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    METHOD OF PREPARING PLANT EXTRACTS WITH A REDUCED CONTENT OF UNPOLAR ENVIRONMENTAL CONTAMINANTS
    2.
    发明申请
    METHOD OF PREPARING PLANT EXTRACTS WITH A REDUCED CONTENT OF UNPOLAR ENVIRONMENTAL CONTAMINANTS 审中-公开
    用于生产厂与环境管理物质的非极性外国含量降低EXTRACTS

    公开(公告)号：WO2008052754A3

    公开(公告)日：2008-07-10

    申请号：PCT/EP2007009429

    申请日：2007-10-30

    Applicant: WILLMAR SCHWABE GMBH & CO KG ,  ERDELMEIER CLEMENS ,  HAUER HERMANN ,  WAIMER FRANK

    Inventor： ERDELMEIER CLEMENS ,  HAUER HERMANN ,  WAIMER FRANK

    IPC: A61K36/00

    CPC classification number: A61K36/00 ,  A23L33/105

    Abstract: The present invention relates to a method of preparing a plant extract, with the exception of an extract of Ginkgo biloba, with a content of unpolar environmental contaminants which is reduced over that of the starting extract, characterized by the following process steps: (a) preparation of an aqueous-ketonic or aqueous-alcoholic solution of a starting extract, (b) (i) applying the solution to an adsorber resin and (ii) eluting the adsorber resin with an aqueous C 3 -C 6 -ketone of an aqueous C 1 -C 3 -alcohol, and/or (c) extracting the solution thus obtained, or the solution of the starting extract, with a C 5 -C 7 and hydrocarbon or mixtures thereof, and removal of the hydrocarbon phase, and (d) if appropriate, concentrating-drying the resulting solution to give a dry extract. The invention furthermore relates to a plant extract (liquid extract or spissum extract, but also dry extract) with a content of unpolar environmental contaminants which is reduced over that of the starting extract, obtainable by the method according to the invention, and to a composition comprising this plant extract (for example pharmaceutical, foodstuff or other preparations).

    Abstract translation: 本发明涉及一种用于植物提取物的制备方法，用银杏提取物外，相对于所述起始提取物的环境的非极性杂质含量降低，其特征在于以下步骤：（a）制备起始提取物的水 - 酮或水 - 醇溶液 ，（b）（i）施加到吸附器树脂和（ii）洗脱与含水ç吸附剂树脂3 -C 6 酮或含水ç 1 < / SUB> -C 3 醇，和/或（c）提取所得到的溶液或起始提取物与C 5 -C 7 < /烃类或其混合物并分离烃相，和（d）任选浓缩并干燥所得溶液至干燥提取物。 本发明还涉及一种植物提取物（液体提取物或spissum提取物以及干提取物）相对于所述起始提取物的环境的非极性杂质，通过本发明的方法以及一个这种植物含有提取剂（例如，药物，食品或其他制剂）而获得的减小的含量。

    METHOD FOR PRODUCING GINKGO EXTRACTS, HAVING A REDUCED CONTENT OF NON-POLAR PLANT INGREDIENTS AND ECOLOGICAL NON-POLAR FOREIGN SUBSTANCES
    4.
    发明申请
    METHOD FOR PRODUCING GINKGO EXTRACTS, HAVING A REDUCED CONTENT OF NON-POLAR PLANT INGREDIENTS AND ECOLOGICAL NON-POLAR FOREIGN SUBSTANCES 审中-公开
    于制备银杏具有降低含量的非极性植物成分和环境管理物质的非极性外国EXTRACTS

    公开(公告)号：WO2006117168A3

    公开(公告)日：2007-02-15

    申请号：PCT/EP2006004028

    申请日：2006-04-28

    Applicant: SCHWABE WILLMAR GMBH & CO ,  OSCHMANN RAINER ,  HAUER HERMANN ,  WAIMER FRANK ,  STUMPF KARL-HEINZ

    Inventor： OSCHMANN RAINER ,  HAUER HERMANN ,  WAIMER FRANK ,  STUMPF KARL-HEINZ

    IPC: A61K36/16 ,  A23L33/00

    CPC classification number: A61K36/16 ,  A23L33/105 ,  A23V2002/00 ,  A23V2250/2122

    Abstract: The invention relates to a method for producing an extract of Ginkgo biloba, having a content of non-polar plant ingredients and ecological non-polar foreign substances, reduced compared with the initial extract. Said method is characterised in that it comprises the steps of (a) producing an aqueous ketonic or aqueous alcoholic solution of a Ginkgo biloba initial extract and applying said solution to an adsorbent resin, (b) eluting the adsorbent resin with an aqueous C 3 -C 6 ketone or an aqueous C 1 -C 3 alcohol and (c), optionally, concentrating and drying the obtained extract solution into a dry extract. Said invention also relates to an extract (liquid or thick or dry extract) of Ginkgo biloba obtained by said method, said extract having a content of non-polar plant ingredients and ecological non-polar foreign substances, reduced compared with the initial extract.

    Abstract translation: 本发明涉及一种用于从银杏叶提取物的制备方法相对于所述起始提取物非极性植物成分和环境方面的非极性杂质的含量降低，其特征在于以下步骤：（a）制备银杏的水 - 酮或水 - 醇溶液起始提取物和 施加到吸附器树脂，（b）洗脱与含水ç 3 -C 6 酮或含水ç 1 -C 3 醇和（c）任选地浓缩并干燥由此得到的提取物溶液，以干提取物。 本发明还涉及一种银杏叶提取物（液体提取物或spissum提取物以及干提取物）相对于所述起始提取物非极性植物成分和环境方面的非极性杂质，用本发明的方法获得的含量降低。

    USE OF TRISUBSTITUTED BENZOPYRANONES
    5.
    发明申请
    USE OF TRISUBSTITUTED BENZOPYRANONES 审中-公开
    使用三取代BENZOPYRANONEN的

    公开(公告)号：WO2006002918A3

    公开(公告)日：2006-05-04

    申请号：PCT/EP2005007051

    申请日：2005-06-30

    Applicant: BIOPLANTA ARZNEIMITTEL GMBH ,  GERMER STEFAN ,  HAUER HERMANN ,  KOCH EGON ,  SCHOETZ KARL

    Inventor： GERMER STEFAN ,  HAUER HERMANN ,  KOCH EGON ,  SCHOETZ KARL

    IPC: C07D311/18 ,  A61K31/352

    CPC classification number: C07D311/16 ,  A23L33/105 ,  A61K31/352 ,  C07D311/14 ,  C07D311/18

    Abstract: The invention relates to the use of the trisubstituted benzopyranones of general formula (I), wherein R 6 , R 7 and R 8 independently represent H or SO 3 H, and to the physiologically acceptable salts thereof for use in the treatment or prophylaxis of pathological conditions that are related to oxidative stress and/or inflammatory reactions. The invention also relates to novel trisubstituted benzopyranones and to the physiologically acceptable salts thereof, and to plant extracts, drugs, dietetic food and pharmaceutical preparations containing said compounds.

    Abstract translation: 本发明涉及使用三取代Benzopyranonen通式（I），其中基团R 6 ，R 7 和R 8 彼此独立地 H或3 为H SO ，以及它们用于治疗与氧化应激和/或炎性反应和新的三取代benzopyranones，和生理学可接受的盐有关的病理症状的治疗或预防生理学可接受的盐。 本发明还涉及含有这些化合物的组合物，植物提取物，药物，营养食品和药物制剂。

    BENZOPYRANONES, METHOD OF PREPARING THEM AND THEIR USE
    7.
    发明申请
    BENZOPYRANONES, METHOD OF PREPARING THEM AND THEIR USE 审中-公开
    新benzopyranones，方法用于生产和使用

    公开(公告)号：WO1994008985A1

    公开(公告)日：1994-04-28

    申请号：PCT/EP1993002742

    申请日：1993-10-06

    Applicant: DR. WILLMAR SCHWABE GMBH & CO. ,  NÖLDNER, Michael ,  CHATTERJEE, Shyam, Sunder ,  HAUER, Hermann

    Inventor： DR. WILLMAR SCHWABE GMBH & CO.

    IPC: C07D311/18

    CPC classification number: C07D311/16

    Abstract: Described are 2H-1-benzopyran-2-ones (coumarin derivatives) of general formula (I) in which R is a hydroxyl group, a lower-alkoxy group, a cycloalkoxy group with 4 to 6 C-atoms or the alkyl- or arylsulphonyloxy group R -SO2O-; R and R , independently of each other, are hydrogen atoms, hydroxyl groups, lower-alkyl groups or cycloalkoxy groups with 4 to 6-atoms; R is a hydrogen atom, a lower-alkyl group with 1 to 4 C-atoms or a phenyl group; Y is a nitrogen atom, a CH group or a COH group; R is a phenyl, naphthyl, pyridinyl or pyrimidinyl group which may optionally be substituted by one or two C1-C5 alkyl groups, by one or two halogen atoms, by a halogen and C1-C5 alkyl together, by perfluoroalkyl with 1 to 3 C-atoms by C1-C5 alkoxy, by hydroxy, by methylenedioxy or by nitro; R is a lower-alkyl group, a cycloalkyl group with 4 to 6 C-atoms or a phenyl group which may optionally be substituted by one or two C1-C5 alkyl groups, by one or two halogens atoms, or by perfluoroalkyl with 1 to 3 C-atoms; and n = 1 to 4; plus their addition compounds with physiologically tolerated acids. Also described are methods of preparing these compounds, intermediates in their preparation and methods of preparing such intermediates. The coumarin derivatives described possess a neuroprotective and psychopharmacological action. The invention also concerns drugs containing these compounds.

    EXTRACTS FROM EPIMEDIUM SPECIES METHOD FOR PRODUCTION AND USE THEREOF
    8.
    发明申请
    EXTRACTS FROM EPIMEDIUM SPECIES METHOD FOR PRODUCTION AND USE THEREOF 审中-公开
    淫羊藿提取物种类，方法用于生产和使用

    公开(公告)号：WO2007031140A3

    公开(公告)日：2007-08-09

    申请号：PCT/EP2006006929

    申请日：2006-07-14

    Applicant: SCHWABE WILLMAR GMBH & CO ,  KOCH EGON ,  ERDELMEIER CLEMENS ,  HAUER HERMANN

    Inventor： KOCH EGON ,  ERDELMEIER CLEMENS ,  HAUER HERMANN

    IPC: A61K36/296 ,  A61P5/24 ,  A61P15/08

    CPC classification number: A61K36/296

    Abstract: The invention relates to special purpose extracts (liquid and dry extracts) from Epimedium species, methods for production thereof, medicaments and foodstuffs comprising the same, in particular, dietary products and adjuncts including Medical Food and Dietary Supplements and use of the special purpose extracts for the prophylaxis and treatment of disease states caused by a lack of oestrogen or by a dysregulation of sex hormone metabolism, in particular, oestrogen metabolism.

    Abstract translation: 本发明涉及从淫羊藿物种特殊提取物（Flüssigund干提取物），它们的制备方法，含有它们的食品，特别是营养食品，食品补充剂，以及“医疗食品”和“膳食补充剂”，和使用用于预防和治疗的特殊的萃取药物组合物 疾病状态引起的雌激素缺乏或通过性激素代谢，特别是雌激素代谢失调。

    PYRANONES, METHOD FOR THE PRODUCTION AND USE THEREOF
    10.
    发明申请
    PYRANONES, METHOD FOR THE PRODUCTION AND USE THEREOF 审中-公开
    吡喃酮，它们的制备和使用方法

    公开(公告)号：WO9925716A9

    公开(公告)日：1999-09-02

    申请号：PCT/EP9807241

    申请日：1998-11-12

    Applicant: SCHWABE WILLMAR GMBH & CO ,  CHATTERJEE SHYAM SUNDER ,  HAUER HERMANN

    Inventor： CHATTERJEE SHYAM SUNDER ,  HAUER HERMANN

    IPC: C07D309/38 ,  A61K31/351 ,  A61K31/366 ,  A61P25/00 ,  A61P25/08 ,  C07D309/36 ,  C07D407/06 ,  A61K31/365

    CPC classification number: C07D407/06 ,  C07D309/36

    Abstract: The invention relates to novel 2H-1-pyran-2-ones of general formula (I), wherein R represents an alkyl radical with 2-5 C atoms, a cycloalkyl radical with 4-6 C atoms, a cycloalkyl radical with 4-8 C atoms or an alkoxy alkyl radical with a total of 3-5 C atoms and R represents a 2-(3, 4- methylene dioxyphenyl)ethyl radical or a 2-phenyl ethenyl radical substituted with R , R and R in positions 3, 4 and 5, whereby independently from each other R and R represent methoxy or ethoxy and R is a straight chain or branched alkoxy radical with 1-5 C atoms, an alkenyl radical with 3-5 C atoms, a cycloalkoxy radical with 4-6 C atoms, a cycloalkyl radical with 4-8 C atoms or an alkoxy alkoxy radical with a total of 3-5 C atoms. The invention also relates to a method for producing said compounds in addition to novel intermediate products and to a method for the production thereof. The novel pyranone derivatives have an anti-convulsive and/or anti-epileptic effect in addition to a neuroprotective effect or act against neurodegenerate diseases. The invention further relates to medicaments containing these compounds.

    Abstract translation: 本发明涉及新的通式-2H-1-吡喃-2-酮（I），其中R <1>与具有2至5个碳原子，具有4至6个碳原子，环烷基烷基的环烷基 - 烷基基团 乙基4至8个C原子或烷氧基烷基具有总共3至5个C原子且R <2> 2-（3,4-亚甲二氧苯基），或在位置3，4和5，其中R <3>在苯环 ，R <4>和R <5>取代的2- Phenylethenylrest，其中独立于R <3>和R <5>是甲氧基或乙氧基和R <4>是具有1〜5个碳原子的直链或支链烷氧基， 具有3至5个碳原子，环烷氧基具有4至6个C原子，环烷基烷氧基的碳原子数4至8或烷氧基烷氧基基团，共3至5个碳原子的链烯基氧基。 此外，描述了制备这些化合物和新中间体的方法及其制备方法。 新的吡喃酮衍生物具有抗神经变性疾病抗惊厥剂和/或抗癫痫作用和神经保护作用和/或活性。 含有这些化合物的药物也是本发明的主题。

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