycerol, can be used and that yields may be obtained which are much higher than the yields obtained using state of the art methods for producing citric acid from glycerol. The glycerol is used in combination with one or more other carbon sources.
Abstract translation: 本发明涉及从甘油中生产柠檬酸的方法，其产率高于70％。 该方法包括在包含甘油的底物上发酵丝状真菌。 根据本发明的方法的优点是可以使用广泛可用的底物，即甘油，并且可以获得比从用甘油制备柠檬酸的现有技术方法获得的产量高得多的产率。 甘油与一种或多种其他碳源组合使用。
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4.发明申请
公开(公告)号：WO2008107472A3
公开(公告)日：2008-10-23
申请号：PCT/EP2008052717
申请日：2008-03-06
CPC classification number: C12P7/48 , C07C29/88 , C07C31/225
Abstract: The present invention relates to a method for producing citric acid from glycerol with a yield of more than 70%. The method comprises fermenting a filamentous fungus on a substrate which comprises glycerol. The advantage of the method according to the invention is that a widely available substrate, i.e. glycerol, can be used and that yields may be obtained which are much higher than the yields obtained using state of the art methods for producing citric acid from glycerol. The glycerol is used in combination with one or more other carbon sources.
Abstract translation: 本发明涉及从甘油中生产柠檬酸的方法，其产率高于70％。 该方法包括在包含甘油的底物上发酵丝状真菌。 根据本发明的方法的优点是可以使用广泛可用的底物，即甘油，并且可以获得比从用甘油制备柠檬酸的现有技术方法获得的产量高得多的产率。 甘油与一种或多种其他碳源组合使用。
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